Abstract

Calibration of the diffuse reflectance spectrum for instrument response and time-dependent fluctuation as well as interdevice variations is complicated, time consuming, and potentially inaccurate. We describe a novel fiber optic probe with a real-time self-calibration capability that can be used for tissue optical spectroscopy. The probe was tested in a number of liquid phantoms over a relevant range of tissue optical properties. Absorption and scattering coefficients are extracted with an average absolute error and standard deviation of 6.9%±7.2% and 3.5%±1.5%, respectively.

© 2008 Optical Society of America

Full Article  |  PDF Article
Related Articles
Quantifying the absorption and reduced scattering coefficients of tissuelike turbid media over a broad spectral range with noncontact Fourier-transform hyperspectral imaging

Tuan H. Pham, Frederic Bevilacqua, Thorsten Spott, Jan S. Dam, Bruce J. Tromberg, and Stefan Andersson-Engels
Appl. Opt. 39(34) 6487-6497 (2000)

Analytical model of light reflectance for extraction of the optical properties in small volumes of turbid media

Roberto Reif, Ousama A'Amar, and Irving J. Bigio
Appl. Opt. 46(29) 7317-7328 (2007)

Intrinsic Raman spectroscopy for quantitative biological spectroscopy Part II: Experimental applications

Kate L. Bechtel, Wei-Chuan Shih, and Michael S. Feld
Opt. Express 16(17) 12737-12745 (2008)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (4)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription