Abstract

A coupled waveguide–surface plasmon resonance (CWSPR) biosensor based on the Kretschmann configuration is developed. The CWSPR couples the surface plasmon resonance (SPR) mode and the waveguide mode and generates two sharp resonance dips in the reflectivity spectrum. The proposed biosensor not only retains the same sensing sensitivity as that of a conventional SPR device but also yields sharper dips in the reflectivity spectrum and therefore provides an improved measurement precision. The two reflectivity spectrum dips enable the refractive indices and thicknesses of both the self-assembled monolayer and a layer of human serum albumin absorbed dynamically on the sensing surface to be determined directly on a real-time basis. The CWSPR biosensor provides the capability to detect the biomolecular conformational changes that occur in biomolecular kinetic interactions.

© 2006 Optical Society of America

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F. S. Damos, R. C. S. Luz, and L. T. Kubota, Langmuir 21, 602 (2005).
[CrossRef] [PubMed]

2004

F.-C. Chien and S.-J. Chen, Biosens. Bioelectron. 20, 633 (2004).
[CrossRef] [PubMed]

2003

G. H. Cross, A. A. Reeves, S. Brand, J. F. Popplewell, L. L. Peel, M. J. Swann, and N. J. Freeman, Biosens. Bioelectron. 19, 383 (2003).
[CrossRef] [PubMed]

2000

R. Georgiadis, K. P. Peterlinz, and A. W. Peterson, J. Am. Chem. Soc. 122, 3166 (2000).
[CrossRef]

1999

J. Homola, S. S. Yee, and G. Gauglitz, Sens. Actuators B 54, 3 (1999).
[CrossRef]

1998

L. S. Jung, C. T. Campbell, T. M. Chinowsky, M. N. Mar, and S. S. Yee, Langmuir 14, 5636 (1998).
[CrossRef]

1997

Z. Salamon, H. A. Macleod, and G. Tollin, Biophys. J. 73, 2791 (1997).
[CrossRef] [PubMed]

1996

K. A. Peterlinz and R. Georgiadis, Opt. Commun. 130, 260 (1996).
[CrossRef]

1983

1981

D. Sarid, Phys. Rev. Lett. 47, 1927 (1981).
[CrossRef]

1978

1977

G. J. Kovacs and G. D. Scott, Phys. Rev. B 16, 1297 (1977).
[CrossRef]

Brand, S.

G. H. Cross, A. A. Reeves, S. Brand, J. F. Popplewell, L. L. Peel, M. J. Swann, and N. J. Freeman, Biosens. Bioelectron. 19, 383 (2003).
[CrossRef] [PubMed]

Campbell, C. T.

L. S. Jung, C. T. Campbell, T. M. Chinowsky, M. N. Mar, and S. S. Yee, Langmuir 14, 5636 (1998).
[CrossRef]

Chen, S.-J.

F.-C. Chien and S.-J. Chen, Biosens. Bioelectron. 20, 633 (2004).
[CrossRef] [PubMed]

Chien, F.-C.

F.-C. Chien and S.-J. Chen, Biosens. Bioelectron. 20, 633 (2004).
[CrossRef] [PubMed]

Chinowsky, T. M.

L. S. Jung, C. T. Campbell, T. M. Chinowsky, M. N. Mar, and S. S. Yee, Langmuir 14, 5636 (1998).
[CrossRef]

Craig, A. E.

Cross, G. H.

G. H. Cross, A. A. Reeves, S. Brand, J. F. Popplewell, L. L. Peel, M. J. Swann, and N. J. Freeman, Biosens. Bioelectron. 19, 383 (2003).
[CrossRef] [PubMed]

Damos, F. S.

F. S. Damos, R. C. S. Luz, and L. T. Kubota, Langmuir 21, 602 (2005).
[CrossRef] [PubMed]

Freeman, N. J.

G. H. Cross, A. A. Reeves, S. Brand, J. F. Popplewell, L. L. Peel, M. J. Swann, and N. J. Freeman, Biosens. Bioelectron. 19, 383 (2003).
[CrossRef] [PubMed]

Gauglitz, G.

J. Homola, S. S. Yee, and G. Gauglitz, Sens. Actuators B 54, 3 (1999).
[CrossRef]

Georgiadis, R.

R. Georgiadis, K. P. Peterlinz, and A. W. Peterson, J. Am. Chem. Soc. 122, 3166 (2000).
[CrossRef]

K. A. Peterlinz and R. Georgiadis, Opt. Commun. 130, 260 (1996).
[CrossRef]

Homola, J.

J. Homola, S. S. Yee, and G. Gauglitz, Sens. Actuators B 54, 3 (1999).
[CrossRef]

Jung, L. S.

L. S. Jung, C. T. Campbell, T. M. Chinowsky, M. N. Mar, and S. S. Yee, Langmuir 14, 5636 (1998).
[CrossRef]

Kovacs, G. J.

G. J. Kovacs and G. D. Scott, Appl. Opt. 17, 3314 (1978).
[CrossRef] [PubMed]

G. J. Kovacs and G. D. Scott, Phys. Rev. B 16, 1297 (1977).
[CrossRef]

Kubota, L. T.

F. S. Damos, R. C. S. Luz, and L. T. Kubota, Langmuir 21, 602 (2005).
[CrossRef] [PubMed]

Luz, R. C.

F. S. Damos, R. C. S. Luz, and L. T. Kubota, Langmuir 21, 602 (2005).
[CrossRef] [PubMed]

Macleod, H. A.

Z. Salamon, H. A. Macleod, and G. Tollin, Biophys. J. 73, 2791 (1997).
[CrossRef] [PubMed]

Mar, M. N.

L. S. Jung, C. T. Campbell, T. M. Chinowsky, M. N. Mar, and S. S. Yee, Langmuir 14, 5636 (1998).
[CrossRef]

Olson, G. A.

Peel, L. L.

G. H. Cross, A. A. Reeves, S. Brand, J. F. Popplewell, L. L. Peel, M. J. Swann, and N. J. Freeman, Biosens. Bioelectron. 19, 383 (2003).
[CrossRef] [PubMed]

Peterlinz, K. A.

K. A. Peterlinz and R. Georgiadis, Opt. Commun. 130, 260 (1996).
[CrossRef]

Peterlinz, K. P.

R. Georgiadis, K. P. Peterlinz, and A. W. Peterson, J. Am. Chem. Soc. 122, 3166 (2000).
[CrossRef]

Peterson, A. W.

R. Georgiadis, K. P. Peterlinz, and A. W. Peterson, J. Am. Chem. Soc. 122, 3166 (2000).
[CrossRef]

Popplewell, J. F.

G. H. Cross, A. A. Reeves, S. Brand, J. F. Popplewell, L. L. Peel, M. J. Swann, and N. J. Freeman, Biosens. Bioelectron. 19, 383 (2003).
[CrossRef] [PubMed]

Raether, H.

H. Raether, Surface Plasmons on Smooth and Rough Surfaces and on Gratings (Springer-Verlag, 1988).

Reeves, A. A.

G. H. Cross, A. A. Reeves, S. Brand, J. F. Popplewell, L. L. Peel, M. J. Swann, and N. J. Freeman, Biosens. Bioelectron. 19, 383 (2003).
[CrossRef] [PubMed]

Salamon, Z.

Z. Salamon, H. A. Macleod, and G. Tollin, Biophys. J. 73, 2791 (1997).
[CrossRef] [PubMed]

Sarid, D.

Scott, G. D.

G. J. Kovacs and G. D. Scott, Appl. Opt. 17, 3314 (1978).
[CrossRef] [PubMed]

G. J. Kovacs and G. D. Scott, Phys. Rev. B 16, 1297 (1977).
[CrossRef]

Swann, M. J.

G. H. Cross, A. A. Reeves, S. Brand, J. F. Popplewell, L. L. Peel, M. J. Swann, and N. J. Freeman, Biosens. Bioelectron. 19, 383 (2003).
[CrossRef] [PubMed]

Tollin, G.

Z. Salamon, H. A. Macleod, and G. Tollin, Biophys. J. 73, 2791 (1997).
[CrossRef] [PubMed]

Yee, S. S.

J. Homola, S. S. Yee, and G. Gauglitz, Sens. Actuators B 54, 3 (1999).
[CrossRef]

L. S. Jung, C. T. Campbell, T. M. Chinowsky, M. N. Mar, and S. S. Yee, Langmuir 14, 5636 (1998).
[CrossRef]

Appl. Opt.

Biophys. J.

Z. Salamon, H. A. Macleod, and G. Tollin, Biophys. J. 73, 2791 (1997).
[CrossRef] [PubMed]

Biosens. Bioelectron.

G. H. Cross, A. A. Reeves, S. Brand, J. F. Popplewell, L. L. Peel, M. J. Swann, and N. J. Freeman, Biosens. Bioelectron. 19, 383 (2003).
[CrossRef] [PubMed]

F.-C. Chien and S.-J. Chen, Biosens. Bioelectron. 20, 633 (2004).
[CrossRef] [PubMed]

J. Am. Chem. Soc.

R. Georgiadis, K. P. Peterlinz, and A. W. Peterson, J. Am. Chem. Soc. 122, 3166 (2000).
[CrossRef]

Langmuir

F. S. Damos, R. C. S. Luz, and L. T. Kubota, Langmuir 21, 602 (2005).
[CrossRef] [PubMed]

L. S. Jung, C. T. Campbell, T. M. Chinowsky, M. N. Mar, and S. S. Yee, Langmuir 14, 5636 (1998).
[CrossRef]

Opt. Commun.

K. A. Peterlinz and R. Georgiadis, Opt. Commun. 130, 260 (1996).
[CrossRef]

Opt. Lett.

Phys. Rev. B

G. J. Kovacs and G. D. Scott, Phys. Rev. B 16, 1297 (1977).
[CrossRef]

Phys. Rev. Lett.

D. Sarid, Phys. Rev. Lett. 47, 1927 (1981).
[CrossRef]

Sens. Actuators B

J. Homola, S. S. Yee, and G. Gauglitz, Sens. Actuators B 54, 3 (1999).
[CrossRef]

Other

H. Raether, Surface Plasmons on Smooth and Rough Surfaces and on Gratings (Springer-Verlag, 1988).

J.Davies, ed., Surface Analytical Techniques for Probing Biomaterial Processes (CRC Press, 1996).

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Figures (3)

Fig. 1
Fig. 1

(a) Configuration of the CWSPR biosensor. (b) Reflectivity spectra of two SPR-type biosensors as a function of the incident angle (conventional SPR, dashed curve; CWSPR, solid curve).

Fig. 2
Fig. 2

Solutions for SAM of 16-mercaptohexadecanoic acid.

Fig. 3
Fig. 3

(a) CWSPR adsorption profiles for 1 μ M HSA showing the difference in two CWSPR dips (dashed curve, first CWSPR dip; solid curve, second CWSPR dip). (b) Change in thickness (dashed curve) and refractive index (solid curve) of the HSA monolayer during HSA adsorption on the carboxyl-modified surface of the CWSPR biosensor.

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