Abstract

This investigation explores the feasibility of performing diffuse optical tomography based on time-domain wide-field illumination and detection strategies. Wide-field patterned excitation and detection schemes are investigated in transmittance geometry with time-gated detection channels. A Monte Carlo forward model is employed to compute the time-resolved Jacobians for rigorous light propagation modeling. We demonstrate both in silico and experimentally that reconstructions of absorption structures based on wide-field patterned-light strategies are feasible and outperform classical point excitation schemes for similar data set sizes. Moreover, we demonstrate that time-domain information is retained even though large spatial areas are illuminated. The enhanced time-domain data set allows for quantitative three-dimensional imaging in thick tissue based on relatively small data sets associated with much shorter acquisition times.

© 2010 Optical Society of America

Full Article  |  PDF Article
More Like This
Full-field time-resolved fluorescence tomography of small animals

Vivek Venugopal, Jin Chen, Frederic Lesage, and Xavier Intes
Opt. Lett. 35(19) 3189-3191 (2010)

Hyperspectral time-resolved wide-field fluorescence molecular tomography based on structured light and single-pixel detection

Qi Pian, Ruoyang Yao, Lingling Zhao, and Xavier Intes
Opt. Lett. 40(3) 431-434 (2015)

Full-wavelet approach for fluorescence diffuse optical tomography with structured illumination

Nicolas Ducros, Cosimo D'andrea, Gianluca Valentini, Tim Rudge, Simon Arridge, and Andrea Bassi
Opt. Lett. 35(21) 3676-3678 (2010)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Figures (4)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Tables (1)

You do not have subscription access to this journal. Article tables are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Metrics