Abstract

Acoustomotive optical coherence elastography (AM-OCE), a dynamic and internal excitation optical coherence elastography technique, is reported. Acoustic radiation force was used for internal mechanical excitation, and spectral-domain optical coherence tomography was used for detection. Mechanical properties of gelatin tissue phantoms were measured by AM-OCE and verified using rheometry results. Measured mechanical properties including shear moduli and shear damping parameters of the gelatin samples double when their polymer concentration increases from 3% to 4%. Spectral analysis was also performed on the acquired data, which improved the processing speed by a factor of 5 compared with a least-square fitting approach. Quantitative measurement, microscale resolution, and remote excitation are the main features of AM-OCE, which make the technique promising for measuring biomechanical properties.

© 2009 Optical Society of America

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  1. S. Huang and D. E. Ingber, Cancer Cells 8, 175 (2005).
    [CrossRef]
  2. L. S. Wilson, D. E. Robinson, and M. J. Dadd, Phys. Med. Biol. 45, 1409 (2000).
    [CrossRef] [PubMed]
  3. R. Sinkus, M. Tanter, S. Catheline, J. Lorenzen, C. Kuhl, E. Sondermann, and M. Fink, Magn. Reson. Med. 53, 372 (2005).
    [CrossRef] [PubMed]
  4. E. K. Dimitriadis, F. Horkay, J. Maresca, B. Kachar, and R. S. Chadwick, Biophys. J. 82, 2798 (2002).
    [CrossRef] [PubMed]
  5. J. M. Schmitt, Opt. Express 3, 199 (1998).
    [CrossRef] [PubMed]
  6. A. S. Khalil, R. C. Chan, A. H. Chau, B. E. Bouma, and M. M. R. Kaazempur, Ann. Biomed. Eng. 33, 1631 (2005).
    [CrossRef] [PubMed]
  7. H. Ko, W. Tan, R. Stack, and S. A. Boppart, Tissue Eng. 12, 63 (2006).
    [CrossRef] [PubMed]
  8. X. Liang, A. L. Oldenburg, V. Crecea, E. J. Chaney, and S. A. Boppart, Opt. Express 16, 11052 (2008).
    [CrossRef] [PubMed]
  9. Q. Wang, Y. Ahn, C. Kim, L. Yu, W. Jia, B. Rao, Z. Chen, and H. K. Chiang, Proc. SPIE 6847, 68471B (2008).
    [CrossRef]
  10. M. Xu and L. V. Wang, Rev. Sci. Instrum. 77, 041101 (2006).
    [CrossRef]
  11. A. L. Oldenburg, V. Crecea, S. A. Rinne, and S. A. Boppart, Opt. Express 16, 11525 (2008).
    [PubMed]
  12. M. W. Urban, R. R. Kinnick, and J. F. Greenleaf, in Acoustical Imaging, M.P.Andre, ed. (Springer, 2007), Vol. 28, pp. 119-126.
    [CrossRef]
  13. M. Orescanin, K. S. Toohey, and M. F. Insana, J. Acoust. Soc. Am. 125, 2928 (2009).
    [CrossRef] [PubMed]
  14. B. J. Fahey, R. C. Nelson, D. P. Bradway, S. J. Hsu, D. M. Dumont, and G. E. Trahey, Phys. Med. Biol. 53, 279 (2008).
    [CrossRef] [PubMed]
  15. K. R. Nightingale, M. L. Palmeri, R. W. Nightingale, and G. E. Trahey, J. Acoust. Soc. Am. 110, 1 (2001).
    [CrossRef]

2009 (1)

M. Orescanin, K. S. Toohey, and M. F. Insana, J. Acoust. Soc. Am. 125, 2928 (2009).
[CrossRef] [PubMed]

2008 (4)

B. J. Fahey, R. C. Nelson, D. P. Bradway, S. J. Hsu, D. M. Dumont, and G. E. Trahey, Phys. Med. Biol. 53, 279 (2008).
[CrossRef] [PubMed]

X. Liang, A. L. Oldenburg, V. Crecea, E. J. Chaney, and S. A. Boppart, Opt. Express 16, 11052 (2008).
[CrossRef] [PubMed]

A. L. Oldenburg, V. Crecea, S. A. Rinne, and S. A. Boppart, Opt. Express 16, 11525 (2008).
[PubMed]

Q. Wang, Y. Ahn, C. Kim, L. Yu, W. Jia, B. Rao, Z. Chen, and H. K. Chiang, Proc. SPIE 6847, 68471B (2008).
[CrossRef]

2006 (2)

M. Xu and L. V. Wang, Rev. Sci. Instrum. 77, 041101 (2006).
[CrossRef]

H. Ko, W. Tan, R. Stack, and S. A. Boppart, Tissue Eng. 12, 63 (2006).
[CrossRef] [PubMed]

2005 (3)

A. S. Khalil, R. C. Chan, A. H. Chau, B. E. Bouma, and M. M. R. Kaazempur, Ann. Biomed. Eng. 33, 1631 (2005).
[CrossRef] [PubMed]

S. Huang and D. E. Ingber, Cancer Cells 8, 175 (2005).
[CrossRef]

R. Sinkus, M. Tanter, S. Catheline, J. Lorenzen, C. Kuhl, E. Sondermann, and M. Fink, Magn. Reson. Med. 53, 372 (2005).
[CrossRef] [PubMed]

2002 (1)

E. K. Dimitriadis, F. Horkay, J. Maresca, B. Kachar, and R. S. Chadwick, Biophys. J. 82, 2798 (2002).
[CrossRef] [PubMed]

2001 (1)

K. R. Nightingale, M. L. Palmeri, R. W. Nightingale, and G. E. Trahey, J. Acoust. Soc. Am. 110, 1 (2001).
[CrossRef]

2000 (1)

L. S. Wilson, D. E. Robinson, and M. J. Dadd, Phys. Med. Biol. 45, 1409 (2000).
[CrossRef] [PubMed]

1998 (1)

Ahn, Y.

Q. Wang, Y. Ahn, C. Kim, L. Yu, W. Jia, B. Rao, Z. Chen, and H. K. Chiang, Proc. SPIE 6847, 68471B (2008).
[CrossRef]

Boppart, S. A.

Bouma, B. E.

A. S. Khalil, R. C. Chan, A. H. Chau, B. E. Bouma, and M. M. R. Kaazempur, Ann. Biomed. Eng. 33, 1631 (2005).
[CrossRef] [PubMed]

Bradway, D. P.

B. J. Fahey, R. C. Nelson, D. P. Bradway, S. J. Hsu, D. M. Dumont, and G. E. Trahey, Phys. Med. Biol. 53, 279 (2008).
[CrossRef] [PubMed]

Catheline, S.

R. Sinkus, M. Tanter, S. Catheline, J. Lorenzen, C. Kuhl, E. Sondermann, and M. Fink, Magn. Reson. Med. 53, 372 (2005).
[CrossRef] [PubMed]

Chadwick, R. S.

E. K. Dimitriadis, F. Horkay, J. Maresca, B. Kachar, and R. S. Chadwick, Biophys. J. 82, 2798 (2002).
[CrossRef] [PubMed]

Chan, R. C.

A. S. Khalil, R. C. Chan, A. H. Chau, B. E. Bouma, and M. M. R. Kaazempur, Ann. Biomed. Eng. 33, 1631 (2005).
[CrossRef] [PubMed]

Chaney, E. J.

Chau, A. H.

A. S. Khalil, R. C. Chan, A. H. Chau, B. E. Bouma, and M. M. R. Kaazempur, Ann. Biomed. Eng. 33, 1631 (2005).
[CrossRef] [PubMed]

Chen, Z.

Q. Wang, Y. Ahn, C. Kim, L. Yu, W. Jia, B. Rao, Z. Chen, and H. K. Chiang, Proc. SPIE 6847, 68471B (2008).
[CrossRef]

Chiang, H. K.

Q. Wang, Y. Ahn, C. Kim, L. Yu, W. Jia, B. Rao, Z. Chen, and H. K. Chiang, Proc. SPIE 6847, 68471B (2008).
[CrossRef]

Crecea, V.

Dadd, M. J.

L. S. Wilson, D. E. Robinson, and M. J. Dadd, Phys. Med. Biol. 45, 1409 (2000).
[CrossRef] [PubMed]

Dimitriadis, E. K.

E. K. Dimitriadis, F. Horkay, J. Maresca, B. Kachar, and R. S. Chadwick, Biophys. J. 82, 2798 (2002).
[CrossRef] [PubMed]

Dumont, D. M.

B. J. Fahey, R. C. Nelson, D. P. Bradway, S. J. Hsu, D. M. Dumont, and G. E. Trahey, Phys. Med. Biol. 53, 279 (2008).
[CrossRef] [PubMed]

Fahey, B. J.

B. J. Fahey, R. C. Nelson, D. P. Bradway, S. J. Hsu, D. M. Dumont, and G. E. Trahey, Phys. Med. Biol. 53, 279 (2008).
[CrossRef] [PubMed]

Fink, M.

R. Sinkus, M. Tanter, S. Catheline, J. Lorenzen, C. Kuhl, E. Sondermann, and M. Fink, Magn. Reson. Med. 53, 372 (2005).
[CrossRef] [PubMed]

Greenleaf, J. F.

M. W. Urban, R. R. Kinnick, and J. F. Greenleaf, in Acoustical Imaging, M.P.Andre, ed. (Springer, 2007), Vol. 28, pp. 119-126.
[CrossRef]

Horkay, F.

E. K. Dimitriadis, F. Horkay, J. Maresca, B. Kachar, and R. S. Chadwick, Biophys. J. 82, 2798 (2002).
[CrossRef] [PubMed]

Hsu, S. J.

B. J. Fahey, R. C. Nelson, D. P. Bradway, S. J. Hsu, D. M. Dumont, and G. E. Trahey, Phys. Med. Biol. 53, 279 (2008).
[CrossRef] [PubMed]

Huang, S.

S. Huang and D. E. Ingber, Cancer Cells 8, 175 (2005).
[CrossRef]

Ingber, D. E.

S. Huang and D. E. Ingber, Cancer Cells 8, 175 (2005).
[CrossRef]

Insana, M. F.

M. Orescanin, K. S. Toohey, and M. F. Insana, J. Acoust. Soc. Am. 125, 2928 (2009).
[CrossRef] [PubMed]

Jia, W.

Q. Wang, Y. Ahn, C. Kim, L. Yu, W. Jia, B. Rao, Z. Chen, and H. K. Chiang, Proc. SPIE 6847, 68471B (2008).
[CrossRef]

Kaazempur, M. M. R.

A. S. Khalil, R. C. Chan, A. H. Chau, B. E. Bouma, and M. M. R. Kaazempur, Ann. Biomed. Eng. 33, 1631 (2005).
[CrossRef] [PubMed]

Kachar, B.

E. K. Dimitriadis, F. Horkay, J. Maresca, B. Kachar, and R. S. Chadwick, Biophys. J. 82, 2798 (2002).
[CrossRef] [PubMed]

Khalil, A. S.

A. S. Khalil, R. C. Chan, A. H. Chau, B. E. Bouma, and M. M. R. Kaazempur, Ann. Biomed. Eng. 33, 1631 (2005).
[CrossRef] [PubMed]

Kim, C.

Q. Wang, Y. Ahn, C. Kim, L. Yu, W. Jia, B. Rao, Z. Chen, and H. K. Chiang, Proc. SPIE 6847, 68471B (2008).
[CrossRef]

Kinnick, R. R.

M. W. Urban, R. R. Kinnick, and J. F. Greenleaf, in Acoustical Imaging, M.P.Andre, ed. (Springer, 2007), Vol. 28, pp. 119-126.
[CrossRef]

Ko, H.

H. Ko, W. Tan, R. Stack, and S. A. Boppart, Tissue Eng. 12, 63 (2006).
[CrossRef] [PubMed]

Kuhl, C.

R. Sinkus, M. Tanter, S. Catheline, J. Lorenzen, C. Kuhl, E. Sondermann, and M. Fink, Magn. Reson. Med. 53, 372 (2005).
[CrossRef] [PubMed]

Liang, X.

Lorenzen, J.

R. Sinkus, M. Tanter, S. Catheline, J. Lorenzen, C. Kuhl, E. Sondermann, and M. Fink, Magn. Reson. Med. 53, 372 (2005).
[CrossRef] [PubMed]

Maresca, J.

E. K. Dimitriadis, F. Horkay, J. Maresca, B. Kachar, and R. S. Chadwick, Biophys. J. 82, 2798 (2002).
[CrossRef] [PubMed]

Nelson, R. C.

B. J. Fahey, R. C. Nelson, D. P. Bradway, S. J. Hsu, D. M. Dumont, and G. E. Trahey, Phys. Med. Biol. 53, 279 (2008).
[CrossRef] [PubMed]

Nightingale, K. R.

K. R. Nightingale, M. L. Palmeri, R. W. Nightingale, and G. E. Trahey, J. Acoust. Soc. Am. 110, 1 (2001).
[CrossRef]

Nightingale, R. W.

K. R. Nightingale, M. L. Palmeri, R. W. Nightingale, and G. E. Trahey, J. Acoust. Soc. Am. 110, 1 (2001).
[CrossRef]

Oldenburg, A. L.

Orescanin, M.

M. Orescanin, K. S. Toohey, and M. F. Insana, J. Acoust. Soc. Am. 125, 2928 (2009).
[CrossRef] [PubMed]

Palmeri, M. L.

K. R. Nightingale, M. L. Palmeri, R. W. Nightingale, and G. E. Trahey, J. Acoust. Soc. Am. 110, 1 (2001).
[CrossRef]

Rao, B.

Q. Wang, Y. Ahn, C. Kim, L. Yu, W. Jia, B. Rao, Z. Chen, and H. K. Chiang, Proc. SPIE 6847, 68471B (2008).
[CrossRef]

Rinne, S. A.

Robinson, D. E.

L. S. Wilson, D. E. Robinson, and M. J. Dadd, Phys. Med. Biol. 45, 1409 (2000).
[CrossRef] [PubMed]

Schmitt, J. M.

Sinkus, R.

R. Sinkus, M. Tanter, S. Catheline, J. Lorenzen, C. Kuhl, E. Sondermann, and M. Fink, Magn. Reson. Med. 53, 372 (2005).
[CrossRef] [PubMed]

Sondermann, E.

R. Sinkus, M. Tanter, S. Catheline, J. Lorenzen, C. Kuhl, E. Sondermann, and M. Fink, Magn. Reson. Med. 53, 372 (2005).
[CrossRef] [PubMed]

Stack, R.

H. Ko, W. Tan, R. Stack, and S. A. Boppart, Tissue Eng. 12, 63 (2006).
[CrossRef] [PubMed]

Tan, W.

H. Ko, W. Tan, R. Stack, and S. A. Boppart, Tissue Eng. 12, 63 (2006).
[CrossRef] [PubMed]

Tanter, M.

R. Sinkus, M. Tanter, S. Catheline, J. Lorenzen, C. Kuhl, E. Sondermann, and M. Fink, Magn. Reson. Med. 53, 372 (2005).
[CrossRef] [PubMed]

Toohey, K. S.

M. Orescanin, K. S. Toohey, and M. F. Insana, J. Acoust. Soc. Am. 125, 2928 (2009).
[CrossRef] [PubMed]

Trahey, G. E.

B. J. Fahey, R. C. Nelson, D. P. Bradway, S. J. Hsu, D. M. Dumont, and G. E. Trahey, Phys. Med. Biol. 53, 279 (2008).
[CrossRef] [PubMed]

K. R. Nightingale, M. L. Palmeri, R. W. Nightingale, and G. E. Trahey, J. Acoust. Soc. Am. 110, 1 (2001).
[CrossRef]

Urban, M. W.

M. W. Urban, R. R. Kinnick, and J. F. Greenleaf, in Acoustical Imaging, M.P.Andre, ed. (Springer, 2007), Vol. 28, pp. 119-126.
[CrossRef]

Wang, L. V.

M. Xu and L. V. Wang, Rev. Sci. Instrum. 77, 041101 (2006).
[CrossRef]

Wang, Q.

Q. Wang, Y. Ahn, C. Kim, L. Yu, W. Jia, B. Rao, Z. Chen, and H. K. Chiang, Proc. SPIE 6847, 68471B (2008).
[CrossRef]

Wilson, L. S.

L. S. Wilson, D. E. Robinson, and M. J. Dadd, Phys. Med. Biol. 45, 1409 (2000).
[CrossRef] [PubMed]

Xu, M.

M. Xu and L. V. Wang, Rev. Sci. Instrum. 77, 041101 (2006).
[CrossRef]

Yu, L.

Q. Wang, Y. Ahn, C. Kim, L. Yu, W. Jia, B. Rao, Z. Chen, and H. K. Chiang, Proc. SPIE 6847, 68471B (2008).
[CrossRef]

Ann. Biomed. Eng. (1)

A. S. Khalil, R. C. Chan, A. H. Chau, B. E. Bouma, and M. M. R. Kaazempur, Ann. Biomed. Eng. 33, 1631 (2005).
[CrossRef] [PubMed]

Biophys. J. (1)

E. K. Dimitriadis, F. Horkay, J. Maresca, B. Kachar, and R. S. Chadwick, Biophys. J. 82, 2798 (2002).
[CrossRef] [PubMed]

Cancer Cells (1)

S. Huang and D. E. Ingber, Cancer Cells 8, 175 (2005).
[CrossRef]

J. Acoust. Soc. Am. (2)

K. R. Nightingale, M. L. Palmeri, R. W. Nightingale, and G. E. Trahey, J. Acoust. Soc. Am. 110, 1 (2001).
[CrossRef]

M. Orescanin, K. S. Toohey, and M. F. Insana, J. Acoust. Soc. Am. 125, 2928 (2009).
[CrossRef] [PubMed]

Magn. Reson. Med. (1)

R. Sinkus, M. Tanter, S. Catheline, J. Lorenzen, C. Kuhl, E. Sondermann, and M. Fink, Magn. Reson. Med. 53, 372 (2005).
[CrossRef] [PubMed]

Opt. Express (3)

Phys. Med. Biol. (2)

B. J. Fahey, R. C. Nelson, D. P. Bradway, S. J. Hsu, D. M. Dumont, and G. E. Trahey, Phys. Med. Biol. 53, 279 (2008).
[CrossRef] [PubMed]

L. S. Wilson, D. E. Robinson, and M. J. Dadd, Phys. Med. Biol. 45, 1409 (2000).
[CrossRef] [PubMed]

Proc. SPIE (1)

Q. Wang, Y. Ahn, C. Kim, L. Yu, W. Jia, B. Rao, Z. Chen, and H. K. Chiang, Proc. SPIE 6847, 68471B (2008).
[CrossRef]

Rev. Sci. Instrum. (1)

M. Xu and L. V. Wang, Rev. Sci. Instrum. 77, 041101 (2006).
[CrossRef]

Tissue Eng. (1)

H. Ko, W. Tan, R. Stack, and S. A. Boppart, Tissue Eng. 12, 63 (2006).
[CrossRef] [PubMed]

Other (1)

M. W. Urban, R. R. Kinnick, and J. F. Greenleaf, in Acoustical Imaging, M.P.Andre, ed. (Springer, 2007), Vol. 28, pp. 119-126.
[CrossRef]

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Figures (3)

Fig. 1
Fig. 1

(a) OCE classifications. (b) Schematic diagram of AM-OCE.

Fig. 2
Fig. 2

AM-OCE data analysis. (a) B-mode (brightness mode) OCT image of a sphere embedded in tissue phantom. (b) Amplitude of the M-mode OCT image of the sphere recorded at the position shown by the arrow in (a). (c) Phase of the M-mode OCT image and its fitting curve in the time domain. (d) Power spectrum of (c).

Fig. 3
Fig. 3

AM-OCE results on gelatin phantoms. (a) AM-OCE shear modulus. (b) AM-OCE shear damping parameter. * denotes no statistical or calculation error estimations.

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