Abstract

We demonstrate the simultaneous optical manipulation and analysis of microscale particles in a microfluidic channel. Whispering gallery modes (WGMs) in dielectric microspheres are excited using the evanescent field from a silicon nitride waveguide. A supercontinuum source is used to both trap the microspheres to the surface of the waveguide and excite their resonant modes. All measurements are in plane, thus providing an integrated optofluidic platform for lab-on-a-chip biosensing applications.

© 2010 Optical Society of America

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2009 (3)

A. H. J. Yang, S. D. Moore, B. S. Schmidt, M. Klug, M. Lipson, and D. Erickson, Nature 547, 71 (2009).
[CrossRef]

S. Kuhn, P. Measor, E. J. Lunt, B. S. Phillips, D. W. Deamer, A. R. Hawkins, and H. Schmidt, Lab Chip 9, 2212 (2009).
[CrossRef] [PubMed]

A. Gondarenko, J. S. Levy, and M. Lipson, Opt. Express 17, 11366 (2009).
[CrossRef] [PubMed]

2008 (1)

2007 (4)

D. L. Yin, E. J. Lunt, M. I. Rudenko, D. W. Deamer, A. R. Hawkins, and H. Schmidt, Lab Chip 7, 1171 (2007).
[CrossRef] [PubMed]

S. Gaugiran, S. Getin, J. M. Fedeli, and J. Derouard, Opt. Express 15, 8146 (2007).
[CrossRef] [PubMed]

B. S. Schmidt, A. H. J. Yang, D. Erickson, and M. Lipson, Opt. Express 15, 14322 (2007).
[CrossRef] [PubMed]

K. B. Shi, P. Li, and Z. W. Liu, Appl. Phys. Lett. 90, 141116 (2007).
[CrossRef]

2006 (1)

D. Psaltis, S. R. Quake, and C. H. Yang, Nature 442, 381 (2006).
[CrossRef] [PubMed]

2005 (2)

2002 (1)

F. Vollmer, D. Braun, A. Libchaber, M. Khoshsima, I. Teraoka, and S. Arnold, Appl. Phys. Lett. 80, 4057 (2002).
[CrossRef]

1996 (1)

Y. Liu, G. J. Sonek, M. W. Berns, and B. J. Tromberg, Biophys. J. 71, 2158 (1996).
[CrossRef] [PubMed]

1992 (2)

A. Ashkin, Biophys. J. 61, 569 (1992).
[CrossRef] [PubMed]

C. C. Lam, P. T. Leung, and K. Young, Biophys. J. 9, 1585 (1992).

1987 (1)

A. Ashkin and J. M. Dziedzic, Science 235, 1517 (1987).
[CrossRef] [PubMed]

Alfano, R. R.

Arnold, S.

F. Vollmer, D. Braun, A. Libchaber, M. Khoshsima, I. Teraoka, and S. Arnold, Appl. Phys. Lett. 80, 4057 (2002).
[CrossRef]

Ashkin, A.

A. Ashkin, Biophys. J. 61, 569 (1992).
[CrossRef] [PubMed]

A. Ashkin and J. M. Dziedzic, Science 235, 1517 (1987).
[CrossRef] [PubMed]

Berns, M. W.

Y. Liu, G. J. Sonek, M. W. Berns, and B. J. Tromberg, Biophys. J. 71, 2158 (1996).
[CrossRef] [PubMed]

Braun, D.

F. Vollmer, D. Braun, A. Libchaber, M. Khoshsima, I. Teraoka, and S. Arnold, Appl. Phys. Lett. 80, 4057 (2002).
[CrossRef]

Deamer, D. W.

S. Kuhn, P. Measor, E. J. Lunt, B. S. Phillips, D. W. Deamer, A. R. Hawkins, and H. Schmidt, Lab Chip 9, 2212 (2009).
[CrossRef] [PubMed]

D. L. Yin, E. J. Lunt, M. I. Rudenko, D. W. Deamer, A. R. Hawkins, and H. Schmidt, Lab Chip 7, 1171 (2007).
[CrossRef] [PubMed]

Derouard, J.

Dziedzic, J. M.

A. Ashkin and J. M. Dziedzic, Science 235, 1517 (1987).
[CrossRef] [PubMed]

Erickson, D.

A. H. J. Yang, S. D. Moore, B. S. Schmidt, M. Klug, M. Lipson, and D. Erickson, Nature 547, 71 (2009).
[CrossRef]

B. S. Schmidt, A. H. J. Yang, D. Erickson, and M. Lipson, Opt. Express 15, 14322 (2007).
[CrossRef] [PubMed]

Fedeli, J. M.

Gaugiran, S.

Getin, S.

Gondarenko, A.

Hawkins, A. R.

S. Kuhn, P. Measor, E. J. Lunt, B. S. Phillips, D. W. Deamer, A. R. Hawkins, and H. Schmidt, Lab Chip 9, 2212 (2009).
[CrossRef] [PubMed]

D. L. Yin, E. J. Lunt, M. I. Rudenko, D. W. Deamer, A. R. Hawkins, and H. Schmidt, Lab Chip 7, 1171 (2007).
[CrossRef] [PubMed]

Kartazaev, V.

Khoshsima, M.

F. Vollmer, D. Braun, A. Libchaber, M. Khoshsima, I. Teraoka, and S. Arnold, Appl. Phys. Lett. 80, 4057 (2002).
[CrossRef]

Klug, M.

A. H. J. Yang, S. D. Moore, B. S. Schmidt, M. Klug, M. Lipson, and D. Erickson, Nature 547, 71 (2009).
[CrossRef]

Kuhn, S.

S. Kuhn, P. Measor, E. J. Lunt, B. S. Phillips, D. W. Deamer, A. R. Hawkins, and H. Schmidt, Lab Chip 9, 2212 (2009).
[CrossRef] [PubMed]

Lam, C. C.

C. C. Lam, P. T. Leung, and K. Young, Biophys. J. 9, 1585 (1992).

Leung, P. T.

C. C. Lam, P. T. Leung, and K. Young, Biophys. J. 9, 1585 (1992).

Levy, J. S.

Li, P.

K. B. Shi, P. Li, and Z. W. Liu, Appl. Phys. Lett. 90, 141116 (2007).
[CrossRef]

P. Li, K. B. Shi, and Z. W. Liu, Opt. Lett. 30, 156 (2005).
[CrossRef] [PubMed]

Libchaber, A.

F. Vollmer, D. Braun, A. Libchaber, M. Khoshsima, I. Teraoka, and S. Arnold, Appl. Phys. Lett. 80, 4057 (2002).
[CrossRef]

Lin, L. Y.

Lipson, M.

Liu, Y.

Y. Liu, G. J. Sonek, M. W. Berns, and B. J. Tromberg, Biophys. J. 71, 2158 (1996).
[CrossRef] [PubMed]

Liu, Z. W.

K. B. Shi, P. Li, and Z. W. Liu, Appl. Phys. Lett. 90, 141116 (2007).
[CrossRef]

P. Li, K. B. Shi, and Z. W. Liu, Opt. Lett. 30, 156 (2005).
[CrossRef] [PubMed]

Lunt, E. J.

S. Kuhn, P. Measor, E. J. Lunt, B. S. Phillips, D. W. Deamer, A. R. Hawkins, and H. Schmidt, Lab Chip 9, 2212 (2009).
[CrossRef] [PubMed]

D. L. Yin, E. J. Lunt, M. I. Rudenko, D. W. Deamer, A. R. Hawkins, and H. Schmidt, Lab Chip 7, 1171 (2007).
[CrossRef] [PubMed]

Measor, P.

S. Kuhn, P. Measor, E. J. Lunt, B. S. Phillips, D. W. Deamer, A. R. Hawkins, and H. Schmidt, Lab Chip 9, 2212 (2009).
[CrossRef] [PubMed]

Miao, X. Y.

Moore, S. D.

A. H. J. Yang, S. D. Moore, B. S. Schmidt, M. Klug, M. Lipson, and D. Erickson, Nature 547, 71 (2009).
[CrossRef]

Phillips, B. S.

S. Kuhn, P. Measor, E. J. Lunt, B. S. Phillips, D. W. Deamer, A. R. Hawkins, and H. Schmidt, Lab Chip 9, 2212 (2009).
[CrossRef] [PubMed]

Psaltis, D.

D. Psaltis, S. R. Quake, and C. H. Yang, Nature 442, 381 (2006).
[CrossRef] [PubMed]

Pun, S. H.

Quake, S. R.

D. Psaltis, S. R. Quake, and C. H. Yang, Nature 442, 381 (2006).
[CrossRef] [PubMed]

Rudenko, M. I.

D. L. Yin, E. J. Lunt, M. I. Rudenko, D. W. Deamer, A. R. Hawkins, and H. Schmidt, Lab Chip 7, 1171 (2007).
[CrossRef] [PubMed]

Schmidt, B. S.

A. H. J. Yang, S. D. Moore, B. S. Schmidt, M. Klug, M. Lipson, and D. Erickson, Nature 547, 71 (2009).
[CrossRef]

B. S. Schmidt, A. H. J. Yang, D. Erickson, and M. Lipson, Opt. Express 15, 14322 (2007).
[CrossRef] [PubMed]

Schmidt, H.

S. Kuhn, P. Measor, E. J. Lunt, B. S. Phillips, D. W. Deamer, A. R. Hawkins, and H. Schmidt, Lab Chip 9, 2212 (2009).
[CrossRef] [PubMed]

D. L. Yin, E. J. Lunt, M. I. Rudenko, D. W. Deamer, A. R. Hawkins, and H. Schmidt, Lab Chip 7, 1171 (2007).
[CrossRef] [PubMed]

Shi, K. B.

K. B. Shi, P. Li, and Z. W. Liu, Appl. Phys. Lett. 90, 141116 (2007).
[CrossRef]

P. Li, K. B. Shi, and Z. W. Liu, Opt. Lett. 30, 156 (2005).
[CrossRef] [PubMed]

Sonek, G. J.

Y. Liu, G. J. Sonek, M. W. Berns, and B. J. Tromberg, Biophys. J. 71, 2158 (1996).
[CrossRef] [PubMed]

Teraoka, I.

F. Vollmer, D. Braun, A. Libchaber, M. Khoshsima, I. Teraoka, and S. Arnold, Appl. Phys. Lett. 80, 4057 (2002).
[CrossRef]

Tromberg, B. J.

Y. Liu, G. J. Sonek, M. W. Berns, and B. J. Tromberg, Biophys. J. 71, 2158 (1996).
[CrossRef] [PubMed]

Vollmer, F.

F. Vollmer, D. Braun, A. Libchaber, M. Khoshsima, I. Teraoka, and S. Arnold, Appl. Phys. Lett. 80, 4057 (2002).
[CrossRef]

Wilson, B. K.

Yang, A. H. J.

A. H. J. Yang, S. D. Moore, B. S. Schmidt, M. Klug, M. Lipson, and D. Erickson, Nature 547, 71 (2009).
[CrossRef]

B. S. Schmidt, A. H. J. Yang, D. Erickson, and M. Lipson, Opt. Express 15, 14322 (2007).
[CrossRef] [PubMed]

Yang, C. H.

D. Psaltis, S. R. Quake, and C. H. Yang, Nature 442, 381 (2006).
[CrossRef] [PubMed]

Yin, D. L.

D. L. Yin, E. J. Lunt, M. I. Rudenko, D. W. Deamer, A. R. Hawkins, and H. Schmidt, Lab Chip 7, 1171 (2007).
[CrossRef] [PubMed]

Young, K.

C. C. Lam, P. T. Leung, and K. Young, Biophys. J. 9, 1585 (1992).

Zeylikovich, I.

Appl. Phys. Lett. (2)

K. B. Shi, P. Li, and Z. W. Liu, Appl. Phys. Lett. 90, 141116 (2007).
[CrossRef]

F. Vollmer, D. Braun, A. Libchaber, M. Khoshsima, I. Teraoka, and S. Arnold, Appl. Phys. Lett. 80, 4057 (2002).
[CrossRef]

Biophys. J. (3)

C. C. Lam, P. T. Leung, and K. Young, Biophys. J. 9, 1585 (1992).

Y. Liu, G. J. Sonek, M. W. Berns, and B. J. Tromberg, Biophys. J. 71, 2158 (1996).
[CrossRef] [PubMed]

A. Ashkin, Biophys. J. 61, 569 (1992).
[CrossRef] [PubMed]

J. Opt. Soc. Am. B (1)

Lab Chip (2)

D. L. Yin, E. J. Lunt, M. I. Rudenko, D. W. Deamer, A. R. Hawkins, and H. Schmidt, Lab Chip 7, 1171 (2007).
[CrossRef] [PubMed]

S. Kuhn, P. Measor, E. J. Lunt, B. S. Phillips, D. W. Deamer, A. R. Hawkins, and H. Schmidt, Lab Chip 9, 2212 (2009).
[CrossRef] [PubMed]

Nature (2)

D. Psaltis, S. R. Quake, and C. H. Yang, Nature 442, 381 (2006).
[CrossRef] [PubMed]

A. H. J. Yang, S. D. Moore, B. S. Schmidt, M. Klug, M. Lipson, and D. Erickson, Nature 547, 71 (2009).
[CrossRef]

Opt. Express (4)

Opt. Lett. (1)

Science (1)

A. Ashkin and J. M. Dziedzic, Science 235, 1517 (1987).
[CrossRef] [PubMed]

Supplementary Material (1)

» Media 1: MPEG (3180 KB)     

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Figures (5)

Fig. 1
Fig. 1

3D simulation results for the electric field ( E y ) profile of the quasi-TM mode at a wavelength of 850 nm in a silicon nitride waveguide. The optical forces on a dielectric microsphere can be decomposed into a transverse gradient force ( F grad ) that traps the sphere to the waveguide surface and a longitudinal force ( F scatt ) that propels it along the direction (z axis) of light propagation.

Fig. 2
Fig. 2

Spectra of the supercontinuum source and waveguide transmission showing efficient broadband coupling to the waveguide from 700 nm to 1400 nm .

Fig. 3
Fig. 3

Optical trapping and transport of 3 - μ m -diameter polystyrene microspheres in a microfluidic channel using a supercontinuum broadband light source. Video (Media 1) ⟨medioref⟩ shows optical trapping of several polystyrene microspheres using 10 mW of guided power. Playback is 2 × real time.

Fig. 4
Fig. 4

Waveguide transmission spectrum showing WGM resonances of an optically trapped 18 - μ m - diameter polystyrene microsphere with quality factors of 2,000 .

Fig. 5
Fig. 5

Experimental (circles) free spectral range in microspheres of different diameters with theoretical (solid lines) curves for WGMs in spherical cavities.

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