Abstract

We propose a fluorescent x-ray computed tomography method using an array of detectors with an incident sheet beam, aimed at providing molecular imaging with high sensitivity and good spatial resolution. In this study, we prove the feasibility of this concept and investigate its imaging properties, including spatial and contrast resolutions and quantitativeness, by imaging an acrylic phantom and a normal mouse brain using a preliminary imaging system with monochromatic synchrotron x rays.

© 2008 Optical Society of America

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  1. P. Boisseau, Hyperfine Interact. 33, 283 (1987).
    [Crossref]
  2. J. P. Hogan, IEEE Trans. Nucl. Sci. 38, 1721 (1991).
  3. R. Cesareo, Nucl. Instrum. Methods Phys. Res. A 277, 669 (1989).
    [Crossref]
  4. T. Yuasa, M. Akiba, T. Takeda, M. Kazama, A. Hoshino, Y. Watanabe, K. Hyodo, F. A. Dilmanian, T. Akatsuka, and Y. Itai, IEEE Trans. Nucl. Sci. 44, 54 (1997).
    [Crossref]
  5. G. F. Rust and J. Weigelt, IEEE Trans. Nucl. Sci. 45, 75 (1998).
    [Crossref]
  6. A. Simionovici, M. Chukalina, C. Schroer, M. Drakopoulos, A. Snigirev, I. Snigireva, B. Lengeler, K. Janssens, and F. Adams, IEEE Trans. Nucl. Sci. 47, 2736 (2000).
    [Crossref]
  7. T. Takeda, A. Momose, Q. W. Yu, T. Yuasa, F. A. Dilmanian, T. Akatsuka, and Y. Itai, Cell. Mol. Biol. (Oxford) 46, 1077 (2000).
  8. C. Schroer, Appl. Phys. Lett. 79, 1912 (2001).
    [Crossref]
  9. B. Golosio, A. Simionovici, A. Somogyi, L. Lemelle, M. Chukalina, and A. Brunetti, J. Appl. Phys. 94, 145 (2003).
    [Crossref]
  10. P. J. Riviere and P. A. Vargas, IEEE Trans. Med. Imaging 25, 1117 (2006).
    [Crossref] [PubMed]

2006 (1)

P. J. Riviere and P. A. Vargas, IEEE Trans. Med. Imaging 25, 1117 (2006).
[Crossref] [PubMed]

2003 (1)

B. Golosio, A. Simionovici, A. Somogyi, L. Lemelle, M. Chukalina, and A. Brunetti, J. Appl. Phys. 94, 145 (2003).
[Crossref]

2001 (1)

C. Schroer, Appl. Phys. Lett. 79, 1912 (2001).
[Crossref]

2000 (2)

A. Simionovici, M. Chukalina, C. Schroer, M. Drakopoulos, A. Snigirev, I. Snigireva, B. Lengeler, K. Janssens, and F. Adams, IEEE Trans. Nucl. Sci. 47, 2736 (2000).
[Crossref]

T. Takeda, A. Momose, Q. W. Yu, T. Yuasa, F. A. Dilmanian, T. Akatsuka, and Y. Itai, Cell. Mol. Biol. (Oxford) 46, 1077 (2000).

1998 (1)

G. F. Rust and J. Weigelt, IEEE Trans. Nucl. Sci. 45, 75 (1998).
[Crossref]

1997 (1)

T. Yuasa, M. Akiba, T. Takeda, M. Kazama, A. Hoshino, Y. Watanabe, K. Hyodo, F. A. Dilmanian, T. Akatsuka, and Y. Itai, IEEE Trans. Nucl. Sci. 44, 54 (1997).
[Crossref]

1991 (1)

J. P. Hogan, IEEE Trans. Nucl. Sci. 38, 1721 (1991).

1989 (1)

R. Cesareo, Nucl. Instrum. Methods Phys. Res. A 277, 669 (1989).
[Crossref]

1987 (1)

P. Boisseau, Hyperfine Interact. 33, 283 (1987).
[Crossref]

Adams, F.

A. Simionovici, M. Chukalina, C. Schroer, M. Drakopoulos, A. Snigirev, I. Snigireva, B. Lengeler, K. Janssens, and F. Adams, IEEE Trans. Nucl. Sci. 47, 2736 (2000).
[Crossref]

Akatsuka, T.

T. Takeda, A. Momose, Q. W. Yu, T. Yuasa, F. A. Dilmanian, T. Akatsuka, and Y. Itai, Cell. Mol. Biol. (Oxford) 46, 1077 (2000).

T. Yuasa, M. Akiba, T. Takeda, M. Kazama, A. Hoshino, Y. Watanabe, K. Hyodo, F. A. Dilmanian, T. Akatsuka, and Y. Itai, IEEE Trans. Nucl. Sci. 44, 54 (1997).
[Crossref]

Akiba, M.

T. Yuasa, M. Akiba, T. Takeda, M. Kazama, A. Hoshino, Y. Watanabe, K. Hyodo, F. A. Dilmanian, T. Akatsuka, and Y. Itai, IEEE Trans. Nucl. Sci. 44, 54 (1997).
[Crossref]

Boisseau, P.

P. Boisseau, Hyperfine Interact. 33, 283 (1987).
[Crossref]

Brunetti, A.

B. Golosio, A. Simionovici, A. Somogyi, L. Lemelle, M. Chukalina, and A. Brunetti, J. Appl. Phys. 94, 145 (2003).
[Crossref]

Cesareo, R.

R. Cesareo, Nucl. Instrum. Methods Phys. Res. A 277, 669 (1989).
[Crossref]

Chukalina, M.

B. Golosio, A. Simionovici, A. Somogyi, L. Lemelle, M. Chukalina, and A. Brunetti, J. Appl. Phys. 94, 145 (2003).
[Crossref]

A. Simionovici, M. Chukalina, C. Schroer, M. Drakopoulos, A. Snigirev, I. Snigireva, B. Lengeler, K. Janssens, and F. Adams, IEEE Trans. Nucl. Sci. 47, 2736 (2000).
[Crossref]

Dilmanian, F. A.

T. Takeda, A. Momose, Q. W. Yu, T. Yuasa, F. A. Dilmanian, T. Akatsuka, and Y. Itai, Cell. Mol. Biol. (Oxford) 46, 1077 (2000).

T. Yuasa, M. Akiba, T. Takeda, M. Kazama, A. Hoshino, Y. Watanabe, K. Hyodo, F. A. Dilmanian, T. Akatsuka, and Y. Itai, IEEE Trans. Nucl. Sci. 44, 54 (1997).
[Crossref]

Drakopoulos, M.

A. Simionovici, M. Chukalina, C. Schroer, M. Drakopoulos, A. Snigirev, I. Snigireva, B. Lengeler, K. Janssens, and F. Adams, IEEE Trans. Nucl. Sci. 47, 2736 (2000).
[Crossref]

Golosio, B.

B. Golosio, A. Simionovici, A. Somogyi, L. Lemelle, M. Chukalina, and A. Brunetti, J. Appl. Phys. 94, 145 (2003).
[Crossref]

Hogan, J. P.

J. P. Hogan, IEEE Trans. Nucl. Sci. 38, 1721 (1991).

Hoshino, A.

T. Yuasa, M. Akiba, T. Takeda, M. Kazama, A. Hoshino, Y. Watanabe, K. Hyodo, F. A. Dilmanian, T. Akatsuka, and Y. Itai, IEEE Trans. Nucl. Sci. 44, 54 (1997).
[Crossref]

Hyodo, K.

T. Yuasa, M. Akiba, T. Takeda, M. Kazama, A. Hoshino, Y. Watanabe, K. Hyodo, F. A. Dilmanian, T. Akatsuka, and Y. Itai, IEEE Trans. Nucl. Sci. 44, 54 (1997).
[Crossref]

Itai, Y.

T. Takeda, A. Momose, Q. W. Yu, T. Yuasa, F. A. Dilmanian, T. Akatsuka, and Y. Itai, Cell. Mol. Biol. (Oxford) 46, 1077 (2000).

T. Yuasa, M. Akiba, T. Takeda, M. Kazama, A. Hoshino, Y. Watanabe, K. Hyodo, F. A. Dilmanian, T. Akatsuka, and Y. Itai, IEEE Trans. Nucl. Sci. 44, 54 (1997).
[Crossref]

Janssens, K.

A. Simionovici, M. Chukalina, C. Schroer, M. Drakopoulos, A. Snigirev, I. Snigireva, B. Lengeler, K. Janssens, and F. Adams, IEEE Trans. Nucl. Sci. 47, 2736 (2000).
[Crossref]

Kazama, M.

T. Yuasa, M. Akiba, T. Takeda, M. Kazama, A. Hoshino, Y. Watanabe, K. Hyodo, F. A. Dilmanian, T. Akatsuka, and Y. Itai, IEEE Trans. Nucl. Sci. 44, 54 (1997).
[Crossref]

Lemelle, L.

B. Golosio, A. Simionovici, A. Somogyi, L. Lemelle, M. Chukalina, and A. Brunetti, J. Appl. Phys. 94, 145 (2003).
[Crossref]

Lengeler, B.

A. Simionovici, M. Chukalina, C. Schroer, M. Drakopoulos, A. Snigirev, I. Snigireva, B. Lengeler, K. Janssens, and F. Adams, IEEE Trans. Nucl. Sci. 47, 2736 (2000).
[Crossref]

Momose, A.

T. Takeda, A. Momose, Q. W. Yu, T. Yuasa, F. A. Dilmanian, T. Akatsuka, and Y. Itai, Cell. Mol. Biol. (Oxford) 46, 1077 (2000).

Riviere, P. J.

P. J. Riviere and P. A. Vargas, IEEE Trans. Med. Imaging 25, 1117 (2006).
[Crossref] [PubMed]

Rust, G. F.

G. F. Rust and J. Weigelt, IEEE Trans. Nucl. Sci. 45, 75 (1998).
[Crossref]

Schroer, C.

C. Schroer, Appl. Phys. Lett. 79, 1912 (2001).
[Crossref]

A. Simionovici, M. Chukalina, C. Schroer, M. Drakopoulos, A. Snigirev, I. Snigireva, B. Lengeler, K. Janssens, and F. Adams, IEEE Trans. Nucl. Sci. 47, 2736 (2000).
[Crossref]

Simionovici, A.

B. Golosio, A. Simionovici, A. Somogyi, L. Lemelle, M. Chukalina, and A. Brunetti, J. Appl. Phys. 94, 145 (2003).
[Crossref]

A. Simionovici, M. Chukalina, C. Schroer, M. Drakopoulos, A. Snigirev, I. Snigireva, B. Lengeler, K. Janssens, and F. Adams, IEEE Trans. Nucl. Sci. 47, 2736 (2000).
[Crossref]

Snigirev, A.

A. Simionovici, M. Chukalina, C. Schroer, M. Drakopoulos, A. Snigirev, I. Snigireva, B. Lengeler, K. Janssens, and F. Adams, IEEE Trans. Nucl. Sci. 47, 2736 (2000).
[Crossref]

Snigireva, I.

A. Simionovici, M. Chukalina, C. Schroer, M. Drakopoulos, A. Snigirev, I. Snigireva, B. Lengeler, K. Janssens, and F. Adams, IEEE Trans. Nucl. Sci. 47, 2736 (2000).
[Crossref]

Somogyi, A.

B. Golosio, A. Simionovici, A. Somogyi, L. Lemelle, M. Chukalina, and A. Brunetti, J. Appl. Phys. 94, 145 (2003).
[Crossref]

Takeda, T.

T. Takeda, A. Momose, Q. W. Yu, T. Yuasa, F. A. Dilmanian, T. Akatsuka, and Y. Itai, Cell. Mol. Biol. (Oxford) 46, 1077 (2000).

T. Yuasa, M. Akiba, T. Takeda, M. Kazama, A. Hoshino, Y. Watanabe, K. Hyodo, F. A. Dilmanian, T. Akatsuka, and Y. Itai, IEEE Trans. Nucl. Sci. 44, 54 (1997).
[Crossref]

Vargas, P. A.

P. J. Riviere and P. A. Vargas, IEEE Trans. Med. Imaging 25, 1117 (2006).
[Crossref] [PubMed]

Watanabe, Y.

T. Yuasa, M. Akiba, T. Takeda, M. Kazama, A. Hoshino, Y. Watanabe, K. Hyodo, F. A. Dilmanian, T. Akatsuka, and Y. Itai, IEEE Trans. Nucl. Sci. 44, 54 (1997).
[Crossref]

Weigelt, J.

G. F. Rust and J. Weigelt, IEEE Trans. Nucl. Sci. 45, 75 (1998).
[Crossref]

Yu, Q. W.

T. Takeda, A. Momose, Q. W. Yu, T. Yuasa, F. A. Dilmanian, T. Akatsuka, and Y. Itai, Cell. Mol. Biol. (Oxford) 46, 1077 (2000).

Yuasa, T.

T. Takeda, A. Momose, Q. W. Yu, T. Yuasa, F. A. Dilmanian, T. Akatsuka, and Y. Itai, Cell. Mol. Biol. (Oxford) 46, 1077 (2000).

T. Yuasa, M. Akiba, T. Takeda, M. Kazama, A. Hoshino, Y. Watanabe, K. Hyodo, F. A. Dilmanian, T. Akatsuka, and Y. Itai, IEEE Trans. Nucl. Sci. 44, 54 (1997).
[Crossref]

Appl. Phys. Lett. (1)

C. Schroer, Appl. Phys. Lett. 79, 1912 (2001).
[Crossref]

Cell. Mol. Biol. (Oxford) (1)

T. Takeda, A. Momose, Q. W. Yu, T. Yuasa, F. A. Dilmanian, T. Akatsuka, and Y. Itai, Cell. Mol. Biol. (Oxford) 46, 1077 (2000).

Hyperfine Interact. (1)

P. Boisseau, Hyperfine Interact. 33, 283 (1987).
[Crossref]

IEEE Trans. Med. Imaging (1)

P. J. Riviere and P. A. Vargas, IEEE Trans. Med. Imaging 25, 1117 (2006).
[Crossref] [PubMed]

IEEE Trans. Nucl. Sci. (4)

J. P. Hogan, IEEE Trans. Nucl. Sci. 38, 1721 (1991).

T. Yuasa, M. Akiba, T. Takeda, M. Kazama, A. Hoshino, Y. Watanabe, K. Hyodo, F. A. Dilmanian, T. Akatsuka, and Y. Itai, IEEE Trans. Nucl. Sci. 44, 54 (1997).
[Crossref]

G. F. Rust and J. Weigelt, IEEE Trans. Nucl. Sci. 45, 75 (1998).
[Crossref]

A. Simionovici, M. Chukalina, C. Schroer, M. Drakopoulos, A. Snigirev, I. Snigireva, B. Lengeler, K. Janssens, and F. Adams, IEEE Trans. Nucl. Sci. 47, 2736 (2000).
[Crossref]

J. Appl. Phys. (1)

B. Golosio, A. Simionovici, A. Somogyi, L. Lemelle, M. Chukalina, and A. Brunetti, J. Appl. Phys. 94, 145 (2003).
[Crossref]

Nucl. Instrum. Methods Phys. Res. A (1)

R. Cesareo, Nucl. Instrum. Methods Phys. Res. A 277, 669 (1989).
[Crossref]

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Figures (3)

Fig. 1
Fig. 1

Schematic diagram of FXCT imaging geometry using sheet-beam and linear detector arrays.

Fig. 2
Fig. 2

CT measurement of a physical phantom: (a) FXCT image, (b) differential profile at the white line drawn in (a), (c) relationship between the average reconstructed value and the actual iodine concentration. Correlation coefficient, R 2 , is about 0.99.

Fig. 3
Fig. 3

Ex vivo FXCT image of a normal mouse brain.

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