Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

Spatially offset Raman spectroscopy of layered soft tissues

Not Accessible

Your library or personal account may give you access

Abstract

Raman spectroscopy has been widely used for cancer diagnosis, but conventional forms provide limited depth information. Spatially offset Raman spectroscopy (SORS) can solve the depth issue, but it has only been used to detect hard tissues such as bone. We explore the feasibility of using SORS to discriminate two layers of soft tissue. Measurements were taken with individual source and detector fibers at a number of spatial offsets from samples consisting of various thicknesses of normal human breast tissues overlying breast tumors. Results show that SORS can detect tumors beneath normal tissue, marking, to the best of our knowledge, the first application of SORS for discriminating two layers of soft tissue.

© 2009 Optical Society of America

Full Article  |  PDF Article
More Like This
Use of a mechanical iris-based fiber optic probe for spatially offset Raman spectroscopy

Zhiyong Wang, Hao Ding, Guijin Lu, and Xiaohong Bi
Opt. Lett. 39(13) 3790-3793 (2014)

Snapshot depth sensitive Raman spectroscopy in layered tissues

Wei Liu, Yi Hong Ong, Xiao Jun Yu, Jian Ju, Clint Michael Perlaki, Lin Bo Liu, and Quan Liu
Opt. Express 24(25) 28312-28325 (2016)

Spatially-offset Raman spectroscopy for monitoring mineralization of bone tissue engineering scaffolds: feasibility study based on phantom samples

Max Dooley, Aruna Prasopthum, Zhiyu Liao, Faris Sinjab, Jane McLaren, Felicity R. A. J. Rose, Jing Yang, and Ioan Notingher
Biomed. Opt. Express 10(4) 1678-1690 (2019)

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Figures (4)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved