Abstract

We introduce a novel contrast mechanism for imaging blood flow by use of magnetomotive optical Doppler tomography (MM-ODT), which combines an externally applied temporally oscillating high-strength magnetic field with ODT to detect erythrocytes moving according to the field gradient. Hemoglobin contrast was demonstrated in a capillary tube filled with moving blood by imaging the Doppler frequency shift, which was observed independently of blood flow rate and direction. Results suggest that MM-ODT may be a promising technique with which to image blood flow.

© 2006 Optical Society of America

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References

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  1. T. M. Lee, O. L. Oldenburg, S. Sitafalwalla, D. L. Marks, W. Luo, F. J. J. Toublan, K. S. Suslick, and S. A. Boppart, Opt. Lett. 28, 1546 (2003).
    [CrossRef] [PubMed]
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    [PubMed]
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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]

2005 (1)

2004 (1)

C. Loo, A. Lin, L. Hirsch, M. H. Lee, J. Barton, N. Halas, J. West, and R. Drezek, Technol. Cancer Res. Treat. 3, 33 (2004).
[PubMed]

2003 (2)

1987 (1)

M. Okazaki, N. Maeda, and T. Shiga, Eur. Biophys. J. 14, 139 (1987).
[CrossRef] [PubMed]

Barton, J.

C. Loo, A. Lin, L. Hirsch, M. H. Lee, J. Barton, N. Halas, J. West, and R. Drezek, Technol. Cancer Res. Treat. 3, 33 (2004).
[PubMed]

Boppart, S. A.

Drezek, R.

C. Loo, A. Lin, L. Hirsch, M. H. Lee, J. Barton, N. Halas, J. West, and R. Drezek, Technol. Cancer Res. Treat. 3, 33 (2004).
[PubMed]

Gordon, M. L.

Gunther, J. R.

Halas, N.

C. Loo, A. Lin, L. Hirsch, M. H. Lee, J. Barton, N. Halas, J. West, and R. Drezek, Technol. Cancer Res. Treat. 3, 33 (2004).
[PubMed]

Hirsch, L.

C. Loo, A. Lin, L. Hirsch, M. H. Lee, J. Barton, N. Halas, J. West, and R. Drezek, Technol. Cancer Res. Treat. 3, 33 (2004).
[PubMed]

Lee, M. H.

C. Loo, A. Lin, L. Hirsch, M. H. Lee, J. Barton, N. Halas, J. West, and R. Drezek, Technol. Cancer Res. Treat. 3, 33 (2004).
[PubMed]

Lee, T. M.

Lin, A.

C. Loo, A. Lin, L. Hirsch, M. H. Lee, J. Barton, N. Halas, J. West, and R. Drezek, Technol. Cancer Res. Treat. 3, 33 (2004).
[PubMed]

Lo, S.

Loo, C.

C. Loo, A. Lin, L. Hirsch, M. H. Lee, J. Barton, N. Halas, J. West, and R. Drezek, Technol. Cancer Res. Treat. 3, 33 (2004).
[PubMed]

Luo, W.

Maeda, N.

M. Okazaki, N. Maeda, and T. Shiga, Eur. Biophys. J. 14, 139 (1987).
[CrossRef] [PubMed]

Marks, D. L.

Mok, A.

Okazaki, M.

M. Okazaki, N. Maeda, and T. Shiga, Eur. Biophys. J. 14, 139 (1987).
[CrossRef] [PubMed]

Oldenburg, A. L.

Oldenburg, O. L.

Pekar, J.

Qi, B.

Seng-Yue, E.

Shiga, T.

M. Okazaki, N. Maeda, and T. Shiga, Eur. Biophys. J. 14, 139 (1987).
[CrossRef] [PubMed]

Sitafalwalla, S.

Suslick, K. S.

Toublan, F. J. J.

Vitkin, I. A.

West, J.

C. Loo, A. Lin, L. Hirsch, M. H. Lee, J. Barton, N. Halas, J. West, and R. Drezek, Technol. Cancer Res. Treat. 3, 33 (2004).
[PubMed]

Wilson, B. C.

Yang, V. X. D.

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Figures (4)

Fig. 1
Fig. 1

(Color online) Schematic diagram of the probe beam, the flow sample, and the solenoid coil.

Fig. 2
Fig. 2

(Color online) (a), (b) OCT and ODT M-mode images, respectively, without an external magnetic field. (c), (d) OCT and ODT images, respectively, with a 50 Hz magnetic field. White vertical bar, 200 μ m ; white horizontal bar, 20 ms .

Fig. 3
Fig. 3

(Color online) (a), (b) M-mode ODT images of 5 mm s blood flow without and with a 50 Hz magnetic field, respectively. (c), (d) M-mode ODT images of 30 mm s blood flow without and with a 50 Hz magnetic field, respectively. Black vertical bar, 200 μ m ; black horizontal bar, 20 ms .

Fig. 4
Fig. 4

(Color online) Doppler frequency shift profiles (a) without an external magnetic field and (b) with a 50 Hz magnetic field.

Equations (2)

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F z = Δ χ V μ 0 B B z ,
I f 2 I R I S exp { i [ 2 π f 0 t + 4 π n z ( t ) λ 0 ] } ,

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