Abstract

A highly simplified architecture for stimulated-Raman-scattering microscopy is demonstrated, where multiple tunable narrowband picosecond pulses are generated by spectral compression of femtosecond pulses emitted by a single compact Er-fiber oscillator. The system provides high sensitivity (2×107) and spectral resolution (sub-15cm1), and it offers an unprecedented flexibility for multicolor imaging.

© 2010 Optical Society of America

Full Article  |  PDF Article

References

  • View by:
  • |
  • |
  • |

  1. R. Yuste, Nat. Methods 2, 902 (2005).
    [CrossRef] [PubMed]
  2. C. L. Evans and X. S. Xie, Annu. Rev. Anal. Chem. 1, 883 (2008).
    [CrossRef]
  3. A. Zumbusch, G. R. Holtom, and X. S. Xie, Phys. Rev. Lett. 82, 4142 (1999).
    [CrossRef]
  4. F. Ganikhanov, C. L. Evans, B. G. Saar, and X. S. Xie, Opt. Lett. 31, 1872 (2006).
    [CrossRef] [PubMed]
  5. M. Jurna, J. P. Korterik, C. Otto, J. L. Herek, and H. L. Offerhaus, Opt. Express 16, 15863 (2008).
    [CrossRef] [PubMed]
  6. E. Ploetz, S. Laimgruber, S. Berner, W. Zinth, and P. Gilch, Appl. Phys. B 87, 389 (2007).
    [CrossRef]
  7. Ch. W. Freudiger, W. Min, B. G. Saar, S. Lu, G. R. Holtom, C. He, J. C. Tsai, J. X. Kang, and X. S. Xie, Science 322, 1857 (2008).
    [CrossRef] [PubMed]
  8. P. Nandakumar, A. Kovalev, and A. Volkmer, New J. Phys. 11, 033026 (2009).
    [CrossRef]
  9. P. Kukura, D. W. McCamant, and R. A. Mathies, Annu. Rev. Phys. Chem. 58, 461 (2007).
    [CrossRef]
  10. Y. Ozeki, F. Dake, S. Kajiyama, K. Fukui, and K. Itoh, Opt. Express 17, 3651 (2009).
    [CrossRef] [PubMed]
  11. E. Ploetz, B. Marx, T. Klein, R. Huber, and P. Gilch, Opt. Express 17, 18612 (2009).
    [CrossRef]
  12. M. A. Marangoni, D. Brida, M. Quintavalle, G. Cirmi, F. M. Pigozzo, C. Manzoni, F. Baronio, A. D. Capobianco, and G. Cerullo, Opt. Express 15, 8884 (2007).
    [CrossRef] [PubMed]
  13. M. Marangoni, D. Brida, M. Conforti, A. D. Capobianco, C. Manzoni, F. Baronio, G. F. Nalesso, C. De Angelis, R. Ramponi, and G. Cerullo, Opt. Lett. 34, 241 (2009).
    [CrossRef] [PubMed]
  14. M. Marangoni, A. Gambetta, C. Manzoni, V. Kumar, R. Ramponi, and G. Cerullo, Opt. Lett. 34, 3262 (2009).
    [CrossRef] [PubMed]
  15. G. Krauss, T. Hanke, A. Sell, D. Träutlein, A. Leitenstorfer, R. Selm, M. Winterhalder, and A. Zumbusch, Opt. Lett. 34, 2847 (2009).
    [CrossRef] [PubMed]
  16. F. Tauser, F. Adler, and A. Leitenstorfer, Opt. Lett. 29, 516 (2004).
    [CrossRef] [PubMed]
  17. J. Chapell and D. D. G. Lidzey, J. Microsc. 209, 188 (2003).
    [CrossRef]

2009

2008

M. Jurna, J. P. Korterik, C. Otto, J. L. Herek, and H. L. Offerhaus, Opt. Express 16, 15863 (2008).
[CrossRef] [PubMed]

Ch. W. Freudiger, W. Min, B. G. Saar, S. Lu, G. R. Holtom, C. He, J. C. Tsai, J. X. Kang, and X. S. Xie, Science 322, 1857 (2008).
[CrossRef] [PubMed]

C. L. Evans and X. S. Xie, Annu. Rev. Anal. Chem. 1, 883 (2008).
[CrossRef]

2007

E. Ploetz, S. Laimgruber, S. Berner, W. Zinth, and P. Gilch, Appl. Phys. B 87, 389 (2007).
[CrossRef]

P. Kukura, D. W. McCamant, and R. A. Mathies, Annu. Rev. Phys. Chem. 58, 461 (2007).
[CrossRef]

M. A. Marangoni, D. Brida, M. Quintavalle, G. Cirmi, F. M. Pigozzo, C. Manzoni, F. Baronio, A. D. Capobianco, and G. Cerullo, Opt. Express 15, 8884 (2007).
[CrossRef] [PubMed]

2006

2005

R. Yuste, Nat. Methods 2, 902 (2005).
[CrossRef] [PubMed]

2004

2003

J. Chapell and D. D. G. Lidzey, J. Microsc. 209, 188 (2003).
[CrossRef]

1999

A. Zumbusch, G. R. Holtom, and X. S. Xie, Phys. Rev. Lett. 82, 4142 (1999).
[CrossRef]

Adler, F.

Baronio, F.

Berner, S.

E. Ploetz, S. Laimgruber, S. Berner, W. Zinth, and P. Gilch, Appl. Phys. B 87, 389 (2007).
[CrossRef]

Brida, D.

Capobianco, A. D.

Cerullo, G.

Chapell, J.

J. Chapell and D. D. G. Lidzey, J. Microsc. 209, 188 (2003).
[CrossRef]

Cirmi, G.

Conforti, M.

Dake, F.

De Angelis, C.

Evans, C. L.

Freudiger, Ch. W.

Ch. W. Freudiger, W. Min, B. G. Saar, S. Lu, G. R. Holtom, C. He, J. C. Tsai, J. X. Kang, and X. S. Xie, Science 322, 1857 (2008).
[CrossRef] [PubMed]

Fukui, K.

Gambetta, A.

Ganikhanov, F.

Gilch, P.

E. Ploetz, B. Marx, T. Klein, R. Huber, and P. Gilch, Opt. Express 17, 18612 (2009).
[CrossRef]

E. Ploetz, S. Laimgruber, S. Berner, W. Zinth, and P. Gilch, Appl. Phys. B 87, 389 (2007).
[CrossRef]

Hanke, T.

He, C.

Ch. W. Freudiger, W. Min, B. G. Saar, S. Lu, G. R. Holtom, C. He, J. C. Tsai, J. X. Kang, and X. S. Xie, Science 322, 1857 (2008).
[CrossRef] [PubMed]

Herek, J. L.

Holtom, G. R.

Ch. W. Freudiger, W. Min, B. G. Saar, S. Lu, G. R. Holtom, C. He, J. C. Tsai, J. X. Kang, and X. S. Xie, Science 322, 1857 (2008).
[CrossRef] [PubMed]

A. Zumbusch, G. R. Holtom, and X. S. Xie, Phys. Rev. Lett. 82, 4142 (1999).
[CrossRef]

Huber, R.

Itoh, K.

Jurna, M.

Kajiyama, S.

Kang, J. X.

Ch. W. Freudiger, W. Min, B. G. Saar, S. Lu, G. R. Holtom, C. He, J. C. Tsai, J. X. Kang, and X. S. Xie, Science 322, 1857 (2008).
[CrossRef] [PubMed]

Klein, T.

Korterik, J. P.

Kovalev, A.

P. Nandakumar, A. Kovalev, and A. Volkmer, New J. Phys. 11, 033026 (2009).
[CrossRef]

Krauss, G.

Kukura, P.

P. Kukura, D. W. McCamant, and R. A. Mathies, Annu. Rev. Phys. Chem. 58, 461 (2007).
[CrossRef]

Kumar, V.

Laimgruber, S.

E. Ploetz, S. Laimgruber, S. Berner, W. Zinth, and P. Gilch, Appl. Phys. B 87, 389 (2007).
[CrossRef]

Leitenstorfer, A.

Lidzey, D. D. G.

J. Chapell and D. D. G. Lidzey, J. Microsc. 209, 188 (2003).
[CrossRef]

Lu, S.

Ch. W. Freudiger, W. Min, B. G. Saar, S. Lu, G. R. Holtom, C. He, J. C. Tsai, J. X. Kang, and X. S. Xie, Science 322, 1857 (2008).
[CrossRef] [PubMed]

Manzoni, C.

Marangoni, M.

Marangoni, M. A.

Marx, B.

Mathies, R. A.

P. Kukura, D. W. McCamant, and R. A. Mathies, Annu. Rev. Phys. Chem. 58, 461 (2007).
[CrossRef]

McCamant, D. W.

P. Kukura, D. W. McCamant, and R. A. Mathies, Annu. Rev. Phys. Chem. 58, 461 (2007).
[CrossRef]

Min, W.

Ch. W. Freudiger, W. Min, B. G. Saar, S. Lu, G. R. Holtom, C. He, J. C. Tsai, J. X. Kang, and X. S. Xie, Science 322, 1857 (2008).
[CrossRef] [PubMed]

Nalesso, G. F.

Nandakumar, P.

P. Nandakumar, A. Kovalev, and A. Volkmer, New J. Phys. 11, 033026 (2009).
[CrossRef]

Offerhaus, H. L.

Otto, C.

Ozeki, Y.

Pigozzo, F. M.

Ploetz, E.

E. Ploetz, B. Marx, T. Klein, R. Huber, and P. Gilch, Opt. Express 17, 18612 (2009).
[CrossRef]

E. Ploetz, S. Laimgruber, S. Berner, W. Zinth, and P. Gilch, Appl. Phys. B 87, 389 (2007).
[CrossRef]

Quintavalle, M.

Ramponi, R.

Saar, B. G.

Ch. W. Freudiger, W. Min, B. G. Saar, S. Lu, G. R. Holtom, C. He, J. C. Tsai, J. X. Kang, and X. S. Xie, Science 322, 1857 (2008).
[CrossRef] [PubMed]

F. Ganikhanov, C. L. Evans, B. G. Saar, and X. S. Xie, Opt. Lett. 31, 1872 (2006).
[CrossRef] [PubMed]

Sell, A.

Selm, R.

Tauser, F.

Träutlein, D.

Tsai, J. C.

Ch. W. Freudiger, W. Min, B. G. Saar, S. Lu, G. R. Holtom, C. He, J. C. Tsai, J. X. Kang, and X. S. Xie, Science 322, 1857 (2008).
[CrossRef] [PubMed]

Volkmer, A.

P. Nandakumar, A. Kovalev, and A. Volkmer, New J. Phys. 11, 033026 (2009).
[CrossRef]

Winterhalder, M.

Xie, X. S.

Ch. W. Freudiger, W. Min, B. G. Saar, S. Lu, G. R. Holtom, C. He, J. C. Tsai, J. X. Kang, and X. S. Xie, Science 322, 1857 (2008).
[CrossRef] [PubMed]

C. L. Evans and X. S. Xie, Annu. Rev. Anal. Chem. 1, 883 (2008).
[CrossRef]

F. Ganikhanov, C. L. Evans, B. G. Saar, and X. S. Xie, Opt. Lett. 31, 1872 (2006).
[CrossRef] [PubMed]

A. Zumbusch, G. R. Holtom, and X. S. Xie, Phys. Rev. Lett. 82, 4142 (1999).
[CrossRef]

Yuste, R.

R. Yuste, Nat. Methods 2, 902 (2005).
[CrossRef] [PubMed]

Zinth, W.

E. Ploetz, S. Laimgruber, S. Berner, W. Zinth, and P. Gilch, Appl. Phys. B 87, 389 (2007).
[CrossRef]

Zumbusch, A.

Annu. Rev. Anal. Chem.

C. L. Evans and X. S. Xie, Annu. Rev. Anal. Chem. 1, 883 (2008).
[CrossRef]

Annu. Rev. Phys. Chem.

P. Kukura, D. W. McCamant, and R. A. Mathies, Annu. Rev. Phys. Chem. 58, 461 (2007).
[CrossRef]

Appl. Phys. B

E. Ploetz, S. Laimgruber, S. Berner, W. Zinth, and P. Gilch, Appl. Phys. B 87, 389 (2007).
[CrossRef]

J. Microsc.

J. Chapell and D. D. G. Lidzey, J. Microsc. 209, 188 (2003).
[CrossRef]

Nat. Methods

R. Yuste, Nat. Methods 2, 902 (2005).
[CrossRef] [PubMed]

New J. Phys.

P. Nandakumar, A. Kovalev, and A. Volkmer, New J. Phys. 11, 033026 (2009).
[CrossRef]

Opt. Express

Opt. Lett.

Phys. Rev. Lett.

A. Zumbusch, G. R. Holtom, and X. S. Xie, Phys. Rev. Lett. 82, 4142 (1999).
[CrossRef]

Science

Ch. W. Freudiger, W. Min, B. G. Saar, S. Lu, G. R. Holtom, C. He, J. C. Tsai, J. X. Kang, and X. S. Xie, Science 322, 1857 (2008).
[CrossRef] [PubMed]

Cited By

OSA participates in CrossRef's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (3)

Fig. 1
Fig. 1

(a) Experimental setup for fiber-format SRS microscope. DBS, dichroic beam splitter; BS, beam splitter; LPF, long-pass filter; AOM, acousto-optical modulator; PPLN, periodically poled lithium-niobate; VA, variable attenuator; SC, supercontinuum. (b) Intensity noise spectrum of the laser. (c) Pump spectrum (left) and a few examples of Stokes spectra at different frequency detuning.

Fig. 2
Fig. 2

SRS spectrum of DMSO. Inset, pump-power dependence of the SRS signal.

Fig. 3
Fig. 3

SRS image of a blend of PFO in PMMA at (a) 1590 cm 1 and (b) 2950 cm 1 . (c) SRS spectrum acquired on a PFO domain.

Metrics