Abstract

Low-cost, compact, automated optical microsystems for chemical analysis, such as microflow cytometers for identification of individual biological cells, require monolithically integrated microlenses for focusing in microfluidic channels, to enable high-resolution scattering and fluorescence measurements. The multimode interference device (MMI), which makes use of self-imaging in multimode waveguides, is shown to be a simple and effective alternative to the microlens for microflow cytometry. The MMIs have been designed, realized, and integrated with microfluidic channels in a silica-based glass waveguide material system. Focal spot sizes of 2.4 μm for MMIs have been measured at foci as far as 43.7 μm into the microfluidic channel.

© 2011 Optical Society of America

PDF Article

References

  • View by:
  • |
  • |
  • |

  1. A. Ateya, J. S. Erickson, P. B. Howell, Jr., L. R. Hilliard, J. P. Golden, and F. S. Ligler, Anal. Bioanal. Chem. 391, 1485 (2008).
    [CrossRef]
  2. H. C. Hunt and J. S. Wilkinson, Microfluid. Nanofluid. 4, 53 (2008).
    [CrossRef]
  3. C. Dongre, J. van Weerd, G. A. J. Besselink, R. van Weeghel, R. M. Vazquez, R. Osellame, G. Cerullo, M. Cretich, M. Chiari, H. J. W. M. Hoekstra, and M. Pollnau, Electrophoresis 31, 2584 (2010).
    [CrossRef]
  4. S. Camou, H. Fujita, and T. Fujii, Lab Chip 3, 40 (2003).
    [CrossRef]
  5. J. Seo and L. P. Lee, Sens. Actuators B 99, 615 (2004).
    [CrossRef]
  6. J. Godin, V. Lien, and Y.-H. Lo, Appl. Phys. Lett. 89, 061106 (2006).
    [CrossRef]
  7. V. Moreno, J. Roman, and J. Salgueiro, Am. J. Phys. 65, 556 (1997).
    [CrossRef]
  8. H. C. Hunt and J. S. Wilkinson, in Proceedings of Photon10 (Institute of Physics, 2010), pp. 254–255.
  9. H. C. Hunt and J. S. Wilkinson, in Proceedings of the 15th Micro-optics Conference (MOC’09) (Optical Society of Japan, 2009), pp. 152–153.
  10. L. B. Soldano and E. C. M. Pennings, J. Lightwave Technol. 13, 615 (1995).
    [CrossRef]
  11. K. Okamoto, Fundamentals of Optical Waveguides, 2nd ed. (Academic, 2006).

2010 (2)

C. Dongre, J. van Weerd, G. A. J. Besselink, R. van Weeghel, R. M. Vazquez, R. Osellame, G. Cerullo, M. Cretich, M. Chiari, H. J. W. M. Hoekstra, and M. Pollnau, Electrophoresis 31, 2584 (2010).
[CrossRef]

H. C. Hunt and J. S. Wilkinson, in Proceedings of Photon10 (Institute of Physics, 2010), pp. 254–255.

2009 (1)

H. C. Hunt and J. S. Wilkinson, in Proceedings of the 15th Micro-optics Conference (MOC’09) (Optical Society of Japan, 2009), pp. 152–153.

2008 (2)

A. Ateya, J. S. Erickson, P. B. Howell, Jr., L. R. Hilliard, J. P. Golden, and F. S. Ligler, Anal. Bioanal. Chem. 391, 1485 (2008).
[CrossRef]

H. C. Hunt and J. S. Wilkinson, Microfluid. Nanofluid. 4, 53 (2008).
[CrossRef]

2006 (2)

J. Godin, V. Lien, and Y.-H. Lo, Appl. Phys. Lett. 89, 061106 (2006).
[CrossRef]

K. Okamoto, Fundamentals of Optical Waveguides, 2nd ed. (Academic, 2006).

2004 (1)

J. Seo and L. P. Lee, Sens. Actuators B 99, 615 (2004).
[CrossRef]

2003 (1)

S. Camou, H. Fujita, and T. Fujii, Lab Chip 3, 40 (2003).
[CrossRef]

1997 (1)

V. Moreno, J. Roman, and J. Salgueiro, Am. J. Phys. 65, 556 (1997).
[CrossRef]

1995 (1)

L. B. Soldano and E. C. M. Pennings, J. Lightwave Technol. 13, 615 (1995).
[CrossRef]

Ateya, A.

A. Ateya, J. S. Erickson, P. B. Howell, Jr., L. R. Hilliard, J. P. Golden, and F. S. Ligler, Anal. Bioanal. Chem. 391, 1485 (2008).
[CrossRef]

Besselink, G. A. J.

C. Dongre, J. van Weerd, G. A. J. Besselink, R. van Weeghel, R. M. Vazquez, R. Osellame, G. Cerullo, M. Cretich, M. Chiari, H. J. W. M. Hoekstra, and M. Pollnau, Electrophoresis 31, 2584 (2010).
[CrossRef]

Camou, S.

S. Camou, H. Fujita, and T. Fujii, Lab Chip 3, 40 (2003).
[CrossRef]

Cerullo, G.

C. Dongre, J. van Weerd, G. A. J. Besselink, R. van Weeghel, R. M. Vazquez, R. Osellame, G. Cerullo, M. Cretich, M. Chiari, H. J. W. M. Hoekstra, and M. Pollnau, Electrophoresis 31, 2584 (2010).
[CrossRef]

Chiari, M.

C. Dongre, J. van Weerd, G. A. J. Besselink, R. van Weeghel, R. M. Vazquez, R. Osellame, G. Cerullo, M. Cretich, M. Chiari, H. J. W. M. Hoekstra, and M. Pollnau, Electrophoresis 31, 2584 (2010).
[CrossRef]

Cretich, M.

C. Dongre, J. van Weerd, G. A. J. Besselink, R. van Weeghel, R. M. Vazquez, R. Osellame, G. Cerullo, M. Cretich, M. Chiari, H. J. W. M. Hoekstra, and M. Pollnau, Electrophoresis 31, 2584 (2010).
[CrossRef]

Dongre, C.

C. Dongre, J. van Weerd, G. A. J. Besselink, R. van Weeghel, R. M. Vazquez, R. Osellame, G. Cerullo, M. Cretich, M. Chiari, H. J. W. M. Hoekstra, and M. Pollnau, Electrophoresis 31, 2584 (2010).
[CrossRef]

Erickson, J. S.

A. Ateya, J. S. Erickson, P. B. Howell, Jr., L. R. Hilliard, J. P. Golden, and F. S. Ligler, Anal. Bioanal. Chem. 391, 1485 (2008).
[CrossRef]

Fujii, T.

S. Camou, H. Fujita, and T. Fujii, Lab Chip 3, 40 (2003).
[CrossRef]

Fujita, H.

S. Camou, H. Fujita, and T. Fujii, Lab Chip 3, 40 (2003).
[CrossRef]

Godin, J.

J. Godin, V. Lien, and Y.-H. Lo, Appl. Phys. Lett. 89, 061106 (2006).
[CrossRef]

Golden, J. P.

A. Ateya, J. S. Erickson, P. B. Howell, Jr., L. R. Hilliard, J. P. Golden, and F. S. Ligler, Anal. Bioanal. Chem. 391, 1485 (2008).
[CrossRef]

Hilliard, L. R.

A. Ateya, J. S. Erickson, P. B. Howell, Jr., L. R. Hilliard, J. P. Golden, and F. S. Ligler, Anal. Bioanal. Chem. 391, 1485 (2008).
[CrossRef]

Hoekstra, H. J. W. M.

C. Dongre, J. van Weerd, G. A. J. Besselink, R. van Weeghel, R. M. Vazquez, R. Osellame, G. Cerullo, M. Cretich, M. Chiari, H. J. W. M. Hoekstra, and M. Pollnau, Electrophoresis 31, 2584 (2010).
[CrossRef]

Howell, P. B.

A. Ateya, J. S. Erickson, P. B. Howell, Jr., L. R. Hilliard, J. P. Golden, and F. S. Ligler, Anal. Bioanal. Chem. 391, 1485 (2008).
[CrossRef]

Hunt, H. C.

H. C. Hunt and J. S. Wilkinson, in Proceedings of Photon10 (Institute of Physics, 2010), pp. 254–255.

H. C. Hunt and J. S. Wilkinson, in Proceedings of the 15th Micro-optics Conference (MOC’09) (Optical Society of Japan, 2009), pp. 152–153.

H. C. Hunt and J. S. Wilkinson, Microfluid. Nanofluid. 4, 53 (2008).
[CrossRef]

Lee, L. P.

J. Seo and L. P. Lee, Sens. Actuators B 99, 615 (2004).
[CrossRef]

Lien, V.

J. Godin, V. Lien, and Y.-H. Lo, Appl. Phys. Lett. 89, 061106 (2006).
[CrossRef]

Ligler, F. S.

A. Ateya, J. S. Erickson, P. B. Howell, Jr., L. R. Hilliard, J. P. Golden, and F. S. Ligler, Anal. Bioanal. Chem. 391, 1485 (2008).
[CrossRef]

Lo, Y.-H.

J. Godin, V. Lien, and Y.-H. Lo, Appl. Phys. Lett. 89, 061106 (2006).
[CrossRef]

Moreno, V.

V. Moreno, J. Roman, and J. Salgueiro, Am. J. Phys. 65, 556 (1997).
[CrossRef]

Okamoto, K.

K. Okamoto, Fundamentals of Optical Waveguides, 2nd ed. (Academic, 2006).

Osellame, R.

C. Dongre, J. van Weerd, G. A. J. Besselink, R. van Weeghel, R. M. Vazquez, R. Osellame, G. Cerullo, M. Cretich, M. Chiari, H. J. W. M. Hoekstra, and M. Pollnau, Electrophoresis 31, 2584 (2010).
[CrossRef]

Pennings, E. C. M.

L. B. Soldano and E. C. M. Pennings, J. Lightwave Technol. 13, 615 (1995).
[CrossRef]

Pollnau, M.

C. Dongre, J. van Weerd, G. A. J. Besselink, R. van Weeghel, R. M. Vazquez, R. Osellame, G. Cerullo, M. Cretich, M. Chiari, H. J. W. M. Hoekstra, and M. Pollnau, Electrophoresis 31, 2584 (2010).
[CrossRef]

Roman, J.

V. Moreno, J. Roman, and J. Salgueiro, Am. J. Phys. 65, 556 (1997).
[CrossRef]

Salgueiro, J.

V. Moreno, J. Roman, and J. Salgueiro, Am. J. Phys. 65, 556 (1997).
[CrossRef]

Seo, J.

J. Seo and L. P. Lee, Sens. Actuators B 99, 615 (2004).
[CrossRef]

Soldano, L. B.

L. B. Soldano and E. C. M. Pennings, J. Lightwave Technol. 13, 615 (1995).
[CrossRef]

van Weeghel, R.

C. Dongre, J. van Weerd, G. A. J. Besselink, R. van Weeghel, R. M. Vazquez, R. Osellame, G. Cerullo, M. Cretich, M. Chiari, H. J. W. M. Hoekstra, and M. Pollnau, Electrophoresis 31, 2584 (2010).
[CrossRef]

van Weerd, J.

C. Dongre, J. van Weerd, G. A. J. Besselink, R. van Weeghel, R. M. Vazquez, R. Osellame, G. Cerullo, M. Cretich, M. Chiari, H. J. W. M. Hoekstra, and M. Pollnau, Electrophoresis 31, 2584 (2010).
[CrossRef]

Vazquez, R. M.

C. Dongre, J. van Weerd, G. A. J. Besselink, R. van Weeghel, R. M. Vazquez, R. Osellame, G. Cerullo, M. Cretich, M. Chiari, H. J. W. M. Hoekstra, and M. Pollnau, Electrophoresis 31, 2584 (2010).
[CrossRef]

Wilkinson, J. S.

H. C. Hunt and J. S. Wilkinson, in Proceedings of Photon10 (Institute of Physics, 2010), pp. 254–255.

H. C. Hunt and J. S. Wilkinson, in Proceedings of the 15th Micro-optics Conference (MOC’09) (Optical Society of Japan, 2009), pp. 152–153.

H. C. Hunt and J. S. Wilkinson, Microfluid. Nanofluid. 4, 53 (2008).
[CrossRef]

Am. J. Phys. (1)

V. Moreno, J. Roman, and J. Salgueiro, Am. J. Phys. 65, 556 (1997).
[CrossRef]

Anal. Bioanal. Chem. (1)

A. Ateya, J. S. Erickson, P. B. Howell, Jr., L. R. Hilliard, J. P. Golden, and F. S. Ligler, Anal. Bioanal. Chem. 391, 1485 (2008).
[CrossRef]

Appl. Phys. Lett. (1)

J. Godin, V. Lien, and Y.-H. Lo, Appl. Phys. Lett. 89, 061106 (2006).
[CrossRef]

Electrophoresis (1)

C. Dongre, J. van Weerd, G. A. J. Besselink, R. van Weeghel, R. M. Vazquez, R. Osellame, G. Cerullo, M. Cretich, M. Chiari, H. J. W. M. Hoekstra, and M. Pollnau, Electrophoresis 31, 2584 (2010).
[CrossRef]

J. Lightwave Technol. (1)

L. B. Soldano and E. C. M. Pennings, J. Lightwave Technol. 13, 615 (1995).
[CrossRef]

Lab Chip (1)

S. Camou, H. Fujita, and T. Fujii, Lab Chip 3, 40 (2003).
[CrossRef]

Microfluid. Nanofluid. (1)

H. C. Hunt and J. S. Wilkinson, Microfluid. Nanofluid. 4, 53 (2008).
[CrossRef]

Sens. Actuators B (1)

J. Seo and L. P. Lee, Sens. Actuators B 99, 615 (2004).
[CrossRef]

Other (3)

K. Okamoto, Fundamentals of Optical Waveguides, 2nd ed. (Academic, 2006).

H. C. Hunt and J. S. Wilkinson, in Proceedings of Photon10 (Institute of Physics, 2010), pp. 254–255.

H. C. Hunt and J. S. Wilkinson, in Proceedings of the 15th Micro-optics Conference (MOC’09) (Optical Society of Japan, 2009), pp. 152–153.

Cited By

OSA participates in CrossRef's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Metrics