Abstract

The invention of intraocular lens (IOL), a substitute for crystalline lens, represents a major advancement in cataract surgery. After about sixty years of IOL development, one key remaining problem is its limited accommodation range compared with natural eyes. To overcome this performance limit, we explore bio-inspired fluidic IOL. By mimicking the working principle of natural eyes, a fluidic intraocular lens can achieve an exceedingly large accommodation range. An experiment on fluidic IOL demonstrated a very high tuning range of 12โ€‰D. This accommodation range was achieved with a modest amount of force (0.06โ€‰N) and equatorial radius change (0.286โ€‰mm), in conditions matching well with the characteristics of aged eyes.

© 2009 Optical Society of America

Full Article  |  PDF Article

References

  • View by:
  • |
  • |
  • |

  1. J. S. Cumming, D. M. Colvard, S. J. Dell, J. Doane, I. H. Fine, R. S. Hoffman, M. Packer, and S. G. Slade, J. Cataract Refractive Surg. 32, 812 (2006).
    [CrossRef]
  2. A. Galand, J. Cataract Refractive Surg. 32, 3 (2006).
    [CrossRef]
  3. S. D. McLeod, V. Portney, and A. Ting, Br. J. Ophthamol. 87, 1083 (2003).
    [CrossRef]
  4. A. Duane, J. Am. Med. Assoc. 59, 1010 (1912).
    [CrossRef]
  5. F. S. Tsai, S. H. Cho, Y. H. Lo, B. Vasko, and J. Vasko, Opt. Lett. 33, 291 (2008).
    [CrossRef] [PubMed]
  6. W. Qiao, F. S. Tsai, S. H. Cho, H. Yan, and Y. H. Lo, Intel Technol. J. 21, 304 (2009).
  7. W. Qiao, F. S. Tsai, S. H. Cho, H. Yan, and Y.-H. Lo, in Frontiers in Optics, OSA Technical Digest (CD) (Optical Society of America, 2008), paper FThG4.
  8. M. Lombardo, M. P. De Santo, G. Lombardo, R. Barberi, and S. Serrao, J. Cataract Refractive Surg. 32, 1378 (2006).
    [CrossRef]
  9. T. Tanaka, M. Shigeta, N. Yamakawa, and M. Usui, J. Cataract Refractive Surg. 31, 1648 (2005).
    [CrossRef]
  10. M. Renard, M. Delmelle, and A. Galand, Graefe's Arch. Clin. Exp. Ophthalmol. 223, 205 (1985).
    [CrossRef]
  11. S. D. McLeod, L. G. Vargas, V. Portney, and A. Ting, J. Cataract Refractive Surg. 33, 37 (2007).
    [CrossRef]
  12. E. A. Hermans, M. Dubbelman, G. L. van der Heijde, and R. M. Heethaar, Vision Res. 46, 3642 (2006).
    [CrossRef] [PubMed]

2009 (1)

W. Qiao, F. S. Tsai, S. H. Cho, H. Yan, and Y. H. Lo, Intel Technol. J. 21, 304 (2009).

2008 (1)

2007 (1)

S. D. McLeod, L. G. Vargas, V. Portney, and A. Ting, J. Cataract Refractive Surg. 33, 37 (2007).
[CrossRef]

2006 (4)

E. A. Hermans, M. Dubbelman, G. L. van der Heijde, and R. M. Heethaar, Vision Res. 46, 3642 (2006).
[CrossRef] [PubMed]

M. Lombardo, M. P. De Santo, G. Lombardo, R. Barberi, and S. Serrao, J. Cataract Refractive Surg. 32, 1378 (2006).
[CrossRef]

J. S. Cumming, D. M. Colvard, S. J. Dell, J. Doane, I. H. Fine, R. S. Hoffman, M. Packer, and S. G. Slade, J. Cataract Refractive Surg. 32, 812 (2006).
[CrossRef]

A. Galand, J. Cataract Refractive Surg. 32, 3 (2006).
[CrossRef]

2005 (1)

T. Tanaka, M. Shigeta, N. Yamakawa, and M. Usui, J. Cataract Refractive Surg. 31, 1648 (2005).
[CrossRef]

2003 (1)

S. D. McLeod, V. Portney, and A. Ting, Br. J. Ophthamol. 87, 1083 (2003).
[CrossRef]

1985 (1)

M. Renard, M. Delmelle, and A. Galand, Graefe's Arch. Clin. Exp. Ophthalmol. 223, 205 (1985).
[CrossRef]

1912 (1)

A. Duane, J. Am. Med. Assoc. 59, 1010 (1912).
[CrossRef]

Barberi, R.

M. Lombardo, M. P. De Santo, G. Lombardo, R. Barberi, and S. Serrao, J. Cataract Refractive Surg. 32, 1378 (2006).
[CrossRef]

Cho, S. H.

W. Qiao, F. S. Tsai, S. H. Cho, H. Yan, and Y. H. Lo, Intel Technol. J. 21, 304 (2009).

F. S. Tsai, S. H. Cho, Y. H. Lo, B. Vasko, and J. Vasko, Opt. Lett. 33, 291 (2008).
[CrossRef] [PubMed]

W. Qiao, F. S. Tsai, S. H. Cho, H. Yan, and Y.-H. Lo, in Frontiers in Optics, OSA Technical Digest (CD) (Optical Society of America, 2008), paper FThG4.

Colvard, D. M.

J. S. Cumming, D. M. Colvard, S. J. Dell, J. Doane, I. H. Fine, R. S. Hoffman, M. Packer, and S. G. Slade, J. Cataract Refractive Surg. 32, 812 (2006).
[CrossRef]

Cumming, J. S.

J. S. Cumming, D. M. Colvard, S. J. Dell, J. Doane, I. H. Fine, R. S. Hoffman, M. Packer, and S. G. Slade, J. Cataract Refractive Surg. 32, 812 (2006).
[CrossRef]

De Santo, M. P.

M. Lombardo, M. P. De Santo, G. Lombardo, R. Barberi, and S. Serrao, J. Cataract Refractive Surg. 32, 1378 (2006).
[CrossRef]

Dell, S. J.

J. S. Cumming, D. M. Colvard, S. J. Dell, J. Doane, I. H. Fine, R. S. Hoffman, M. Packer, and S. G. Slade, J. Cataract Refractive Surg. 32, 812 (2006).
[CrossRef]

Delmelle, M.

M. Renard, M. Delmelle, and A. Galand, Graefe's Arch. Clin. Exp. Ophthalmol. 223, 205 (1985).
[CrossRef]

Doane, J.

J. S. Cumming, D. M. Colvard, S. J. Dell, J. Doane, I. H. Fine, R. S. Hoffman, M. Packer, and S. G. Slade, J. Cataract Refractive Surg. 32, 812 (2006).
[CrossRef]

Duane, A.

A. Duane, J. Am. Med. Assoc. 59, 1010 (1912).
[CrossRef]

Dubbelman, M.

E. A. Hermans, M. Dubbelman, G. L. van der Heijde, and R. M. Heethaar, Vision Res. 46, 3642 (2006).
[CrossRef] [PubMed]

Fine, I. H.

J. S. Cumming, D. M. Colvard, S. J. Dell, J. Doane, I. H. Fine, R. S. Hoffman, M. Packer, and S. G. Slade, J. Cataract Refractive Surg. 32, 812 (2006).
[CrossRef]

Galand, A.

A. Galand, J. Cataract Refractive Surg. 32, 3 (2006).
[CrossRef]

M. Renard, M. Delmelle, and A. Galand, Graefe's Arch. Clin. Exp. Ophthalmol. 223, 205 (1985).
[CrossRef]

Heethaar, R. M.

E. A. Hermans, M. Dubbelman, G. L. van der Heijde, and R. M. Heethaar, Vision Res. 46, 3642 (2006).
[CrossRef] [PubMed]

Hermans, E. A.

E. A. Hermans, M. Dubbelman, G. L. van der Heijde, and R. M. Heethaar, Vision Res. 46, 3642 (2006).
[CrossRef] [PubMed]

Hoffman, R. S.

J. S. Cumming, D. M. Colvard, S. J. Dell, J. Doane, I. H. Fine, R. S. Hoffman, M. Packer, and S. G. Slade, J. Cataract Refractive Surg. 32, 812 (2006).
[CrossRef]

Lo, Y. H.

W. Qiao, F. S. Tsai, S. H. Cho, H. Yan, and Y. H. Lo, Intel Technol. J. 21, 304 (2009).

F. S. Tsai, S. H. Cho, Y. H. Lo, B. Vasko, and J. Vasko, Opt. Lett. 33, 291 (2008).
[CrossRef] [PubMed]

Lo, Y.-H.

W. Qiao, F. S. Tsai, S. H. Cho, H. Yan, and Y.-H. Lo, in Frontiers in Optics, OSA Technical Digest (CD) (Optical Society of America, 2008), paper FThG4.

Lombardo, G.

M. Lombardo, M. P. De Santo, G. Lombardo, R. Barberi, and S. Serrao, J. Cataract Refractive Surg. 32, 1378 (2006).
[CrossRef]

Lombardo, M.

M. Lombardo, M. P. De Santo, G. Lombardo, R. Barberi, and S. Serrao, J. Cataract Refractive Surg. 32, 1378 (2006).
[CrossRef]

McLeod, S. D.

S. D. McLeod, L. G. Vargas, V. Portney, and A. Ting, J. Cataract Refractive Surg. 33, 37 (2007).
[CrossRef]

S. D. McLeod, V. Portney, and A. Ting, Br. J. Ophthamol. 87, 1083 (2003).
[CrossRef]

Packer, M.

J. S. Cumming, D. M. Colvard, S. J. Dell, J. Doane, I. H. Fine, R. S. Hoffman, M. Packer, and S. G. Slade, J. Cataract Refractive Surg. 32, 812 (2006).
[CrossRef]

Portney, V.

S. D. McLeod, L. G. Vargas, V. Portney, and A. Ting, J. Cataract Refractive Surg. 33, 37 (2007).
[CrossRef]

S. D. McLeod, V. Portney, and A. Ting, Br. J. Ophthamol. 87, 1083 (2003).
[CrossRef]

Qiao, W.

W. Qiao, F. S. Tsai, S. H. Cho, H. Yan, and Y. H. Lo, Intel Technol. J. 21, 304 (2009).

W. Qiao, F. S. Tsai, S. H. Cho, H. Yan, and Y.-H. Lo, in Frontiers in Optics, OSA Technical Digest (CD) (Optical Society of America, 2008), paper FThG4.

Renard, M.

M. Renard, M. Delmelle, and A. Galand, Graefe's Arch. Clin. Exp. Ophthalmol. 223, 205 (1985).
[CrossRef]

Serrao, S.

M. Lombardo, M. P. De Santo, G. Lombardo, R. Barberi, and S. Serrao, J. Cataract Refractive Surg. 32, 1378 (2006).
[CrossRef]

Shigeta, M.

T. Tanaka, M. Shigeta, N. Yamakawa, and M. Usui, J. Cataract Refractive Surg. 31, 1648 (2005).
[CrossRef]

Slade, S. G.

J. S. Cumming, D. M. Colvard, S. J. Dell, J. Doane, I. H. Fine, R. S. Hoffman, M. Packer, and S. G. Slade, J. Cataract Refractive Surg. 32, 812 (2006).
[CrossRef]

Tanaka, T.

T. Tanaka, M. Shigeta, N. Yamakawa, and M. Usui, J. Cataract Refractive Surg. 31, 1648 (2005).
[CrossRef]

Ting, A.

S. D. McLeod, L. G. Vargas, V. Portney, and A. Ting, J. Cataract Refractive Surg. 33, 37 (2007).
[CrossRef]

S. D. McLeod, V. Portney, and A. Ting, Br. J. Ophthamol. 87, 1083 (2003).
[CrossRef]

Tsai, F. S.

W. Qiao, F. S. Tsai, S. H. Cho, H. Yan, and Y. H. Lo, Intel Technol. J. 21, 304 (2009).

F. S. Tsai, S. H. Cho, Y. H. Lo, B. Vasko, and J. Vasko, Opt. Lett. 33, 291 (2008).
[CrossRef] [PubMed]

W. Qiao, F. S. Tsai, S. H. Cho, H. Yan, and Y.-H. Lo, in Frontiers in Optics, OSA Technical Digest (CD) (Optical Society of America, 2008), paper FThG4.

Usui, M.

T. Tanaka, M. Shigeta, N. Yamakawa, and M. Usui, J. Cataract Refractive Surg. 31, 1648 (2005).
[CrossRef]

van der Heijde, G. L.

E. A. Hermans, M. Dubbelman, G. L. van der Heijde, and R. M. Heethaar, Vision Res. 46, 3642 (2006).
[CrossRef] [PubMed]

Vargas, L. G.

S. D. McLeod, L. G. Vargas, V. Portney, and A. Ting, J. Cataract Refractive Surg. 33, 37 (2007).
[CrossRef]

Vasko, B.

Vasko, J.

Yamakawa, N.

T. Tanaka, M. Shigeta, N. Yamakawa, and M. Usui, J. Cataract Refractive Surg. 31, 1648 (2005).
[CrossRef]

Yan, H.

W. Qiao, F. S. Tsai, S. H. Cho, H. Yan, and Y. H. Lo, Intel Technol. J. 21, 304 (2009).

W. Qiao, F. S. Tsai, S. H. Cho, H. Yan, and Y.-H. Lo, in Frontiers in Optics, OSA Technical Digest (CD) (Optical Society of America, 2008), paper FThG4.

Br. J. Ophthamol. (1)

S. D. McLeod, V. Portney, and A. Ting, Br. J. Ophthamol. 87, 1083 (2003).
[CrossRef]

Graefe's Arch. Clin. Exp. Ophthalmol. (1)

M. Renard, M. Delmelle, and A. Galand, Graefe's Arch. Clin. Exp. Ophthalmol. 223, 205 (1985).
[CrossRef]

Intel Technol. J. (1)

W. Qiao, F. S. Tsai, S. H. Cho, H. Yan, and Y. H. Lo, Intel Technol. J. 21, 304 (2009).

J. Am. Med. Assoc. (1)

A. Duane, J. Am. Med. Assoc. 59, 1010 (1912).
[CrossRef]

J. Cataract Refractive Surg. (5)

J. S. Cumming, D. M. Colvard, S. J. Dell, J. Doane, I. H. Fine, R. S. Hoffman, M. Packer, and S. G. Slade, J. Cataract Refractive Surg. 32, 812 (2006).
[CrossRef]

A. Galand, J. Cataract Refractive Surg. 32, 3 (2006).
[CrossRef]

M. Lombardo, M. P. De Santo, G. Lombardo, R. Barberi, and S. Serrao, J. Cataract Refractive Surg. 32, 1378 (2006).
[CrossRef]

T. Tanaka, M. Shigeta, N. Yamakawa, and M. Usui, J. Cataract Refractive Surg. 31, 1648 (2005).
[CrossRef]

S. D. McLeod, L. G. Vargas, V. Portney, and A. Ting, J. Cataract Refractive Surg. 33, 37 (2007).
[CrossRef]

Opt. Lett. (1)

Vision Res. (1)

E. A. Hermans, M. Dubbelman, G. L. van der Heijde, and R. M. Heethaar, Vision Res. 46, 3642 (2006).
[CrossRef] [PubMed]

Other (1)

W. Qiao, F. S. Tsai, S. H. Cho, H. Yan, and Y.-H. Lo, in Frontiers in Optics, OSA Technical Digest (CD) (Optical Society of America, 2008), paper FThG4.

Cited By

OSA participates in CrossRef's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (5)

Fig. 1
Fig. 1

Structure of bio-inspired fluidic IOL, consisting of a support ring, a lens chamber, and a reservoir. Fluid can be exchanged between these two chambers via eight channels in the support ring. The optical fluid is sealed inside both chambers by two elastic membranes.

Fig. 2
Fig. 2

Working principle of the bio-inspired fluidic IOL: (a) the fluidic IOL before insertion, (b) the fluidic IOL after insertion where the lens is focused on far objects, (c) the fluidic IOL accommodated to focus on near objects.

Fig. 3
Fig. 3

Fabrication process of fluidic IOL: (a) membrane preparation, (b) support-ring preparation, (c) bonding of membranes and support ring, (d) device filled with optical fluid by vacuum, (e) pin inserted to seal the IOL.

Fig. 4
Fig. 4

Schematic diagram of (a) a mechanical model simulating the actions of a capsular bag with an acrylic band actuator, (b) a setup for lens curvature measurement, and (c) a setup for force measurements.

Fig. 5
Fig. 5

Dependence of accommodation on muscle force for a bio-inspired fluidic IOL.

Metrics