Abstract

We report on a new detection scheme for Fourier domain optical coherence microscopy that exhibits high transverse resolution along an axially extended focal range. Nearly constant transverse resolution of 1.5μm along a focal range of 200μm is experimentally verified with a maximum sensitivity of 105dB. A broad-bandwidth Ti:sapphire laser allowed for an axial resolution of 3μm in air.

© 2006 Optical Society of America

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References

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2006 (2)

2005 (3)

Y. Yasuno, Y. Sando, J. I. Sugisaka, T. Endo, S. Makita, G. Aoki, M. Itoh, and T. Yatagai, Opt. Quantum Electron. 37, 1185 (2005).
[CrossRef]

M. A. Choma, A. K. Ellerbee, C. Yang, T. L. Creazzo, and J. A. Izatt, Opt. Lett. 30, 1162 (2005).
[CrossRef] [PubMed]

T. S. Ralston, D. L. Marks, F. Kamalabadi, and S. A. Boppart, IEEE Trans. Image Process. 14, 1254 (2005).
[CrossRef] [PubMed]

2004 (1)

2003 (1)

2002 (1)

1997 (1)

J. M. Schmitt, S. L. Lee, and K. M. Yung, Opt. Commun. 142, 203 (1997).
[CrossRef]

1995 (1)

A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. Elzaiat, Opt. Commun. 117, 43 (1995).
[CrossRef]

1991 (1)

Aoki, G.

Y. Yasuno, Y. Sando, J. I. Sugisaka, T. Endo, S. Makita, G. Aoki, M. Itoh, and T. Yatagai, Opt. Quantum Electron. 37, 1185 (2005).
[CrossRef]

Boppart, S. A.

T. S. Ralston, D. L. Marks, F. Kamalabadi, and S. A. Boppart, IEEE Trans. Image Process. 14, 1254 (2005).
[CrossRef] [PubMed]

Bouma, B. E.

Cable, A.

Cense, B.

Chen, T. C.

Chen, Z. P.

Choma, M. A.

Creazzo, T. L.

de Boer, J. F.

Ding, Z. H.

Ellerbee, A. K.

Elzaiat, S. Y.

A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. Elzaiat, Opt. Commun. 117, 43 (1995).
[CrossRef]

Endo, T.

Y. Yasuno, Y. Sando, J. I. Sugisaka, T. Endo, S. Makita, G. Aoki, M. Itoh, and T. Yatagai, Opt. Quantum Electron. 37, 1185 (2005).
[CrossRef]

Fercher, A. F.

R. Leitgeb, C. K. Hitzenberger, and A. F. Fercher, Opt. Express 11, 889 (2003).
[CrossRef] [PubMed]

A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. Elzaiat, Opt. Commun. 117, 43 (1995).
[CrossRef]

Fujimoto, J. G.

Herman, R. M.

Hitzenberger, C. K.

R. Leitgeb, C. K. Hitzenberger, and A. F. Fercher, Opt. Express 11, 889 (2003).
[CrossRef] [PubMed]

A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. Elzaiat, Opt. Commun. 117, 43 (1995).
[CrossRef]

Huber, R.

Itoh, M.

Y. Yasuno, J. I. Sugisaka, Y. Sando, Y. Nakamura, S. Makita, M. Itoh, and T. Yatagai, Opt. Express 14, 1006 (2006).
[CrossRef] [PubMed]

Y. Yasuno, Y. Sando, J. I. Sugisaka, T. Endo, S. Makita, G. Aoki, M. Itoh, and T. Yatagai, Opt. Quantum Electron. 37, 1185 (2005).
[CrossRef]

Izatt, J. A.

Jiang, J. Y.

Kamalabadi, F.

T. S. Ralston, D. L. Marks, F. Kamalabadi, and S. A. Boppart, IEEE Trans. Image Process. 14, 1254 (2005).
[CrossRef] [PubMed]

Kamp, G.

A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. Elzaiat, Opt. Commun. 117, 43 (1995).
[CrossRef]

Lee, S. L.

J. M. Schmitt, S. L. Lee, and K. M. Yung, Opt. Commun. 142, 203 (1997).
[CrossRef]

Leitgeb, R.

Makita, S.

Y. Yasuno, J. I. Sugisaka, Y. Sando, Y. Nakamura, S. Makita, M. Itoh, and T. Yatagai, Opt. Express 14, 1006 (2006).
[CrossRef] [PubMed]

Y. Yasuno, Y. Sando, J. I. Sugisaka, T. Endo, S. Makita, G. Aoki, M. Itoh, and T. Yatagai, Opt. Quantum Electron. 37, 1185 (2005).
[CrossRef]

Marks, D. L.

T. S. Ralston, D. L. Marks, F. Kamalabadi, and S. A. Boppart, IEEE Trans. Image Process. 14, 1254 (2005).
[CrossRef] [PubMed]

Nakamura, Y.

Nassif, N.

Nelson, J. S.

Park, B. H.

Ralston, T. S.

T. S. Ralston, D. L. Marks, F. Kamalabadi, and S. A. Boppart, IEEE Trans. Image Process. 14, 1254 (2005).
[CrossRef] [PubMed]

Ren, H. W.

Sando, Y.

Y. Yasuno, J. I. Sugisaka, Y. Sando, Y. Nakamura, S. Makita, M. Itoh, and T. Yatagai, Opt. Express 14, 1006 (2006).
[CrossRef] [PubMed]

Y. Yasuno, Y. Sando, J. I. Sugisaka, T. Endo, S. Makita, G. Aoki, M. Itoh, and T. Yatagai, Opt. Quantum Electron. 37, 1185 (2005).
[CrossRef]

Schmitt, J. M.

J. M. Schmitt, S. L. Lee, and K. M. Yung, Opt. Commun. 142, 203 (1997).
[CrossRef]

Sugisaka, J. I.

Y. Yasuno, J. I. Sugisaka, Y. Sando, Y. Nakamura, S. Makita, M. Itoh, and T. Yatagai, Opt. Express 14, 1006 (2006).
[CrossRef] [PubMed]

Y. Yasuno, Y. Sando, J. I. Sugisaka, T. Endo, S. Makita, G. Aoki, M. Itoh, and T. Yatagai, Opt. Quantum Electron. 37, 1185 (2005).
[CrossRef]

Tearney, G. J.

Wiggins, T. A.

Wojtkowski, M.

Yang, C.

Yasuno, Y.

Y. Yasuno, J. I. Sugisaka, Y. Sando, Y. Nakamura, S. Makita, M. Itoh, and T. Yatagai, Opt. Express 14, 1006 (2006).
[CrossRef] [PubMed]

Y. Yasuno, Y. Sando, J. I. Sugisaka, T. Endo, S. Makita, G. Aoki, M. Itoh, and T. Yatagai, Opt. Quantum Electron. 37, 1185 (2005).
[CrossRef]

Yatagai, T.

Y. Yasuno, J. I. Sugisaka, Y. Sando, Y. Nakamura, S. Makita, M. Itoh, and T. Yatagai, Opt. Express 14, 1006 (2006).
[CrossRef] [PubMed]

Y. Yasuno, Y. Sando, J. I. Sugisaka, T. Endo, S. Makita, G. Aoki, M. Itoh, and T. Yatagai, Opt. Quantum Electron. 37, 1185 (2005).
[CrossRef]

Yun, S. H.

Yung, K. M.

J. M. Schmitt, S. L. Lee, and K. M. Yung, Opt. Commun. 142, 203 (1997).
[CrossRef]

Zhao, Y. H.

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Figures (3)

Fig. 1
Fig. 1

Optical setup: L1–L6, lenses; BS, nonpolarizing beam splitter 50:50; He–Ne, helium–neon laser for adjustment; pol cntrl, polarization control. (a) Dark field illumination (light gray) and detection field (dark gray) at the sample position.

Fig. 2
Fig. 2

Tomograms of 1 μ m beads for (a) cf-FDOCM, (b) xf-FDOCM; (c) close-up of selected rearranged microbead signals with indicated theoretical resolution for cf-FDOCM with NA = 0.12 (dashed line), NA = 0.23 (dotted line), and xf-FDOCM (solid line); (d) (left) Q-factor for xf/cf, NA = 0.12 (dashed curve), and NA = 0.23 (dotted curve); xf/xf (double pass) (light solid curve). (right) Transverse detected intensity profiles normalized to the xf-FDOCM intensity maximum for cf, NA = 0.12 (dashed curve), NA = 0.23 (dotted curve), xf (solid curve), xf (double pass) (light solid curve).

Fig. 3
Fig. 3

Rendered three-dimensional image of onion skin cells [ 1024 ( x ) × 150 ( y ) × 105 ( z ) voxels covering a geometric volume of 250 μ m × 30 μ m × 150 μ m ]. The arrow indicates a cell core.

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