Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

Development and preliminary results of an endoscopic Raman probe for potential in vivo diagnosis of lung cancers

Not Accessible

Your library or personal account may give you access

Abstract

A near-infrared Raman system was developed to collect real-time in vivo human lung spectra. The excitation light and the emission were guided to and from the tissue surface by a reusable fiber catheter passed down the instrument channel of a bronchoscope. Two-stage filtering was used to reduce laser noise, fluorescence, and Raman emissions from the fibers. A second fiber bundle guided the emission to a spectrometer where the fibers, in a round packing geometry, were spread out to form a parabolic arc that improved the signal-to-noise ratio 20-fold, facilitating real-time spectral measurements. Preliminary clinical tests show that clear and reliable Raman spectra can be obtained.

© 2008 Optical Society of America

Full Article  |  PDF Article
More Like This
Rapid near-infrared Raman spectroscopy system for real-time in vivo skin measurements

Zhiwei Huang, Haishan Zeng, Iltefat Hamzavi, David I. McLean, and Harvey Lui
Opt. Lett. 26(22) 1782-1784 (2001)

Using high frequency Raman spectra for colonic neoplasia detection

Michael A. Short, Isabella T. Tai, David Owen, and Haishan Zeng
Opt. Express 21(4) 5025-5034 (2013)

Development of a beveled fiber-optic confocal Raman probe for enhancing in vivo epithelial tissue Raman measurements at endoscopy

Jianfeng Wang, Mads Sylvest Bergholt, Wei Zheng, and Zhiwei Huang
Opt. Lett. 38(13) 2321-2323 (2013)

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Figures (2)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved