Abstract

We present an algorithm to directly reconstruct chromophore concentrations and acoustic velocity by multispectral photoacoustic tomography. We also derive the criterions to minimize the cross talk for simultaneous recovery of chromophore concentrations and acoustic velocity using multispectral photoacoustic data. We found that the image quality and the separation between acoustic velocity and different chromophore concentrations strongly depend on the measurement wavelengths of incident laser source.

© 2009 Optical Society of America

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References

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2007 (2)

J. Laufer, D. Delpy, C. Elwell, and P. C. Beard, Phys. Med. Biol. 52, 141168 (2007).
[CrossRef]

L. Yin, Q. Wang, Q. Zhang, and H. Jiang, Opt. Lett. 32, 2556 (2007).
[CrossRef] [PubMed]

2006 (2)

2005 (2)

2003 (2)

1999 (1)

A. A. Karabutov, E. Savateeva, and A. Oraevsky, Proc. SPIE 3601, 284 (1999).
[CrossRef]

Arridge, S. R.

Beard, P. C.

J. Laufer, D. Delpy, C. Elwell, and P. C. Beard, Phys. Med. Biol. 52, 141168 (2007).
[CrossRef]

Choe, R.

Corlu, A.

Delpy, D.

J. Laufer, D. Delpy, C. Elwell, and P. C. Beard, Phys. Med. Biol. 52, 141168 (2007).
[CrossRef]

Durduran, T.

Elwell, C.

J. Laufer, D. Delpy, C. Elwell, and P. C. Beard, Phys. Med. Biol. 52, 141168 (2007).
[CrossRef]

Hillman, E.

Jiang, H.

Jiang, H. B.

Karabutov, A. A.

A. A. Karabutov, E. Savateeva, and A. Oraevsky, Proc. SPIE 3601, 284 (1999).
[CrossRef]

Laufer, J.

J. Laufer, D. Delpy, C. Elwell, and P. C. Beard, Phys. Med. Biol. 52, 141168 (2007).
[CrossRef]

Norton, S. J.

Ntziachristos, V.

J. Ripoll and V. Ntziachristos, Phys. Rev. E 71, 031912 (2005).
[CrossRef]

Oraevsky, A.

A. A. Karabutov, E. Savateeva, and A. Oraevsky, Proc. SPIE 3601, 284 (1999).
[CrossRef]

Pahl, S.

S. Pahl, http://omlc.ogi.edu/spectra/index.html (2003).

Ripoll, J.

J. Ripoll and V. Ntziachristos, Phys. Rev. E 71, 031912 (2005).
[CrossRef]

Savateeva, E.

A. A. Karabutov, E. Savateeva, and A. Oraevsky, Proc. SPIE 3601, 284 (1999).
[CrossRef]

Schweiger, M.

Vo-Dinh, T.

Wang, Q.

Wu, C. F.

Yin, L.

Yodh, A. G.

Yuan, Z.

Zhang, Q.

Zhao, H. Z.

Appl. Phys. Lett. (1)

Z. Yuan and H. Jiang, Appl. Phys. Lett. 88, 231101 (2006).
[CrossRef]

J. Opt. Soc. Am. A (1)

Opt. Express (1)

Opt. Lett. (3)

Phys. Med. Biol. (1)

J. Laufer, D. Delpy, C. Elwell, and P. C. Beard, Phys. Med. Biol. 52, 141168 (2007).
[CrossRef]

Phys. Rev. E (1)

J. Ripoll and V. Ntziachristos, Phys. Rev. E 71, 031912 (2005).
[CrossRef]

Proc. SPIE (1)

A. A. Karabutov, E. Savateeva, and A. Oraevsky, Proc. SPIE 3601, 284 (1999).
[CrossRef]

Other (1)

S. Pahl, http://omlc.ogi.edu/spectra/index.html (2003).

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Figures (1)

Fig. 1
Fig. 1

Reconstructed images for the selected wavelength groups. The first, second, third, and fourth rows are the recovered HbR, Hb O 2 , H 2 O , and acoustic velocity images, respectively. Columns correspond to different wavelength sets.

Tables (2)

Tables Icon

Table 1 Chromophore Concentrations and Acoustic Velocity for Test Objects

Tables Icon

Table 2 Wavelength Sets and Relative Condition Number k and Residual Norms R

Equations (7)

Equations on this page are rendered with MathJax. Learn more.

2 p ( r , ω , λ ) + k 0 2 ( 1 + O ) p ( r , ω , λ ) = i k 0 v 0 β i = 1 3 ϵ i ( λ ) c i ϕ ( r , λ ) C p ,
( J T J + λ I ) Δ χ = J T ( p o p c ) ,
p o = ( p 1 o , p 2 o , , p M o ) T ( ω , λ ) ,
p c = ( p 1 c , p 2 c , , p M c ) T ( ω , λ ) .
( τ ) p ( r , ω , λ ) = i v 0 β i = 1 ϵ i ( λ ) Δ c i ϕ ( λ ) C p .
[ ϵ 1 ( λ 1 ) ϵ n ( λ n ) ϵ 1 ( λ m ) ϵ n ( λ m ) ] ( i v 0 β ϕ τ p C p [ Δ c 1 Δ c n ] ) = [ 1 1 ] .
[ μ a ( λ 1 ) μ a ( λ m ) ] = [ ϵ 1 ( λ 1 ) ϵ n ( λ n ) ϵ 1 ( λ m ) ϵ n ( λ m ) ] [ c 1 c n ] .

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