Abstract

Retinal blood flow quantification by retinal vessel segmentation with Doppler optical coherence angiography is presented. Vessel diameter, orientation, and position are determined in an en face vessel image and two representative cross-sectional flow images of the vessel. Absolute blood flow velocity is calculated with the help of the measured Doppler frequency shift and determined vessel angle. The volumetric flow rate is obtained with the position and the region of the vessel lumen. The volumetric blood flow rate of retinal arteries before and after a bifurcation is verified in a healthy human eye.

© 2008 Optical Society of America

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References

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  1. C. E. Riva, J. E. Grunwald, S. H. Sinclair, and B. L. Petrig, Invest. Ophthalmol. Visual Sci. 26, 1124 (1985).
  2. R. Leitgeb, L. Schmetterer, W. Drexler, A. Fercher, R. Zawadzki, and T. Bajraszewski, Opt. Express 11, 3116 (2003).
    [CrossRef] [PubMed]
  3. B. R. White, M. C. Pierce, N. Nassif, B. Cense, B. H. Park, G. J. Tearney, B. E. Bouma, T. C. Chen, and J. F. de Boer, Opt. Express 11, 3490 (2003).
    [CrossRef] [PubMed]
  4. S. Makita, Y. Hong, M. Yamanari, T. Yatagai, and Y. Yasuno, Opt. Express 14, 7821 (2006).
    [CrossRef] [PubMed]
  5. A. H. Bachmann, M. L. Villiger, C. Blatter, T. Lasser, and R. A. Leitgeb, Opt. Express 15, 408 (2007).
    [CrossRef] [PubMed]
  6. D. Piao and Q. Zhu, Appl. Opt. 42, 5158 (2003).
    [CrossRef] [PubMed]
  7. C. J. Pedersen, D. Huang, M. A. Shure, and A. M. Rollins, Opt. Lett. 32, 506 (2007).
    [CrossRef] [PubMed]
  8. Y. C. Ahn, W. Jung, and Z. Chen, Opt. Lett. 32, 1587 (2007).
    [CrossRef] [PubMed]
  9. Y. Wang, B. A. Bower, J. A. Izatt, O. Tan, and D. Huang, J. Biomed. Opt. 12, 041215 (2007).
    [CrossRef] [PubMed]
  10. R. Michaely, A. H. Bachmann, M. L. Villiger, C. Blatter, T. Lasser, and R. A. Leitgeb, J. Biomed. Opt. 12, 041213 (2007).
    [CrossRef] [PubMed]
  11. T. Koller, G. Gerig, G. Szekely, and D. Dettwiler, in Proceedings of the Fifth International Conference on Computer Vision (IEEE, 1995), p. 864.
  12. Y. Hong, S. Makita, M. Yamanari, M. Miura, S. Kim, T. Yatagai, and Y. Yasuno, Opt. Express 15, 7538 (2007).
    [CrossRef] [PubMed]
  13. D. Ghiglia and L. Romero, J. Opt. Soc. Am. A 11, 107 (1994).
    [CrossRef]

2007 (6)

2006 (1)

2003 (3)

1994 (1)

1985 (1)

C. E. Riva, J. E. Grunwald, S. H. Sinclair, and B. L. Petrig, Invest. Ophthalmol. Visual Sci. 26, 1124 (1985).

Appl. Opt. (1)

Invest. Ophthalmol. Visual Sci. (1)

C. E. Riva, J. E. Grunwald, S. H. Sinclair, and B. L. Petrig, Invest. Ophthalmol. Visual Sci. 26, 1124 (1985).

J. Biomed. Opt. (2)

Y. Wang, B. A. Bower, J. A. Izatt, O. Tan, and D. Huang, J. Biomed. Opt. 12, 041215 (2007).
[CrossRef] [PubMed]

R. Michaely, A. H. Bachmann, M. L. Villiger, C. Blatter, T. Lasser, and R. A. Leitgeb, J. Biomed. Opt. 12, 041213 (2007).
[CrossRef] [PubMed]

J. Opt. Soc. Am. A (1)

Opt. Express (5)

Opt. Lett. (2)

Other (1)

T. Koller, G. Gerig, G. Szekely, and D. Dettwiler, in Proceedings of the Fifth International Conference on Computer Vision (IEEE, 1995), p. 864.

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Figures (4)

Fig. 1
Fig. 1

Schematic of vessel geometry.

Fig. 2
Fig. 2

Multiscale line filtering results: A, from the en face vessel image; B, distributions of the vesselness; C, azimuth; and D, diameter are obtained.

Fig. 3
Fig. 3

Vessel segmentation results for a bifurcation of a retinal artery. C, E, G, cross-sectional flow images of each vessel in the P plane; D, F, H, those in the A plane.

Fig. 4
Fig. 4

Relationship of measured blood flow volume rate before and after the bifurcation at different times during the heat beat.

Tables (1)

Tables Icon

Table 1 Blood Flow Measurement Results

Metrics