Abstract

We present a speckle reduction technique for optical coherence tomography based on strain compounding. Decorrelation is introduced between B-scans by altering the sample’s strain. A theoretical description of the technique, based on a transfer-function formalism, and experimental results on silicone phantoms are presented. Nearly complete decorrelation between successive B-scan speckle patterns was observed for a variation in strain of 0.045. Strain compounding by averaging nine B-scans, with 0.003 strain increments between them, resulted in a 1.5-fold reduction in speckle contrast ratio.

© 2010 Optical Society of America

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References

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2010 (1)

2009 (1)

2007 (2)

A. E. Desjardins, B. J. Vakoc, W. Y. Oh, S. M. R. Motaghiannezam, G. J. Tearney, and B. E. Bouma, Opt. Express 15, 6200 (2007).
[CrossRef] [PubMed]

T. M. Jørgensen, L. Thrane, M. Mogensen, F. Pedersen, and P. E. Andersen, Proc. SPIE 6627, 66270P (2007).
[CrossRef]

2005 (1)

2004 (1)

2003 (1)

M. Pircher, E. Gotzinger, R. Leitgeb, A. F. Fercher, and C. K. Hitzenberger, J. Biomed. Opt. 8, 565 (2003).
[CrossRef] [PubMed]

2001 (1)

P. C. Li and C. L. Wu, Ultrasound Med. Biol. 27, 1535 (2001).
[CrossRef] [PubMed]

2000 (1)

1999 (2)

J. M. Schmitt, S. H. Xiang, and K. M. Yung, J. Biomed. Opt. 4, 95 (1999).
[CrossRef]

R. L. Maurice and M. Bertrand, IEEE Trans. Ultrason. Ferroelectr. Freq. Control 46, 584 (1999).
[CrossRef]

1998 (1)

Adler, D. C.

Andersen, P. E.

T. M. Jørgensen, L. Thrane, M. Mogensen, F. Pedersen, and P. E. Andersen, Proc. SPIE 6627, 66270P (2007).
[CrossRef]

Bashkansky, M.

Bertrand, M.

R. L. Maurice and M. Bertrand, IEEE Trans. Ultrason. Ferroelectr. Freq. Control 46, 584 (1999).
[CrossRef]

Boppart, S. A.

Bouma, B. E.

Curatolo, A.

Desjardins, A. E.

Fercher, A. F.

M. Pircher, E. Gotzinger, R. Leitgeb, A. F. Fercher, and C. K. Hitzenberger, J. Biomed. Opt. 8, 565 (2003).
[CrossRef] [PubMed]

Fujimoto, J. G.

Goodman, J. W.

J. W. Goodman, Speckle Phenomena in Optics: Theory and Applications (Roberts, 2007).

Gotzinger, E.

M. Pircher, E. Gotzinger, R. Leitgeb, A. F. Fercher, and C. K. Hitzenberger, J. Biomed. Opt. 8, 565 (2003).
[CrossRef] [PubMed]

Hillman, T. R.

Hitzenberger, C. K.

M. Pircher, E. Gotzinger, R. Leitgeb, A. F. Fercher, and C. K. Hitzenberger, J. Biomed. Opt. 8, 565 (2003).
[CrossRef] [PubMed]

Izatt, J. A.

J. A. Izatt, M. D. Kulkarni, and M. V. Sivak, “Depth-resolved spectroscopic optical coherence tomography,” U.S. patent 6,002,480 (December 14, 1999).

Jørgensen, T. M.

T. M. Jørgensen, L. Thrane, M. Mogensen, F. Pedersen, and P. E. Andersen, Proc. SPIE 6627, 66270P (2007).
[CrossRef]

Kennedy, B. F.

Ko, T. H.

Kulkarni, M. D.

J. A. Izatt, M. D. Kulkarni, and M. V. Sivak, “Depth-resolved spectroscopic optical coherence tomography,” U.S. patent 6,002,480 (December 14, 1999).

Leitgeb, R.

M. Pircher, E. Gotzinger, R. Leitgeb, A. F. Fercher, and C. K. Hitzenberger, J. Biomed. Opt. 8, 565 (2003).
[CrossRef] [PubMed]

Li, P. C.

P. C. Li and C. L. Wu, Ultrasound Med. Biol. 27, 1535 (2001).
[CrossRef] [PubMed]

Marks, D. L.

Maurice, R. L.

R. L. Maurice and M. Bertrand, IEEE Trans. Ultrason. Ferroelectr. Freq. Control 46, 584 (1999).
[CrossRef]

McLaughlin, R. A.

Mogensen, M.

T. M. Jørgensen, L. Thrane, M. Mogensen, F. Pedersen, and P. E. Andersen, Proc. SPIE 6627, 66270P (2007).
[CrossRef]

Motaghiannezam, S. M. R.

Oh, W. Y.

Pedersen, F.

T. M. Jørgensen, L. Thrane, M. Mogensen, F. Pedersen, and P. E. Andersen, Proc. SPIE 6627, 66270P (2007).
[CrossRef]

Pircher, M.

M. Pircher, E. Gotzinger, R. Leitgeb, A. F. Fercher, and C. K. Hitzenberger, J. Biomed. Opt. 8, 565 (2003).
[CrossRef] [PubMed]

Quirk, B. C.

Ralston, T. S.

Reintjes, J.

Sampson, D. D.

Schmitt, J. M.

J. M. Schmitt, S. H. Xiang, and K. M. Yung, J. Biomed. Opt. 4, 95 (1999).
[CrossRef]

J. M. Schmitt, Opt. Express 3, 199 (1998).
[CrossRef] [PubMed]

Sivak, M. V.

J. A. Izatt, M. D. Kulkarni, and M. V. Sivak, “Depth-resolved spectroscopic optical coherence tomography,” U.S. patent 6,002,480 (December 14, 1999).

Tearney, G. J.

Thrane, L.

T. M. Jørgensen, L. Thrane, M. Mogensen, F. Pedersen, and P. E. Andersen, Proc. SPIE 6627, 66270P (2007).
[CrossRef]

Vakoc, B. J.

Wu, C. L.

P. C. Li and C. L. Wu, Ultrasound Med. Biol. 27, 1535 (2001).
[CrossRef] [PubMed]

Xiang, S. H.

J. M. Schmitt, S. H. Xiang, and K. M. Yung, J. Biomed. Opt. 4, 95 (1999).
[CrossRef]

Yung, K. M.

J. M. Schmitt, S. H. Xiang, and K. M. Yung, J. Biomed. Opt. 4, 95 (1999).
[CrossRef]

IEEE Trans. Ultrason. Ferroelectr. Freq. Control (1)

R. L. Maurice and M. Bertrand, IEEE Trans. Ultrason. Ferroelectr. Freq. Control 46, 584 (1999).
[CrossRef]

J. Biomed. Opt. (2)

J. M. Schmitt, S. H. Xiang, and K. M. Yung, J. Biomed. Opt. 4, 95 (1999).
[CrossRef]

M. Pircher, E. Gotzinger, R. Leitgeb, A. F. Fercher, and C. K. Hitzenberger, J. Biomed. Opt. 8, 565 (2003).
[CrossRef] [PubMed]

J. Opt. Soc. Am. A (1)

Opt. Express (3)

Opt. Lett. (3)

Proc. SPIE (1)

T. M. Jørgensen, L. Thrane, M. Mogensen, F. Pedersen, and P. E. Andersen, Proc. SPIE 6627, 66270P (2007).
[CrossRef]

Ultrasound Med. Biol. (1)

P. C. Li and C. L. Wu, Ultrasound Med. Biol. 27, 1535 (2001).
[CrossRef] [PubMed]

Other (2)

J. A. Izatt, M. D. Kulkarni, and M. V. Sivak, “Depth-resolved spectroscopic optical coherence tomography,” U.S. patent 6,002,480 (December 14, 1999).

J. W. Goodman, Speckle Phenomena in Optics: Theory and Applications (Roberts, 2007).

Supplementary Material (1)

» Media 1: AVI (1147 KB)     

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Figures (3)

Fig. 1
Fig. 1

Theoretical (dashed blue curve) and experimental correlation coefficient modulus, | μ | , versus strain difference, before (lower black curve) and after (central red curve) correction for spatial distortion.

Fig. 2
Fig. 2

(a) Sequence of bilayer phantom for increasing strain; frame area is 135 μm × 585 μm (Media 1). (b)–(g) Boxed region ( 45 μm × 120 μm ) of (a) for successive strain increments of 0.003.

Fig. 3
Fig. 3

B-scans of bilayer phantom (a) before and (c) after strain compounding, plotted with a loga rithmic color scale. (b) Strain compounding before applying affine-transformation distortion correction. Image area is 135 μm × 585 μm .

Equations (2)

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μ = τ ( k m ) τ * ( k ) d 3 k | τ ( k ) | 2 d 3 k ,
[ x z ] = [ A B C D ] [ x z ] + [ E F ] .

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