Abstract

Two novel control methods based on adiabatic passage are proposed to be implemented in coherent anti-Stokes Raman scattering (CARS) microscopy for noninvasive imaging of biological structure and dynamics. The first method provides optimal pulse-area control of the resonant vibrational transitions by using a pair of equally linear-chirped pulses. The second method, named the “roof” method, utilizes the chirp sign variation at the central time and gives robust adiabatic excitation of the resonant vibrational mode. Both methods are robust with respect to suppression of the off-resonant transitions. The methods allow one to achieve chemical sensitivity with high resolution and can be used to obtain CARS spectra of biological molecules with efficiently suppressed background.

© 2007 Optical Society of America

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2006 (4)

2005 (2)

B. Yellampalle, R. D. Averitt, A. Efimov, and A. J. Taylor, Opt. Express 13, 7672 (2005).
[CrossRef] [PubMed]

C. L. Evans, E. O. Potma, M. Puorishaag, D. Cote, C. P. Lin, and X. S. Xie, Proc. Natl. Acad. Sci. USA 102, 16807 (2005).
[CrossRef] [PubMed]

2004 (3)

E. O. Potma and X. S. Xie, Opt. Photon. News 15(11), 40 (2004).
[CrossRef]

T. Hellerer, A. M. K. Enejder, and A. Zumbusch, Appl. Phys. Lett. 85, 25 (2004).
[CrossRef]

K. P. Knutsen, J. C. Johnson, A. E. Miller, P. B. Petersen, and R. J. Saykally, Chem. Phys. Lett. 387, 436 (2004).
[CrossRef]

2003 (1)

2002 (2)

2001 (1)

E. O. Potma, W. P. de Boeij, P. J. M. van Haastert, and D. A. Wiersma, Proc. Natl. Acad. Sci. USA 98, 1577 (2001).
[CrossRef] [PubMed]

1999 (1)

A. Zumbusch, G. Holtom, and X. S. Xie, Phys. Rev. Lett. 92, 4142 (1999).
[CrossRef]

Averitt, R. D.

Bartels, R. A.

Beaurepaire, E.

Bonn, M.

Cote, D.

C. L. Evans, E. O. Potma, M. Puorishaag, D. Cote, C. P. Lin, and X. S. Xie, Proc. Natl. Acad. Sci. USA 102, 16807 (2005).
[CrossRef] [PubMed]

de Boeij, W. P.

E. O. Potma, W. P. de Boeij, P. J. M. van Haastert, and D. A. Wiersma, Proc. Natl. Acad. Sci. USA 98, 1577 (2001).
[CrossRef] [PubMed]

Debarre, D.

Dudovich, N.

N. Dudovich, D. Oron, and Y. Silberberg, Nature 418, 512 (2002).
[CrossRef] [PubMed]

Efimov, A.

Enejder, A. M. K.

T. Hellerer, A. M. K. Enejder, and A. Zumbusch, Appl. Phys. Lett. 85, 25 (2004).
[CrossRef]

Evans, C. L.

C. L. Evans, E. O. Potma, M. Puorishaag, D. Cote, C. P. Lin, and X. S. Xie, Proc. Natl. Acad. Sci. USA 102, 16807 (2005).
[CrossRef] [PubMed]

Fourkas, J. T.

Gershgoren, E.

Hellerer, T.

T. Hellerer, A. M. K. Enejder, and A. Zumbusch, Appl. Phys. Lett. 85, 25 (2004).
[CrossRef]

Holtom, G.

A. Zumbusch, G. Holtom, and X. S. Xie, Phys. Rev. Lett. 92, 4142 (1999).
[CrossRef]

Joffre, M.

Johnson, J. C.

K. P. Knutsen, J. C. Johnson, A. E. Miller, P. B. Petersen, and R. J. Saykally, Chem. Phys. Lett. 387, 436 (2004).
[CrossRef]

Kapteyn, H. C.

Knutsen, K. P.

K. P. Knutsen, B. M. Messer, R. M. Onorato, and R. J. Saykally, J. Phys. Chem. B 110, 5854 (2006).
[CrossRef] [PubMed]

K. P. Knutsen, J. C. Johnson, A. E. Miller, P. B. Petersen, and R. J. Saykally, Chem. Phys. Lett. 387, 436 (2004).
[CrossRef]

Lin, C. P.

C. L. Evans, E. O. Potma, M. Puorishaag, D. Cote, C. P. Lin, and X. S. Xie, Proc. Natl. Acad. Sci. USA 102, 16807 (2005).
[CrossRef] [PubMed]

Malinovskaya, S. A.

S. A. Malinovskaya, Phys. Rev. A 73, 033416 (2006).
[CrossRef]

Martin, J.

Messer, B. M.

K. P. Knutsen, B. M. Messer, R. M. Onorato, and R. J. Saykally, J. Phys. Chem. B 110, 5854 (2006).
[CrossRef] [PubMed]

Miller, A. E.

K. P. Knutsen, J. C. Johnson, A. E. Miller, P. B. Petersen, and R. J. Saykally, Chem. Phys. Lett. 387, 436 (2004).
[CrossRef]

Müller, M.

Murnane, M. M.

Ogilvie, J.

Onorato, R. M.

K. P. Knutsen, B. M. Messer, R. M. Onorato, and R. J. Saykally, J. Phys. Chem. B 110, 5854 (2006).
[CrossRef] [PubMed]

Oron, D.

N. Dudovich, D. Oron, and Y. Silberberg, Nature 418, 512 (2002).
[CrossRef] [PubMed]

Petersen, P. B.

K. P. Knutsen, J. C. Johnson, A. E. Miller, P. B. Petersen, and R. J. Saykally, Chem. Phys. Lett. 387, 436 (2004).
[CrossRef]

Potma, E. O.

C. L. Evans, E. O. Potma, M. Puorishaag, D. Cote, C. P. Lin, and X. S. Xie, Proc. Natl. Acad. Sci. USA 102, 16807 (2005).
[CrossRef] [PubMed]

E. O. Potma and X. S. Xie, Opt. Photon. News 15(11), 40 (2004).
[CrossRef]

E. O. Potma, W. P. de Boeij, P. J. M. van Haastert, and D. A. Wiersma, Proc. Natl. Acad. Sci. USA 98, 1577 (2001).
[CrossRef] [PubMed]

Puorishaag, M.

C. L. Evans, E. O. Potma, M. Puorishaag, D. Cote, C. P. Lin, and X. S. Xie, Proc. Natl. Acad. Sci. USA 102, 16807 (2005).
[CrossRef] [PubMed]

Rinia, H. A.

Saykally, R. J.

K. P. Knutsen, B. M. Messer, R. M. Onorato, and R. J. Saykally, J. Phys. Chem. B 110, 5854 (2006).
[CrossRef] [PubMed]

K. P. Knutsen, J. C. Johnson, A. E. Miller, P. B. Petersen, and R. J. Saykally, Chem. Phys. Lett. 387, 436 (2004).
[CrossRef]

Schins, J. M.

Silberberg, Y.

N. Dudovich, D. Oron, and Y. Silberberg, Nature 418, 512 (2002).
[CrossRef] [PubMed]

Solinas, X.

Taylor, A. J.

Tobey, R.

van Haastert, P. J. M.

E. O. Potma, W. P. de Boeij, P. J. M. van Haastert, and D. A. Wiersma, Proc. Natl. Acad. Sci. USA 98, 1577 (2001).
[CrossRef] [PubMed]

Vartiainen, E. M.

Wiersma, D. A.

E. O. Potma, W. P. de Boeij, P. J. M. van Haastert, and D. A. Wiersma, Proc. Natl. Acad. Sci. USA 98, 1577 (2001).
[CrossRef] [PubMed]

Wurpel, G. W. H.

Xie, X. S.

C. L. Evans, E. O. Potma, M. Puorishaag, D. Cote, C. P. Lin, and X. S. Xie, Proc. Natl. Acad. Sci. USA 102, 16807 (2005).
[CrossRef] [PubMed]

E. O. Potma and X. S. Xie, Opt. Photon. News 15(11), 40 (2004).
[CrossRef]

A. Zumbusch, G. Holtom, and X. S. Xie, Phys. Rev. Lett. 92, 4142 (1999).
[CrossRef]

Yellampalle, B.

Zumbusch, A.

T. Hellerer, A. M. K. Enejder, and A. Zumbusch, Appl. Phys. Lett. 85, 25 (2004).
[CrossRef]

A. Zumbusch, G. Holtom, and X. S. Xie, Phys. Rev. Lett. 92, 4142 (1999).
[CrossRef]

Appl. Phys. Lett. (1)

T. Hellerer, A. M. K. Enejder, and A. Zumbusch, Appl. Phys. Lett. 85, 25 (2004).
[CrossRef]

Chem. Phys. Lett. (1)

K. P. Knutsen, J. C. Johnson, A. E. Miller, P. B. Petersen, and R. J. Saykally, Chem. Phys. Lett. 387, 436 (2004).
[CrossRef]

J. Phys. Chem. B (1)

K. P. Knutsen, B. M. Messer, R. M. Onorato, and R. J. Saykally, J. Phys. Chem. B 110, 5854 (2006).
[CrossRef] [PubMed]

Nature (1)

N. Dudovich, D. Oron, and Y. Silberberg, Nature 418, 512 (2002).
[CrossRef] [PubMed]

Opt. Express (3)

Opt. Lett. (2)

Opt. Photon. News (1)

E. O. Potma and X. S. Xie, Opt. Photon. News 15(11), 40 (2004).
[CrossRef]

Phys. Rev. A (1)

S. A. Malinovskaya, Phys. Rev. A 73, 033416 (2006).
[CrossRef]

Phys. Rev. Lett. (1)

A. Zumbusch, G. Holtom, and X. S. Xie, Phys. Rev. Lett. 92, 4142 (1999).
[CrossRef]

Proc. Natl. Acad. Sci. USA (2)

E. O. Potma, W. P. de Boeij, P. J. M. van Haastert, and D. A. Wiersma, Proc. Natl. Acad. Sci. USA 98, 1577 (2001).
[CrossRef] [PubMed]

C. L. Evans, E. O. Potma, M. Puorishaag, D. Cote, C. P. Lin, and X. S. Xie, Proc. Natl. Acad. Sci. USA 102, 16807 (2005).
[CrossRef] [PubMed]

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Figures (4)

Fig. 1
Fig. 1

Schematic of the CARS.

Fig. 2
Fig. 2

The coherence density plot as a function of Ω R ef and α in first proposed method at τ 0 = 15 [ ω 1 ] for (a) δ = 0 and for (b) δ = 0.1 [ ω ] .

Fig. 3
Fig. 3

Same as Fig. 2 for the roof method.

Fig. 4
Fig. 4

The energy of the bare (dashed curves) and the dressed states (solid curves) as a function of time for the roof method at α τ 0 2 = ± 10 . (a) δ = 0 , Ω R ef = 1.1 [ ω ] ; (b) δ = 0.1 [ ω ] , Ω R ef = 0.2 [ ω ] .

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