Abstract

Cerenkov radiation is a well-known phenomenon in which optical photons are emitted by charged particles moving faster than the speed of light in a medium. We have observed Cerenkov photons emitted from β-emitting radiotracers such as F18-fluorodeoxyglucose using a sensitive CCD camera. Phantom and in vivo mouse imaging experiments have demonstrated that surface measurements of the emitted Cerenkov optical photons could be used to reconstruct the radiotracer activity distribution inside an object by modeling the optical photon propagation with the diffusion equation and reconstructing the optical emission source distribution iteratively with a preconditioned conjugate gradient method.

© 2010 Optical Society of America

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    [CrossRef]
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2009

R. Robertson, M. S. Germanos, C. Q. Li, G. S. Mitchell, S. R. Cherry, and M. D. Silva, Phys. Med. Biol. 54, N355 (2009).
[CrossRef] [PubMed]

C. Q. Li, G. S. Mitchell, J. Dutta, S. Ahn, R. M. Leahy, and S. R. Cherry, Opt. Express 17, 7571 (2009).
[CrossRef] [PubMed]

2005

A. J. Chaudhari, F. Darvas, J. R. Bading, R. A. Moats, P. S. Conti, D. J. Smith, S. R. Cherry, and R. M. Leahy, Phys. Med. Biol. 50, 5421 (2005).
[CrossRef] [PubMed]

2003

M. F. L'Annunciata, Handbook of Radioactivity Analysis (Academic, 2003).

T. Vo-Dinh, Biomedical Photonics Handbook (CRC Press, 2003).
[CrossRef]

1998

J. Y. Qi, R. M. Leahy, S. R. Cherry, A. Chatziioannou, and T. H. Farquhar, Phys. Med. Biol. 43, 1001 (1998).
[CrossRef] [PubMed]

1955

J. V. Jelley, Br. J. Appl. Phys. 6, 227 (1955).
[CrossRef]

Ahn, S.

Bading, J. R.

A. J. Chaudhari, F. Darvas, J. R. Bading, R. A. Moats, P. S. Conti, D. J. Smith, S. R. Cherry, and R. M. Leahy, Phys. Med. Biol. 50, 5421 (2005).
[CrossRef] [PubMed]

Chatziioannou, A.

J. Y. Qi, R. M. Leahy, S. R. Cherry, A. Chatziioannou, and T. H. Farquhar, Phys. Med. Biol. 43, 1001 (1998).
[CrossRef] [PubMed]

Chaudhari, A. J.

A. J. Chaudhari, F. Darvas, J. R. Bading, R. A. Moats, P. S. Conti, D. J. Smith, S. R. Cherry, and R. M. Leahy, Phys. Med. Biol. 50, 5421 (2005).
[CrossRef] [PubMed]

Cherry, S. R.

R. Robertson, M. S. Germanos, C. Q. Li, G. S. Mitchell, S. R. Cherry, and M. D. Silva, Phys. Med. Biol. 54, N355 (2009).
[CrossRef] [PubMed]

C. Q. Li, G. S. Mitchell, J. Dutta, S. Ahn, R. M. Leahy, and S. R. Cherry, Opt. Express 17, 7571 (2009).
[CrossRef] [PubMed]

A. J. Chaudhari, F. Darvas, J. R. Bading, R. A. Moats, P. S. Conti, D. J. Smith, S. R. Cherry, and R. M. Leahy, Phys. Med. Biol. 50, 5421 (2005).
[CrossRef] [PubMed]

J. Y. Qi, R. M. Leahy, S. R. Cherry, A. Chatziioannou, and T. H. Farquhar, Phys. Med. Biol. 43, 1001 (1998).
[CrossRef] [PubMed]

Conti, P. S.

A. J. Chaudhari, F. Darvas, J. R. Bading, R. A. Moats, P. S. Conti, D. J. Smith, S. R. Cherry, and R. M. Leahy, Phys. Med. Biol. 50, 5421 (2005).
[CrossRef] [PubMed]

Darvas, F.

A. J. Chaudhari, F. Darvas, J. R. Bading, R. A. Moats, P. S. Conti, D. J. Smith, S. R. Cherry, and R. M. Leahy, Phys. Med. Biol. 50, 5421 (2005).
[CrossRef] [PubMed]

Dutta, J.

Farquhar, T. H.

J. Y. Qi, R. M. Leahy, S. R. Cherry, A. Chatziioannou, and T. H. Farquhar, Phys. Med. Biol. 43, 1001 (1998).
[CrossRef] [PubMed]

Germanos, M. S.

R. Robertson, M. S. Germanos, C. Q. Li, G. S. Mitchell, S. R. Cherry, and M. D. Silva, Phys. Med. Biol. 54, N355 (2009).
[CrossRef] [PubMed]

Jelley, J. V.

J. V. Jelley, Br. J. Appl. Phys. 6, 227 (1955).
[CrossRef]

L'Annunciata, M. F.

M. F. L'Annunciata, Handbook of Radioactivity Analysis (Academic, 2003).

Leahy, R. M.

C. Q. Li, G. S. Mitchell, J. Dutta, S. Ahn, R. M. Leahy, and S. R. Cherry, Opt. Express 17, 7571 (2009).
[CrossRef] [PubMed]

A. J. Chaudhari, F. Darvas, J. R. Bading, R. A. Moats, P. S. Conti, D. J. Smith, S. R. Cherry, and R. M. Leahy, Phys. Med. Biol. 50, 5421 (2005).
[CrossRef] [PubMed]

J. Y. Qi, R. M. Leahy, S. R. Cherry, A. Chatziioannou, and T. H. Farquhar, Phys. Med. Biol. 43, 1001 (1998).
[CrossRef] [PubMed]

Li, C. Q.

R. Robertson, M. S. Germanos, C. Q. Li, G. S. Mitchell, S. R. Cherry, and M. D. Silva, Phys. Med. Biol. 54, N355 (2009).
[CrossRef] [PubMed]

C. Q. Li, G. S. Mitchell, J. Dutta, S. Ahn, R. M. Leahy, and S. R. Cherry, Opt. Express 17, 7571 (2009).
[CrossRef] [PubMed]

Mitchell, G. S.

C. Q. Li, G. S. Mitchell, J. Dutta, S. Ahn, R. M. Leahy, and S. R. Cherry, Opt. Express 17, 7571 (2009).
[CrossRef] [PubMed]

R. Robertson, M. S. Germanos, C. Q. Li, G. S. Mitchell, S. R. Cherry, and M. D. Silva, Phys. Med. Biol. 54, N355 (2009).
[CrossRef] [PubMed]

Moats, R. A.

A. J. Chaudhari, F. Darvas, J. R. Bading, R. A. Moats, P. S. Conti, D. J. Smith, S. R. Cherry, and R. M. Leahy, Phys. Med. Biol. 50, 5421 (2005).
[CrossRef] [PubMed]

Qi, J. Y.

J. Y. Qi, R. M. Leahy, S. R. Cherry, A. Chatziioannou, and T. H. Farquhar, Phys. Med. Biol. 43, 1001 (1998).
[CrossRef] [PubMed]

Robertson, R.

R. Robertson, M. S. Germanos, C. Q. Li, G. S. Mitchell, S. R. Cherry, and M. D. Silva, Phys. Med. Biol. 54, N355 (2009).
[CrossRef] [PubMed]

Silva, M. D.

R. Robertson, M. S. Germanos, C. Q. Li, G. S. Mitchell, S. R. Cherry, and M. D. Silva, Phys. Med. Biol. 54, N355 (2009).
[CrossRef] [PubMed]

Smith, D. J.

A. J. Chaudhari, F. Darvas, J. R. Bading, R. A. Moats, P. S. Conti, D. J. Smith, S. R. Cherry, and R. M. Leahy, Phys. Med. Biol. 50, 5421 (2005).
[CrossRef] [PubMed]

Vo-Dinh, T.

T. Vo-Dinh, Biomedical Photonics Handbook (CRC Press, 2003).
[CrossRef]

Br. J. Appl. Phys.

J. V. Jelley, Br. J. Appl. Phys. 6, 227 (1955).
[CrossRef]

Opt. Express

Phys. Med. Biol.

R. Robertson, M. S. Germanos, C. Q. Li, G. S. Mitchell, S. R. Cherry, and M. D. Silva, Phys. Med. Biol. 54, N355 (2009).
[CrossRef] [PubMed]

A. J. Chaudhari, F. Darvas, J. R. Bading, R. A. Moats, P. S. Conti, D. J. Smith, S. R. Cherry, and R. M. Leahy, Phys. Med. Biol. 50, 5421 (2005).
[CrossRef] [PubMed]

J. Y. Qi, R. M. Leahy, S. R. Cherry, A. Chatziioannou, and T. H. Farquhar, Phys. Med. Biol. 43, 1001 (1998).
[CrossRef] [PubMed]

Other

M. F. L'Annunciata, Handbook of Radioactivity Analysis (Academic, 2003).

T. Vo-Dinh, Biomedical Photonics Handbook (CRC Press, 2003).
[CrossRef]

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Figures (3)

Fig. 1
Fig. 1

(a) Experimental setup for phantom measurements; (b) Cerenkov luminescence measurement from phantom; (c) reconstructed CLT images of FDG concentration fused with PET images and CT images in transverse and coronal sections; (d) horizontal profile across the target from the transverse section. Peak values are normalized to 1.

Fig. 2
Fig. 2

(a) Experimental setup for in vivo measurement; (b) Cerenkov luminescence measurements from two side views; (c) microCT images in transverse and coronal sections; (d) finite-element mesh derived from microCT imaging for use in CLT reconstruction.

Fig. 3
Fig. 3

Reconstructed Cerenkov luminescence tomography images fused with microCT images: (a) coronal cross section showing bladder and heart and (b) sagittal cross section at tumor. (c), (d) Corresponding fused microPET/CT images.

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