Abstract

Phase detection has been utilized to enhance the sensitivity of surface plasmon resonance (SPR) sensors for a long time. However, an inherent drawback for phase sensitive SPR sensors are their limited dynamic range, which has greatly hindered wide applications of such sensors. In this Letter, a design combining phase detection and angular interrogation has been proposed to provide an SPR sensor with both high sensitivity and wide dynamic range. As a result, a resolution of 2.2×107RIU with a dynamic range of over 0.06RIU has been achieved simultaneously. An added advantage of this design is the flexibility for sensitivity and dynamic range adjustment.

© 2011 Optical Society of America

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2011 (1)

2009 (2)

A. V. Kabashin, S. Patskovsky, and A. N. Grigorenko, Opt. Express 17, 21191 (2009).
[CrossRef] [PubMed]

W. Yuan, H. P. Ho, S. Y. Wu, Y. K. Suen, and S. K. Kong, Sens. Actuators A 151, 23 (2009).
[CrossRef]

2008 (3)

Y. C. Li, Y. F. Chang, L. C. Su, and C. Chou, Anal. Chem. 80, 5590 (2008).
[CrossRef] [PubMed]

J. Homola, Chem. Rev. 108, 462 (2008).
[CrossRef] [PubMed]

S. Patskovsky, M. Maisonneuve, M. Meunier, and A. V. Kabashin, Opt. Express 16, 21305 (2008).
[CrossRef] [PubMed]

2007 (2)

P. P. Markowicz, W. C. Law, A. Baev, P. Prasad, S. Patskovsky, and A. V. Kabashin, Opt. Express 15, 1745 (2007).
[CrossRef] [PubMed]

W. C. Law, P. Markowicz, K. T. Yong, I. Roy, A. Baev, S. Patskovsky, A. V. Kabashin, H. P. Ho, and P. N. Prasad, Biosens. Bioelectron. 23, 627 (2007).
[CrossRef] [PubMed]

2006 (1)

S. Rodriguez-Mozaz, M. J. L. de Alda, and D. Barcelo, Anal. Bioanal. Chem. 386, 1025 (2006).
[CrossRef] [PubMed]

2004 (3)

2002 (1)

H. P. Ho, W. W. Lam, and S. Y. Wu, Rev. Sci. Instrum. 73, 3534 (2002).
[CrossRef]

1994 (1)

S. S. Deshpande and R. M. Rocco, Food Technol. 48, 146(1994).

Baev, A.

P. P. Markowicz, W. C. Law, A. Baev, P. Prasad, S. Patskovsky, and A. V. Kabashin, Opt. Express 15, 1745 (2007).
[CrossRef] [PubMed]

W. C. Law, P. Markowicz, K. T. Yong, I. Roy, A. Baev, S. Patskovsky, A. V. Kabashin, H. P. Ho, and P. N. Prasad, Biosens. Bioelectron. 23, 627 (2007).
[CrossRef] [PubMed]

Barcelo, D.

S. Rodriguez-Mozaz, M. J. L. de Alda, and D. Barcelo, Anal. Bioanal. Chem. 386, 1025 (2006).
[CrossRef] [PubMed]

Chang, Y. F.

Y. C. Li, Y. F. Chang, L. C. Su, and C. Chou, Anal. Chem. 80, 5590 (2008).
[CrossRef] [PubMed]

Chou, C.

Y. C. Li, Y. F. Chang, L. C. Su, and C. Chou, Anal. Chem. 80, 5590 (2008).
[CrossRef] [PubMed]

de Alda, M. J. L.

S. Rodriguez-Mozaz, M. J. L. de Alda, and D. Barcelo, Anal. Bioanal. Chem. 386, 1025 (2006).
[CrossRef] [PubMed]

Deshpande, S. S.

S. S. Deshpande and R. M. Rocco, Food Technol. 48, 146(1994).

Duyne, R. P. V.

A. J. Haes and R. P. V. Duyne, Exp. Rev. Mol. Diagn. 4, 527(2004).
[CrossRef]

Grigorenko, A. N.

Haes, A. J.

A. J. Haes and R. P. V. Duyne, Exp. Rev. Mol. Diagn. 4, 527(2004).
[CrossRef]

Ho, H. P.

S. P. Ng, C. M. L. Wu, S. Y. Wu, and H. P. Ho, Opt. Express 19, 4521 (2011).
[CrossRef] [PubMed]

W. Yuan, H. P. Ho, S. Y. Wu, Y. K. Suen, and S. K. Kong, Sens. Actuators A 151, 23 (2009).
[CrossRef]

W. C. Law, P. Markowicz, K. T. Yong, I. Roy, A. Baev, S. Patskovsky, A. V. Kabashin, H. P. Ho, and P. N. Prasad, Biosens. Bioelectron. 23, 627 (2007).
[CrossRef] [PubMed]

S. Y. Wu, H. P. Ho, W. C. Law, C. L. Lin, and S. K. Kong, Opt. Lett. 29, 2378 (2004).
[CrossRef] [PubMed]

H. P. Ho, W. W. Lam, and S. Y. Wu, Rev. Sci. Instrum. 73, 3534 (2002).
[CrossRef]

Y. H. Huang, H. P. Ho, S. Y. Wu, S. K. Kong, and M. Somekh, ““Phase sensitive surface plasmon resonance sensors: a review,” Opt. Express, submitted for publication.

Homola, J.

J. Homola, Chem. Rev. 108, 462 (2008).
[CrossRef] [PubMed]

J. Homola, Surface Plasmon Resonance Based Sensors (Springer, 2006).
[CrossRef]

Huang, Y. H.

Y. H. Huang, H. P. Ho, S. Y. Wu, S. K. Kong, and M. Somekh, ““Phase sensitive surface plasmon resonance sensors: a review,” Opt. Express, submitted for publication.

Kabashin, A. V.

Kong, S. K.

W. Yuan, H. P. Ho, S. Y. Wu, Y. K. Suen, and S. K. Kong, Sens. Actuators A 151, 23 (2009).
[CrossRef]

S. Y. Wu, H. P. Ho, W. C. Law, C. L. Lin, and S. K. Kong, Opt. Lett. 29, 2378 (2004).
[CrossRef] [PubMed]

Y. H. Huang, H. P. Ho, S. Y. Wu, S. K. Kong, and M. Somekh, ““Phase sensitive surface plasmon resonance sensors: a review,” Opt. Express, submitted for publication.

Lam, W. W.

H. P. Ho, W. W. Lam, and S. Y. Wu, Rev. Sci. Instrum. 73, 3534 (2002).
[CrossRef]

Law, W. C.

Li, Y. C.

Y. C. Li, Y. F. Chang, L. C. Su, and C. Chou, Anal. Chem. 80, 5590 (2008).
[CrossRef] [PubMed]

Lin, C. L.

Maisonneuve, M.

Markowicz, P.

W. C. Law, P. Markowicz, K. T. Yong, I. Roy, A. Baev, S. Patskovsky, A. V. Kabashin, H. P. Ho, and P. N. Prasad, Biosens. Bioelectron. 23, 627 (2007).
[CrossRef] [PubMed]

Markowicz, P. P.

Meunier, M.

Ng, S. P.

Pao, M. C.

Patskovsky, S.

Prasad, P.

Prasad, P. N.

W. C. Law, P. Markowicz, K. T. Yong, I. Roy, A. Baev, S. Patskovsky, A. V. Kabashin, H. P. Ho, and P. N. Prasad, Biosens. Bioelectron. 23, 627 (2007).
[CrossRef] [PubMed]

Rocco, R. M.

S. S. Deshpande and R. M. Rocco, Food Technol. 48, 146(1994).

Rodriguez-Mozaz, S.

S. Rodriguez-Mozaz, M. J. L. de Alda, and D. Barcelo, Anal. Bioanal. Chem. 386, 1025 (2006).
[CrossRef] [PubMed]

Roy, I.

W. C. Law, P. Markowicz, K. T. Yong, I. Roy, A. Baev, S. Patskovsky, A. V. Kabashin, H. P. Ho, and P. N. Prasad, Biosens. Bioelectron. 23, 627 (2007).
[CrossRef] [PubMed]

Schasfoort, R. B. M.

R. B. M. Schasfoort and A. J. Tudos, Handbook of Surface Plasmon Resonance (Royal Society of Chemistry, 2008).
[CrossRef]

Somekh, M.

Y. H. Huang, H. P. Ho, S. Y. Wu, S. K. Kong, and M. Somekh, ““Phase sensitive surface plasmon resonance sensors: a review,” Opt. Express, submitted for publication.

Su, L. C.

Y. C. Li, Y. F. Chang, L. C. Su, and C. Chou, Anal. Chem. 80, 5590 (2008).
[CrossRef] [PubMed]

Suen, Y. K.

W. Yuan, H. P. Ho, S. Y. Wu, Y. K. Suen, and S. K. Kong, Sens. Actuators A 151, 23 (2009).
[CrossRef]

Tudos, A. J.

R. B. M. Schasfoort and A. J. Tudos, Handbook of Surface Plasmon Resonance (Royal Society of Chemistry, 2008).
[CrossRef]

Wu, C. M.

Wu, C. M. L.

Wu, S. Y.

S. P. Ng, C. M. L. Wu, S. Y. Wu, and H. P. Ho, Opt. Express 19, 4521 (2011).
[CrossRef] [PubMed]

W. Yuan, H. P. Ho, S. Y. Wu, Y. K. Suen, and S. K. Kong, Sens. Actuators A 151, 23 (2009).
[CrossRef]

S. Y. Wu, H. P. Ho, W. C. Law, C. L. Lin, and S. K. Kong, Opt. Lett. 29, 2378 (2004).
[CrossRef] [PubMed]

H. P. Ho, W. W. Lam, and S. Y. Wu, Rev. Sci. Instrum. 73, 3534 (2002).
[CrossRef]

Y. H. Huang, H. P. Ho, S. Y. Wu, S. K. Kong, and M. Somekh, ““Phase sensitive surface plasmon resonance sensors: a review,” Opt. Express, submitted for publication.

Yong, K. T.

W. C. Law, P. Markowicz, K. T. Yong, I. Roy, A. Baev, S. Patskovsky, A. V. Kabashin, H. P. Ho, and P. N. Prasad, Biosens. Bioelectron. 23, 627 (2007).
[CrossRef] [PubMed]

Yuan, W.

W. Yuan, H. P. Ho, S. Y. Wu, Y. K. Suen, and S. K. Kong, Sens. Actuators A 151, 23 (2009).
[CrossRef]

Anal. Bioanal. Chem. (1)

S. Rodriguez-Mozaz, M. J. L. de Alda, and D. Barcelo, Anal. Bioanal. Chem. 386, 1025 (2006).
[CrossRef] [PubMed]

Anal. Chem. (1)

Y. C. Li, Y. F. Chang, L. C. Su, and C. Chou, Anal. Chem. 80, 5590 (2008).
[CrossRef] [PubMed]

Biosens. Bioelectron. (1)

W. C. Law, P. Markowicz, K. T. Yong, I. Roy, A. Baev, S. Patskovsky, A. V. Kabashin, H. P. Ho, and P. N. Prasad, Biosens. Bioelectron. 23, 627 (2007).
[CrossRef] [PubMed]

Chem. Rev. (1)

J. Homola, Chem. Rev. 108, 462 (2008).
[CrossRef] [PubMed]

Exp. Rev. Mol. Diagn. (1)

A. J. Haes and R. P. V. Duyne, Exp. Rev. Mol. Diagn. 4, 527(2004).
[CrossRef]

Food Technol. (1)

S. S. Deshpande and R. M. Rocco, Food Technol. 48, 146(1994).

Opt. Express (5)

Opt. Lett. (1)

Rev. Sci. Instrum. (1)

H. P. Ho, W. W. Lam, and S. Y. Wu, Rev. Sci. Instrum. 73, 3534 (2002).
[CrossRef]

Sens. Actuators A (1)

W. Yuan, H. P. Ho, S. Y. Wu, Y. K. Suen, and S. K. Kong, Sens. Actuators A 151, 23 (2009).
[CrossRef]

Other (5)

J. Homola, Surface Plasmon Resonance Based Sensors (Springer, 2006).
[CrossRef]

R. B. M. Schasfoort and A. J. Tudos, Handbook of Surface Plasmon Resonance (Royal Society of Chemistry, 2008).
[CrossRef]

http://www.biacore.com.

http://www.sensata.com/sensors/spreeta-analytical-sensor.htm

Y. H. Huang, H. P. Ho, S. Y. Wu, S. K. Kong, and M. Somekh, ““Phase sensitive surface plasmon resonance sensors: a review,” Opt. Express, submitted for publication.

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Figures (6)

Fig. 1
Fig. 1

Experimental setup of wide dynamic range phase sensitive SPR sensor with angular interrogation.

Fig. 2
Fig. 2

Phase changes at different pixels (angles) for glycerin solutions with concentrations ranging from 0% to 8%.

Fig. 3
Fig. 3

Accumulated phase changes by adding up the maximum phase response for each refractive index increment.

Fig. 4
Fig. 4

Phase change vs. refractive index at a series of incident angles for a 46.6 nm gold film.

Fig. 5
Fig. 5

Change of sensitivity and dynamic range by changing the thickness of the supporting gold film.

Fig. 6
Fig. 6

Phase response for glycerin solutions with different concentrations obtained from a single pixel close to the resonant angle.

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