Abstract

Fluorescence tomography of diffuse media can yield optimal three-dimensional imaging when multiple projections over 360° geometries are captured, compared with limited projection angle systems such as implementations in the slab geometry. We demonstrate how it is possible to perform noncontact, 360° projection fluorescence tomography of mice using CCD-camera-based detection in free space, i.e., in the absence of matching fluids. This approach achieves high spatial sampling of photons propagating through tissue and yields a superior information content data set compared with fiber-based 360° implementations. Reconstruction feasibility using 36 projections in 10° steps is demonstrated in mice.

© 2007 Optical Society of America

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