Abstract

We demonstrate the depth-resolved and detailed ocular perfusion maps within retina and choroid can be obtained from an ultrahigh sensitive optical microangiography (OMAG). As opposed to the conventional OMAG, we apply the OMAG algorithm along the slow scanning axis to achieve the ultrahigh sensitive imaging to the slow flows within capillaries. We use an 840nm system operating at an imaging rate of 400  framess that requires 3s to complete one 3D scan of 3×3mm2 area on retina. We show the superior imaging performance of OMAG to provide functional images of capillary level microcirculation at different land-marked depths within retina and choroid that correlate well with the standard retinal pathology.

© 2010 Optical Society of America

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References

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2009

2008

2007

2005

P. H. Tomlins and R. K. Wang, J. Phys. D 38, 2519 (2005).
[CrossRef]

2003

A. F. Fercher, W. Drexler, C. K. Hitzenberger, and T. Lasser, Rep. Prog. Phys. 66, 239 (2003).
[CrossRef]

An, L.

Drexler, W.

A. F. Fercher, W. Drexler, C. K. Hitzenberger, and T. Lasser, Rep. Prog. Phys. 66, 239 (2003).
[CrossRef]

Fercher, A. F.

A. F. Fercher, W. Drexler, C. K. Hitzenberger, and T. Lasser, Rep. Prog. Phys. 66, 239 (2003).
[CrossRef]

Gruber, A.

Hansen, R. I.

P. Henkind, R. I. Hansen, and J. Szalay, in Ocular Circulation, R.E.Records, ed. (Harper & Row, 1979), pp. 98–155.

Hanson, S.

Henkind, P.

P. Henkind, R. I. Hansen, and J. Szalay, in Ocular Circulation, R.E.Records, ed. (Harper & Row, 1979), pp. 98–155.

Hitzenberger, C. K.

A. F. Fercher, W. Drexler, C. K. Hitzenberger, and T. Lasser, Rep. Prog. Phys. 66, 239 (2003).
[CrossRef]

Hurst, S.

Jacques, S.

Kolbitsch, C.

Lasser, T.

A. F. Fercher, W. Drexler, C. K. Hitzenberger, and T. Lasser, Rep. Prog. Phys. 66, 239 (2003).
[CrossRef]

Leitgeb, R. A.

Ma, Z.

Schmoll, T.

Szalay, J.

P. Henkind, R. I. Hansen, and J. Szalay, in Ocular Circulation, R.E.Records, ed. (Harper & Row, 1979), pp. 98–155.

Tomlins, P. H.

P. H. Tomlins and R. K. Wang, J. Phys. D 38, 2519 (2005).
[CrossRef]

Wang, R. K.

IEEE J. Sel. Top. Quantum Electron.

R. K. Wang, IEEE J. Sel. Top. Quantum Electron. doi: 10.1109/JSTQE.2009.2033609.
[PubMed]

J. Phys. D

P. H. Tomlins and R. K. Wang, J. Phys. D 38, 2519 (2005).
[CrossRef]

Opt. Express

Rep. Prog. Phys.

A. F. Fercher, W. Drexler, C. K. Hitzenberger, and T. Lasser, Rep. Prog. Phys. 66, 239 (2003).
[CrossRef]

Other

P. Henkind, R. I. Hansen, and J. Szalay, in Ocular Circulation, R.E.Records, ed. (Harper & Row, 1979), pp. 98–155.

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Figures (3)

Fig. 1
Fig. 1

Schematic system diagram. PC, polarization controller.

Fig. 2
Fig. 2

Typical in vivo OMAG imaging of the posterior segment of eye near the macular region toward optic nerve head. (A) One typical OMAG B-scan of microstructures showing morphological features and (B) the corresponding OMAG blood flow image. The projection maps of blood flow distribution within (C) retina and (D) choroid, obtained from one 3D scan of an area of 3 × 3 mm 2 near macular region. White bar = 500 μ m .

Fig. 3
Fig. 3

Depth-resolved images of patent blood vessels within the retina (top row) and choroid (bottom row) at the land-marked depths annotated in the left of Fig. 2b: (A) R1, beyond 425 μ m above RPE; (B) R2, between 300 and 425 μ m above RPE; (C) R3, between 50 and 300 μ m above RPE; (D) C1, between 0 to 70 μ m below RPE; (E) C2, between 70 to 200 μ m below RPE; and (F) C3, beyond 200 μ m below RPE. White bar = 500 μ m .

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