Abstract

We report an integrated Raman spectroscopy and trimodal (white-light reflectance, autofluorescence, and narrow-band) imaging techniques for real-time in vivo tissue Raman measurements at endoscopy. A special 1.8mm endoscopic Raman probe with filtering modules is developed, permitting effective elimination of interference of fluorescence background and silica Raman in fibers while maximizing tissue Raman collections. We demonstrate that high-quality in vivo Raman spectra of upper gastrointestinal tract can be acquired within 1s or subseconds under the guidance of wide-field endoscopic imaging modalities, greatly facilitating the adoption of Raman spectroscopy into clinical research and practice during routine endoscopic inspections.

© 2009 Optical Society of America

Full Article  |  PDF Article
Related Articles
Three-dimensional endomicroscopy of the human colon using optical coherence tomography

Desmond C. Adler, Chao Zhou, Tsung-Han Tsai, Joe Schmitt, Qin Huang, Hiroshi Mashimo, and James G. Fujimoto
Opt. Express 17(2) 784-796 (2009)

Development of a beveled fiber-optic confocal Raman probe for enhancing in vivo epithelial tissue Raman measurements at endoscopy

Jianfeng Wang, Mads Sylvest Bergholt, Wei Zheng, and Zhiwei Huang
Opt. Lett. 38(13) 2321-2323 (2013)

Towards clinically translatable NIR fluorescence molecular guidance for colonoscopy

P. Beatriz Garcia-Allende, Jürgen Glatz, Maximilian Koch, Jolien J. Tjalma, Elmire Hartmans, Anton G.T. Terwisscha van Scheltinga, Panagiotis Symvoulidis, Gooitzen M. van Dam, Wouter B. Nagengast, and Vasilis Ntziachristos
Biomed. Opt. Express 5(1) 78-92 (2014)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (3)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription