Abstract

We report a silicon-on-insulator ring resonator biosensor array with one output port, using wavelength division multiplexing as the addressing scheme. With the use of on-chip referencing for environmental drift cancellation, simultaneous monitoring of multiplexed molecular bindings is demonstrated, with a resolution of 0.3pg/mm2 (40ag of total mass) for protein concentrations over 4 orders of magnitude down to 20pM. Reactions are measured over time periods as long as 3h with high stability.

Full Article  |  PDF Article

References

  • View by:
  • |
  • |
  • |

  1. A. Densmore, M. Vachon, D.-X. Xu, S. Janz, R. Ma, Y.-H. Li, G. Lopinski, A. Delâge, J. Lapointe, C. C. Luebbert, Q. Y. Liu, P. Cheben, and J. H. Schmid, Opt. Lett. 34, 3598 (2009).
    [CrossRef] [PubMed]
  2. D.-X. Xu, A. Densmore, A. Delâge, P. Waldron, R. McKinnon, S. Janz, J. Lapointe, G. Lopinski, T. Mischki, E. Post, P. Cheben, and J. H. Schmid, Opt. Express 16, 15137 (2008).
    [CrossRef] [PubMed]
  3. A. L. Washburn, L. C. Gunn, and R. C. Bailey, Anal. Chem. 81, 9499 (2009).
    [CrossRef] [PubMed]
  4. N. Skivesen, A. Tu, M. Kristensen, L. Frandsen, and P. Borel, Opt. Express 15, 3169 (2007).
    [CrossRef] [PubMed]
  5. K. De Vos, J. Girones, T. Claes, Y. De Koninck, S. Popelka, E. Schacht, R. Baets, and P. Bienstman, IEEE Photonics J. 1, 225 (2009).
    [CrossRef]
  6. N. Jokerst, M. Royal, S. Palit, L. Luan, S. Dhar, and T. Tyler, J. Biophoton. 2, 212 (2009).
    [CrossRef]
  7. J. H. Schmid, W. Sinclair, J. García, S. Janz, J. Lapointe, D. Poitras, Y. Li, T. Mischki, G. Lopinski, P. Cheben, A. Delâge, A. Densmore, P. Waldron, and D.-X. Xu, Opt. Express 17, 18371 (2009).
    [CrossRef] [PubMed]
  8. W. R. McKinnon, D.-X. Xu, C. Storey, E. Post, A. Densmore, A. Delâge, P. Waldron, J. H. Schmid, and S. Janz, Opt. Express 17, 18971 (2009).
    [CrossRef]
  9. D.-X. Xu, A. Densmore, R. Ma, J. H. Schmid, M. Vachon, J. Lapointe, S. Janz, E. Post, A. Delâge, and P. Cheben, in 6th IEEE International Conference on Group IV Photonics (IEEE, 2009), WC3, pp. 34–36.
    [CrossRef]
  10. E. Olle, J. Messamore, M. Deogracias, S. McClintock, T. Anderson, and K. Johnson, Exp. Mol. Pathol. 79, 206 (2005).
    [CrossRef] [PubMed]
  11. J. Stepánek, H. Vaisocherová, and M. Piliarik, eds., Surface Plasmon Resonance Based Sensors (Springer, 2006), Vol. 4, pp. 69–91.
    [CrossRef]
  12. H. Elwing, Biomaterials 19, 397 (1998).
    [CrossRef] [PubMed]

2009 (6)

2008 (1)

2007 (1)

2005 (1)

E. Olle, J. Messamore, M. Deogracias, S. McClintock, T. Anderson, and K. Johnson, Exp. Mol. Pathol. 79, 206 (2005).
[CrossRef] [PubMed]

1998 (1)

H. Elwing, Biomaterials 19, 397 (1998).
[CrossRef] [PubMed]

Anderson, T.

E. Olle, J. Messamore, M. Deogracias, S. McClintock, T. Anderson, and K. Johnson, Exp. Mol. Pathol. 79, 206 (2005).
[CrossRef] [PubMed]

Baets, R.

K. De Vos, J. Girones, T. Claes, Y. De Koninck, S. Popelka, E. Schacht, R. Baets, and P. Bienstman, IEEE Photonics J. 1, 225 (2009).
[CrossRef]

Bailey, R. C.

A. L. Washburn, L. C. Gunn, and R. C. Bailey, Anal. Chem. 81, 9499 (2009).
[CrossRef] [PubMed]

Bienstman, P.

K. De Vos, J. Girones, T. Claes, Y. De Koninck, S. Popelka, E. Schacht, R. Baets, and P. Bienstman, IEEE Photonics J. 1, 225 (2009).
[CrossRef]

Borel, P.

Cheben, P.

Claes, T.

K. De Vos, J. Girones, T. Claes, Y. De Koninck, S. Popelka, E. Schacht, R. Baets, and P. Bienstman, IEEE Photonics J. 1, 225 (2009).
[CrossRef]

De Koninck, Y.

K. De Vos, J. Girones, T. Claes, Y. De Koninck, S. Popelka, E. Schacht, R. Baets, and P. Bienstman, IEEE Photonics J. 1, 225 (2009).
[CrossRef]

De Vos, K.

K. De Vos, J. Girones, T. Claes, Y. De Koninck, S. Popelka, E. Schacht, R. Baets, and P. Bienstman, IEEE Photonics J. 1, 225 (2009).
[CrossRef]

Delâge, A.

Densmore, A.

Deogracias, M.

E. Olle, J. Messamore, M. Deogracias, S. McClintock, T. Anderson, and K. Johnson, Exp. Mol. Pathol. 79, 206 (2005).
[CrossRef] [PubMed]

Dhar, S.

N. Jokerst, M. Royal, S. Palit, L. Luan, S. Dhar, and T. Tyler, J. Biophoton. 2, 212 (2009).
[CrossRef]

Elwing, H.

H. Elwing, Biomaterials 19, 397 (1998).
[CrossRef] [PubMed]

Frandsen, L.

García, J.

Girones, J.

K. De Vos, J. Girones, T. Claes, Y. De Koninck, S. Popelka, E. Schacht, R. Baets, and P. Bienstman, IEEE Photonics J. 1, 225 (2009).
[CrossRef]

Gunn, L. C.

A. L. Washburn, L. C. Gunn, and R. C. Bailey, Anal. Chem. 81, 9499 (2009).
[CrossRef] [PubMed]

Janz, S.

Johnson, K.

E. Olle, J. Messamore, M. Deogracias, S. McClintock, T. Anderson, and K. Johnson, Exp. Mol. Pathol. 79, 206 (2005).
[CrossRef] [PubMed]

Jokerst, N.

N. Jokerst, M. Royal, S. Palit, L. Luan, S. Dhar, and T. Tyler, J. Biophoton. 2, 212 (2009).
[CrossRef]

Kristensen, M.

Lapointe, J.

Li, Y.

Li, Y.-H.

Liu, Q. Y.

Lopinski, G.

Luan, L.

N. Jokerst, M. Royal, S. Palit, L. Luan, S. Dhar, and T. Tyler, J. Biophoton. 2, 212 (2009).
[CrossRef]

Luebbert, C. C.

Ma, R.

A. Densmore, M. Vachon, D.-X. Xu, S. Janz, R. Ma, Y.-H. Li, G. Lopinski, A. Delâge, J. Lapointe, C. C. Luebbert, Q. Y. Liu, P. Cheben, and J. H. Schmid, Opt. Lett. 34, 3598 (2009).
[CrossRef] [PubMed]

D.-X. Xu, A. Densmore, R. Ma, J. H. Schmid, M. Vachon, J. Lapointe, S. Janz, E. Post, A. Delâge, and P. Cheben, in 6th IEEE International Conference on Group IV Photonics (IEEE, 2009), WC3, pp. 34–36.
[CrossRef]

McClintock, S.

E. Olle, J. Messamore, M. Deogracias, S. McClintock, T. Anderson, and K. Johnson, Exp. Mol. Pathol. 79, 206 (2005).
[CrossRef] [PubMed]

McKinnon, R.

McKinnon, W. R.

Messamore, J.

E. Olle, J. Messamore, M. Deogracias, S. McClintock, T. Anderson, and K. Johnson, Exp. Mol. Pathol. 79, 206 (2005).
[CrossRef] [PubMed]

Mischki, T.

Olle, E.

E. Olle, J. Messamore, M. Deogracias, S. McClintock, T. Anderson, and K. Johnson, Exp. Mol. Pathol. 79, 206 (2005).
[CrossRef] [PubMed]

Palit, S.

N. Jokerst, M. Royal, S. Palit, L. Luan, S. Dhar, and T. Tyler, J. Biophoton. 2, 212 (2009).
[CrossRef]

Piliarik, M.

J. Stepánek, H. Vaisocherová, and M. Piliarik, eds., Surface Plasmon Resonance Based Sensors (Springer, 2006), Vol. 4, pp. 69–91.
[CrossRef]

Poitras, D.

Popelka, S.

K. De Vos, J. Girones, T. Claes, Y. De Koninck, S. Popelka, E. Schacht, R. Baets, and P. Bienstman, IEEE Photonics J. 1, 225 (2009).
[CrossRef]

Post, E.

Royal, M.

N. Jokerst, M. Royal, S. Palit, L. Luan, S. Dhar, and T. Tyler, J. Biophoton. 2, 212 (2009).
[CrossRef]

Schacht, E.

K. De Vos, J. Girones, T. Claes, Y. De Koninck, S. Popelka, E. Schacht, R. Baets, and P. Bienstman, IEEE Photonics J. 1, 225 (2009).
[CrossRef]

Schmid, J. H.

Sinclair, W.

Skivesen, N.

Stepánek, J.

J. Stepánek, H. Vaisocherová, and M. Piliarik, eds., Surface Plasmon Resonance Based Sensors (Springer, 2006), Vol. 4, pp. 69–91.
[CrossRef]

Storey, C.

Tu, A.

Tyler, T.

N. Jokerst, M. Royal, S. Palit, L. Luan, S. Dhar, and T. Tyler, J. Biophoton. 2, 212 (2009).
[CrossRef]

Vachon, M.

A. Densmore, M. Vachon, D.-X. Xu, S. Janz, R. Ma, Y.-H. Li, G. Lopinski, A. Delâge, J. Lapointe, C. C. Luebbert, Q. Y. Liu, P. Cheben, and J. H. Schmid, Opt. Lett. 34, 3598 (2009).
[CrossRef] [PubMed]

D.-X. Xu, A. Densmore, R. Ma, J. H. Schmid, M. Vachon, J. Lapointe, S. Janz, E. Post, A. Delâge, and P. Cheben, in 6th IEEE International Conference on Group IV Photonics (IEEE, 2009), WC3, pp. 34–36.
[CrossRef]

Vaisocherová, H.

J. Stepánek, H. Vaisocherová, and M. Piliarik, eds., Surface Plasmon Resonance Based Sensors (Springer, 2006), Vol. 4, pp. 69–91.
[CrossRef]

Waldron, P.

Washburn, A. L.

A. L. Washburn, L. C. Gunn, and R. C. Bailey, Anal. Chem. 81, 9499 (2009).
[CrossRef] [PubMed]

Xu, D.-X.

Anal. Chem. (1)

A. L. Washburn, L. C. Gunn, and R. C. Bailey, Anal. Chem. 81, 9499 (2009).
[CrossRef] [PubMed]

Biomaterials (1)

H. Elwing, Biomaterials 19, 397 (1998).
[CrossRef] [PubMed]

Exp. Mol. Pathol. (1)

E. Olle, J. Messamore, M. Deogracias, S. McClintock, T. Anderson, and K. Johnson, Exp. Mol. Pathol. 79, 206 (2005).
[CrossRef] [PubMed]

IEEE Photonics J. (1)

K. De Vos, J. Girones, T. Claes, Y. De Koninck, S. Popelka, E. Schacht, R. Baets, and P. Bienstman, IEEE Photonics J. 1, 225 (2009).
[CrossRef]

J. Biophoton. (1)

N. Jokerst, M. Royal, S. Palit, L. Luan, S. Dhar, and T. Tyler, J. Biophoton. 2, 212 (2009).
[CrossRef]

Opt. Express (4)

Opt. Lett. (1)

Other (2)

D.-X. Xu, A. Densmore, R. Ma, J. H. Schmid, M. Vachon, J. Lapointe, S. Janz, E. Post, A. Delâge, and P. Cheben, in 6th IEEE International Conference on Group IV Photonics (IEEE, 2009), WC3, pp. 34–36.
[CrossRef]

J. Stepánek, H. Vaisocherová, and M. Piliarik, eds., Surface Plasmon Resonance Based Sensors (Springer, 2006), Vol. 4, pp. 69–91.
[CrossRef]

Cited By

OSA participates in CrossRef's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (4)

Fig. 1
Fig. 1

(a) Schematic of the WDM addressed ring sensor array, (b) corresponding cross section, (c) fabricated sensor array, and (d) sensor array with microfluidic channel.

Fig. 2
Fig. 2

(a) Transmission spectrum of the ring sensor array. The labels indicate the resonators that the resonances originate from, as marked in Figs. 1c, 1b. (b) As-measured wavelength shift of the sensors in 0.5%, 1%, and 2% sucrose solutions relative to DI water.

Fig. 3
Fig. 3

(a) Wavelength shift of sensor 3 (spotted with rabbit IgG) upon exposure to varying concentrations of antirabbit IgG. Inset, a close up of the response to 0.02 nM IgG. (b) Response rate between complementary protein pairs at varying IgG concentrations.

Fig. 4
Fig. 4

(a) Corrected wavelength shift of the sensor array in response to consecutively injected 2 nM IgG solutions. (a) and (b) sensor 1 and 2—goat IgG spotted, (c) sensor 3—rabbit IgG spotted, and (d) sensor 4—BSA spotted.

Metrics