Abstract

This is believed to be the first demonstration of near-infrared (NIR) optical tomography employed at the endoscope scale and at a rapid sampling speed that allows translation to in vivo use. A spread-spectral-encoding technique based on a broadband light source and linear-to-circular fiber bundling was used to provide endoscopic probing of many source–detector fibers for tomography as well as parallel sampling of all source–detector pairs for rapid imaging. Endoscopic NIR tomography at an 8Hz frame rate was achieved in phantoms and tissue specimens with a 12mm probe housing eight sources and eight detectors. This novel approach provides the key feasibility studies to allow this blood-based contrast imaging technology to be attempted in detection of cancer in internal organs via endoscopic interrogation.

© 2006 Optical Society of America

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