Abstract

We introduce a new Monte Carlo (MC) method for simulating optical coherence tomography (OCT) images of complex multilayered turbid scattering media. We demonstrate, for the first time of our knowledge, the use of a MC technique to imitate two-dimensional polarization-sensitive OCT images with nonplanar boundaries of layers in the medium like a human skin. The simulation of polarized low-coherent optical radiation is based on the vector approach generalized from the iterative procedure of the solution of Bethe–Saltpeter equation. The performances of the developed method are demonstrated both for conventional and polarization-sensitive OCT modalities.

© 2008 Optical Society of America

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2007 (4)

V. L. Kuzmin and I. V. Meglinski, Opt. Commun. 273, 307 (2007).
[CrossRef]

M. Yu. Kirillin, A. V. Priezzhev, and R. Myllylä, Proc. SPIE 6534, 65340H (2007).
[CrossRef]

M. Yu Kirillin, E. Alarousu, T. Fabritius, R. Myllylä, and A. V. Priezzhev, J. Eur. Opt. Soc. Rapid Publ. 2, 07031 (2007).
[CrossRef]

V. L. Kuzmin and I. V. Meglinski, J. Exp. Theor. Phys. 105, 285 (2007).
[CrossRef]

2005 (2)

J. C. Ramella-Roman, S. A. Prahl, and S. L. Jacques, Opt. Express 13, 4420 (2005).
[CrossRef] [PubMed]

I. V. Meglinski, V. L. Kuzmin, D. Y. Churmakov, and D. A. Greenhalgh, Proc. R. Soc. London, Ser. A 461, 43 (2005).
[CrossRef]

2004 (2)

2003 (1)

V. L. Kuzmin and E. V. Aksenova, J. Exp. Theor. Phys. 123, 929 (2003).

2002 (4)

2001 (2)

L. V. Wang, Opt. Lett. 26, 1191 (2001).
[CrossRef]

I. V. Meglinsky and S. J. Matcher, Med. Biol. Eng. Comput. 39, 44 (2001).
[CrossRef] [PubMed]

2000 (1)

1997 (1)

1996 (1)

1995 (1)

L.-H. Wang, S. L. Jacques, and L.-Q. Zheng, Comput. Methods Programs Biomed. 47, 131 (1995).
[CrossRef] [PubMed]

1994 (1)

V. L. Kuzmin, V. P. Romanov, and L. A. Zubkov, Phys. Rep. 248, 71 (1994).
[CrossRef]

1983 (1)

B. C. Wilson and G. Adam, Med. Phys. 10, 824 (1983).
[CrossRef] [PubMed]

Adam, G.

B. C. Wilson and G. Adam, Med. Phys. 10, 824 (1983).
[CrossRef] [PubMed]

Agarwal, G. S.

Aksenova, E. V.

V. L. Kuzmin and E. V. Aksenova, J. Exp. Theor. Phys. 123, 929 (2003).

Alarousu, E.

M. Yu Kirillin, E. Alarousu, T. Fabritius, R. Myllylä, and A. V. Priezzhev, J. Eur. Opt. Soc. Rapid Publ. 2, 07031 (2007).
[CrossRef]

Andersen, P. E.

Bartel, S.

Ben-Letaief, K.

Boas, D.

Carney, P. S.

Churmakov, D. Y.

I. V. Meglinski, V. L. Kuzmin, D. Y. Churmakov, and D. A. Greenhalgh, Proc. R. Soc. London, Ser. A 461, 43 (2005).
[CrossRef]

D. Y. Churmakov, I. V. Meglinski, and D. A. Greenhalgh, Phys. Med. Biol. 47, 4271 (2002).
[CrossRef] [PubMed]

Culver, J.

Dunn, A.

Fabritius, T.

M. Yu Kirillin, E. Alarousu, T. Fabritius, R. Myllylä, and A. V. Priezzhev, J. Eur. Opt. Soc. Rapid Publ. 2, 07031 (2007).
[CrossRef]

Gan, X.

Greenhalgh, D. A.

I. V. Meglinski, V. L. Kuzmin, D. Y. Churmakov, and D. A. Greenhalgh, Proc. R. Soc. London, Ser. A 461, 43 (2005).
[CrossRef]

D. Y. Churmakov, I. V. Meglinski, and D. A. Greenhalgh, Phys. Med. Biol. 47, 4271 (2002).
[CrossRef] [PubMed]

Gu, M.

Hielscher, A. H.

Ishimaru, A.

A. Ishimaru, Wave Propagation and Scattering in Random Media, Vols. 1 and 2 (Academic Press, 1978).

Jacques, S. L.

J. C. Ramella-Roman, S. A. Prahl, and S. L. Jacques, Opt. Express 13, 4420 (2005).
[CrossRef] [PubMed]

L.-H. Wang, S. L. Jacques, and L.-Q. Zheng, Comput. Methods Programs Biomed. 47, 131 (1995).
[CrossRef] [PubMed]

Jorgensen, T. M.

Kirillin, M. Yu

M. Yu Kirillin, E. Alarousu, T. Fabritius, R. Myllylä, and A. V. Priezzhev, J. Eur. Opt. Soc. Rapid Publ. 2, 07031 (2007).
[CrossRef]

Kuzmin, V. L.

V. L. Kuzmin and I. V. Meglinski, J. Exp. Theor. Phys. 105, 285 (2007).
[CrossRef]

V. L. Kuzmin and I. V. Meglinski, Opt. Commun. 273, 307 (2007).
[CrossRef]

I. V. Meglinski, V. L. Kuzmin, D. Y. Churmakov, and D. A. Greenhalgh, Proc. R. Soc. London, Ser. A 461, 43 (2005).
[CrossRef]

V. L. Kuzmin and E. V. Aksenova, J. Exp. Theor. Phys. 123, 929 (2003).

V. L. Kuzmin, V. P. Romanov, and L. A. Zubkov, Phys. Rep. 248, 71 (1994).
[CrossRef]

Lacoste, D.

Lenke, R.

Lu, Q.

Luo, Q.

Matcher, S. J.

I. V. Meglinsky and S. J. Matcher, Med. Biol. Eng. Comput. 39, 44 (2001).
[CrossRef] [PubMed]

Meglinski, I. V.

V. L. Kuzmin and I. V. Meglinski, Opt. Commun. 273, 307 (2007).
[CrossRef]

V. L. Kuzmin and I. V. Meglinski, J. Exp. Theor. Phys. 105, 285 (2007).
[CrossRef]

I. V. Meglinski, V. L. Kuzmin, D. Y. Churmakov, and D. A. Greenhalgh, Proc. R. Soc. London, Ser. A 461, 43 (2005).
[CrossRef]

D. Y. Churmakov, I. V. Meglinski, and D. A. Greenhalgh, Phys. Med. Biol. 47, 4271 (2002).
[CrossRef] [PubMed]

Meglinsky, I. V.

I. V. Meglinsky and S. J. Matcher, Med. Biol. Eng. Comput. 39, 44 (2001).
[CrossRef] [PubMed]

Myllylä, R.

M. Yu. Kirillin, A. V. Priezzhev, and R. Myllylä, Proc. SPIE 6534, 65340H (2007).
[CrossRef]

M. Yu Kirillin, E. Alarousu, T. Fabritius, R. Myllylä, and A. V. Priezzhev, J. Eur. Opt. Soc. Rapid Publ. 2, 07031 (2007).
[CrossRef]

Prahl, S. A.

Priezzhev, A. V.

M. Yu. Kirillin, A. V. Priezzhev, and R. Myllylä, Proc. SPIE 6534, 65340H (2007).
[CrossRef]

M. Yu Kirillin, E. Alarousu, T. Fabritius, R. Myllylä, and A. V. Priezzhev, J. Eur. Opt. Soc. Rapid Publ. 2, 07031 (2007).
[CrossRef]

Ramella-Roman, J. C.

Rojas-Ochoa, L. F.

Romanov, V. P.

V. L. Kuzmin, V. P. Romanov, and L. A. Zubkov, Phys. Rep. 248, 71 (1994).
[CrossRef]

Scheffold, F.

Schmitt, J. M.

Schurtenberger, P.

Stott, J.

Tycho, A.

Wang, L. V.

X. Wang and L. V. Wang, J. Biomed. Opt. 7, 279 (2002).
[CrossRef] [PubMed]

L. V. Wang, Opt. Lett. 26, 1191 (2001).
[CrossRef]

Wang, L.-H.

L.-H. Wang, S. L. Jacques, and L.-Q. Zheng, Comput. Methods Programs Biomed. 47, 131 (1995).
[CrossRef] [PubMed]

Wang, X.

X. Wang and L. V. Wang, J. Biomed. Opt. 7, 279 (2002).
[CrossRef] [PubMed]

Wilson, B. C.

B. C. Wilson and G. Adam, Med. Phys. 10, 824 (1983).
[CrossRef] [PubMed]

Wolf, E.

Yu. Kirillin, M.

M. Yu. Kirillin, A. V. Priezzhev, and R. Myllylä, Proc. SPIE 6534, 65340H (2007).
[CrossRef]

Yura, H. T.

Zheng, L.-Q.

L.-H. Wang, S. L. Jacques, and L.-Q. Zheng, Comput. Methods Programs Biomed. 47, 131 (1995).
[CrossRef] [PubMed]

Zubkov, L. A.

V. L. Kuzmin, V. P. Romanov, and L. A. Zubkov, Phys. Rep. 248, 71 (1994).
[CrossRef]

Appl. Opt. (3)

Comput. Methods Programs Biomed. (1)

L.-H. Wang, S. L. Jacques, and L.-Q. Zheng, Comput. Methods Programs Biomed. 47, 131 (1995).
[CrossRef] [PubMed]

J. Biomed. Opt. (1)

X. Wang and L. V. Wang, J. Biomed. Opt. 7, 279 (2002).
[CrossRef] [PubMed]

J. Eur. Opt. Soc. Rapid Publ. (1)

M. Yu Kirillin, E. Alarousu, T. Fabritius, R. Myllylä, and A. V. Priezzhev, J. Eur. Opt. Soc. Rapid Publ. 2, 07031 (2007).
[CrossRef]

J. Exp. Theor. Phys. (2)

V. L. Kuzmin and I. V. Meglinski, J. Exp. Theor. Phys. 105, 285 (2007).
[CrossRef]

V. L. Kuzmin and E. V. Aksenova, J. Exp. Theor. Phys. 123, 929 (2003).

J. Opt. Soc. Am. A (3)

Med. Biol. Eng. Comput. (1)

I. V. Meglinsky and S. J. Matcher, Med. Biol. Eng. Comput. 39, 44 (2001).
[CrossRef] [PubMed]

Med. Phys. (1)

B. C. Wilson and G. Adam, Med. Phys. 10, 824 (1983).
[CrossRef] [PubMed]

Opt. Commun. (1)

V. L. Kuzmin and I. V. Meglinski, Opt. Commun. 273, 307 (2007).
[CrossRef]

Opt. Express (2)

Opt. Lett. (1)

Phys. Med. Biol. (1)

D. Y. Churmakov, I. V. Meglinski, and D. A. Greenhalgh, Phys. Med. Biol. 47, 4271 (2002).
[CrossRef] [PubMed]

Phys. Rep. (1)

V. L. Kuzmin, V. P. Romanov, and L. A. Zubkov, Phys. Rep. 248, 71 (1994).
[CrossRef]

Proc. R. Soc. London, Ser. A (1)

I. V. Meglinski, V. L. Kuzmin, D. Y. Churmakov, and D. A. Greenhalgh, Proc. R. Soc. London, Ser. A 461, 43 (2005).
[CrossRef]

Proc. SPIE (1)

M. Yu. Kirillin, A. V. Priezzhev, and R. Myllylä, Proc. SPIE 6534, 65340H (2007).
[CrossRef]

Other (1)

A. Ishimaru, Wave Propagation and Scattering in Random Media, Vols. 1 and 2 (Academic Press, 1978).

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Figures (1)

Fig. 1
Fig. 1

Schematic presentation of a skin model used in the simulation. a: 1, upper stratum corneum (average thickness 0.02 mm ); 2, lower stratum corneum ( 0.18 mm ) ; 3, epidermis ( 0.2 mm ) ; 4, upper blood net dermis ( 0.2 mm ) ; 5, reticular dermis ( 0.8 mm ) ; 6, deep blood net dermis ( 0.6 mm ) . 2D simulated images for b, convention OCT and c, copolarized and d, cross-polarized OCT modalities, respectively.

Equations (8)

Equations on this page are rendered with MathJax. Learn more.

I ( z ) = 2 j = 1 N ph W r W s ( L j ) exp [ ( z L j l coh ) 2 ] ,
P i = e i [ e i P i 1 ] = [ I ̂ e i e i ] P i 1 ,
P = ( I ̂ k 2 k s k s ) i = 2 N ( I ̂ k 2 k j j 1 k j j 1 ) P 0 .
k 0 4 G ̃ ( k i , k s ) d Ω s = 1 l ,
k 0 4 G ̃ ( k i , k s ) d Ω s = 1 l 2 1 + cos 2 θ ¯ .
Γ = 2 1 + cos 2 θ ¯
I ( χ ) = j = 1 N ph W j Γ N j P j 2 ,
I ( χ ) = j = 1 N ph W j Γ N j P j 2 ,

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