Abstract

In vivo full-field (FF) optical coherence tomography (OCT) images of human retina are presented by using a rapidly tunable laser source in combination with an ultra-high-speed camera. Fourier-domain FF-OCT provided a way to increase the speed of retinal imaging by parallel acquisition of A-scans. Reduced contrast caused by cross talk was observed only below the retinal pigment epithelium. With a 100Hz sweep rate, FF-OCT was fast enough to acquire OCT images with acceptable motion artifacts. FF-OCT allows ultrafast retinal imaging, boosting image speed by a lack of moving parts and a considerably higher irradiation power.

© 2010 Optical Society of America

Full Article  |  PDF Article

References

  • View by:
  • |
  • |
  • |

  1. A. F. Fercher, C. K. Hitzenberger, W. Drexler, G. Kamp, and H. Sattmann, Am. J. Ophth. 116, 113 (1993).
    [PubMed]
  2. M. Hangai, M. Yamamoto, A. Sakamoto, and N. Yoshimura, Opt. Express 17, 4221 (2009).
    [CrossRef] [PubMed]
  3. R. A. Leitgeb, C. K. Hitzenberger, and A. F. Fercher, Opt. Express 11, 889 (2003).
    [CrossRef] [PubMed]
  4. B. Potsaid, I. Gorczynska, V. J. Srinivasan, Y. Chen, J. Jiang, A. Cable, and J. G. Fujimoto, Opt. Express 16, 15149 (2008).
    [CrossRef] [PubMed]
  5. E. Beaurepaire, A. C. Boccara, M. Lebec, L. Blanchot, and H. Saint-Jalmes, Opt. Lett. 23, 244 (1998).
    [CrossRef]
  6. A. Dubois, L. Vabre, A. C. Boccara, and E. Beaurepaire, Appl. Opt. 41, 805 (2002).
    [CrossRef] [PubMed]
  7. L. Vabre, A. Dubois, and A. C. Boccara, Opt. Lett. 27, 530(2002).
    [CrossRef]
  8. A. Dubois, K. Grieve, G. Moneron, R. Lecaque, L. Vabre, and C. Boccara, Appl. Opt. 43, 2874 (2004).
    [CrossRef] [PubMed]
  9. D. Sacchet, M. Brzezinski, J. Moreau, P. Georges, and A. Dubois, Appl. Opt. 49, 1480 (2010).
    [CrossRef] [PubMed]
  10. M. Mujat, N. V. Iftimia, R. D. Ferguson, and D. X. Hammer, Proc. SPIE 7168, 71681E (2009).
    [CrossRef]
  11. Y. Nakamura, S. Makita, M. Yamanari, M. Itoh, T. Yatagai, and Y. Yasuno, Opt. Express 15, 7103 (2007).
    [CrossRef] [PubMed]
  12. S. K. Dubey, T. Anna, C. Shakher, and D. S. Mehta, Appl. Phys. Lett. 91, 181106 (2007).
    [CrossRef]
  13. S. K. Dubey, D. S. Mehta, A. Anand, and C. Shakher, J. Opt. A 10, 015307 (2008).
    [CrossRef]
  14. B. Považay, A. Unterhuber, B. Hermann, H. Sattmann, H. Arthaber, and W. Drexler, Opt. Express 14, 7661 (2006).
    [CrossRef] [PubMed]
  15. J. Fergusson, B. Považay, B. Hofer, and W. Drexler, Proc. SPIE 7554, 75540I (2010).
    [CrossRef]
  16. S.-H. Park, J.-S. An, T.-S. Oh, and I.-H. Kim, Proc. SPIE 6794, 679414 (2007).
    [CrossRef]
  17. A. Dubois, A. C. Boccara, and M. Lebec, Opt. Lett. 24, 309 (1999).
    [CrossRef]

2010 (2)

D. Sacchet, M. Brzezinski, J. Moreau, P. Georges, and A. Dubois, Appl. Opt. 49, 1480 (2010).
[CrossRef] [PubMed]

J. Fergusson, B. Považay, B. Hofer, and W. Drexler, Proc. SPIE 7554, 75540I (2010).
[CrossRef]

2009 (2)

M. Mujat, N. V. Iftimia, R. D. Ferguson, and D. X. Hammer, Proc. SPIE 7168, 71681E (2009).
[CrossRef]

M. Hangai, M. Yamamoto, A. Sakamoto, and N. Yoshimura, Opt. Express 17, 4221 (2009).
[CrossRef] [PubMed]

2008 (2)

2007 (3)

S.-H. Park, J.-S. An, T.-S. Oh, and I.-H. Kim, Proc. SPIE 6794, 679414 (2007).
[CrossRef]

Y. Nakamura, S. Makita, M. Yamanari, M. Itoh, T. Yatagai, and Y. Yasuno, Opt. Express 15, 7103 (2007).
[CrossRef] [PubMed]

S. K. Dubey, T. Anna, C. Shakher, and D. S. Mehta, Appl. Phys. Lett. 91, 181106 (2007).
[CrossRef]

2006 (1)

2004 (1)

2003 (1)

2002 (2)

1999 (1)

1998 (1)

1993 (1)

A. F. Fercher, C. K. Hitzenberger, W. Drexler, G. Kamp, and H. Sattmann, Am. J. Ophth. 116, 113 (1993).
[PubMed]

An, J.-S.

S.-H. Park, J.-S. An, T.-S. Oh, and I.-H. Kim, Proc. SPIE 6794, 679414 (2007).
[CrossRef]

Anand, A.

S. K. Dubey, D. S. Mehta, A. Anand, and C. Shakher, J. Opt. A 10, 015307 (2008).
[CrossRef]

Anna, T.

S. K. Dubey, T. Anna, C. Shakher, and D. S. Mehta, Appl. Phys. Lett. 91, 181106 (2007).
[CrossRef]

Arthaber, H.

Beaurepaire, E.

Blanchot, L.

Boccara, A. C.

Boccara, C.

Brzezinski, M.

Cable, A.

Chen, Y.

Drexler, W.

J. Fergusson, B. Považay, B. Hofer, and W. Drexler, Proc. SPIE 7554, 75540I (2010).
[CrossRef]

B. Považay, A. Unterhuber, B. Hermann, H. Sattmann, H. Arthaber, and W. Drexler, Opt. Express 14, 7661 (2006).
[CrossRef] [PubMed]

A. F. Fercher, C. K. Hitzenberger, W. Drexler, G. Kamp, and H. Sattmann, Am. J. Ophth. 116, 113 (1993).
[PubMed]

Dubey, S. K.

S. K. Dubey, D. S. Mehta, A. Anand, and C. Shakher, J. Opt. A 10, 015307 (2008).
[CrossRef]

S. K. Dubey, T. Anna, C. Shakher, and D. S. Mehta, Appl. Phys. Lett. 91, 181106 (2007).
[CrossRef]

Dubois, A.

Fercher, A. F.

R. A. Leitgeb, C. K. Hitzenberger, and A. F. Fercher, Opt. Express 11, 889 (2003).
[CrossRef] [PubMed]

A. F. Fercher, C. K. Hitzenberger, W. Drexler, G. Kamp, and H. Sattmann, Am. J. Ophth. 116, 113 (1993).
[PubMed]

Ferguson, R. D.

M. Mujat, N. V. Iftimia, R. D. Ferguson, and D. X. Hammer, Proc. SPIE 7168, 71681E (2009).
[CrossRef]

Fergusson, J.

J. Fergusson, B. Považay, B. Hofer, and W. Drexler, Proc. SPIE 7554, 75540I (2010).
[CrossRef]

Fujimoto, J. G.

Georges, P.

Gorczynska, I.

Grieve, K.

Hammer, D. X.

M. Mujat, N. V. Iftimia, R. D. Ferguson, and D. X. Hammer, Proc. SPIE 7168, 71681E (2009).
[CrossRef]

Hangai, M.

Hermann, B.

Hitzenberger, C. K.

R. A. Leitgeb, C. K. Hitzenberger, and A. F. Fercher, Opt. Express 11, 889 (2003).
[CrossRef] [PubMed]

A. F. Fercher, C. K. Hitzenberger, W. Drexler, G. Kamp, and H. Sattmann, Am. J. Ophth. 116, 113 (1993).
[PubMed]

Hofer, B.

J. Fergusson, B. Považay, B. Hofer, and W. Drexler, Proc. SPIE 7554, 75540I (2010).
[CrossRef]

Iftimia, N. V.

M. Mujat, N. V. Iftimia, R. D. Ferguson, and D. X. Hammer, Proc. SPIE 7168, 71681E (2009).
[CrossRef]

Itoh, M.

Jiang, J.

Kamp, G.

A. F. Fercher, C. K. Hitzenberger, W. Drexler, G. Kamp, and H. Sattmann, Am. J. Ophth. 116, 113 (1993).
[PubMed]

Kim, I.-H.

S.-H. Park, J.-S. An, T.-S. Oh, and I.-H. Kim, Proc. SPIE 6794, 679414 (2007).
[CrossRef]

Lebec, M.

Lecaque, R.

Leitgeb, R. A.

Makita, S.

Mehta, D. S.

S. K. Dubey, D. S. Mehta, A. Anand, and C. Shakher, J. Opt. A 10, 015307 (2008).
[CrossRef]

S. K. Dubey, T. Anna, C. Shakher, and D. S. Mehta, Appl. Phys. Lett. 91, 181106 (2007).
[CrossRef]

Moneron, G.

Moreau, J.

Mujat, M.

M. Mujat, N. V. Iftimia, R. D. Ferguson, and D. X. Hammer, Proc. SPIE 7168, 71681E (2009).
[CrossRef]

Nakamura, Y.

Oh, T.-S.

S.-H. Park, J.-S. An, T.-S. Oh, and I.-H. Kim, Proc. SPIE 6794, 679414 (2007).
[CrossRef]

Park, S.-H.

S.-H. Park, J.-S. An, T.-S. Oh, and I.-H. Kim, Proc. SPIE 6794, 679414 (2007).
[CrossRef]

Potsaid, B.

Považay, B.

Sacchet, D.

Saint-Jalmes, H.

Sakamoto, A.

Sattmann, H.

B. Považay, A. Unterhuber, B. Hermann, H. Sattmann, H. Arthaber, and W. Drexler, Opt. Express 14, 7661 (2006).
[CrossRef] [PubMed]

A. F. Fercher, C. K. Hitzenberger, W. Drexler, G. Kamp, and H. Sattmann, Am. J. Ophth. 116, 113 (1993).
[PubMed]

Shakher, C.

S. K. Dubey, D. S. Mehta, A. Anand, and C. Shakher, J. Opt. A 10, 015307 (2008).
[CrossRef]

S. K. Dubey, T. Anna, C. Shakher, and D. S. Mehta, Appl. Phys. Lett. 91, 181106 (2007).
[CrossRef]

Srinivasan, V. J.

Unterhuber, A.

Vabre, L.

Yamamoto, M.

Yamanari, M.

Yasuno, Y.

Yatagai, T.

Yoshimura, N.

Am. J. Ophth. (1)

A. F. Fercher, C. K. Hitzenberger, W. Drexler, G. Kamp, and H. Sattmann, Am. J. Ophth. 116, 113 (1993).
[PubMed]

Appl. Opt. (3)

Appl. Phys. Lett. (1)

S. K. Dubey, T. Anna, C. Shakher, and D. S. Mehta, Appl. Phys. Lett. 91, 181106 (2007).
[CrossRef]

J. Opt. A (1)

S. K. Dubey, D. S. Mehta, A. Anand, and C. Shakher, J. Opt. A 10, 015307 (2008).
[CrossRef]

Opt. Express (5)

Opt. Lett. (3)

Proc. SPIE (3)

J. Fergusson, B. Považay, B. Hofer, and W. Drexler, Proc. SPIE 7554, 75540I (2010).
[CrossRef]

S.-H. Park, J.-S. An, T.-S. Oh, and I.-H. Kim, Proc. SPIE 6794, 679414 (2007).
[CrossRef]

M. Mujat, N. V. Iftimia, R. D. Ferguson, and D. X. Hammer, Proc. SPIE 7168, 71681E (2009).
[CrossRef]

Cited By

OSA participates in CrossRef's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (3)

Fig. 1
Fig. 1

Schematic drawing of the swept-source full-field setup.

Fig. 2
Fig. 2

(a) Single A-scan of a mirror imaged through a 1.5 optical density attenuating filter. (b) Averaged image of 50 A-scans. An SNR of 42 dB was achieved. The number of detected photoelectrons N e and the corresponding sample reflectivities r are shown on a logarithmic scale.

Fig. 3
Fig. 3

(a) Single B-scan of human retina recorded with 1,500,000 A-scans/s at 1.5 mW radiant flux. (b) Averaged image of 24 A-scans of the imaged volume.

Metrics