Abstract

We report the development of an all-fiber multimodal system, based on a double-cladding fiber (DCF) and related devices, suitable for simultaneous measurements of optical coherence tomography (OCT) and fluorescence spectroscopy (FS). The DCF together with a DCF coupler and a single-body DCF lens has assisted in the realization of a multimodal but single-unit probe for the combined system. The DCF lens allowed simultaneous focusing of input beams for OCT and FS and also the effective collection of both signal beams from a sample. The DCF coupler could extract the OCT signal via the core channel and the FS signal through the cladding channel. The OCT image and the fluorescence spectra of a plant tissue were then simultaneously measured to validate the performance of the proposed multimodal system.

© 2008 Optical Society of America

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2008 (2)

2007 (1)

2006 (1)

2004 (4)

2003 (1)

2002 (1)

2000 (2)

C. Buschmann, G. Langsdorf, and H. K. Lichtenthaler, Photosynthetica 38, 483 (2000).
[CrossRef]

N. Ramanujam, Neoplasia 2, 89 (2000).
[CrossRef] [PubMed]

1991 (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Baek, U. C.

Baker, J. R.

Barton, J. K.

Bosschaart, N.

Bouma, B. E.

Bouwmans, G.

Buschmann, C.

C. Buschmann, G. Langsdorf, and H. K. Lichtenthaler, Photosynthetica 38, 483 (2000).
[CrossRef]

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Choi, H. Y.

Choi, W. J.

Eom, J. B.

Flotte, T.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Fu, L.

Fujimoto, J. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Gu, M.

Hariri, L. P.

Hee, M. R.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Huang, D.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Jung, Y.

Keller, M. D.

Kim, H.

Kim, J.

Kim, K. T.

Knight, J. C.

Langsdorf, G.

C. Buschmann, G. Langsdorf, and H. K. Lichtenthaler, Photosynthetica 38, 483 (2000).
[CrossRef]

Lee, B. H.

Lichtenthaler, H. K.

C. Buschmann, G. Langsdorf, and H. K. Lichtenthaler, Photosynthetica 38, 483 (2000).
[CrossRef]

Lin, C. P.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Mahadevan-Jansen, A.

Moon, D. S.

Myaing, M. T.

Na, J.

Norris, T. B.

Patil, C. A.

Puliafito, C. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Ramanujam, N.

N. Ramanujam, Neoplasia 2, 89 (2000).
[CrossRef] [PubMed]

Russell, P. St.

Ryu, S. Y.

Schuman, J. S.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Swanson, E. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Tearney, G. J.

Thomas, T.

Tumlinson, A. R.

Tumlinson, F. G.

J. K. Barton and F. G. A. Tumlinson, J. Biomed. Opt. 9, 618 (2004).
[CrossRef] [PubMed]

Utzinger, U.

van Leeuwen, T. G.

Wadsworth, W. J.

Wang, L.

Ye, J. Y.

Yelin, D.

Yun, S. H.

Appl. Opt. (2)

J. Biomed. Opt. (1)

J. K. Barton and F. G. A. Tumlinson, J. Biomed. Opt. 9, 618 (2004).
[CrossRef] [PubMed]

Neoplasia (1)

N. Ramanujam, Neoplasia 2, 89 (2000).
[CrossRef] [PubMed]

Opt. Express (1)

Opt. Lett. (6)

Photosynthetica (1)

C. Buschmann, G. Langsdorf, and H. K. Lichtenthaler, Photosynthetica 38, 483 (2000).
[CrossRef]

Science (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

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Figures (3)

Fig. 1
Fig. 1

Schematic of the combined OCT-FS system. SLD, superluminescent diode; WDM, wavelength division multiplexer; SMF, single-mode fiber; DCF, double-cladding fiber; DCF lens, fiber lens made on a DCF; NDF, neutral density filter; LPF, long-pass filter; PD, photodiode; and ×, fiber fusion spliced point.

Fig. 2
Fig. 2

(a) Measured coupling efficiency of the DCF coupler and (b) the measured focal length of the DCF lens at 1310 nm .

Fig. 3
Fig. 3

(a) The OCT image and (b) a stack of fluorescence spectra of a sliced tomato, simultaneously taken with the proposed OCT-FS system. Both the spectra taken at position (c) 1.0 mm and (d) 2.0 mm had main fluorescence peaks at 690 and 740 nm , though the spectrum at 2.0 mm was very feeble.

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