Abstract

We present a fully planar integrated optical approach to single-molecule detection based on microfabricated planar networks of intersecting solid and liquid-core waveguides. We study fluorescence from dye molecules in liquid-core antiresonant reflecting optical waveguides, and demonstrate subpicoliter excitation volumes, parallel excitation through multiple pump waveguides, and single-molecule detection sensitivity. Integrated silicon photonics combined with single-molecule detection in solution create a compact, robust, and sensitive platform that has applications in numerous fields ranging from atomic physics to the life sciences.

© 2006 Optical Society of America

Full Article  |  PDF Article
More Like This
Microphotonic control of single molecule fluorescence correlation spectroscopy using planar optofluidics

D. Yin, E.J. Lunt, A. Barman, A.R. Hawkins, and H. Schmidt
Opt. Express 15(12) 7290-7295 (2007)

Planar photonic crystals infiltrated with liquid crystals: optical characterization of molecule orientation

R. Ferrini, J. Martz, L. Zuppiroli, B. Wild, V. Zabelin, L. A. Dunbar, R. Houdré, M. Mulot, and S. Anand
Opt. Lett. 31(9) 1238-1240 (2006)

Multidimensional single-molecule imaging in live cells using total-internal-reflection fluorescence microscopy

S. E. D. Webb, S. R. Needham, S. K. Roberts, and M. L. Martin-Fernandez
Opt. Lett. 31(14) 2157-2159 (2006)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Figures (4)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription