Abstract

A novel electro-optically modulated surface plasmon resonance (EOMSPR) biosensor based on phase detection by collinear heterodyne interferometry is presented. Its operation is by means of modulating the SPR-induced phase variation by electro-optic effect. Because the relation between the phase change and the applied voltage is highly sensitive to analyte properties, the linear regression slope of this relation can be used in the analyte detection. The detection characteristics of this EOMSPR biosensor are measured, and their dependences on waveguide width and gold-film thickness are discussed. This novel EOMSPR biosensor has attractive features, such as compactness, resolution tunability, and noise reduction.

© 2007 Optical Society of America

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References

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  1. H. Raether, Surface Plasmons on Smooth and Rough Surfaces and on Gratings (Springer, 1988).
  2. J. Dostáltek, J. Ctyroký, J. Homola, E. Brynda, M. Skalský, P. Nekvindová, J. Spirková, J. Skvor, and J. Schröfel, Sens. Actuators B 76, 8 (2001).
    [CrossRef]
  3. K. Mitsui, Y. Handa, and K. Kajikawa, Appl. Phys. Lett. 85, 4231 (2004).
    [CrossRef]
  4. J. Homola, S. S. Yee, and G. Gauglitz, Sens. Actuators B 54, 3 (1999).
    [CrossRef]
  5. S. Shen, T. Liu, and J. Guo, Appl. Opt. 37, 1747 (1998).
    [CrossRef]
  6. T. Akimoto, S. Sasaki, K. Ikebukuro, and I. Karube, Biosens. Bioelectron. 15, 355 (2000).
    [CrossRef]
  7. T. J. Wang, W. S. Lin, and F. K. Liu, Biosens. Bioelectron. 22, 1441 (2007).
    [CrossRef]
  8. A. K. Sheridan, R. D. Harris, P. N. Bartlett, and J. S. Wilkinson, Sens. Actuators B 97, 114 (2004).
    [CrossRef]
  9. M. H. Chiu, S. F. Wang, and R. S. Chang, Opt. Lett. 30, 233 (2005).
    [CrossRef] [PubMed]

2007

T. J. Wang, W. S. Lin, and F. K. Liu, Biosens. Bioelectron. 22, 1441 (2007).
[CrossRef]

2005

2004

A. K. Sheridan, R. D. Harris, P. N. Bartlett, and J. S. Wilkinson, Sens. Actuators B 97, 114 (2004).
[CrossRef]

K. Mitsui, Y. Handa, and K. Kajikawa, Appl. Phys. Lett. 85, 4231 (2004).
[CrossRef]

2001

J. Dostáltek, J. Ctyroký, J. Homola, E. Brynda, M. Skalský, P. Nekvindová, J. Spirková, J. Skvor, and J. Schröfel, Sens. Actuators B 76, 8 (2001).
[CrossRef]

2000

T. Akimoto, S. Sasaki, K. Ikebukuro, and I. Karube, Biosens. Bioelectron. 15, 355 (2000).
[CrossRef]

1999

J. Homola, S. S. Yee, and G. Gauglitz, Sens. Actuators B 54, 3 (1999).
[CrossRef]

1998

Appl. Opt.

Appl. Phys. Lett.

K. Mitsui, Y. Handa, and K. Kajikawa, Appl. Phys. Lett. 85, 4231 (2004).
[CrossRef]

Biosens. Bioelectron.

T. Akimoto, S. Sasaki, K. Ikebukuro, and I. Karube, Biosens. Bioelectron. 15, 355 (2000).
[CrossRef]

T. J. Wang, W. S. Lin, and F. K. Liu, Biosens. Bioelectron. 22, 1441 (2007).
[CrossRef]

Opt. Lett.

Sens. Actuators B

A. K. Sheridan, R. D. Harris, P. N. Bartlett, and J. S. Wilkinson, Sens. Actuators B 97, 114 (2004).
[CrossRef]

J. Homola, S. S. Yee, and G. Gauglitz, Sens. Actuators B 54, 3 (1999).
[CrossRef]

J. Dostáltek, J. Ctyroký, J. Homola, E. Brynda, M. Skalský, P. Nekvindová, J. Spirková, J. Skvor, and J. Schröfel, Sens. Actuators B 76, 8 (2001).
[CrossRef]

Other

H. Raether, Surface Plasmons on Smooth and Rough Surfaces and on Gratings (Springer, 1988).

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Figures (4)

Fig. 1
Fig. 1

Device structure of the EOMSPR biosensor based on phase detection.

Fig. 2
Fig. 2

Schematic configuration of the EOMSPR biosensing measurement setup for phase detection using the collinear heterodyne interferometry. M, mirror; PBS, polarizing beam splitter; AOM, acousto-optic modulator; BS, beam splitter; PD, photodetector.

Fig. 3
Fig. 3

Dependence of phase shift on the (a) beta-blocker concentration and (b) applied voltage in the SPR biosensor.

Fig. 4
Fig. 4

Dependence of linear regression slope on the beta-blocker concentration for (a) waveguide width of 4 20 μ m and (b) gold-film thickness of 5 20 nm in the EOMSPR biosensor.

Equations (5)

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r q = r 12 q + r 23 q exp ( i 2 k z 2 d 2 ) 1 + r 12 q r 23 q exp ( i 2 k z 2 d 2 ) = r q exp ( i ϕ q ) ,
q = TM , TE ,
r i j q = ( z i q z j q ) ( z i q + z j q ) ,
k z i = k 0 ( n i 2 n 1 2 sin 2 θ ) 1 2 ,
ϕ = m ( ϕ TM ϕ TE ) .

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