Abstract

Recently, we presented a method using laser-induced ultrasound from an external absorber (passive element) to image the ultrasound transmission parameters of an object under photoacoustic tomographic investigation. The method suffers from long measurement times due to the requirement for a large number of views and consequently physical projections around the object. Here we propose and validate an approach that permits a multitude of views to be obtained within a limited projection scenario. The approach uses a plurality of spatially distributed external absorbers in the path of the light, that results in multiple laser-induced ultrasound sources to interrogate the object from a number of angles. This reduces the required number of rotation angles or physical projections around the object, permitting a considerable reduction in imaging time without significant degradation in image quality. The approach brings the concept of hybrid imaging of ultrasound transmission parameters together with photoacoustic imaging, into the realm of practical application.

© 2011 Optical Society of America

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References

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  1. L. V. Wang, Nat. Photon. 3, 503 (2009).
    [CrossRef]
  2. D. Piras, W. Xia, W. Steenbergen, T. G. Van Leeuwen, and S. Manohar, IEEE J. Sel. Top. Quantum Electron. 16, 730(2010).
    [CrossRef]
  3. S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, J. Biomed. Opt. 14, 024007 (2009).
    [CrossRef] [PubMed]
  4. S. Manohar, G. H. Willemink, F. Van der Heijden, C. H. Slump, and T. G. Van Leeuwen, Appl. Phys. Lett. 91, 131911(2007).
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    [CrossRef]
  6. J. Jose, R. G. H. Willemink, S. Resink, D. Piras, J. C. G. Van Hespen, C. H. Slump, W. Steenbergen, T. G. Van Leeuwen, and S. Manohar, Opt. Express 19, 2093 (2011).
    [CrossRef] [PubMed]
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    [CrossRef]
  8. P. M. Joseph and R. A. Schulz, Med. Phys. 7, 692 (1980).
    [CrossRef] [PubMed]

2011

2010

D. Piras, W. Xia, W. Steenbergen, T. G. Van Leeuwen, and S. Manohar, IEEE J. Sel. Top. Quantum Electron. 16, 730(2010).
[CrossRef]

2009

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, J. Biomed. Opt. 14, 024007 (2009).
[CrossRef] [PubMed]

L. V. Wang, Nat. Photon. 3, 503 (2009).
[CrossRef]

R. G. H. Willemink, S. Manohar, J. Jose, C. H. Slump, F. Van der Heijden, and T. G. Van Leeuwen, Proc. SPIE 7265, 72650J (2009).
[CrossRef]

2008

R. G. H. Willemink, S. Manohar, Y. Purwar, C. H. Slump, F. Van der Heijden, and T. G. Van Leeuwen, Proc. SPIE 6920, 692013 (2008).
[CrossRef]

2007

S. Manohar, G. H. Willemink, F. Van der Heijden, C. H. Slump, and T. G. Van Leeuwen, Appl. Phys. Lett. 91, 131911(2007).
[CrossRef]

1980

P. M. Joseph and R. A. Schulz, Med. Phys. 7, 692 (1980).
[CrossRef] [PubMed]

Conjusteau, A.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, J. Biomed. Opt. 14, 024007 (2009).
[CrossRef] [PubMed]

Ermilov, S. A.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, J. Biomed. Opt. 14, 024007 (2009).
[CrossRef] [PubMed]

Jose, J.

Joseph, P. M.

P. M. Joseph and R. A. Schulz, Med. Phys. 7, 692 (1980).
[CrossRef] [PubMed]

Khamapirad, T.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, J. Biomed. Opt. 14, 024007 (2009).
[CrossRef] [PubMed]

Lacewell, R.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, J. Biomed. Opt. 14, 024007 (2009).
[CrossRef] [PubMed]

Leonard, M. H.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, J. Biomed. Opt. 14, 024007 (2009).
[CrossRef] [PubMed]

Manohar, S.

J. Jose, R. G. H. Willemink, S. Resink, D. Piras, J. C. G. Van Hespen, C. H. Slump, W. Steenbergen, T. G. Van Leeuwen, and S. Manohar, Opt. Express 19, 2093 (2011).
[CrossRef] [PubMed]

D. Piras, W. Xia, W. Steenbergen, T. G. Van Leeuwen, and S. Manohar, IEEE J. Sel. Top. Quantum Electron. 16, 730(2010).
[CrossRef]

R. G. H. Willemink, S. Manohar, J. Jose, C. H. Slump, F. Van der Heijden, and T. G. Van Leeuwen, Proc. SPIE 7265, 72650J (2009).
[CrossRef]

R. G. H. Willemink, S. Manohar, Y. Purwar, C. H. Slump, F. Van der Heijden, and T. G. Van Leeuwen, Proc. SPIE 6920, 692013 (2008).
[CrossRef]

S. Manohar, G. H. Willemink, F. Van der Heijden, C. H. Slump, and T. G. Van Leeuwen, Appl. Phys. Lett. 91, 131911(2007).
[CrossRef]

Mehta, K.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, J. Biomed. Opt. 14, 024007 (2009).
[CrossRef] [PubMed]

Miller, T.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, J. Biomed. Opt. 14, 024007 (2009).
[CrossRef] [PubMed]

Oraevsky, A. A.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, J. Biomed. Opt. 14, 024007 (2009).
[CrossRef] [PubMed]

Piras, D.

Purwar, Y.

R. G. H. Willemink, S. Manohar, Y. Purwar, C. H. Slump, F. Van der Heijden, and T. G. Van Leeuwen, Proc. SPIE 6920, 692013 (2008).
[CrossRef]

Resink, S.

Schulz, R. A.

P. M. Joseph and R. A. Schulz, Med. Phys. 7, 692 (1980).
[CrossRef] [PubMed]

Slump, C. H.

J. Jose, R. G. H. Willemink, S. Resink, D. Piras, J. C. G. Van Hespen, C. H. Slump, W. Steenbergen, T. G. Van Leeuwen, and S. Manohar, Opt. Express 19, 2093 (2011).
[CrossRef] [PubMed]

R. G. H. Willemink, S. Manohar, J. Jose, C. H. Slump, F. Van der Heijden, and T. G. Van Leeuwen, Proc. SPIE 7265, 72650J (2009).
[CrossRef]

R. G. H. Willemink, S. Manohar, Y. Purwar, C. H. Slump, F. Van der Heijden, and T. G. Van Leeuwen, Proc. SPIE 6920, 692013 (2008).
[CrossRef]

S. Manohar, G. H. Willemink, F. Van der Heijden, C. H. Slump, and T. G. Van Leeuwen, Appl. Phys. Lett. 91, 131911(2007).
[CrossRef]

Steenbergen, W.

Van der Heijden, F.

R. G. H. Willemink, S. Manohar, J. Jose, C. H. Slump, F. Van der Heijden, and T. G. Van Leeuwen, Proc. SPIE 7265, 72650J (2009).
[CrossRef]

R. G. H. Willemink, S. Manohar, Y. Purwar, C. H. Slump, F. Van der Heijden, and T. G. Van Leeuwen, Proc. SPIE 6920, 692013 (2008).
[CrossRef]

S. Manohar, G. H. Willemink, F. Van der Heijden, C. H. Slump, and T. G. Van Leeuwen, Appl. Phys. Lett. 91, 131911(2007).
[CrossRef]

Van Hespen, J. C. G.

Van Leeuwen, T. G.

J. Jose, R. G. H. Willemink, S. Resink, D. Piras, J. C. G. Van Hespen, C. H. Slump, W. Steenbergen, T. G. Van Leeuwen, and S. Manohar, Opt. Express 19, 2093 (2011).
[CrossRef] [PubMed]

D. Piras, W. Xia, W. Steenbergen, T. G. Van Leeuwen, and S. Manohar, IEEE J. Sel. Top. Quantum Electron. 16, 730(2010).
[CrossRef]

R. G. H. Willemink, S. Manohar, J. Jose, C. H. Slump, F. Van der Heijden, and T. G. Van Leeuwen, Proc. SPIE 7265, 72650J (2009).
[CrossRef]

R. G. H. Willemink, S. Manohar, Y. Purwar, C. H. Slump, F. Van der Heijden, and T. G. Van Leeuwen, Proc. SPIE 6920, 692013 (2008).
[CrossRef]

S. Manohar, G. H. Willemink, F. Van der Heijden, C. H. Slump, and T. G. Van Leeuwen, Appl. Phys. Lett. 91, 131911(2007).
[CrossRef]

Wang, L. V.

L. V. Wang, Nat. Photon. 3, 503 (2009).
[CrossRef]

Willemink, G. H.

S. Manohar, G. H. Willemink, F. Van der Heijden, C. H. Slump, and T. G. Van Leeuwen, Appl. Phys. Lett. 91, 131911(2007).
[CrossRef]

Willemink, R. G. H.

J. Jose, R. G. H. Willemink, S. Resink, D. Piras, J. C. G. Van Hespen, C. H. Slump, W. Steenbergen, T. G. Van Leeuwen, and S. Manohar, Opt. Express 19, 2093 (2011).
[CrossRef] [PubMed]

R. G. H. Willemink, S. Manohar, J. Jose, C. H. Slump, F. Van der Heijden, and T. G. Van Leeuwen, Proc. SPIE 7265, 72650J (2009).
[CrossRef]

R. G. H. Willemink, S. Manohar, Y. Purwar, C. H. Slump, F. Van der Heijden, and T. G. Van Leeuwen, Proc. SPIE 6920, 692013 (2008).
[CrossRef]

Xia, W.

D. Piras, W. Xia, W. Steenbergen, T. G. Van Leeuwen, and S. Manohar, IEEE J. Sel. Top. Quantum Electron. 16, 730(2010).
[CrossRef]

Appl. Phys. Lett.

S. Manohar, G. H. Willemink, F. Van der Heijden, C. H. Slump, and T. G. Van Leeuwen, Appl. Phys. Lett. 91, 131911(2007).
[CrossRef]

IEEE J. Sel. Top. Quantum Electron.

D. Piras, W. Xia, W. Steenbergen, T. G. Van Leeuwen, and S. Manohar, IEEE J. Sel. Top. Quantum Electron. 16, 730(2010).
[CrossRef]

J. Biomed. Opt.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, J. Biomed. Opt. 14, 024007 (2009).
[CrossRef] [PubMed]

Med. Phys.

P. M. Joseph and R. A. Schulz, Med. Phys. 7, 692 (1980).
[CrossRef] [PubMed]

Nat. Photon.

L. V. Wang, Nat. Photon. 3, 503 (2009).
[CrossRef]

Opt. Express

Proc. SPIE

R. G. H. Willemink, S. Manohar, J. Jose, C. H. Slump, F. Van der Heijden, and T. G. Van Leeuwen, Proc. SPIE 7265, 72650J (2009).
[CrossRef]

R. G. H. Willemink, S. Manohar, Y. Purwar, C. H. Slump, F. Van der Heijden, and T. G. Van Leeuwen, Proc. SPIE 6920, 692013 (2008).
[CrossRef]

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Figures (3)

Fig. 1
Fig. 1

Schematic of the multi-PER PACT which allows short measurement times while maintaining image quality. Nine passive elements are shown, and for simplicity only a few projection rays of ultrasound propagation are shown.

Fig. 2
Fig. 2

(a) Agar gel test sample with agar milk inclusions. SOS tomograms obtained with only nine projections (measurement time of 1.5 minutes) using an increasing number of passive elements: (b) element 9, (c) elements 7–9, (d) elements 4–9, and (e) all nine elements. For comparison, (f) used element 1 with 80 projections that requires a measurement time of 13.3 minutes.

Fig. 3
Fig. 3

AA tomograms obtained with only nine projections using (a) element 9 and (b) all nine elements. For comparison (c) used element 1 with 80 projections.

Equations (1)

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N min = 4 π ν R 1 sin ( ζ / 2 ) , with     ν = 1 2 a = M 2 ( π + ζ ) R ,

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