Abstract

We developed and fabricated a preclinical photoacoustic imaging endoscope (PAIE) with an acousto-optic coaxial structure for cavity imaging that integrates a Plexiglas tube, an optical fiber, a ring transducer array, a taper reflector, and an ultrasonic coupling medium. A photoacoustic image for a section of pig colorectal tissue embedded in a transparent gelatin phantom was reconstructed. Furthermore, human colorectal cancer and normal colorectal tissue were imaged ex vivo with a contrast ratio of ~2.3. Experimental results demonstrate that the PAIE has potential for detecting colorectal cancer in clinical use.

© 2010 Optical Society of America

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S. B. Ma, S. H. Yang, and H. Guo, J. Appl. Phys. 106, 123104(2009).
[CrossRef]

M. Pramanik and L. V. Wang, J. Biomed. Opt. 14, 054024(2009).
[CrossRef] [PubMed]

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, J. Biomed. Opt. 14, 024007 (2009).
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J. M. Yang, K. Maslov, H. C. Yang, Q. F. Zhou, K. K. Shung, and L. V. Wang, Opt. Lett. 34, 1591 (2009).
[CrossRef] [PubMed]

2008

S. Sethuraman, J. H. Amirian, S. H. Litovsky, R. W. Smalling, and S. Y. Emelianov, Opt. Express 16, 3362 (2008).
[CrossRef] [PubMed]

K. Maslov, H. F. Zhang, S. Hu, and L. V. Wang, Opt. Lett. 33, 929 (2008).
[CrossRef] [PubMed]

Y. Q. Lao, D. Xing, S. H. Yang, and L. Z. Xiang, Phys. Med. Biol. 53, 4203 (2008).
[CrossRef] [PubMed]

H. L. Ao, D. Xing, H. J. Wei, H. M. Gu, G. Y. Wu, and J. J. Lu, Phys. Med. Biol. 53, 2197 (2008).
[CrossRef] [PubMed]

2007

S. H. Yang, D. Xing, Y. Q. Lao, L. M. Zeng, L. Z. Xiang, and W. Chen, Appl. Phys. Lett. 90, 243902 (2007).
[CrossRef]

S. Sethuraman, J. H. Amirian, S. H. Litovsky, R. W. Smalling, and S. Y. Emelianov, Opt. Express 15, 16657 (2007).
[CrossRef] [PubMed]

2004

2001

D. M. Parkin, Lancet Oncol. 2, 533 (2001).
[CrossRef]

1998

Amirian, J. H.

Ao, H. L.

H. L. Ao, D. Xing, H. J. Wei, H. M. Gu, G. Y. Wu, and J. J. Lu, Phys. Med. Biol. 53, 2197 (2008).
[CrossRef] [PubMed]

Chen, Q.

Chen, W.

S. H. Yang, D. Xing, Y. Q. Lao, L. M. Zeng, L. Z. Xiang, and W. Chen, Appl. Phys. Lett. 90, 243902 (2007).
[CrossRef]

Conjusteau, A.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, J. Biomed. Opt. 14, 024007 (2009).
[CrossRef] [PubMed]

Emelianov, S. Y.

Ermilov, S. A.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, J. Biomed. Opt. 14, 024007 (2009).
[CrossRef] [PubMed]

Ge, Z. F.

Gu, H. M.

H. L. Ao, D. Xing, H. J. Wei, H. M. Gu, G. Y. Wu, and J. J. Lu, Phys. Med. Biol. 53, 2197 (2008).
[CrossRef] [PubMed]

Guo, H.

S. B. Ma, S. H. Yang, and H. Guo, J. Appl. Phys. 106, 123104(2009).
[CrossRef]

Hu, S.

Khamapirad, T.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, J. Biomed. Opt. 14, 024007 (2009).
[CrossRef] [PubMed]

Lacewell, R.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, J. Biomed. Opt. 14, 024007 (2009).
[CrossRef] [PubMed]

Lao, Y. Q.

Y. Q. Lao, D. Xing, S. H. Yang, and L. Z. Xiang, Phys. Med. Biol. 53, 4203 (2008).
[CrossRef] [PubMed]

S. H. Yang, D. Xing, Y. Q. Lao, L. M. Zeng, L. Z. Xiang, and W. Chen, Appl. Phys. Lett. 90, 243902 (2007).
[CrossRef]

Leonard, M. H.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, J. Biomed. Opt. 14, 024007 (2009).
[CrossRef] [PubMed]

Litovsky, S. H.

Lu, J. J.

H. L. Ao, D. Xing, H. J. Wei, H. M. Gu, G. Y. Wu, and J. J. Lu, Phys. Med. Biol. 53, 2197 (2008).
[CrossRef] [PubMed]

Ma, S. B.

S. B. Ma, S. H. Yang, and H. Guo, J. Appl. Phys. 106, 123104(2009).
[CrossRef]

Maslov, K.

Mehta, K.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, J. Biomed. Opt. 14, 024007 (2009).
[CrossRef] [PubMed]

Miller, T.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, J. Biomed. Opt. 14, 024007 (2009).
[CrossRef] [PubMed]

Nishioka, N. S.

Oraevsky, A. A.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, J. Biomed. Opt. 14, 024007 (2009).
[CrossRef] [PubMed]

Parkin, D. M.

D. M. Parkin, Lancet Oncol. 2, 533 (2001).
[CrossRef]

Pramanik, M.

M. Pramanik and L. V. Wang, J. Biomed. Opt. 14, 054024(2009).
[CrossRef] [PubMed]

Schomacker, K. T.

Sethuraman, S.

Shung, K. K.

Smalling, R. W.

Wang, L. V.

Wang, Y.

Wei, H. J.

H. L. Ao, D. Xing, H. J. Wei, H. M. Gu, G. Y. Wu, and J. J. Lu, Phys. Med. Biol. 53, 2197 (2008).
[CrossRef] [PubMed]

Wu, G. Y.

H. L. Ao, D. Xing, H. J. Wei, H. M. Gu, G. Y. Wu, and J. J. Lu, Phys. Med. Biol. 53, 2197 (2008).
[CrossRef] [PubMed]

Xiang, L. Z.

Y. Yuan, S. H. Yang, and L. Z. Xiang, Eur. Phys. J. Appl. Phys. 49, 30901 (2010)
[CrossRef]

Y. Q. Lao, D. Xing, S. H. Yang, and L. Z. Xiang, Phys. Med. Biol. 53, 4203 (2008).
[CrossRef] [PubMed]

S. H. Yang, D. Xing, Y. Q. Lao, L. M. Zeng, L. Z. Xiang, and W. Chen, Appl. Phys. Lett. 90, 243902 (2007).
[CrossRef]

Xing, D.

Y. Q. Lao, D. Xing, S. H. Yang, and L. Z. Xiang, Phys. Med. Biol. 53, 4203 (2008).
[CrossRef] [PubMed]

H. L. Ao, D. Xing, H. J. Wei, H. M. Gu, G. Y. Wu, and J. J. Lu, Phys. Med. Biol. 53, 2197 (2008).
[CrossRef] [PubMed]

S. H. Yang, D. Xing, Y. Q. Lao, L. M. Zeng, L. Z. Xiang, and W. Chen, Appl. Phys. Lett. 90, 243902 (2007).
[CrossRef]

Y. G. Zeng, D. Xing, Y. Wang, B. Z. Yin, and Q. Chen, Opt. Lett. 29, 1760 (2004).
[CrossRef] [PubMed]

Yang, H. C.

Yang, J. M.

Yang, S. H.

Y. Yuan, S. H. Yang, and L. Z. Xiang, Eur. Phys. J. Appl. Phys. 49, 30901 (2010)
[CrossRef]

S. B. Ma, S. H. Yang, and H. Guo, J. Appl. Phys. 106, 123104(2009).
[CrossRef]

Y. Q. Lao, D. Xing, S. H. Yang, and L. Z. Xiang, Phys. Med. Biol. 53, 4203 (2008).
[CrossRef] [PubMed]

S. H. Yang, D. Xing, Y. Q. Lao, L. M. Zeng, L. Z. Xiang, and W. Chen, Appl. Phys. Lett. 90, 243902 (2007).
[CrossRef]

Yin, B. Z.

Yuan, Y.

Y. Yuan, S. H. Yang, and L. Z. Xiang, Eur. Phys. J. Appl. Phys. 49, 30901 (2010)
[CrossRef]

Zeng, L. M.

S. H. Yang, D. Xing, Y. Q. Lao, L. M. Zeng, L. Z. Xiang, and W. Chen, Appl. Phys. Lett. 90, 243902 (2007).
[CrossRef]

Zeng, Y. G.

Zhang, H. F.

Zhou, Q. F.

Appl. Phys. Lett.

S. H. Yang, D. Xing, Y. Q. Lao, L. M. Zeng, L. Z. Xiang, and W. Chen, Appl. Phys. Lett. 90, 243902 (2007).
[CrossRef]

Appl. Spectrosc.

Eur. Phys. J. Appl. Phys.

Y. Yuan, S. H. Yang, and L. Z. Xiang, Eur. Phys. J. Appl. Phys. 49, 30901 (2010)
[CrossRef]

J. Appl. Phys.

S. B. Ma, S. H. Yang, and H. Guo, J. Appl. Phys. 106, 123104(2009).
[CrossRef]

J. Biomed. Opt.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, J. Biomed. Opt. 14, 024007 (2009).
[CrossRef] [PubMed]

M. Pramanik and L. V. Wang, J. Biomed. Opt. 14, 054024(2009).
[CrossRef] [PubMed]

Lancet Oncol.

D. M. Parkin, Lancet Oncol. 2, 533 (2001).
[CrossRef]

Opt. Express

Opt. Lett.

Phys. Med. Biol.

Y. Q. Lao, D. Xing, S. H. Yang, and L. Z. Xiang, Phys. Med. Biol. 53, 4203 (2008).
[CrossRef] [PubMed]

H. L. Ao, D. Xing, H. J. Wei, H. M. Gu, G. Y. Wu, and J. J. Lu, Phys. Med. Biol. 53, 2197 (2008).
[CrossRef] [PubMed]

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Figures (3)

Fig. 1
Fig. 1

(a) Schematic of the PAIE. (b) Photograph of the taper reflector. (c) Photograph of the hollow ring transducer array.

Fig. 2
Fig. 2

(a) Photograph of the ex vivo pig colorectal tissue embedded in the transparent gelatin phantom. (b) Reconstructed PA tomography of pig colorectal wall.

Fig. 3
Fig. 3

(a) Photograph of the test sample: normal human colorectal tissue and colorectal cancer tissue embedded in the transparent gelatin phantom. (b) PA signals of the human normal colorectal tissue and colorectal cancer tissue. (c) Reconstructed PA image of a section of human colon with cancerous tissue.

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