Abstract

Although ultrasound arrays have been exploited in photoacoustic imaging to improve imaging speed, ultrasound-array-based optical-resolution photoacoustic microscopy (OR-PAM) has never been achieved previously to our knowledge. Here we present our development of multifocal OR-PAM using a microlens array for optical illumination and an ultrasound array for photoacoustic detection. Our system is capable of imaging hemoglobin concentration and oxygenation in individual microvessels in vivo at high speed. Compared with a single focus, multiple foci reduce the scanning load and increase the imaging speed significantly. The current multifocal system can acquire 1000×500×200 voxels at 10μm lateral resolution within 4min.

© 2011 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
Wide-field two-dimensional multifocal optical-resolution photoacoustic-computed microscopy

Jun Xia, Guo Li, Lidai Wang, Mohammadreza Nasiriavanaki, Konstantin Maslov, John A. Engelbach, Joel R. Garbow, and Lihong V. Wang
Opt. Lett. 38(24) 5236-5239 (2013)

Optical-resolution photoacoustic microscopy for in vivo imaging of single capillaries

Konstantin Maslov, Hao F. Zhang, Song Hu, and Lihong V. Wang
Opt. Lett. 33(9) 929-931 (2008)

Multi-parametric quantitative microvascular imaging with optical-resolution photoacoustic microscopy in vivo

Zhenyuan Yang, Jianhua Chen, Junjie Yao, Riqiang Lin, Jing Meng, Chengbo Liu, Jinhua Yang, Xiang Li, Lihong Wang, and Liang Song
Opt. Express 22(2) 1500-1511 (2014)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Supplementary Material (1)

» Media 1: MPG (3356 KB)     

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (3)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription