Abstract

We introduce a methodology to determine quantitatively the depth resolution limit in luminescence diffuse optical imaging. The approach is based on a Cramer–Rao statistical analysis, a noise model, and calculations of photon transport in tissues. We illustrate the method in the case of luminescence imaging in a brain–skull model, showing its potential applications in molecular imaging on small animals.

© 2008 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
Depth sensitivity and image reconstruction analysis of dense imaging arrays for mapping brain function with diffuse optical tomography

Hamid Dehghani, Brian R. White, Benjamin W. Zeff, Andrew Tizzard, and Joseph P. Culver
Appl. Opt. 48(10) D137-D143 (2009)

Multispectral Cerenkov luminescence tomography for small animal optical imaging

Antonello E Spinelli, Chaincy Kuo, Brad W Rice, Riccardo Calandrino, Pasquina Marzola, Andrea Sbarbati, and Federico Boschi
Opt. Express 19(13) 12605-12618 (2011)

Sparsity enhanced spatial resolution and depth localization in diffuse optical tomography

Venkaiah C. Kavuri, Zi-Jing Lin, Fenghua Tian, and Hanli Liu
Biomed. Opt. Express 3(5) 943-957 (2012)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (3)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Tables (1)

You do not have subscription access to this journal. Article tables are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Equations (7)

You do not have subscription access to this journal. Equations are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription