Abstract

We propose three-dimensional fluorescence optical tomography imaging for small animals guided by simultaneous priors from positron emission tomography (PET). Using a sparsity regularization, the target prior from PET images was incorporated into the reconstruction algorithm for optical imaging. The method and algorithms are validated with numerical simulations and a phantom experiment performed on a combined optical-PET scanner based on a conical mirror geometry.

© 2009 Optical Society of America

Full Article  |  PDF Article

References

  • View by:
  • |
  • |
  • |

  1. A. J. Chaudhari, F. Darvas, J. R. Bading, R. A. Moats, P. S. Conti, D. J. Smith, S. R. Cherry, and R. M. Leahy, Phys. Med. Biol. 50, 5421 (2005).
    [CrossRef] [PubMed]
  2. Z. Yuan, X. H. Hu, and H. B. Jiang, Phys. Med. Biol. 54, 65 (2009).
    [CrossRef]
  3. S. Ahn, A. J. Chaudhari, F. Darvas, C. A. Bouman, and R. M. Leahy, Phys. Med. Biol. 53, 3921 (2008).
    [CrossRef] [PubMed]
  4. A. H. Barnett, J. P. Culver, A. G. Sorensen, A. Dale, and D. A. Boas, Appl. Opt. 42, 3095 (2003).
    [CrossRef]
  5. C. Comtat, P. E. Kinahan, J. A. Fessler, T. Beyer, D. W. Townsend, M. Defrise, and C. Michel, Phys. Med. Biol. 47, 1 (2002).
    [CrossRef] [PubMed]
  6. J. Culver, W. Akers, and S. Achilefu, J. Nucl. Med. 49, 169 (2008).
    [CrossRef] [PubMed]
  7. W. B. Edwards, B. Xu, W. Akers, P. P. Cheney, K. Liang, B. E. Rogers, C. J. Anderson, and S. Achilefu, Bioconjugate Chem. 19, 192 (2008).
    [CrossRef]
  8. Y. F. Yang, Y. B. Wu, J. Y. Qi, S. S. James, H. N. Du, P. A. Dokhale, K. S. Shah, R. Farrell, and S. R. Cherry, J. Nucl. Med. 49, 1132 (2008).
    [CrossRef] [PubMed]
  9. G. Zacharakis, J. Ripoll, R. Weissleder, and V. Ntziachristos, IEEE Trans. Med. Imaging 24, 878 (2005).
    [CrossRef] [PubMed]
  10. R. Weissleder, C. H. Tung, U. Mahmood, and A. Bogdanov, Jr., Nat. Biotechnol. 17, 375 (1999).
    [CrossRef] [PubMed]
  11. C. Q. Li, G. S. Mitchell, J. Dutta, S. Ahn, R. M. Leahy, and S. R. Cherry, Opt. Express 17, 7571 (2009).
    [CrossRef] [PubMed]
  12. Y. Yang, Y. C. Tai, S. Siegel, D. F. Newport, B. Bai, Q. Li, R. M. Leahy, and S. R. Cherry, Phys. Med. Biol. 49, 2527 (2004).
    [CrossRef] [PubMed]

2009 (2)

2008 (4)

S. Ahn, A. J. Chaudhari, F. Darvas, C. A. Bouman, and R. M. Leahy, Phys. Med. Biol. 53, 3921 (2008).
[CrossRef] [PubMed]

J. Culver, W. Akers, and S. Achilefu, J. Nucl. Med. 49, 169 (2008).
[CrossRef] [PubMed]

W. B. Edwards, B. Xu, W. Akers, P. P. Cheney, K. Liang, B. E. Rogers, C. J. Anderson, and S. Achilefu, Bioconjugate Chem. 19, 192 (2008).
[CrossRef]

Y. F. Yang, Y. B. Wu, J. Y. Qi, S. S. James, H. N. Du, P. A. Dokhale, K. S. Shah, R. Farrell, and S. R. Cherry, J. Nucl. Med. 49, 1132 (2008).
[CrossRef] [PubMed]

2005 (2)

G. Zacharakis, J. Ripoll, R. Weissleder, and V. Ntziachristos, IEEE Trans. Med. Imaging 24, 878 (2005).
[CrossRef] [PubMed]

A. J. Chaudhari, F. Darvas, J. R. Bading, R. A. Moats, P. S. Conti, D. J. Smith, S. R. Cherry, and R. M. Leahy, Phys. Med. Biol. 50, 5421 (2005).
[CrossRef] [PubMed]

2004 (1)

Y. Yang, Y. C. Tai, S. Siegel, D. F. Newport, B. Bai, Q. Li, R. M. Leahy, and S. R. Cherry, Phys. Med. Biol. 49, 2527 (2004).
[CrossRef] [PubMed]

2003 (1)

2002 (1)

C. Comtat, P. E. Kinahan, J. A. Fessler, T. Beyer, D. W. Townsend, M. Defrise, and C. Michel, Phys. Med. Biol. 47, 1 (2002).
[CrossRef] [PubMed]

1999 (1)

R. Weissleder, C. H. Tung, U. Mahmood, and A. Bogdanov, Jr., Nat. Biotechnol. 17, 375 (1999).
[CrossRef] [PubMed]

Achilefu, S.

J. Culver, W. Akers, and S. Achilefu, J. Nucl. Med. 49, 169 (2008).
[CrossRef] [PubMed]

W. B. Edwards, B. Xu, W. Akers, P. P. Cheney, K. Liang, B. E. Rogers, C. J. Anderson, and S. Achilefu, Bioconjugate Chem. 19, 192 (2008).
[CrossRef]

Ahn, S.

C. Q. Li, G. S. Mitchell, J. Dutta, S. Ahn, R. M. Leahy, and S. R. Cherry, Opt. Express 17, 7571 (2009).
[CrossRef] [PubMed]

S. Ahn, A. J. Chaudhari, F. Darvas, C. A. Bouman, and R. M. Leahy, Phys. Med. Biol. 53, 3921 (2008).
[CrossRef] [PubMed]

Akers, W.

J. Culver, W. Akers, and S. Achilefu, J. Nucl. Med. 49, 169 (2008).
[CrossRef] [PubMed]

W. B. Edwards, B. Xu, W. Akers, P. P. Cheney, K. Liang, B. E. Rogers, C. J. Anderson, and S. Achilefu, Bioconjugate Chem. 19, 192 (2008).
[CrossRef]

Anderson, C. J.

W. B. Edwards, B. Xu, W. Akers, P. P. Cheney, K. Liang, B. E. Rogers, C. J. Anderson, and S. Achilefu, Bioconjugate Chem. 19, 192 (2008).
[CrossRef]

Bading, J. R.

A. J. Chaudhari, F. Darvas, J. R. Bading, R. A. Moats, P. S. Conti, D. J. Smith, S. R. Cherry, and R. M. Leahy, Phys. Med. Biol. 50, 5421 (2005).
[CrossRef] [PubMed]

Bai, B.

Y. Yang, Y. C. Tai, S. Siegel, D. F. Newport, B. Bai, Q. Li, R. M. Leahy, and S. R. Cherry, Phys. Med. Biol. 49, 2527 (2004).
[CrossRef] [PubMed]

Barnett, A. H.

Beyer, T.

C. Comtat, P. E. Kinahan, J. A. Fessler, T. Beyer, D. W. Townsend, M. Defrise, and C. Michel, Phys. Med. Biol. 47, 1 (2002).
[CrossRef] [PubMed]

Boas, D. A.

Bogdanov, A.

R. Weissleder, C. H. Tung, U. Mahmood, and A. Bogdanov, Jr., Nat. Biotechnol. 17, 375 (1999).
[CrossRef] [PubMed]

Bouman, C. A.

S. Ahn, A. J. Chaudhari, F. Darvas, C. A. Bouman, and R. M. Leahy, Phys. Med. Biol. 53, 3921 (2008).
[CrossRef] [PubMed]

Chaudhari, A. J.

S. Ahn, A. J. Chaudhari, F. Darvas, C. A. Bouman, and R. M. Leahy, Phys. Med. Biol. 53, 3921 (2008).
[CrossRef] [PubMed]

A. J. Chaudhari, F. Darvas, J. R. Bading, R. A. Moats, P. S. Conti, D. J. Smith, S. R. Cherry, and R. M. Leahy, Phys. Med. Biol. 50, 5421 (2005).
[CrossRef] [PubMed]

Cheney, P. P.

W. B. Edwards, B. Xu, W. Akers, P. P. Cheney, K. Liang, B. E. Rogers, C. J. Anderson, and S. Achilefu, Bioconjugate Chem. 19, 192 (2008).
[CrossRef]

Cherry, S. R.

C. Q. Li, G. S. Mitchell, J. Dutta, S. Ahn, R. M. Leahy, and S. R. Cherry, Opt. Express 17, 7571 (2009).
[CrossRef] [PubMed]

Y. F. Yang, Y. B. Wu, J. Y. Qi, S. S. James, H. N. Du, P. A. Dokhale, K. S. Shah, R. Farrell, and S. R. Cherry, J. Nucl. Med. 49, 1132 (2008).
[CrossRef] [PubMed]

A. J. Chaudhari, F. Darvas, J. R. Bading, R. A. Moats, P. S. Conti, D. J. Smith, S. R. Cherry, and R. M. Leahy, Phys. Med. Biol. 50, 5421 (2005).
[CrossRef] [PubMed]

Y. Yang, Y. C. Tai, S. Siegel, D. F. Newport, B. Bai, Q. Li, R. M. Leahy, and S. R. Cherry, Phys. Med. Biol. 49, 2527 (2004).
[CrossRef] [PubMed]

Comtat, C.

C. Comtat, P. E. Kinahan, J. A. Fessler, T. Beyer, D. W. Townsend, M. Defrise, and C. Michel, Phys. Med. Biol. 47, 1 (2002).
[CrossRef] [PubMed]

Conti, P. S.

A. J. Chaudhari, F. Darvas, J. R. Bading, R. A. Moats, P. S. Conti, D. J. Smith, S. R. Cherry, and R. M. Leahy, Phys. Med. Biol. 50, 5421 (2005).
[CrossRef] [PubMed]

Culver, J.

J. Culver, W. Akers, and S. Achilefu, J. Nucl. Med. 49, 169 (2008).
[CrossRef] [PubMed]

Culver, J. P.

Dale, A.

Darvas, F.

S. Ahn, A. J. Chaudhari, F. Darvas, C. A. Bouman, and R. M. Leahy, Phys. Med. Biol. 53, 3921 (2008).
[CrossRef] [PubMed]

A. J. Chaudhari, F. Darvas, J. R. Bading, R. A. Moats, P. S. Conti, D. J. Smith, S. R. Cherry, and R. M. Leahy, Phys. Med. Biol. 50, 5421 (2005).
[CrossRef] [PubMed]

Defrise, M.

C. Comtat, P. E. Kinahan, J. A. Fessler, T. Beyer, D. W. Townsend, M. Defrise, and C. Michel, Phys. Med. Biol. 47, 1 (2002).
[CrossRef] [PubMed]

Dokhale, P. A.

Y. F. Yang, Y. B. Wu, J. Y. Qi, S. S. James, H. N. Du, P. A. Dokhale, K. S. Shah, R. Farrell, and S. R. Cherry, J. Nucl. Med. 49, 1132 (2008).
[CrossRef] [PubMed]

Du, H. N.

Y. F. Yang, Y. B. Wu, J. Y. Qi, S. S. James, H. N. Du, P. A. Dokhale, K. S. Shah, R. Farrell, and S. R. Cherry, J. Nucl. Med. 49, 1132 (2008).
[CrossRef] [PubMed]

Dutta, J.

Edwards, W. B.

W. B. Edwards, B. Xu, W. Akers, P. P. Cheney, K. Liang, B. E. Rogers, C. J. Anderson, and S. Achilefu, Bioconjugate Chem. 19, 192 (2008).
[CrossRef]

Farrell, R.

Y. F. Yang, Y. B. Wu, J. Y. Qi, S. S. James, H. N. Du, P. A. Dokhale, K. S. Shah, R. Farrell, and S. R. Cherry, J. Nucl. Med. 49, 1132 (2008).
[CrossRef] [PubMed]

Fessler, J. A.

C. Comtat, P. E. Kinahan, J. A. Fessler, T. Beyer, D. W. Townsend, M. Defrise, and C. Michel, Phys. Med. Biol. 47, 1 (2002).
[CrossRef] [PubMed]

Hu, X. H.

Z. Yuan, X. H. Hu, and H. B. Jiang, Phys. Med. Biol. 54, 65 (2009).
[CrossRef]

James, S. S.

Y. F. Yang, Y. B. Wu, J. Y. Qi, S. S. James, H. N. Du, P. A. Dokhale, K. S. Shah, R. Farrell, and S. R. Cherry, J. Nucl. Med. 49, 1132 (2008).
[CrossRef] [PubMed]

Jiang, H. B.

Z. Yuan, X. H. Hu, and H. B. Jiang, Phys. Med. Biol. 54, 65 (2009).
[CrossRef]

Kinahan, P. E.

C. Comtat, P. E. Kinahan, J. A. Fessler, T. Beyer, D. W. Townsend, M. Defrise, and C. Michel, Phys. Med. Biol. 47, 1 (2002).
[CrossRef] [PubMed]

Leahy, R. M.

C. Q. Li, G. S. Mitchell, J. Dutta, S. Ahn, R. M. Leahy, and S. R. Cherry, Opt. Express 17, 7571 (2009).
[CrossRef] [PubMed]

S. Ahn, A. J. Chaudhari, F. Darvas, C. A. Bouman, and R. M. Leahy, Phys. Med. Biol. 53, 3921 (2008).
[CrossRef] [PubMed]

A. J. Chaudhari, F. Darvas, J. R. Bading, R. A. Moats, P. S. Conti, D. J. Smith, S. R. Cherry, and R. M. Leahy, Phys. Med. Biol. 50, 5421 (2005).
[CrossRef] [PubMed]

Y. Yang, Y. C. Tai, S. Siegel, D. F. Newport, B. Bai, Q. Li, R. M. Leahy, and S. R. Cherry, Phys. Med. Biol. 49, 2527 (2004).
[CrossRef] [PubMed]

Li, C. Q.

Li, Q.

Y. Yang, Y. C. Tai, S. Siegel, D. F. Newport, B. Bai, Q. Li, R. M. Leahy, and S. R. Cherry, Phys. Med. Biol. 49, 2527 (2004).
[CrossRef] [PubMed]

Liang, K.

W. B. Edwards, B. Xu, W. Akers, P. P. Cheney, K. Liang, B. E. Rogers, C. J. Anderson, and S. Achilefu, Bioconjugate Chem. 19, 192 (2008).
[CrossRef]

Mahmood, U.

R. Weissleder, C. H. Tung, U. Mahmood, and A. Bogdanov, Jr., Nat. Biotechnol. 17, 375 (1999).
[CrossRef] [PubMed]

Michel, C.

C. Comtat, P. E. Kinahan, J. A. Fessler, T. Beyer, D. W. Townsend, M. Defrise, and C. Michel, Phys. Med. Biol. 47, 1 (2002).
[CrossRef] [PubMed]

Mitchell, G. S.

Moats, R. A.

A. J. Chaudhari, F. Darvas, J. R. Bading, R. A. Moats, P. S. Conti, D. J. Smith, S. R. Cherry, and R. M. Leahy, Phys. Med. Biol. 50, 5421 (2005).
[CrossRef] [PubMed]

Newport, D. F.

Y. Yang, Y. C. Tai, S. Siegel, D. F. Newport, B. Bai, Q. Li, R. M. Leahy, and S. R. Cherry, Phys. Med. Biol. 49, 2527 (2004).
[CrossRef] [PubMed]

Ntziachristos, V.

G. Zacharakis, J. Ripoll, R. Weissleder, and V. Ntziachristos, IEEE Trans. Med. Imaging 24, 878 (2005).
[CrossRef] [PubMed]

Qi, J. Y.

Y. F. Yang, Y. B. Wu, J. Y. Qi, S. S. James, H. N. Du, P. A. Dokhale, K. S. Shah, R. Farrell, and S. R. Cherry, J. Nucl. Med. 49, 1132 (2008).
[CrossRef] [PubMed]

Ripoll, J.

G. Zacharakis, J. Ripoll, R. Weissleder, and V. Ntziachristos, IEEE Trans. Med. Imaging 24, 878 (2005).
[CrossRef] [PubMed]

Rogers, B. E.

W. B. Edwards, B. Xu, W. Akers, P. P. Cheney, K. Liang, B. E. Rogers, C. J. Anderson, and S. Achilefu, Bioconjugate Chem. 19, 192 (2008).
[CrossRef]

Shah, K. S.

Y. F. Yang, Y. B. Wu, J. Y. Qi, S. S. James, H. N. Du, P. A. Dokhale, K. S. Shah, R. Farrell, and S. R. Cherry, J. Nucl. Med. 49, 1132 (2008).
[CrossRef] [PubMed]

Siegel, S.

Y. Yang, Y. C. Tai, S. Siegel, D. F. Newport, B. Bai, Q. Li, R. M. Leahy, and S. R. Cherry, Phys. Med. Biol. 49, 2527 (2004).
[CrossRef] [PubMed]

Smith, D. J.

A. J. Chaudhari, F. Darvas, J. R. Bading, R. A. Moats, P. S. Conti, D. J. Smith, S. R. Cherry, and R. M. Leahy, Phys. Med. Biol. 50, 5421 (2005).
[CrossRef] [PubMed]

Sorensen, A. G.

Tai, Y. C.

Y. Yang, Y. C. Tai, S. Siegel, D. F. Newport, B. Bai, Q. Li, R. M. Leahy, and S. R. Cherry, Phys. Med. Biol. 49, 2527 (2004).
[CrossRef] [PubMed]

Townsend, D. W.

C. Comtat, P. E. Kinahan, J. A. Fessler, T. Beyer, D. W. Townsend, M. Defrise, and C. Michel, Phys. Med. Biol. 47, 1 (2002).
[CrossRef] [PubMed]

Tung, C. H.

R. Weissleder, C. H. Tung, U. Mahmood, and A. Bogdanov, Jr., Nat. Biotechnol. 17, 375 (1999).
[CrossRef] [PubMed]

Weissleder, R.

G. Zacharakis, J. Ripoll, R. Weissleder, and V. Ntziachristos, IEEE Trans. Med. Imaging 24, 878 (2005).
[CrossRef] [PubMed]

R. Weissleder, C. H. Tung, U. Mahmood, and A. Bogdanov, Jr., Nat. Biotechnol. 17, 375 (1999).
[CrossRef] [PubMed]

Wu, Y. B.

Y. F. Yang, Y. B. Wu, J. Y. Qi, S. S. James, H. N. Du, P. A. Dokhale, K. S. Shah, R. Farrell, and S. R. Cherry, J. Nucl. Med. 49, 1132 (2008).
[CrossRef] [PubMed]

Xu, B.

W. B. Edwards, B. Xu, W. Akers, P. P. Cheney, K. Liang, B. E. Rogers, C. J. Anderson, and S. Achilefu, Bioconjugate Chem. 19, 192 (2008).
[CrossRef]

Yang, Y.

Y. Yang, Y. C. Tai, S. Siegel, D. F. Newport, B. Bai, Q. Li, R. M. Leahy, and S. R. Cherry, Phys. Med. Biol. 49, 2527 (2004).
[CrossRef] [PubMed]

Yang, Y. F.

Y. F. Yang, Y. B. Wu, J. Y. Qi, S. S. James, H. N. Du, P. A. Dokhale, K. S. Shah, R. Farrell, and S. R. Cherry, J. Nucl. Med. 49, 1132 (2008).
[CrossRef] [PubMed]

Yuan, Z.

Z. Yuan, X. H. Hu, and H. B. Jiang, Phys. Med. Biol. 54, 65 (2009).
[CrossRef]

Zacharakis, G.

G. Zacharakis, J. Ripoll, R. Weissleder, and V. Ntziachristos, IEEE Trans. Med. Imaging 24, 878 (2005).
[CrossRef] [PubMed]

Appl. Opt. (1)

Bioconjugate Chem. (1)

W. B. Edwards, B. Xu, W. Akers, P. P. Cheney, K. Liang, B. E. Rogers, C. J. Anderson, and S. Achilefu, Bioconjugate Chem. 19, 192 (2008).
[CrossRef]

IEEE Trans. Med. Imaging (1)

G. Zacharakis, J. Ripoll, R. Weissleder, and V. Ntziachristos, IEEE Trans. Med. Imaging 24, 878 (2005).
[CrossRef] [PubMed]

J. Nucl. Med. (2)

Y. F. Yang, Y. B. Wu, J. Y. Qi, S. S. James, H. N. Du, P. A. Dokhale, K. S. Shah, R. Farrell, and S. R. Cherry, J. Nucl. Med. 49, 1132 (2008).
[CrossRef] [PubMed]

J. Culver, W. Akers, and S. Achilefu, J. Nucl. Med. 49, 169 (2008).
[CrossRef] [PubMed]

Nat. Biotechnol. (1)

R. Weissleder, C. H. Tung, U. Mahmood, and A. Bogdanov, Jr., Nat. Biotechnol. 17, 375 (1999).
[CrossRef] [PubMed]

Opt. Express (1)

Phys. Med. Biol. (5)

Y. Yang, Y. C. Tai, S. Siegel, D. F. Newport, B. Bai, Q. Li, R. M. Leahy, and S. R. Cherry, Phys. Med. Biol. 49, 2527 (2004).
[CrossRef] [PubMed]

C. Comtat, P. E. Kinahan, J. A. Fessler, T. Beyer, D. W. Townsend, M. Defrise, and C. Michel, Phys. Med. Biol. 47, 1 (2002).
[CrossRef] [PubMed]

A. J. Chaudhari, F. Darvas, J. R. Bading, R. A. Moats, P. S. Conti, D. J. Smith, S. R. Cherry, and R. M. Leahy, Phys. Med. Biol. 50, 5421 (2005).
[CrossRef] [PubMed]

Z. Yuan, X. H. Hu, and H. B. Jiang, Phys. Med. Biol. 54, 65 (2009).
[CrossRef]

S. Ahn, A. J. Chaudhari, F. Darvas, C. A. Bouman, and R. M. Leahy, Phys. Med. Biol. 53, 3921 (2008).
[CrossRef] [PubMed]

Cited By

OSA participates in CrossRef's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (4)

Fig. 1
Fig. 1

Schematic of simultaneous 3D FOT and PET imaging system.

Fig. 2
Fig. 2

(a) Cubic phantom with four embedded capillary targets (T1–T4); (b) fluorescence measurements from different surfaces of the cubic phantom placed in the conical mirror. PET images showing (c) transverse, (d) sagittal, and (e) coronal sections.

Fig. 3
Fig. 3

Reconstructed 3D FOT images from the phantom experiment showing sagittal sections (top row) and transverse sections (bottom row); (a), (b) without prior, (c), (d) with correct prior, and (e), (f), with redundant prior. The color bar indicates relative fluorescence concentration.

Fig. 4
Fig. 4

Numerical simulations: True fluorescence concentration for cubic phantom in (a) sagittal and (b) transverse sections. Reconstructed images (c), (d) without prior and (e), (f) with prior. The color bar indicates relative fluorescence concentration.

Equations (3)

Equations on this page are rendered with MathJax. Learn more.

x ̂ = arg min x 0 Φ ( x ) ,
Φ ( x ) = y P x 2 + α U w PET sparsity ( x ) ,
U w PET sparsity ( x ) = j = 1 n j w j | x j | ,

Metrics