Abstract

A two-dimensional phase-detection system for a surface-plasmon-resonance sensor is presented. The sensor utilizes polarization interferometry to detect phase differences between the s and p polarizations. We successfully detected a spatial phase-difference variation, resulting from the biomolecular interactions, of less than 1×1mm2. The phase stability demonstrated in the experimental results was approximately 0.09°, and the corresponding change in the refractive index detection limit was approximately 4.3×106. The common-optical-path configuration of the proposed method allowed us to reduce disturbances from ambient conditions. Furthermore, this method is capable of real-time array detection.

© 2008 Optical Society of America

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References

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2007

P. P. Markowicz, W. C. Law, A. Baev, P. N. Prasad, S. Patskovsky, and A. V. Kabashin, Opt. Express 15, 1748 (2007).
[CrossRef]

J. Y. Lee, H. C. Shih, C. T. Hong, and T. K. Chou, Opt. Commun. 276, 283 (2007).
[CrossRef]

2006

2005

C. L. Wong, H. P. Ho, K. S. Chan, S. Y. Wu, and C. Lin, Opt. Eng. (Bellingham) 44, 124403 (2005).
[CrossRef]

S. J. Chen, Y. D. Su, F. M. Hsiu, C. Y. Tsou, and Y. K. Chen, J. Biomed. Opt. 10, 034005 (2005).
[CrossRef] [PubMed]

2004

H. P. Chiang, H. T. Yeh, C. M. Chen, J. C. Wu, S. Y. Su, R. Chang, Y. J. Wu, D. P. Tsai, S. U. Jen, and P. T. Leung, Opt. Commun. 241, 409 (2004).
[CrossRef]

P. Y. Li, B. Lin, J. Gerstenmaier, and B. T. Cunningham, Sens. Actuators B 99, 6 (2004).
[CrossRef]

2003

H. P. Ho and W. W. Lam, Sens. Actuators B 96, 554 (2003).
[CrossRef]

2001

B. P. Nelson, T. E. Grimsrud, M. R. Liles, R. M. Goodman, and R. M. Corn, Anal. Chem. 73, 1 (2001).
[CrossRef] [PubMed]

X. Liu, W. Clegg, D. F. L. Jenkins, and B. Liu, IEEE Trans. Instrum. Meas. 50, 868 (2001).
[CrossRef]

1996

S. G. Nelson, K. S. Johnston, and S. S. Yee, Sens. Actuators B 35, 187 (1996).
[CrossRef]

Anal. Chem.

B. P. Nelson, T. E. Grimsrud, M. R. Liles, R. M. Goodman, and R. M. Corn, Anal. Chem. 73, 1 (2001).
[CrossRef] [PubMed]

IEEE Trans. Instrum. Meas.

X. Liu, W. Clegg, D. F. L. Jenkins, and B. Liu, IEEE Trans. Instrum. Meas. 50, 868 (2001).
[CrossRef]

J. Biomed. Opt.

S. J. Chen, Y. D. Su, F. M. Hsiu, C. Y. Tsou, and Y. K. Chen, J. Biomed. Opt. 10, 034005 (2005).
[CrossRef] [PubMed]

Opt. Commun.

H. P. Chiang, H. T. Yeh, C. M. Chen, J. C. Wu, S. Y. Su, R. Chang, Y. J. Wu, D. P. Tsai, S. U. Jen, and P. T. Leung, Opt. Commun. 241, 409 (2004).
[CrossRef]

J. Y. Lee, H. C. Shih, C. T. Hong, and T. K. Chou, Opt. Commun. 276, 283 (2007).
[CrossRef]

Opt. Eng. (Bellingham)

C. L. Wong, H. P. Ho, K. S. Chan, S. Y. Wu, and C. Lin, Opt. Eng. (Bellingham) 44, 124403 (2005).
[CrossRef]

Opt. Express

P. P. Markowicz, W. C. Law, A. Baev, P. N. Prasad, S. Patskovsky, and A. V. Kabashin, Opt. Express 15, 1748 (2007).
[CrossRef]

Opt. Lett.

Sens. Actuators B

P. Y. Li, B. Lin, J. Gerstenmaier, and B. T. Cunningham, Sens. Actuators B 99, 6 (2004).
[CrossRef]

H. P. Ho and W. W. Lam, Sens. Actuators B 96, 554 (2003).
[CrossRef]

S. G. Nelson, K. S. Johnston, and S. S. Yee, Sens. Actuators B 35, 187 (1996).
[CrossRef]

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Figures (3)

Fig. 1
Fig. 1

Kretschmann’s configuration for the SPR and PI optical configurations. The + z axis is chosen to be along the direction of light propagation.

Fig. 2
Fig. 2

Spatial phase-difference distributions ϕ for the (a) initial and (b) final interactions. (c) The phase difference ϕ of the segment line between (a) and (b). (d) The temporal phase-difference variation Δ ϕ of the local biomolecular interaction area.

Fig. 3
Fig. 3

Results of real-time measurement of the four PBSs.

Equations (4)

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r q = r 12 q + r 23 q exp ( i 2 k z 2 d ) 1 + r 12 q r 23 q exp ( i 2 k z 2 d ) = r q exp ( i ϕ q ) ,
E 1 = J P 1 J Q J SPR E i = 1 2 [ cos α r p exp ( i ϕ p ) + i sin α r s exp ( i ϕ s ) 0 ] ,
I 1 = E 1 2 = A + B sin ( ϕ p ϕ s ) ,
ϕ = ϕ p ϕ s = tan 1 ( I 1 I 2 I 4 I 3 ) ,

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