Abstract

Line-scanning tomographic optical microscopy (LSTOM) requires precise rotation of the scanning line. We demonstrate a method that applies translation-invariant optical elements (polarizer and birefringent plate) to minimize the rotation error. An astigmatic line produced by means of a focused beam through a birefringent plate is used as line illumination. A comparative theoretical and experimental study is presented using an LSTOM system.

© 2011 Optical Society of America

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References

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  1. J. Sharpe, U. Ahlgren, P. Perry, B. Hill, A. Ross, J. Hecksher-Sørensen, R. Baldock, and D. Davidson, Science 296, 541 (2002).
    [CrossRef] [PubMed]
  2. J. Sharpe, “Optical projection tomography,” U.S. patent 8,014,063 (September 6, 2011).
  3. M. Rieckher, U. J. Birk, H. Meyer, J. Ripoll, and N. Tavernarakis, PLoS One 6, e18963 (2011).
    [CrossRef] [PubMed]
  4. K. Iizuka, Engineering Optics, 2nd ed. (Springer-Verlag, 1987).
  5. A. M. Zysk, F. T. Nguyen, A. L. Oldenburg, D. L. Marks, and S. A. Boppart, J. Biomed. Opt. 12, 051403 (2007).
    [CrossRef] [PubMed]
  6. R. Leitgeb, W. Drexler, A. Unterhuber, B. Hermann, T. Bajraszewski, T. Le, A. Stingl, and A. Fercher, Opt. Express 12, 2156 (2004).
    [CrossRef] [PubMed]
  7. V. Lauer, J. Microsc. 205, 165 (2002).
    [CrossRef] [PubMed]
  8. Y. Sung, W. Choi, C. Fang-Yen, K. Badizadegan, R. R. Dasari, and M. S. Feld, Opt. Express 17, 266 (2009).
    [CrossRef] [PubMed]
  9. G. Gajdátsy, L. Dudás, M. Erdélyi, and G. Szabó, J. Opt. 12, 115505 (2010).
    [CrossRef]
  10. D. L. Sullivan, Appl. Opt. 11, 2028 (1972).
    [CrossRef] [PubMed]
  11. A. Yariv and P. Yeh, Optical Waves in Crystals (Wiley, 1984).
  12. M. Erdélyi, M. Bereznai, G. Gajdátsy, and Zs. Bor, Opt. Commun. 281, 4807 (2008).
    [CrossRef]
  13. Y. Suenaga and M. Mizusawa, “Microscope objective lens with variable correction of aberrations imparted by transparent body between the specimen and the objective lens,” U.S. patent 5,940,220 (August 17, 1999).
  14. Lambda Research Corporation, OSLO Optics Software: Optics Reference (Lambda Research Corporation, 2011), Chaps. 2 and 7.
  15. T. R. Corle and G. S. Kino, Confocal Scanning Optical Microscopy and Related Imaging Systems (Academic, 1996).
  16. A. MacGregor, Laser Focus World 42, 115 (2006).

2011 (1)

M. Rieckher, U. J. Birk, H. Meyer, J. Ripoll, and N. Tavernarakis, PLoS One 6, e18963 (2011).
[CrossRef] [PubMed]

2010 (1)

G. Gajdátsy, L. Dudás, M. Erdélyi, and G. Szabó, J. Opt. 12, 115505 (2010).
[CrossRef]

2009 (1)

2008 (1)

M. Erdélyi, M. Bereznai, G. Gajdátsy, and Zs. Bor, Opt. Commun. 281, 4807 (2008).
[CrossRef]

2007 (1)

A. M. Zysk, F. T. Nguyen, A. L. Oldenburg, D. L. Marks, and S. A. Boppart, J. Biomed. Opt. 12, 051403 (2007).
[CrossRef] [PubMed]

2006 (1)

A. MacGregor, Laser Focus World 42, 115 (2006).

2004 (1)

2002 (2)

V. Lauer, J. Microsc. 205, 165 (2002).
[CrossRef] [PubMed]

J. Sharpe, U. Ahlgren, P. Perry, B. Hill, A. Ross, J. Hecksher-Sørensen, R. Baldock, and D. Davidson, Science 296, 541 (2002).
[CrossRef] [PubMed]

1972 (1)

Ahlgren, U.

J. Sharpe, U. Ahlgren, P. Perry, B. Hill, A. Ross, J. Hecksher-Sørensen, R. Baldock, and D. Davidson, Science 296, 541 (2002).
[CrossRef] [PubMed]

Badizadegan, K.

Bajraszewski, T.

Baldock, R.

J. Sharpe, U. Ahlgren, P. Perry, B. Hill, A. Ross, J. Hecksher-Sørensen, R. Baldock, and D. Davidson, Science 296, 541 (2002).
[CrossRef] [PubMed]

Bereznai, M.

M. Erdélyi, M. Bereznai, G. Gajdátsy, and Zs. Bor, Opt. Commun. 281, 4807 (2008).
[CrossRef]

Birk, U. J.

M. Rieckher, U. J. Birk, H. Meyer, J. Ripoll, and N. Tavernarakis, PLoS One 6, e18963 (2011).
[CrossRef] [PubMed]

Boppart, S. A.

A. M. Zysk, F. T. Nguyen, A. L. Oldenburg, D. L. Marks, and S. A. Boppart, J. Biomed. Opt. 12, 051403 (2007).
[CrossRef] [PubMed]

Bor, Zs.

M. Erdélyi, M. Bereznai, G. Gajdátsy, and Zs. Bor, Opt. Commun. 281, 4807 (2008).
[CrossRef]

Choi, W.

Corle, T. R.

T. R. Corle and G. S. Kino, Confocal Scanning Optical Microscopy and Related Imaging Systems (Academic, 1996).

Dasari, R. R.

Davidson, D.

J. Sharpe, U. Ahlgren, P. Perry, B. Hill, A. Ross, J. Hecksher-Sørensen, R. Baldock, and D. Davidson, Science 296, 541 (2002).
[CrossRef] [PubMed]

Drexler, W.

Dudás, L.

G. Gajdátsy, L. Dudás, M. Erdélyi, and G. Szabó, J. Opt. 12, 115505 (2010).
[CrossRef]

Erdélyi, M.

G. Gajdátsy, L. Dudás, M. Erdélyi, and G. Szabó, J. Opt. 12, 115505 (2010).
[CrossRef]

M. Erdélyi, M. Bereznai, G. Gajdátsy, and Zs. Bor, Opt. Commun. 281, 4807 (2008).
[CrossRef]

Fang-Yen, C.

Feld, M. S.

Fercher, A.

Gajdátsy, G.

G. Gajdátsy, L. Dudás, M. Erdélyi, and G. Szabó, J. Opt. 12, 115505 (2010).
[CrossRef]

M. Erdélyi, M. Bereznai, G. Gajdátsy, and Zs. Bor, Opt. Commun. 281, 4807 (2008).
[CrossRef]

Hecksher-Sørensen, J.

J. Sharpe, U. Ahlgren, P. Perry, B. Hill, A. Ross, J. Hecksher-Sørensen, R. Baldock, and D. Davidson, Science 296, 541 (2002).
[CrossRef] [PubMed]

Hermann, B.

Hill, B.

J. Sharpe, U. Ahlgren, P. Perry, B. Hill, A. Ross, J. Hecksher-Sørensen, R. Baldock, and D. Davidson, Science 296, 541 (2002).
[CrossRef] [PubMed]

Iizuka, K.

K. Iizuka, Engineering Optics, 2nd ed. (Springer-Verlag, 1987).

Kino, G. S.

T. R. Corle and G. S. Kino, Confocal Scanning Optical Microscopy and Related Imaging Systems (Academic, 1996).

Lauer, V.

V. Lauer, J. Microsc. 205, 165 (2002).
[CrossRef] [PubMed]

Le, T.

Leitgeb, R.

MacGregor, A.

A. MacGregor, Laser Focus World 42, 115 (2006).

Marks, D. L.

A. M. Zysk, F. T. Nguyen, A. L. Oldenburg, D. L. Marks, and S. A. Boppart, J. Biomed. Opt. 12, 051403 (2007).
[CrossRef] [PubMed]

Meyer, H.

M. Rieckher, U. J. Birk, H. Meyer, J. Ripoll, and N. Tavernarakis, PLoS One 6, e18963 (2011).
[CrossRef] [PubMed]

Mizusawa, M.

Y. Suenaga and M. Mizusawa, “Microscope objective lens with variable correction of aberrations imparted by transparent body between the specimen and the objective lens,” U.S. patent 5,940,220 (August 17, 1999).

Nguyen, F. T.

A. M. Zysk, F. T. Nguyen, A. L. Oldenburg, D. L. Marks, and S. A. Boppart, J. Biomed. Opt. 12, 051403 (2007).
[CrossRef] [PubMed]

Oldenburg, A. L.

A. M. Zysk, F. T. Nguyen, A. L. Oldenburg, D. L. Marks, and S. A. Boppart, J. Biomed. Opt. 12, 051403 (2007).
[CrossRef] [PubMed]

Perry, P.

J. Sharpe, U. Ahlgren, P. Perry, B. Hill, A. Ross, J. Hecksher-Sørensen, R. Baldock, and D. Davidson, Science 296, 541 (2002).
[CrossRef] [PubMed]

Rieckher, M.

M. Rieckher, U. J. Birk, H. Meyer, J. Ripoll, and N. Tavernarakis, PLoS One 6, e18963 (2011).
[CrossRef] [PubMed]

Ripoll, J.

M. Rieckher, U. J. Birk, H. Meyer, J. Ripoll, and N. Tavernarakis, PLoS One 6, e18963 (2011).
[CrossRef] [PubMed]

Ross, A.

J. Sharpe, U. Ahlgren, P. Perry, B. Hill, A. Ross, J. Hecksher-Sørensen, R. Baldock, and D. Davidson, Science 296, 541 (2002).
[CrossRef] [PubMed]

Sharpe, J.

J. Sharpe, U. Ahlgren, P. Perry, B. Hill, A. Ross, J. Hecksher-Sørensen, R. Baldock, and D. Davidson, Science 296, 541 (2002).
[CrossRef] [PubMed]

J. Sharpe, “Optical projection tomography,” U.S. patent 8,014,063 (September 6, 2011).

Stingl, A.

Suenaga, Y.

Y. Suenaga and M. Mizusawa, “Microscope objective lens with variable correction of aberrations imparted by transparent body between the specimen and the objective lens,” U.S. patent 5,940,220 (August 17, 1999).

Sullivan, D. L.

Sung, Y.

Szabó, G.

G. Gajdátsy, L. Dudás, M. Erdélyi, and G. Szabó, J. Opt. 12, 115505 (2010).
[CrossRef]

Tavernarakis, N.

M. Rieckher, U. J. Birk, H. Meyer, J. Ripoll, and N. Tavernarakis, PLoS One 6, e18963 (2011).
[CrossRef] [PubMed]

Unterhuber, A.

Yariv, A.

A. Yariv and P. Yeh, Optical Waves in Crystals (Wiley, 1984).

Yeh, P.

A. Yariv and P. Yeh, Optical Waves in Crystals (Wiley, 1984).

Zysk, A. M.

A. M. Zysk, F. T. Nguyen, A. L. Oldenburg, D. L. Marks, and S. A. Boppart, J. Biomed. Opt. 12, 051403 (2007).
[CrossRef] [PubMed]

Appl. Opt. (1)

J. Biomed. Opt. (1)

A. M. Zysk, F. T. Nguyen, A. L. Oldenburg, D. L. Marks, and S. A. Boppart, J. Biomed. Opt. 12, 051403 (2007).
[CrossRef] [PubMed]

J. Microsc. (1)

V. Lauer, J. Microsc. 205, 165 (2002).
[CrossRef] [PubMed]

J. Opt. (1)

G. Gajdátsy, L. Dudás, M. Erdélyi, and G. Szabó, J. Opt. 12, 115505 (2010).
[CrossRef]

Laser Focus World (1)

A. MacGregor, Laser Focus World 42, 115 (2006).

Opt. Commun. (1)

M. Erdélyi, M. Bereznai, G. Gajdátsy, and Zs. Bor, Opt. Commun. 281, 4807 (2008).
[CrossRef]

Opt. Express (2)

PLoS One (1)

M. Rieckher, U. J. Birk, H. Meyer, J. Ripoll, and N. Tavernarakis, PLoS One 6, e18963 (2011).
[CrossRef] [PubMed]

Science (1)

J. Sharpe, U. Ahlgren, P. Perry, B. Hill, A. Ross, J. Hecksher-Sørensen, R. Baldock, and D. Davidson, Science 296, 541 (2002).
[CrossRef] [PubMed]

Other (6)

J. Sharpe, “Optical projection tomography,” U.S. patent 8,014,063 (September 6, 2011).

K. Iizuka, Engineering Optics, 2nd ed. (Springer-Verlag, 1987).

Y. Suenaga and M. Mizusawa, “Microscope objective lens with variable correction of aberrations imparted by transparent body between the specimen and the objective lens,” U.S. patent 5,940,220 (August 17, 1999).

Lambda Research Corporation, OSLO Optics Software: Optics Reference (Lambda Research Corporation, 2011), Chaps. 2 and 7.

T. R. Corle and G. S. Kino, Confocal Scanning Optical Microscopy and Related Imaging Systems (Academic, 1996).

A. Yariv and P. Yeh, Optical Waves in Crystals (Wiley, 1984).

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Figures (5)

Fig. 1
Fig. 1

Astigmatism in case of extraordinary focus.

Fig. 2
Fig. 2

Axial dependence of the focused extraordinary beam (thickness of the calcite plate, 0.5 mm ; NA of the focusing objective, 0.45; field of view: 70 μm × 70 μm ).

Fig. 3
Fig. 3

Schematic view of the experimental arrangement.

Fig. 4
Fig. 4

Measured and simulated cross sections of the LSF.

Fig. 5
Fig. 5

(a) Measured and (b) simulated RSP and (c) the MTF.

Metrics