Abstract

We demonstrate photothermal optical coherence tomography (OCT) imaging in highly scattering human breast tissue ex vivo. A 120 kHz axial scan rate, swept-source phase-sensitive OCT system at 1300 nm was used to detect phase changes induced by 830 nm photothermal excitation of gold nanoshells. Localized phase modulation was observed 300600μm deep in scattering tissue using an excitation power of only 22 mW at modulation frequencies up to 20 kHz. This technique enables integrated structural and molecular-targeted imaging for cancer markers using nanoshells.

© 2010 Optical Society of America

Full Article  |  PDF Article
Related Articles
Photothermal detection of gold nanoparticles using phase-sensitive optical coherence tomography

Desmond C. Adler, Shu-Wei Huang, Robert Huber, and James G. Fujimoto
Opt. Express 16(7) 4376-4393 (2008)

Concentration dependence of gold nanoshells on the enhancement of optical coherence tomography images: a quantitative study

James Chen Yong Kah, Tzu Hao Chow, Beng Koon Ng, Sirajudeen Gulam Razul, Malini Olivo, and Colin James Richard Sheppard
Appl. Opt. 48(10) D96-D108 (2009)

Depth resolved photothermal OCT detection of macrophages in tissue using nanorose

Amit S. Paranjape, Roman Kuranov, Stepan Baranov, Li Leo Ma, Joseph W. Villard, Tianyi Wang, Konstantin V. Sokolov, Marc D. Feldman, Keith P. Johnston, and Thomas E. Milner
Biomed. Opt. Express 1(1) 2-16 (2010)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (3)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription