Abstract

A noninvasive, high-resolution optoacoustic technique is a promising alternative to currently used invasive methods of brain oxygenation monitoring. We present the results of our pilot clinical test of this technique in healthy volunteers. Multiwavelength optoacoustic measurements (with nanosecond optical parametric oscillator as a source of radiation) were performed on the area of the neck overlying the internal jugular vein, a deeply located large vein that drains blood from the brain and from extracranial tissues. Optoacoustic signals induced in venous blood were measured with high resolution and signal-to-noise ratio despite the presence of a thick layer of overlying tissue (up to 10mm). The characteristic parameters of the signal at different wavelengths correlated well with the spectrum of the effective attenuation coefficient of blood.

© 2006 Optical Society of America

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References

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  1. M. Soehle, M. Jaeger, and J. Meixensberger, Neurol. Res. 25, 411 (2003).
    [CrossRef] [PubMed]
  2. J. M. Murkin, Seminars Cardiothoracic Vascular Anesthesia 8, 13 (2004).
    [CrossRef]
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    [CrossRef]
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    [CrossRef] [PubMed]
  5. J. H. Choi, M. Wolf, V. Toronov, U. Wolf, C. Polzonetti, D. Hueber, L. P. Safonova, R. Gupta, A. Michalos, W. Mantulin, and E. Gratton, J. Biomed. Opt. 9, 221 (2004).
    [CrossRef] [PubMed]
  6. T. Durduran, G. Yu, M. G. Burnett, J. A. Detre, J. H. Greenberg, J. Wang, C. Zhou, and A. G. Yodh, Opt. Lett. 29, 1766 (2004).
    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
  8. Y. Y. Petrov, D. S. Prough, D. E. Deyo, M. Klasing, M. Motamedi, and R. O. Esenaliev, Anesthesiology 102, 69 (2005).
    [CrossRef]
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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]

2005 (2)

Y. Y. Petrov, D. S. Prough, D. E. Deyo, M. Klasing, M. Motamedi, and R. O. Esenaliev, Anesthesiology 102, 69 (2005).
[CrossRef]

I. Y. Petrova, R. O. Esenaliev, Y. Y. Petrov, H.-P. F. Brecht, C. H. Svensen, J. Olsson, D. J. Deyo, and D. S. Prough, Opt. Lett. 30, 1677 (2005).
[CrossRef] [PubMed]

2004 (5)

J. M. Murkin, Seminars Cardiothoracic Vascular Anesthesia 8, 13 (2004).
[CrossRef]

W. J. Stevens, J. Neurosci. Nurs. 36, 332 (2004).
[CrossRef]

J. H. Choi, M. Wolf, V. Toronov, U. Wolf, C. Polzonetti, D. Hueber, L. P. Safonova, R. Gupta, A. Michalos, W. Mantulin, and E. Gratton, J. Biomed. Opt. 9, 221 (2004).
[CrossRef] [PubMed]

T. Durduran, G. Yu, M. G. Burnett, J. A. Detre, J. H. Greenberg, J. Wang, C. Zhou, and A. G. Yodh, Opt. Lett. 29, 1766 (2004).
[CrossRef] [PubMed]

Y. Y. Petrov, D. S. Prough, D. J. Deyo, I. Y. Petrova, M. Motamedi, and R. O. Esenaliev, in Proceedings of the 26th International Conference of the IEEE Engineering in Medicine and Biology Society (Institute of Electrical and Electronics Engineers, 2004), pp. 2052-2054.

2003 (1)

M. Soehle, M. Jaeger, and J. Meixensberger, Neurol. Res. 25, 411 (2003).
[CrossRef] [PubMed]

2002 (1)

2000 (1)

American National Standard for Safe Use of Lasers: ANSI Z136.1-2000 (Laser Institute of America, 2000).

1998 (1)

C. Metz, M. Holzschuh, T. Bien, C. Woertgen, R. Rothoerl, B. Kallenbach, K. Taeger, and A. Brawanski, J. Cereb. Blood Flow Metab. 18, 332 (1998).
[CrossRef] [PubMed]

1995 (1)

A.J.Welch and M.J. C.Van Gemert, eds., Optical-Thermal Response of Laser-Irradiated Tissue (Plenum, 1995).

1993 (1)

R. O. Esenaliev, A. A. Oraevsky, V. S. Letokhov, A. A. Karabutov, and T. V. Malinsky, Lasers Surg. Med. 13, 470 (1993).
[CrossRef] [PubMed]

1977 (1)

F. F. Jobsis, Science 198, 1264 (1977).
[CrossRef] [PubMed]

Bien, T.

C. Metz, M. Holzschuh, T. Bien, C. Woertgen, R. Rothoerl, B. Kallenbach, K. Taeger, and A. Brawanski, J. Cereb. Blood Flow Metab. 18, 332 (1998).
[CrossRef] [PubMed]

Brawanski, A.

C. Metz, M. Holzschuh, T. Bien, C. Woertgen, R. Rothoerl, B. Kallenbach, K. Taeger, and A. Brawanski, J. Cereb. Blood Flow Metab. 18, 332 (1998).
[CrossRef] [PubMed]

Brecht, H.-P. F.

Burnett, M. G.

Choi, J. H.

J. H. Choi, M. Wolf, V. Toronov, U. Wolf, C. Polzonetti, D. Hueber, L. P. Safonova, R. Gupta, A. Michalos, W. Mantulin, and E. Gratton, J. Biomed. Opt. 9, 221 (2004).
[CrossRef] [PubMed]

Detre, J. A.

Deyo, D. E.

Y. Y. Petrov, D. S. Prough, D. E. Deyo, M. Klasing, M. Motamedi, and R. O. Esenaliev, Anesthesiology 102, 69 (2005).
[CrossRef]

R. O. Esenaliev, I. V. Larina, K. V. Larin, D. E. Deyo, M. Motamedi, and D. S. Prough, Appl. Opt. 41, 4722 (2002).
[CrossRef] [PubMed]

Deyo, D. J.

I. Y. Petrova, R. O. Esenaliev, Y. Y. Petrov, H.-P. F. Brecht, C. H. Svensen, J. Olsson, D. J. Deyo, and D. S. Prough, Opt. Lett. 30, 1677 (2005).
[CrossRef] [PubMed]

Y. Y. Petrov, D. S. Prough, D. J. Deyo, I. Y. Petrova, M. Motamedi, and R. O. Esenaliev, in Proceedings of the 26th International Conference of the IEEE Engineering in Medicine and Biology Society (Institute of Electrical and Electronics Engineers, 2004), pp. 2052-2054.

Durduran, T.

Esenaliev, R. O.

Y. Y. Petrov, D. S. Prough, D. E. Deyo, M. Klasing, M. Motamedi, and R. O. Esenaliev, Anesthesiology 102, 69 (2005).
[CrossRef]

I. Y. Petrova, R. O. Esenaliev, Y. Y. Petrov, H.-P. F. Brecht, C. H. Svensen, J. Olsson, D. J. Deyo, and D. S. Prough, Opt. Lett. 30, 1677 (2005).
[CrossRef] [PubMed]

Y. Y. Petrov, D. S. Prough, D. J. Deyo, I. Y. Petrova, M. Motamedi, and R. O. Esenaliev, in Proceedings of the 26th International Conference of the IEEE Engineering in Medicine and Biology Society (Institute of Electrical and Electronics Engineers, 2004), pp. 2052-2054.

R. O. Esenaliev, I. V. Larina, K. V. Larin, D. E. Deyo, M. Motamedi, and D. S. Prough, Appl. Opt. 41, 4722 (2002).
[CrossRef] [PubMed]

R. O. Esenaliev, A. A. Oraevsky, V. S. Letokhov, A. A. Karabutov, and T. V. Malinsky, Lasers Surg. Med. 13, 470 (1993).
[CrossRef] [PubMed]

Gratton, E.

J. H. Choi, M. Wolf, V. Toronov, U. Wolf, C. Polzonetti, D. Hueber, L. P. Safonova, R. Gupta, A. Michalos, W. Mantulin, and E. Gratton, J. Biomed. Opt. 9, 221 (2004).
[CrossRef] [PubMed]

Greenberg, J. H.

Gupta, R.

J. H. Choi, M. Wolf, V. Toronov, U. Wolf, C. Polzonetti, D. Hueber, L. P. Safonova, R. Gupta, A. Michalos, W. Mantulin, and E. Gratton, J. Biomed. Opt. 9, 221 (2004).
[CrossRef] [PubMed]

Holzschuh, M.

C. Metz, M. Holzschuh, T. Bien, C. Woertgen, R. Rothoerl, B. Kallenbach, K. Taeger, and A. Brawanski, J. Cereb. Blood Flow Metab. 18, 332 (1998).
[CrossRef] [PubMed]

Hueber, D.

J. H. Choi, M. Wolf, V. Toronov, U. Wolf, C. Polzonetti, D. Hueber, L. P. Safonova, R. Gupta, A. Michalos, W. Mantulin, and E. Gratton, J. Biomed. Opt. 9, 221 (2004).
[CrossRef] [PubMed]

Jaeger, M.

M. Soehle, M. Jaeger, and J. Meixensberger, Neurol. Res. 25, 411 (2003).
[CrossRef] [PubMed]

Jobsis, F. F.

F. F. Jobsis, Science 198, 1264 (1977).
[CrossRef] [PubMed]

Kallenbach, B.

C. Metz, M. Holzschuh, T. Bien, C. Woertgen, R. Rothoerl, B. Kallenbach, K. Taeger, and A. Brawanski, J. Cereb. Blood Flow Metab. 18, 332 (1998).
[CrossRef] [PubMed]

Karabutov, A. A.

R. O. Esenaliev, A. A. Oraevsky, V. S. Letokhov, A. A. Karabutov, and T. V. Malinsky, Lasers Surg. Med. 13, 470 (1993).
[CrossRef] [PubMed]

Klasing, M.

Y. Y. Petrov, D. S. Prough, D. E. Deyo, M. Klasing, M. Motamedi, and R. O. Esenaliev, Anesthesiology 102, 69 (2005).
[CrossRef]

Larin, K. V.

Larina, I. V.

Letokhov, V. S.

R. O. Esenaliev, A. A. Oraevsky, V. S. Letokhov, A. A. Karabutov, and T. V. Malinsky, Lasers Surg. Med. 13, 470 (1993).
[CrossRef] [PubMed]

Malinsky, T. V.

R. O. Esenaliev, A. A. Oraevsky, V. S. Letokhov, A. A. Karabutov, and T. V. Malinsky, Lasers Surg. Med. 13, 470 (1993).
[CrossRef] [PubMed]

Mantulin, W.

J. H. Choi, M. Wolf, V. Toronov, U. Wolf, C. Polzonetti, D. Hueber, L. P. Safonova, R. Gupta, A. Michalos, W. Mantulin, and E. Gratton, J. Biomed. Opt. 9, 221 (2004).
[CrossRef] [PubMed]

Meixensberger, J.

M. Soehle, M. Jaeger, and J. Meixensberger, Neurol. Res. 25, 411 (2003).
[CrossRef] [PubMed]

Metz, C.

C. Metz, M. Holzschuh, T. Bien, C. Woertgen, R. Rothoerl, B. Kallenbach, K. Taeger, and A. Brawanski, J. Cereb. Blood Flow Metab. 18, 332 (1998).
[CrossRef] [PubMed]

Michalos, A.

J. H. Choi, M. Wolf, V. Toronov, U. Wolf, C. Polzonetti, D. Hueber, L. P. Safonova, R. Gupta, A. Michalos, W. Mantulin, and E. Gratton, J. Biomed. Opt. 9, 221 (2004).
[CrossRef] [PubMed]

Motamedi, M.

Y. Y. Petrov, D. S. Prough, D. E. Deyo, M. Klasing, M. Motamedi, and R. O. Esenaliev, Anesthesiology 102, 69 (2005).
[CrossRef]

Y. Y. Petrov, D. S. Prough, D. J. Deyo, I. Y. Petrova, M. Motamedi, and R. O. Esenaliev, in Proceedings of the 26th International Conference of the IEEE Engineering in Medicine and Biology Society (Institute of Electrical and Electronics Engineers, 2004), pp. 2052-2054.

R. O. Esenaliev, I. V. Larina, K. V. Larin, D. E. Deyo, M. Motamedi, and D. S. Prough, Appl. Opt. 41, 4722 (2002).
[CrossRef] [PubMed]

Murkin, J. M.

J. M. Murkin, Seminars Cardiothoracic Vascular Anesthesia 8, 13 (2004).
[CrossRef]

Olsson, J.

Oraevsky, A. A.

R. O. Esenaliev, A. A. Oraevsky, V. S. Letokhov, A. A. Karabutov, and T. V. Malinsky, Lasers Surg. Med. 13, 470 (1993).
[CrossRef] [PubMed]

Petrov, Y. Y.

I. Y. Petrova, R. O. Esenaliev, Y. Y. Petrov, H.-P. F. Brecht, C. H. Svensen, J. Olsson, D. J. Deyo, and D. S. Prough, Opt. Lett. 30, 1677 (2005).
[CrossRef] [PubMed]

Y. Y. Petrov, D. S. Prough, D. E. Deyo, M. Klasing, M. Motamedi, and R. O. Esenaliev, Anesthesiology 102, 69 (2005).
[CrossRef]

Y. Y. Petrov, D. S. Prough, D. J. Deyo, I. Y. Petrova, M. Motamedi, and R. O. Esenaliev, in Proceedings of the 26th International Conference of the IEEE Engineering in Medicine and Biology Society (Institute of Electrical and Electronics Engineers, 2004), pp. 2052-2054.

Petrova, I. Y.

I. Y. Petrova, R. O. Esenaliev, Y. Y. Petrov, H.-P. F. Brecht, C. H. Svensen, J. Olsson, D. J. Deyo, and D. S. Prough, Opt. Lett. 30, 1677 (2005).
[CrossRef] [PubMed]

Y. Y. Petrov, D. S. Prough, D. J. Deyo, I. Y. Petrova, M. Motamedi, and R. O. Esenaliev, in Proceedings of the 26th International Conference of the IEEE Engineering in Medicine and Biology Society (Institute of Electrical and Electronics Engineers, 2004), pp. 2052-2054.

Polzonetti, C.

J. H. Choi, M. Wolf, V. Toronov, U. Wolf, C. Polzonetti, D. Hueber, L. P. Safonova, R. Gupta, A. Michalos, W. Mantulin, and E. Gratton, J. Biomed. Opt. 9, 221 (2004).
[CrossRef] [PubMed]

Prough, D. S.

Y. Y. Petrov, D. S. Prough, D. E. Deyo, M. Klasing, M. Motamedi, and R. O. Esenaliev, Anesthesiology 102, 69 (2005).
[CrossRef]

I. Y. Petrova, R. O. Esenaliev, Y. Y. Petrov, H.-P. F. Brecht, C. H. Svensen, J. Olsson, D. J. Deyo, and D. S. Prough, Opt. Lett. 30, 1677 (2005).
[CrossRef] [PubMed]

Y. Y. Petrov, D. S. Prough, D. J. Deyo, I. Y. Petrova, M. Motamedi, and R. O. Esenaliev, in Proceedings of the 26th International Conference of the IEEE Engineering in Medicine and Biology Society (Institute of Electrical and Electronics Engineers, 2004), pp. 2052-2054.

R. O. Esenaliev, I. V. Larina, K. V. Larin, D. E. Deyo, M. Motamedi, and D. S. Prough, Appl. Opt. 41, 4722 (2002).
[CrossRef] [PubMed]

Rothoerl, R.

C. Metz, M. Holzschuh, T. Bien, C. Woertgen, R. Rothoerl, B. Kallenbach, K. Taeger, and A. Brawanski, J. Cereb. Blood Flow Metab. 18, 332 (1998).
[CrossRef] [PubMed]

Safonova, L. P.

J. H. Choi, M. Wolf, V. Toronov, U. Wolf, C. Polzonetti, D. Hueber, L. P. Safonova, R. Gupta, A. Michalos, W. Mantulin, and E. Gratton, J. Biomed. Opt. 9, 221 (2004).
[CrossRef] [PubMed]

Soehle, M.

M. Soehle, M. Jaeger, and J. Meixensberger, Neurol. Res. 25, 411 (2003).
[CrossRef] [PubMed]

Stevens, W. J.

W. J. Stevens, J. Neurosci. Nurs. 36, 332 (2004).
[CrossRef]

Svensen, C. H.

Taeger, K.

C. Metz, M. Holzschuh, T. Bien, C. Woertgen, R. Rothoerl, B. Kallenbach, K. Taeger, and A. Brawanski, J. Cereb. Blood Flow Metab. 18, 332 (1998).
[CrossRef] [PubMed]

Toronov, V.

J. H. Choi, M. Wolf, V. Toronov, U. Wolf, C. Polzonetti, D. Hueber, L. P. Safonova, R. Gupta, A. Michalos, W. Mantulin, and E. Gratton, J. Biomed. Opt. 9, 221 (2004).
[CrossRef] [PubMed]

Wang, J.

Woertgen, C.

C. Metz, M. Holzschuh, T. Bien, C. Woertgen, R. Rothoerl, B. Kallenbach, K. Taeger, and A. Brawanski, J. Cereb. Blood Flow Metab. 18, 332 (1998).
[CrossRef] [PubMed]

Wolf, M.

J. H. Choi, M. Wolf, V. Toronov, U. Wolf, C. Polzonetti, D. Hueber, L. P. Safonova, R. Gupta, A. Michalos, W. Mantulin, and E. Gratton, J. Biomed. Opt. 9, 221 (2004).
[CrossRef] [PubMed]

Wolf, U.

J. H. Choi, M. Wolf, V. Toronov, U. Wolf, C. Polzonetti, D. Hueber, L. P. Safonova, R. Gupta, A. Michalos, W. Mantulin, and E. Gratton, J. Biomed. Opt. 9, 221 (2004).
[CrossRef] [PubMed]

Yodh, A. G.

Yu, G.

Zhou, C.

Anesthesiology (1)

Y. Y. Petrov, D. S. Prough, D. E. Deyo, M. Klasing, M. Motamedi, and R. O. Esenaliev, Anesthesiology 102, 69 (2005).
[CrossRef]

Appl. Opt. (1)

J. Biomed. Opt. (1)

J. H. Choi, M. Wolf, V. Toronov, U. Wolf, C. Polzonetti, D. Hueber, L. P. Safonova, R. Gupta, A. Michalos, W. Mantulin, and E. Gratton, J. Biomed. Opt. 9, 221 (2004).
[CrossRef] [PubMed]

J. Cereb. Blood Flow Metab. (1)

C. Metz, M. Holzschuh, T. Bien, C. Woertgen, R. Rothoerl, B. Kallenbach, K. Taeger, and A. Brawanski, J. Cereb. Blood Flow Metab. 18, 332 (1998).
[CrossRef] [PubMed]

J. Neurosci. Nurs. (1)

W. J. Stevens, J. Neurosci. Nurs. 36, 332 (2004).
[CrossRef]

Lasers Surg. Med. (1)

R. O. Esenaliev, A. A. Oraevsky, V. S. Letokhov, A. A. Karabutov, and T. V. Malinsky, Lasers Surg. Med. 13, 470 (1993).
[CrossRef] [PubMed]

Neurol. Res. (1)

M. Soehle, M. Jaeger, and J. Meixensberger, Neurol. Res. 25, 411 (2003).
[CrossRef] [PubMed]

Opt. Lett. (2)

Science (1)

F. F. Jobsis, Science 198, 1264 (1977).
[CrossRef] [PubMed]

Seminars Cardiothoracic Vascular Anesthesia (1)

J. M. Murkin, Seminars Cardiothoracic Vascular Anesthesia 8, 13 (2004).
[CrossRef]

Other (3)

American National Standard for Safe Use of Lasers: ANSI Z136.1-2000 (Laser Institute of America, 2000).

A.J.Welch and M.J. C.Van Gemert, eds., Optical-Thermal Response of Laser-Irradiated Tissue (Plenum, 1995).

Y. Y. Petrov, D. S. Prough, D. J. Deyo, I. Y. Petrova, M. Motamedi, and R. O. Esenaliev, in Proceedings of the 26th International Conference of the IEEE Engineering in Medicine and Biology Society (Institute of Electrical and Electronics Engineers, 2004), pp. 2052-2054.

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Figures (3)

Fig. 1
Fig. 1

Ultrasound image of the right IJV and surrounding tissues. The arrows indicate 1, skin surface; 2, superficial vein; 3, IJV; and 4, carotid artery. For orientation, the trachea is located to the left of the imaged area.

Fig. 2
Fig. 2

Typical optoacoustic signals from the IJV at wavelengths of 680, 800, and 1064 nm (solid, dashed, and dotted curves, respectively). Depth is counted from the skin surface.

Fig. 3
Fig. 3

Inverse integral of the signal from the IJV (circles). Superimposed are the spectra of effective attenuation co - efficient of blood with oxygenation of 55% (dashed curve) and 75% (solid curve) calculated from our in vitro data.[13]

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