Abstract

A highly simplified architecture for stimulated-Raman-scattering microscopy is demonstrated, where multiple tunable narrowband picosecond pulses are generated by spectral compression of femtosecond pulses emitted by a single compact Er-fiber oscillator. The system provides high sensitivity (2×107) and spectral resolution (sub-15cm1), and it offers an unprecedented flexibility for multicolor imaging.

© 2010 Optical Society of America

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References

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2009 (6)

2008 (3)

Ch. W. Freudiger, W. Min, B. G. Saar, S. Lu, G. R. Holtom, C. He, J. C. Tsai, J. X. Kang, and X. S. Xie, Science 322, 1857 (2008).
[CrossRef] [PubMed]

M. Jurna, J. P. Korterik, C. Otto, J. L. Herek, and H. L. Offerhaus, Opt. Express 16, 15863 (2008).
[CrossRef] [PubMed]

C. L. Evans and X. S. Xie, Annu. Rev. Anal. Chem. 1, 883 (2008).
[CrossRef]

2007 (3)

E. Ploetz, S. Laimgruber, S. Berner, W. Zinth, and P. Gilch, Appl. Phys. B 87, 389 (2007).
[CrossRef]

P. Kukura, D. W. McCamant, and R. A. Mathies, Annu. Rev. Phys. Chem. 58, 461 (2007).
[CrossRef]

M. A. Marangoni, D. Brida, M. Quintavalle, G. Cirmi, F. M. Pigozzo, C. Manzoni, F. Baronio, A. D. Capobianco, and G. Cerullo, Opt. Express 15, 8884 (2007).
[CrossRef] [PubMed]

2006 (1)

2005 (1)

R. Yuste, Nat. Methods 2, 902 (2005).
[CrossRef] [PubMed]

2004 (1)

2003 (1)

J. Chapell and D. D. G. Lidzey, J. Microsc. 209, 188 (2003).
[CrossRef]

1999 (1)

A. Zumbusch, G. R. Holtom, and X. S. Xie, Phys. Rev. Lett. 82, 4142 (1999).
[CrossRef]

Adler, F.

Baronio, F.

Berner, S.

E. Ploetz, S. Laimgruber, S. Berner, W. Zinth, and P. Gilch, Appl. Phys. B 87, 389 (2007).
[CrossRef]

Brida, D.

Capobianco, A. D.

Cerullo, G.

Chapell, J.

J. Chapell and D. D. G. Lidzey, J. Microsc. 209, 188 (2003).
[CrossRef]

Cirmi, G.

Conforti, M.

Dake, F.

De Angelis, C.

Evans, C. L.

Freudiger, Ch. W.

Ch. W. Freudiger, W. Min, B. G. Saar, S. Lu, G. R. Holtom, C. He, J. C. Tsai, J. X. Kang, and X. S. Xie, Science 322, 1857 (2008).
[CrossRef] [PubMed]

Fukui, K.

Gambetta, A.

Ganikhanov, F.

Gilch, P.

E. Ploetz, B. Marx, T. Klein, R. Huber, and P. Gilch, Opt. Express 17, 18612 (2009).
[CrossRef]

E. Ploetz, S. Laimgruber, S. Berner, W. Zinth, and P. Gilch, Appl. Phys. B 87, 389 (2007).
[CrossRef]

Hanke, T.

He, C.

Ch. W. Freudiger, W. Min, B. G. Saar, S. Lu, G. R. Holtom, C. He, J. C. Tsai, J. X. Kang, and X. S. Xie, Science 322, 1857 (2008).
[CrossRef] [PubMed]

Herek, J. L.

Holtom, G. R.

Ch. W. Freudiger, W. Min, B. G. Saar, S. Lu, G. R. Holtom, C. He, J. C. Tsai, J. X. Kang, and X. S. Xie, Science 322, 1857 (2008).
[CrossRef] [PubMed]

A. Zumbusch, G. R. Holtom, and X. S. Xie, Phys. Rev. Lett. 82, 4142 (1999).
[CrossRef]

Huber, R.

Itoh, K.

Jurna, M.

Kajiyama, S.

Kang, J. X.

Ch. W. Freudiger, W. Min, B. G. Saar, S. Lu, G. R. Holtom, C. He, J. C. Tsai, J. X. Kang, and X. S. Xie, Science 322, 1857 (2008).
[CrossRef] [PubMed]

Klein, T.

Korterik, J. P.

Kovalev, A.

P. Nandakumar, A. Kovalev, and A. Volkmer, New J. Phys. 11, 033026 (2009).
[CrossRef]

Krauss, G.

Kukura, P.

P. Kukura, D. W. McCamant, and R. A. Mathies, Annu. Rev. Phys. Chem. 58, 461 (2007).
[CrossRef]

Kumar, V.

Laimgruber, S.

E. Ploetz, S. Laimgruber, S. Berner, W. Zinth, and P. Gilch, Appl. Phys. B 87, 389 (2007).
[CrossRef]

Leitenstorfer, A.

Lidzey, D. D. G.

J. Chapell and D. D. G. Lidzey, J. Microsc. 209, 188 (2003).
[CrossRef]

Lu, S.

Ch. W. Freudiger, W. Min, B. G. Saar, S. Lu, G. R. Holtom, C. He, J. C. Tsai, J. X. Kang, and X. S. Xie, Science 322, 1857 (2008).
[CrossRef] [PubMed]

Manzoni, C.

Marangoni, M.

Marangoni, M. A.

Marx, B.

Mathies, R. A.

P. Kukura, D. W. McCamant, and R. A. Mathies, Annu. Rev. Phys. Chem. 58, 461 (2007).
[CrossRef]

McCamant, D. W.

P. Kukura, D. W. McCamant, and R. A. Mathies, Annu. Rev. Phys. Chem. 58, 461 (2007).
[CrossRef]

Min, W.

Ch. W. Freudiger, W. Min, B. G. Saar, S. Lu, G. R. Holtom, C. He, J. C. Tsai, J. X. Kang, and X. S. Xie, Science 322, 1857 (2008).
[CrossRef] [PubMed]

Nalesso, G. F.

Nandakumar, P.

P. Nandakumar, A. Kovalev, and A. Volkmer, New J. Phys. 11, 033026 (2009).
[CrossRef]

Offerhaus, H. L.

Otto, C.

Ozeki, Y.

Pigozzo, F. M.

Ploetz, E.

E. Ploetz, B. Marx, T. Klein, R. Huber, and P. Gilch, Opt. Express 17, 18612 (2009).
[CrossRef]

E. Ploetz, S. Laimgruber, S. Berner, W. Zinth, and P. Gilch, Appl. Phys. B 87, 389 (2007).
[CrossRef]

Quintavalle, M.

Ramponi, R.

Saar, B. G.

Ch. W. Freudiger, W. Min, B. G. Saar, S. Lu, G. R. Holtom, C. He, J. C. Tsai, J. X. Kang, and X. S. Xie, Science 322, 1857 (2008).
[CrossRef] [PubMed]

F. Ganikhanov, C. L. Evans, B. G. Saar, and X. S. Xie, Opt. Lett. 31, 1872 (2006).
[CrossRef] [PubMed]

Sell, A.

Selm, R.

Tauser, F.

Träutlein, D.

Tsai, J. C.

Ch. W. Freudiger, W. Min, B. G. Saar, S. Lu, G. R. Holtom, C. He, J. C. Tsai, J. X. Kang, and X. S. Xie, Science 322, 1857 (2008).
[CrossRef] [PubMed]

Volkmer, A.

P. Nandakumar, A. Kovalev, and A. Volkmer, New J. Phys. 11, 033026 (2009).
[CrossRef]

Winterhalder, M.

Xie, X. S.

Ch. W. Freudiger, W. Min, B. G. Saar, S. Lu, G. R. Holtom, C. He, J. C. Tsai, J. X. Kang, and X. S. Xie, Science 322, 1857 (2008).
[CrossRef] [PubMed]

C. L. Evans and X. S. Xie, Annu. Rev. Anal. Chem. 1, 883 (2008).
[CrossRef]

F. Ganikhanov, C. L. Evans, B. G. Saar, and X. S. Xie, Opt. Lett. 31, 1872 (2006).
[CrossRef] [PubMed]

A. Zumbusch, G. R. Holtom, and X. S. Xie, Phys. Rev. Lett. 82, 4142 (1999).
[CrossRef]

Yuste, R.

R. Yuste, Nat. Methods 2, 902 (2005).
[CrossRef] [PubMed]

Zinth, W.

E. Ploetz, S. Laimgruber, S. Berner, W. Zinth, and P. Gilch, Appl. Phys. B 87, 389 (2007).
[CrossRef]

Zumbusch, A.

Annu. Rev. Anal. Chem. (1)

C. L. Evans and X. S. Xie, Annu. Rev. Anal. Chem. 1, 883 (2008).
[CrossRef]

Annu. Rev. Phys. Chem. (1)

P. Kukura, D. W. McCamant, and R. A. Mathies, Annu. Rev. Phys. Chem. 58, 461 (2007).
[CrossRef]

Appl. Phys. B (1)

E. Ploetz, S. Laimgruber, S. Berner, W. Zinth, and P. Gilch, Appl. Phys. B 87, 389 (2007).
[CrossRef]

J. Microsc. (1)

J. Chapell and D. D. G. Lidzey, J. Microsc. 209, 188 (2003).
[CrossRef]

Nat. Methods (1)

R. Yuste, Nat. Methods 2, 902 (2005).
[CrossRef] [PubMed]

New J. Phys. (1)

P. Nandakumar, A. Kovalev, and A. Volkmer, New J. Phys. 11, 033026 (2009).
[CrossRef]

Opt. Express (4)

Opt. Lett. (5)

Phys. Rev. Lett. (1)

A. Zumbusch, G. R. Holtom, and X. S. Xie, Phys. Rev. Lett. 82, 4142 (1999).
[CrossRef]

Science (1)

Ch. W. Freudiger, W. Min, B. G. Saar, S. Lu, G. R. Holtom, C. He, J. C. Tsai, J. X. Kang, and X. S. Xie, Science 322, 1857 (2008).
[CrossRef] [PubMed]

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Figures (3)

Fig. 1
Fig. 1

(a) Experimental setup for fiber-format SRS microscope. DBS, dichroic beam splitter; BS, beam splitter; LPF, long-pass filter; AOM, acousto-optical modulator; PPLN, periodically poled lithium-niobate; VA, variable attenuator; SC, supercontinuum. (b) Intensity noise spectrum of the laser. (c) Pump spectrum (left) and a few examples of Stokes spectra at different frequency detuning.

Fig. 2
Fig. 2

SRS spectrum of DMSO. Inset, pump-power dependence of the SRS signal.

Fig. 3
Fig. 3

SRS image of a blend of PFO in PMMA at (a) 1590 cm 1 and (b) 2950 cm 1 . (c) SRS spectrum acquired on a PFO domain.

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