Abstract

We report on the quantitative influence of speckles in laser Doppler perfusion imaging. The influence of speckles on the signal amplitude and on the Doppler spectrum is demonstrated experimentally for particle suspensions with different scattering levels and various beam widths. It is shown that the type of tissue affects the instrumental response through the effect of lateral light diffusion on the number of speckles involved in the detection process. These effects are largest for narrow beams.

© 2006 Optical Society of America

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References

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2005 (1)

2004 (1)

T. Binzoni, T. S Leung, M. L. Seghier, and D. T. Delpy, Phys. Med. Biol. 49, 5445 (2004).
[CrossRef]

2001 (1)

1997 (1)

1996 (1)

1995 (1)

J. D. Briers and S. Webster, Opt. Commun. 116, 36 (1995).
[CrossRef]

1993 (1)

K. Wårdell, A. Jakobsson, and G. E. Nilsson, IEEE Trans. Biomed. Eng. 40, 309 (1993).
[CrossRef] [PubMed]

1991 (1)

T. J. H. Essex and P. O. Byrne, J. Biomed. Eng. 13, 189 (1991).
[CrossRef] [PubMed]

1987 (1)

1981 (1)

1955 (1)

A. T. Forrester, R. A. Gudmudsen, and P. O. Johnson, Phys. Rev. 99, 1691 (1955).
[CrossRef]

Binzoni, T.

T. Binzoni, T. S Leung, M. L. Seghier, and D. T. Delpy, Phys. Med. Biol. 49, 5445 (2004).
[CrossRef]

Boas, D. A

Bonner, R.

Briers, J. D

Briers, J. D.

J. D. Briers and S. Webster, Opt. Commun. 116, 36 (1995).
[CrossRef]

Byrne, P. O.

T. J. H. Essex and P. O. Byrne, J. Biomed. Eng. 13, 189 (1991).
[CrossRef] [PubMed]

Cariou, J.

de Mul, F. F.

Delpy, D. T.

T. Binzoni, T. S Leung, M. L. Seghier, and D. T. Delpy, Phys. Med. Biol. 49, 5445 (2004).
[CrossRef]

Essex, T. J.

T. J. H. Essex and P. O. Byrne, J. Biomed. Eng. 13, 189 (1991).
[CrossRef] [PubMed]

Forrester, A. T.

A. T. Forrester, R. A. Gudmudsen, and P. O. Johnson, Phys. Rev. 99, 1691 (1955).
[CrossRef]

Fujii, H.

Gudmudsen, R. A.

A. T. Forrester, R. A. Gudmudsen, and P. O. Johnson, Phys. Rev. 99, 1691 (1955).
[CrossRef]

Guern, Y.

Ikawa, H.

Jakobsson, A.

K. Wårdell, A. Jakobsson, and G. E. Nilsson, IEEE Trans. Biomed. Eng. 40, 309 (1993).
[CrossRef] [PubMed]

Johnson, P. O.

A. T. Forrester, R. A. Gudmudsen, and P. O. Johnson, Phys. Rev. 99, 1691 (1955).
[CrossRef]

Le Brun, G.

Le Jeune, B.

Leung, T. S

T. Binzoni, T. S Leung, M. L. Seghier, and D. T. Delpy, Phys. Med. Biol. 49, 5445 (2004).
[CrossRef]

Lotrian, J.

Nilsson, G. E.

K. Wårdell, A. Jakobsson, and G. E. Nilsson, IEEE Trans. Biomed. Eng. 40, 309 (1993).
[CrossRef] [PubMed]

Nohira, K.

Nossal, R.

Ohura, T.

Piederrière, Y.

Seghier, M. L.

T. Binzoni, T. S Leung, M. L. Seghier, and D. T. Delpy, Phys. Med. Biol. 49, 5445 (2004).
[CrossRef]

Serov, A.

Steenbergen, W.

Wårdell, K.

K. Wårdell, A. Jakobsson, and G. E. Nilsson, IEEE Trans. Biomed. Eng. 40, 309 (1993).
[CrossRef] [PubMed]

Webster, S.

J. D. Briers and S. Webster, Opt. Commun. 116, 36 (1995).
[CrossRef]

Yamamoto, Y.

Yodh, A. G.

Appl. Opt. (2)

IEEE Trans. Biomed. Eng. (1)

K. Wårdell, A. Jakobsson, and G. E. Nilsson, IEEE Trans. Biomed. Eng. 40, 309 (1993).
[CrossRef] [PubMed]

J. Biomed. Eng. (1)

T. J. H. Essex and P. O. Byrne, J. Biomed. Eng. 13, 189 (1991).
[CrossRef] [PubMed]

J. Opt. Soc. Am. A (3)

Opt. Commun. (1)

J. D. Briers and S. Webster, Opt. Commun. 116, 36 (1995).
[CrossRef]

Opt. Express (1)

Phys. Med. Biol. (1)

T. Binzoni, T. S Leung, M. L. Seghier, and D. T. Delpy, Phys. Med. Biol. 49, 5445 (2004).
[CrossRef]

Phys. Rev. (1)

A. T. Forrester, R. A. Gudmudsen, and P. O. Johnson, Phys. Rev. 99, 1691 (1955).
[CrossRef]

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Figures (4)

Fig. 1
Fig. 1

Schematic of diffusely reflected focused (solid double-headed arrows) and unfocused (dashed double-headed arrows) light illuminating a photodetector.

Fig. 2
Fig. 2

Normalized power spectra for μ s = 4.0 mm 1 .

Fig. 3
Fig. 3

M 0 DC 2 versus reduced scattering coefficient for several beam widths.

Fig. 4
Fig. 4

M 1 M 0 versus reduced scattering coefficient for several beam widths.

Equations (4)

Equations on this page are rendered with MathJax. Learn more.

M i = 0 P ( ω ) ω i d ω ,
i AC 2 i DC 2 = 1 N f D ( 2 f D ) ,
i AC 2 i DC 2 = λ 2 l 1 2 A det A tis f D ( 2 f D ) .
i AC 2 i DC 2 = λ 2 l 3 2 A lens A tis f D ( 2 f D ) .

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