Abstract

A simple time-domain optical method for estimating the depth (d) and lifetime (τ) of fluorescent inclusions in a turbid medium is described. We demonstrate the method for depth and lifetime estimation of a fluorescent inclusion directly by fitting a monoexponential decay (τeff) of the temporal position of the temporal point-spread function and the measurement of its maximum temporal position (tmax). Since both of these measurements are intensity independent, this method provides a robust and efficient approach. This method is validated with experimental data.

© 2008 Optical Society of America

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