Abstract

We present what is believed to be the first microstructured polymer optical fiber (mPOF) fabricated from Topas cyclic olefin copolymer, which has attractive material and biochemical properties. This polymer allows for a novel type of fiber-optic biosensor, where localized sensor layers may be activated on the inner side of the air holes in a predetermined section of the mPOF. The concept is demonstrated using a fluorescence-based method for selective detection of fluorophore-labeled antibodies.

© 2007 Optical Society of America

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Corrections

Grigoriy Emiliyanov, Jesper B. Jensen, Ole Bang, Poul E. Hoiby, Lars H. Pedersen, Erik M. Kjær, and Lars Lindvold, "Localized biosensing with Topas microstructured polymer optical fiber: erratum," Opt. Lett. 32, 1059-1059 (2007)
https://www.osapublishing.org/ol/abstract.cfm?uri=ol-32-9-1059

References

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  1. P. St. J. Russell, Science 299, 358 (2003).
    [CrossRef] [PubMed]
  2. T. M. Monro, D. J. Richardson, and P. J. Bennett, Electron. Lett. 35, 1188 (1999).
    [CrossRef]
  3. J. B. Jensen, L. H. Pedersen, P. E. Hoiby, L. B. Nielsen, T. P. Hansen, J. R. Folkenberg, J. Riishede, D. Noordegraaf, K. Nielsen, A. Carlsen, and A. Bjarklev, Opt. Lett. 29, 1974 (2004).
    [CrossRef] [PubMed]
  4. J. B. Jensen, P. E. Hoiby, G. Emiliyanov, O. Bang, L. H. Pedersen, and A. Bjarklev, Opt. Express 13, 5883 (2005).
    [CrossRef] [PubMed]
  5. F. M. Cox, A. Argyros, and M. C. J. Large, Opt. Express 14, 4135 (2006).
    [CrossRef] [PubMed]
  6. J. M. Fini, Meas. Sci. Technol. 15, 1120 (2004).
    [CrossRef]
  7. Y. L. Hoo, W. Jin, C. Shi, H. L. Ho, D. N. Wang, and S. C. Ruan, Appl. Opt. 42, 3509 (2003).
    [CrossRef] [PubMed]
  8. L. Rindorf, P. E. Hoiby, J. B. Jensen, L. H. Pedersen, O. Bang, and O. Geschke, Anal. Bioanal. Chem. 385, 1370 (2006).
    [CrossRef] [PubMed]
  9. M. A. van Eijkelenborg, M. C. J. Large, A. Argyros, J. Zagari, S. Manos, N. A. Issa, I. Bassett, S. Fleming, R. C. McPhedran, C. Martijn de Sterke, and N. A. P. Nicorovici, Opt. Express 9, 319 (2001).
    [CrossRef] [PubMed]
  10. Topas COC brochure, Ticona Company, http://www.ticona.com.
  11. G. Khanarian and H. Celanese, Opt. Eng. (Bellingham) 40, 1024 (2001).
    [CrossRef]
  12. M. J. Brekner, H. Deckers, and H. Osan, 'Cycloolefin copolymers having low melt viscosity and low optical attenuation,' U.S. patent 5,637,400 (June 10, 1997).
  13. M. J. Brekner, H. Deckers, and H. Osan, 'Cycloolefin copolymers having high tear strength and low optical attenuation,' U.S. patent 6,214,951 (April 10, 2001).
  14. M. A. van Eijkelenborg, A. Argyros, G. Barton, M. Fellew, I. Bassett, G. Henry, N. A. Issa, M. C. J. Large, S. Manos, W. Padden, L. Poladian, and J. Zagari, Opt. Fiber Technol. 9, 199 (2003).
    [CrossRef]
  15. S. C. Xue, M. C. J. Large, G. W. Barton, R. I. Tanner, R. Lwin, and L. Poladian, J. Lightwave Technol. 24, 853 (2006).
    [CrossRef]
  16. K. Nielsen, D. Noordegraaf, T. Sørensen, A. Bjarklev, and T. P. Hansen, J. Opt. A, Pure Appl. Opt. 7, L13 (2005).
    [CrossRef]
  17. Exiqon Company, http://www.exiqon.dk.
  18. L. Rindorf, M. Dufva, J. B. Jensen, P. E. Hoiby, L. H. Pedersen, and O. Bang, Opt. Express 14, 8224 (2006).
    [CrossRef] [PubMed]

2006 (4)

2005 (2)

J. B. Jensen, P. E. Hoiby, G. Emiliyanov, O. Bang, L. H. Pedersen, and A. Bjarklev, Opt. Express 13, 5883 (2005).
[CrossRef] [PubMed]

K. Nielsen, D. Noordegraaf, T. Sørensen, A. Bjarklev, and T. P. Hansen, J. Opt. A, Pure Appl. Opt. 7, L13 (2005).
[CrossRef]

2004 (2)

2003 (3)

Y. L. Hoo, W. Jin, C. Shi, H. L. Ho, D. N. Wang, and S. C. Ruan, Appl. Opt. 42, 3509 (2003).
[CrossRef] [PubMed]

M. A. van Eijkelenborg, A. Argyros, G. Barton, M. Fellew, I. Bassett, G. Henry, N. A. Issa, M. C. J. Large, S. Manos, W. Padden, L. Poladian, and J. Zagari, Opt. Fiber Technol. 9, 199 (2003).
[CrossRef]

P. St. J. Russell, Science 299, 358 (2003).
[CrossRef] [PubMed]

2001 (2)

1999 (1)

T. M. Monro, D. J. Richardson, and P. J. Bennett, Electron. Lett. 35, 1188 (1999).
[CrossRef]

Argyros, A.

Bang, O.

Barton, G.

M. A. van Eijkelenborg, A. Argyros, G. Barton, M. Fellew, I. Bassett, G. Henry, N. A. Issa, M. C. J. Large, S. Manos, W. Padden, L. Poladian, and J. Zagari, Opt. Fiber Technol. 9, 199 (2003).
[CrossRef]

Barton, G. W.

Bassett, I.

M. A. van Eijkelenborg, A. Argyros, G. Barton, M. Fellew, I. Bassett, G. Henry, N. A. Issa, M. C. J. Large, S. Manos, W. Padden, L. Poladian, and J. Zagari, Opt. Fiber Technol. 9, 199 (2003).
[CrossRef]

M. A. van Eijkelenborg, M. C. J. Large, A. Argyros, J. Zagari, S. Manos, N. A. Issa, I. Bassett, S. Fleming, R. C. McPhedran, C. Martijn de Sterke, and N. A. P. Nicorovici, Opt. Express 9, 319 (2001).
[CrossRef] [PubMed]

Bennett, P. J.

T. M. Monro, D. J. Richardson, and P. J. Bennett, Electron. Lett. 35, 1188 (1999).
[CrossRef]

Bjarklev, A.

Brekner, M. J.

M. J. Brekner, H. Deckers, and H. Osan, 'Cycloolefin copolymers having low melt viscosity and low optical attenuation,' U.S. patent 5,637,400 (June 10, 1997).

M. J. Brekner, H. Deckers, and H. Osan, 'Cycloolefin copolymers having high tear strength and low optical attenuation,' U.S. patent 6,214,951 (April 10, 2001).

Carlsen, A.

Celanese, H.

G. Khanarian and H. Celanese, Opt. Eng. (Bellingham) 40, 1024 (2001).
[CrossRef]

Cox, F. M.

Deckers, H.

M. J. Brekner, H. Deckers, and H. Osan, 'Cycloolefin copolymers having high tear strength and low optical attenuation,' U.S. patent 6,214,951 (April 10, 2001).

M. J. Brekner, H. Deckers, and H. Osan, 'Cycloolefin copolymers having low melt viscosity and low optical attenuation,' U.S. patent 5,637,400 (June 10, 1997).

Dufva, M.

Emiliyanov, G.

Fellew, M.

M. A. van Eijkelenborg, A. Argyros, G. Barton, M. Fellew, I. Bassett, G. Henry, N. A. Issa, M. C. J. Large, S. Manos, W. Padden, L. Poladian, and J. Zagari, Opt. Fiber Technol. 9, 199 (2003).
[CrossRef]

Fini, J. M.

J. M. Fini, Meas. Sci. Technol. 15, 1120 (2004).
[CrossRef]

Fleming, S.

Folkenberg, J. R.

Geschke, O.

L. Rindorf, P. E. Hoiby, J. B. Jensen, L. H. Pedersen, O. Bang, and O. Geschke, Anal. Bioanal. Chem. 385, 1370 (2006).
[CrossRef] [PubMed]

Hansen, T. P.

Henry, G.

M. A. van Eijkelenborg, A. Argyros, G. Barton, M. Fellew, I. Bassett, G. Henry, N. A. Issa, M. C. J. Large, S. Manos, W. Padden, L. Poladian, and J. Zagari, Opt. Fiber Technol. 9, 199 (2003).
[CrossRef]

Ho, H. L.

Hoiby, P. E.

Hoo, Y. L.

Issa, N. A.

M. A. van Eijkelenborg, A. Argyros, G. Barton, M. Fellew, I. Bassett, G. Henry, N. A. Issa, M. C. J. Large, S. Manos, W. Padden, L. Poladian, and J. Zagari, Opt. Fiber Technol. 9, 199 (2003).
[CrossRef]

M. A. van Eijkelenborg, M. C. J. Large, A. Argyros, J. Zagari, S. Manos, N. A. Issa, I. Bassett, S. Fleming, R. C. McPhedran, C. Martijn de Sterke, and N. A. P. Nicorovici, Opt. Express 9, 319 (2001).
[CrossRef] [PubMed]

Jensen, J. B.

Jin, W.

Khanarian, G.

G. Khanarian and H. Celanese, Opt. Eng. (Bellingham) 40, 1024 (2001).
[CrossRef]

Large, M. C. J.

Lwin, R.

Manos, S.

M. A. van Eijkelenborg, A. Argyros, G. Barton, M. Fellew, I. Bassett, G. Henry, N. A. Issa, M. C. J. Large, S. Manos, W. Padden, L. Poladian, and J. Zagari, Opt. Fiber Technol. 9, 199 (2003).
[CrossRef]

M. A. van Eijkelenborg, M. C. J. Large, A. Argyros, J. Zagari, S. Manos, N. A. Issa, I. Bassett, S. Fleming, R. C. McPhedran, C. Martijn de Sterke, and N. A. P. Nicorovici, Opt. Express 9, 319 (2001).
[CrossRef] [PubMed]

Martijn de Sterke, C.

McPhedran, R. C.

Monro, T. M.

T. M. Monro, D. J. Richardson, and P. J. Bennett, Electron. Lett. 35, 1188 (1999).
[CrossRef]

Nicorovici, N. A. P.

Nielsen, K.

Nielsen, L. B.

Noordegraaf, D.

Osan, H.

M. J. Brekner, H. Deckers, and H. Osan, 'Cycloolefin copolymers having low melt viscosity and low optical attenuation,' U.S. patent 5,637,400 (June 10, 1997).

M. J. Brekner, H. Deckers, and H. Osan, 'Cycloolefin copolymers having high tear strength and low optical attenuation,' U.S. patent 6,214,951 (April 10, 2001).

Padden, W.

M. A. van Eijkelenborg, A. Argyros, G. Barton, M. Fellew, I. Bassett, G. Henry, N. A. Issa, M. C. J. Large, S. Manos, W. Padden, L. Poladian, and J. Zagari, Opt. Fiber Technol. 9, 199 (2003).
[CrossRef]

Pedersen, L. H.

Poladian, L.

S. C. Xue, M. C. J. Large, G. W. Barton, R. I. Tanner, R. Lwin, and L. Poladian, J. Lightwave Technol. 24, 853 (2006).
[CrossRef]

M. A. van Eijkelenborg, A. Argyros, G. Barton, M. Fellew, I. Bassett, G. Henry, N. A. Issa, M. C. J. Large, S. Manos, W. Padden, L. Poladian, and J. Zagari, Opt. Fiber Technol. 9, 199 (2003).
[CrossRef]

Richardson, D. J.

T. M. Monro, D. J. Richardson, and P. J. Bennett, Electron. Lett. 35, 1188 (1999).
[CrossRef]

Riishede, J.

Rindorf, L.

L. Rindorf, M. Dufva, J. B. Jensen, P. E. Hoiby, L. H. Pedersen, and O. Bang, Opt. Express 14, 8224 (2006).
[CrossRef] [PubMed]

L. Rindorf, P. E. Hoiby, J. B. Jensen, L. H. Pedersen, O. Bang, and O. Geschke, Anal. Bioanal. Chem. 385, 1370 (2006).
[CrossRef] [PubMed]

Ruan, S. C.

Russell, P. St. J.

P. St. J. Russell, Science 299, 358 (2003).
[CrossRef] [PubMed]

Shi, C.

Sørensen, T.

K. Nielsen, D. Noordegraaf, T. Sørensen, A. Bjarklev, and T. P. Hansen, J. Opt. A, Pure Appl. Opt. 7, L13 (2005).
[CrossRef]

Tanner, R. I.

van Eijkelenborg, M. A.

M. A. van Eijkelenborg, A. Argyros, G. Barton, M. Fellew, I. Bassett, G. Henry, N. A. Issa, M. C. J. Large, S. Manos, W. Padden, L. Poladian, and J. Zagari, Opt. Fiber Technol. 9, 199 (2003).
[CrossRef]

M. A. van Eijkelenborg, M. C. J. Large, A. Argyros, J. Zagari, S. Manos, N. A. Issa, I. Bassett, S. Fleming, R. C. McPhedran, C. Martijn de Sterke, and N. A. P. Nicorovici, Opt. Express 9, 319 (2001).
[CrossRef] [PubMed]

Wang, D. N.

Xue, S. C.

Zagari, J.

M. A. van Eijkelenborg, A. Argyros, G. Barton, M. Fellew, I. Bassett, G. Henry, N. A. Issa, M. C. J. Large, S. Manos, W. Padden, L. Poladian, and J. Zagari, Opt. Fiber Technol. 9, 199 (2003).
[CrossRef]

M. A. van Eijkelenborg, M. C. J. Large, A. Argyros, J. Zagari, S. Manos, N. A. Issa, I. Bassett, S. Fleming, R. C. McPhedran, C. Martijn de Sterke, and N. A. P. Nicorovici, Opt. Express 9, 319 (2001).
[CrossRef] [PubMed]

Anal. Bioanal. Chem. (1)

L. Rindorf, P. E. Hoiby, J. B. Jensen, L. H. Pedersen, O. Bang, and O. Geschke, Anal. Bioanal. Chem. 385, 1370 (2006).
[CrossRef] [PubMed]

Appl. Opt. (1)

Electron. Lett. (1)

T. M. Monro, D. J. Richardson, and P. J. Bennett, Electron. Lett. 35, 1188 (1999).
[CrossRef]

J. Lightwave Technol. (1)

J. Opt. A, Pure Appl. Opt. (1)

K. Nielsen, D. Noordegraaf, T. Sørensen, A. Bjarklev, and T. P. Hansen, J. Opt. A, Pure Appl. Opt. 7, L13 (2005).
[CrossRef]

Meas. Sci. Technol. (1)

J. M. Fini, Meas. Sci. Technol. 15, 1120 (2004).
[CrossRef]

Opt. Eng. (Bellingham) (1)

G. Khanarian and H. Celanese, Opt. Eng. (Bellingham) 40, 1024 (2001).
[CrossRef]

Opt. Express (4)

Opt. Fiber Technol. (1)

M. A. van Eijkelenborg, A. Argyros, G. Barton, M. Fellew, I. Bassett, G. Henry, N. A. Issa, M. C. J. Large, S. Manos, W. Padden, L. Poladian, and J. Zagari, Opt. Fiber Technol. 9, 199 (2003).
[CrossRef]

Opt. Lett. (1)

Science (1)

P. St. J. Russell, Science 299, 358 (2003).
[CrossRef] [PubMed]

Other (4)

M. J. Brekner, H. Deckers, and H. Osan, 'Cycloolefin copolymers having low melt viscosity and low optical attenuation,' U.S. patent 5,637,400 (June 10, 1997).

M. J. Brekner, H. Deckers, and H. Osan, 'Cycloolefin copolymers having high tear strength and low optical attenuation,' U.S. patent 6,214,951 (April 10, 2001).

Topas COC brochure, Ticona Company, http://www.ticona.com.

Exiqon Company, http://www.exiqon.dk.

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Figures (3)

Fig. 1
Fig. 1

Microscope pictures of the end facets of Topas mPOFs fabricated at COM DTU . Left: 18 hole mPOF with outer diameter 275 μ m , hole diameter 32 μ m , and core diameter 65 μ m . Right: 3 hole mPOF with outer diameter 220 μ m , hole diameter 50 μ m , and core diameter 12 μ m .

Fig. 2
Fig. 2

(a) Concept of immobilization of antibodies with UV light on the Topas surface. (b), (c) Epifluorescence microscope pictures of 2 mm sections of the ends of a Topas mPOF biosensor (b) with and (c) without a UV-activated sensor layer. Fluorescence is observed from only the activated fiber end in (b).

Fig. 3
Fig. 3

Fluorescence measurements from the 3 hole Topas mPOF biosensor (see Fig. 1) showing selective detection of (a) α-streptavidin and (b) α-CRP.

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