Abstract

We present an imaging technique that combines optical projection tomography with ballistic imaging using ultrafast time gating. The method provides high-resolution reconstruction of scattering samples and is suitable for three- dimensional (3D) imaging of biological models.

© 2010 Optical Society of America

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  1. R. Weissleder and V. Ntziachristos, Nat. Med. 9, 123(2003).
    [CrossRef] [PubMed]
  2. J. Sharpe, U. Ahlgren, P. Perry, B. Hill, A. Ross, J. Hecksher, R. Baldock, and D. Davidson, Science 296, 541 (2002).
    [CrossRef] [PubMed]
  3. J. Huisken, J. Swoger, F. Del Bene, J. Wittbrodt, and E. H. K. Stelzer, Science 305, 1007 (2004).
    [CrossRef] [PubMed]
  4. J. Hsieh, Computed Tomography: Principles, Design, Artifacts, and Recent Advances, 2nd ed. (SPIE, 2009).
  5. J. McGinty, K. R. Tahir, R. Laine, C. B. Talbot, C. Dunsby, M. A. A. Neil, L. Quintana, J. Swoger, J. Sharpe, and P. M. W. French, J. Biophoton. 1, 390 (2008).
    [CrossRef]
  6. C. Vinegoni, C. Pitsouli, D. Razansky, N. Perrimon, and V. Ntziachristos, Nat. Methods 5, 45 (2008).
    [CrossRef]
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    [CrossRef] [PubMed]
  8. G. W. Faris and M. Banks, Opt. Lett. 19, 1813 (1994).
    [CrossRef] [PubMed]
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    [CrossRef]
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    [CrossRef] [PubMed]
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    [CrossRef]
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    [CrossRef]
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    [CrossRef]

2009 (1)

2008 (4)

J. McGinty, K. R. Tahir, R. Laine, C. B. Talbot, C. Dunsby, M. A. A. Neil, L. Quintana, J. Swoger, J. Sharpe, and P. M. W. French, J. Biophoton. 1, 390 (2008).
[CrossRef]

C. Vinegoni, C. Pitsouli, D. Razansky, N. Perrimon, and V. Ntziachristos, Nat. Methods 5, 45 (2008).
[CrossRef]

S. H. Cho, W. S. Chang, J. G. Kim, K. H. Whang, K. S. Choi, and S. H. Sohn, Appl. Surf. Sci. 254, 3370 (2008).
[CrossRef]

M. J. Niedre, R. H. de Kleine, E. Aikawa, D. Kirsch, R. Weissleder, and V. Ntziachristos, Proc. Nat. Acad. Sci. 105, 19126 (2008).
[CrossRef] [PubMed]

2005 (1)

2004 (1)

J. Huisken, J. Swoger, F. Del Bene, J. Wittbrodt, and E. H. K. Stelzer, Science 305, 1007 (2004).
[CrossRef] [PubMed]

2003 (1)

R. Weissleder and V. Ntziachristos, Nat. Med. 9, 123(2003).
[CrossRef] [PubMed]

2002 (1)

J. Sharpe, U. Ahlgren, P. Perry, B. Hill, A. Ross, J. Hecksher, R. Baldock, and D. Davidson, Science 296, 541 (2002).
[CrossRef] [PubMed]

2000 (1)

1997 (2)

J. C. Hebden, S. R. Arridge, and D. T. Delpy, Phys. Med. Biol. 42, 825 (1997).
[CrossRef] [PubMed]

G. Le Tolguenec, E. Lantz, and F. Devaux, Appl. Opt. 36, 8292 (1997).
[CrossRef]

1994 (1)

1991 (1)

L. Wang, P. P. Ho, C. Liu, G. Zhang, and R. R. Alfano, Science 253, 769 (1991).
[CrossRef] [PubMed]

Ahlgren, U.

J. Sharpe, U. Ahlgren, P. Perry, B. Hill, A. Ross, J. Hecksher, R. Baldock, and D. Davidson, Science 296, 541 (2002).
[CrossRef] [PubMed]

Aikawa, E.

M. J. Niedre, R. H. de Kleine, E. Aikawa, D. Kirsch, R. Weissleder, and V. Ntziachristos, Proc. Nat. Acad. Sci. 105, 19126 (2008).
[CrossRef] [PubMed]

Alfano, R. R.

L. Wang, P. P. Ho, C. Liu, G. Zhang, and R. R. Alfano, Science 253, 769 (1991).
[CrossRef] [PubMed]

Arridge, S. R.

J. C. Hebden, S. R. Arridge, and D. T. Delpy, Phys. Med. Biol. 42, 825 (1997).
[CrossRef] [PubMed]

Baldock, R.

J. Sharpe, U. Ahlgren, P. Perry, B. Hill, A. Ross, J. Hecksher, R. Baldock, and D. Davidson, Science 296, 541 (2002).
[CrossRef] [PubMed]

Banks, M.

Brun, A.

Chang, W. S.

S. H. Cho, W. S. Chang, J. G. Kim, K. H. Whang, K. S. Choi, and S. H. Sohn, Appl. Surf. Sci. 254, 3370 (2008).
[CrossRef]

Cho, S. H.

S. H. Cho, W. S. Chang, J. G. Kim, K. H. Whang, K. S. Choi, and S. H. Sohn, Appl. Surf. Sci. 254, 3370 (2008).
[CrossRef]

Choi, K. S.

S. H. Cho, W. S. Chang, J. G. Kim, K. H. Whang, K. S. Choi, and S. H. Sohn, Appl. Surf. Sci. 254, 3370 (2008).
[CrossRef]

Davidson, D.

J. Sharpe, U. Ahlgren, P. Perry, B. Hill, A. Ross, J. Hecksher, R. Baldock, and D. Davidson, Science 296, 541 (2002).
[CrossRef] [PubMed]

de Kleine, R. H.

M. J. Niedre, R. H. de Kleine, E. Aikawa, D. Kirsch, R. Weissleder, and V. Ntziachristos, Proc. Nat. Acad. Sci. 105, 19126 (2008).
[CrossRef] [PubMed]

Dehghani, H.

Del Bene, F.

J. Huisken, J. Swoger, F. Del Bene, J. Wittbrodt, and E. H. K. Stelzer, Science 305, 1007 (2004).
[CrossRef] [PubMed]

Delpy, D. T.

J. C. Hebden, S. R. Arridge, and D. T. Delpy, Phys. Med. Biol. 42, 825 (1997).
[CrossRef] [PubMed]

Devaux, F.

Doule, C.

Dunsby, C.

J. McGinty, K. R. Tahir, R. Laine, C. B. Talbot, C. Dunsby, M. A. A. Neil, L. Quintana, J. Swoger, J. Sharpe, and P. M. W. French, J. Biophoton. 1, 390 (2008).
[CrossRef]

Faris, G. W.

French, P. M. W.

J. McGinty, K. R. Tahir, R. Laine, C. B. Talbot, C. Dunsby, M. A. A. Neil, L. Quintana, J. Swoger, J. Sharpe, and P. M. W. French, J. Biophoton. 1, 390 (2008).
[CrossRef]

Georges, P.

Goodman, J. W.

J. W. Goodman, Introduction to Fourier Optics4th ed.(Roberts & Company, Publishers, 2005).

Hebden, J. C.

J. C. Hebden, S. R. Arridge, and D. T. Delpy, Phys. Med. Biol. 42, 825 (1997).
[CrossRef] [PubMed]

Hecksher, J.

J. Sharpe, U. Ahlgren, P. Perry, B. Hill, A. Ross, J. Hecksher, R. Baldock, and D. Davidson, Science 296, 541 (2002).
[CrossRef] [PubMed]

Hill, B.

J. Sharpe, U. Ahlgren, P. Perry, B. Hill, A. Ross, J. Hecksher, R. Baldock, and D. Davidson, Science 296, 541 (2002).
[CrossRef] [PubMed]

Ho, P. P.

L. Wang, P. P. Ho, C. Liu, G. Zhang, and R. R. Alfano, Science 253, 769 (1991).
[CrossRef] [PubMed]

Hsieh, J.

J. Hsieh, Computed Tomography: Principles, Design, Artifacts, and Recent Advances, 2nd ed. (SPIE, 2009).

Huisken, J.

J. Huisken, J. Swoger, F. Del Bene, J. Wittbrodt, and E. H. K. Stelzer, Science 305, 1007 (2004).
[CrossRef] [PubMed]

Kepshire, D.

Kim, J. G.

S. H. Cho, W. S. Chang, J. G. Kim, K. H. Whang, K. S. Choi, and S. H. Sohn, Appl. Surf. Sci. 254, 3370 (2008).
[CrossRef]

Kirsch, D.

M. J. Niedre, R. H. de Kleine, E. Aikawa, D. Kirsch, R. Weissleder, and V. Ntziachristos, Proc. Nat. Acad. Sci. 105, 19126 (2008).
[CrossRef] [PubMed]

Laine, R.

J. McGinty, K. R. Tahir, R. Laine, C. B. Talbot, C. Dunsby, M. A. A. Neil, L. Quintana, J. Swoger, J. Sharpe, and P. M. W. French, J. Biophoton. 1, 390 (2008).
[CrossRef]

Lantz, E.

Le Tolguenec, G.

Leblond, F.

Lepine, T.

Liu, C.

L. Wang, P. P. Ho, C. Liu, G. Zhang, and R. R. Alfano, Science 253, 769 (1991).
[CrossRef] [PubMed]

McGinty, J.

J. McGinty, K. R. Tahir, R. Laine, C. B. Talbot, C. Dunsby, M. A. A. Neil, L. Quintana, J. Swoger, J. Sharpe, and P. M. W. French, J. Biophoton. 1, 390 (2008).
[CrossRef]

Neil, M. A. A.

J. McGinty, K. R. Tahir, R. Laine, C. B. Talbot, C. Dunsby, M. A. A. Neil, L. Quintana, J. Swoger, J. Sharpe, and P. M. W. French, J. Biophoton. 1, 390 (2008).
[CrossRef]

Niedre, M. J.

M. J. Niedre, R. H. de Kleine, E. Aikawa, D. Kirsch, R. Weissleder, and V. Ntziachristos, Proc. Nat. Acad. Sci. 105, 19126 (2008).
[CrossRef] [PubMed]

Ntziachristos, V.

M. J. Niedre, R. H. de Kleine, E. Aikawa, D. Kirsch, R. Weissleder, and V. Ntziachristos, Proc. Nat. Acad. Sci. 105, 19126 (2008).
[CrossRef] [PubMed]

C. Vinegoni, C. Pitsouli, D. Razansky, N. Perrimon, and V. Ntziachristos, Nat. Methods 5, 45 (2008).
[CrossRef]

G. M. Turner, G. Zacharakis, A. Soubret, J. Ripoll, and V. Ntziachristos, Opt. Lett. 30, 409 (2005).
[CrossRef] [PubMed]

R. Weissleder and V. Ntziachristos, Nat. Med. 9, 123(2003).
[CrossRef] [PubMed]

Perrimon, N.

C. Vinegoni, C. Pitsouli, D. Razansky, N. Perrimon, and V. Ntziachristos, Nat. Methods 5, 45 (2008).
[CrossRef]

Perry, P.

J. Sharpe, U. Ahlgren, P. Perry, B. Hill, A. Ross, J. Hecksher, R. Baldock, and D. Davidson, Science 296, 541 (2002).
[CrossRef] [PubMed]

Pitsouli, C.

C. Vinegoni, C. Pitsouli, D. Razansky, N. Perrimon, and V. Ntziachristos, Nat. Methods 5, 45 (2008).
[CrossRef]

Pogue, B. W.

Quintana, L.

J. McGinty, K. R. Tahir, R. Laine, C. B. Talbot, C. Dunsby, M. A. A. Neil, L. Quintana, J. Swoger, J. Sharpe, and P. M. W. French, J. Biophoton. 1, 390 (2008).
[CrossRef]

Razansky, D.

C. Vinegoni, C. Pitsouli, D. Razansky, N. Perrimon, and V. Ntziachristos, Nat. Methods 5, 45 (2008).
[CrossRef]

Ripoll, J.

Ross, A.

J. Sharpe, U. Ahlgren, P. Perry, B. Hill, A. Ross, J. Hecksher, R. Baldock, and D. Davidson, Science 296, 541 (2002).
[CrossRef] [PubMed]

Sharpe, J.

J. McGinty, K. R. Tahir, R. Laine, C. B. Talbot, C. Dunsby, M. A. A. Neil, L. Quintana, J. Swoger, J. Sharpe, and P. M. W. French, J. Biophoton. 1, 390 (2008).
[CrossRef]

J. Sharpe, U. Ahlgren, P. Perry, B. Hill, A. Ross, J. Hecksher, R. Baldock, and D. Davidson, Science 296, 541 (2002).
[CrossRef] [PubMed]

Sohn, S. H.

S. H. Cho, W. S. Chang, J. G. Kim, K. H. Whang, K. S. Choi, and S. H. Sohn, Appl. Surf. Sci. 254, 3370 (2008).
[CrossRef]

Soubret, A.

Stelzer, E. H. K.

J. Huisken, J. Swoger, F. Del Bene, J. Wittbrodt, and E. H. K. Stelzer, Science 305, 1007 (2004).
[CrossRef] [PubMed]

Swoger, J.

J. McGinty, K. R. Tahir, R. Laine, C. B. Talbot, C. Dunsby, M. A. A. Neil, L. Quintana, J. Swoger, J. Sharpe, and P. M. W. French, J. Biophoton. 1, 390 (2008).
[CrossRef]

J. Huisken, J. Swoger, F. Del Bene, J. Wittbrodt, and E. H. K. Stelzer, Science 305, 1007 (2004).
[CrossRef] [PubMed]

Tahir, K. R.

J. McGinty, K. R. Tahir, R. Laine, C. B. Talbot, C. Dunsby, M. A. A. Neil, L. Quintana, J. Swoger, J. Sharpe, and P. M. W. French, J. Biophoton. 1, 390 (2008).
[CrossRef]

Talbot, C. B.

J. McGinty, K. R. Tahir, R. Laine, C. B. Talbot, C. Dunsby, M. A. A. Neil, L. Quintana, J. Swoger, J. Sharpe, and P. M. W. French, J. Biophoton. 1, 390 (2008).
[CrossRef]

Turner, G. M.

Vinegoni, C.

C. Vinegoni, C. Pitsouli, D. Razansky, N. Perrimon, and V. Ntziachristos, Nat. Methods 5, 45 (2008).
[CrossRef]

Wang, L.

L. Wang, P. P. Ho, C. Liu, G. Zhang, and R. R. Alfano, Science 253, 769 (1991).
[CrossRef] [PubMed]

Weissleder, R.

M. J. Niedre, R. H. de Kleine, E. Aikawa, D. Kirsch, R. Weissleder, and V. Ntziachristos, Proc. Nat. Acad. Sci. 105, 19126 (2008).
[CrossRef] [PubMed]

R. Weissleder and V. Ntziachristos, Nat. Med. 9, 123(2003).
[CrossRef] [PubMed]

Whang, K. H.

S. H. Cho, W. S. Chang, J. G. Kim, K. H. Whang, K. S. Choi, and S. H. Sohn, Appl. Surf. Sci. 254, 3370 (2008).
[CrossRef]

Wittbrodt, J.

J. Huisken, J. Swoger, F. Del Bene, J. Wittbrodt, and E. H. K. Stelzer, Science 305, 1007 (2004).
[CrossRef] [PubMed]

Zacharakis, G.

Zhang, G.

L. Wang, P. P. Ho, C. Liu, G. Zhang, and R. R. Alfano, Science 253, 769 (1991).
[CrossRef] [PubMed]

Appl. Opt. (1)

Appl. Surf. Sci. (1)

S. H. Cho, W. S. Chang, J. G. Kim, K. H. Whang, K. S. Choi, and S. H. Sohn, Appl. Surf. Sci. 254, 3370 (2008).
[CrossRef]

J. Biophoton. (1)

J. McGinty, K. R. Tahir, R. Laine, C. B. Talbot, C. Dunsby, M. A. A. Neil, L. Quintana, J. Swoger, J. Sharpe, and P. M. W. French, J. Biophoton. 1, 390 (2008).
[CrossRef]

J. Opt. Soc. Am. A (1)

Nat. Med. (1)

R. Weissleder and V. Ntziachristos, Nat. Med. 9, 123(2003).
[CrossRef] [PubMed]

Nat. Methods (1)

C. Vinegoni, C. Pitsouli, D. Razansky, N. Perrimon, and V. Ntziachristos, Nat. Methods 5, 45 (2008).
[CrossRef]

Opt. Lett. (3)

Phys. Med. Biol. (1)

J. C. Hebden, S. R. Arridge, and D. T. Delpy, Phys. Med. Biol. 42, 825 (1997).
[CrossRef] [PubMed]

Proc. Nat. Acad. Sci. (1)

M. J. Niedre, R. H. de Kleine, E. Aikawa, D. Kirsch, R. Weissleder, and V. Ntziachristos, Proc. Nat. Acad. Sci. 105, 19126 (2008).
[CrossRef] [PubMed]

Science (3)

L. Wang, P. P. Ho, C. Liu, G. Zhang, and R. R. Alfano, Science 253, 769 (1991).
[CrossRef] [PubMed]

J. Sharpe, U. Ahlgren, P. Perry, B. Hill, A. Ross, J. Hecksher, R. Baldock, and D. Davidson, Science 296, 541 (2002).
[CrossRef] [PubMed]

J. Huisken, J. Swoger, F. Del Bene, J. Wittbrodt, and E. H. K. Stelzer, Science 305, 1007 (2004).
[CrossRef] [PubMed]

Other (2)

J. Hsieh, Computed Tomography: Principles, Design, Artifacts, and Recent Advances, 2nd ed. (SPIE, 2009).

J. W. Goodman, Introduction to Fourier Optics4th ed.(Roberts & Company, Publishers, 2005).

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Figures (3)

Fig. 1
Fig. 1

Setup for collinear upconversion: HWP, half-wave plate; L1, L2, lenses; PCS, polarizing cube splitter; BBO, nonlinear crystal; IF, interference filter and shortpass filter.

Fig. 2
Fig. 2

1951 U.S. Air Force target is used to test 2D imaging resolution. Image formed by the linear signal (removing the gate and the filters). (a) Image formed by the upconversion. (b) Image formed by the linear signal and by the upconversion when a scattering medium is placed after the target (c), (d).

Fig. 3
Fig. 3

Drawing of the section of the cylindrical phantom: the diameter is 4 mm , and the hexagon side is 600 μm . (a) Reconstructed section of the phantom. (b) Reconstructed area is indicated with the dashed square on the left-hand side.

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