Abstract

We discovered that laser speckle temporal contrast analysis (LSTCA) is able to access the two-dimensional (2D) cerebral blood flow velocity and vessel structure through the intact rat skull. It is demonstrated that LSTCA can significantly suppress the influence of the laser speckle from the stationary structure, such as the skull, and thus reveal the blood flow and morphology of blood vessels through the laser speckle images recorded from the intact rat skull.

© 2006 Optical Society of America

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References

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  1. J. D. Briers, Physiol. Meas 22, R35 (2001).
    [CrossRef]
  2. Y. Aizu and T. Asakura, J. Biomed. Opt. 4, 61 (1999).
    [CrossRef]
  3. J. Paul, A. Luft, E. Yew, and F. Sheu, Neuroimage 29, 38 (2006).
    [CrossRef]
  4. A. K. Dunn, A. Devor, A. Dale, and D. Boas, Neuroimage 27, 279 (2005).
    [CrossRef] [PubMed]
  5. T. Durduran, M. G. Burnett, G. Yu, C. Zhou, D. Furuya, A. G. Yodh, J. A. Detre, and J. H. Greenberg, J. Cereb. Blood Flow Metab. 24, 518 (2004).
    [CrossRef] [PubMed]
  6. A. K. Dunn, B. Hayrunnisa, M. Moskowitz, and D. Boas, J. Cereb. Blood Flow Metab. 21, 195 (2001).
    [CrossRef] [PubMed]
  7. H. Cheng, Q. Luo, S. Zeng, S. Chen, J. Cen, and H. Gong, J. Biomed. Opt. 8, 559 (2003).
    [CrossRef] [PubMed]
  8. C. Ayata, H. Shin, S. Salomone, Y. Gursoy, D. Boas, A. Dunn, and M. Moskowitz, J. Cereb. Blood Flow Metab. 24, 1172 (2004).
    [CrossRef] [PubMed]
  9. C. Ayata, A. Dunn, Y. Özdemir, Z. Huang, D. Boas, and M. Moskowitz, J. Cereb. Blood Flow Metab. 24, 744 (2004).
    [CrossRef] [PubMed]
  10. J. Culver, T. Durduran, D. Furuya, C. Cheung, J. Greenberg, and A. Yodh, J. Cereb. Blood Flow Metab. 23, 911 (2003).
    [CrossRef] [PubMed]
  11. P. Naulleau, D. Dilworth, E. Leith, and J. Lopez, Opt. Lett. 20, 498 (1995).
    [CrossRef] [PubMed]

2006 (1)

J. Paul, A. Luft, E. Yew, and F. Sheu, Neuroimage 29, 38 (2006).
[CrossRef]

2005 (1)

A. K. Dunn, A. Devor, A. Dale, and D. Boas, Neuroimage 27, 279 (2005).
[CrossRef] [PubMed]

2004 (3)

T. Durduran, M. G. Burnett, G. Yu, C. Zhou, D. Furuya, A. G. Yodh, J. A. Detre, and J. H. Greenberg, J. Cereb. Blood Flow Metab. 24, 518 (2004).
[CrossRef] [PubMed]

C. Ayata, H. Shin, S. Salomone, Y. Gursoy, D. Boas, A. Dunn, and M. Moskowitz, J. Cereb. Blood Flow Metab. 24, 1172 (2004).
[CrossRef] [PubMed]

C. Ayata, A. Dunn, Y. Özdemir, Z. Huang, D. Boas, and M. Moskowitz, J. Cereb. Blood Flow Metab. 24, 744 (2004).
[CrossRef] [PubMed]

2003 (2)

J. Culver, T. Durduran, D. Furuya, C. Cheung, J. Greenberg, and A. Yodh, J. Cereb. Blood Flow Metab. 23, 911 (2003).
[CrossRef] [PubMed]

H. Cheng, Q. Luo, S. Zeng, S. Chen, J. Cen, and H. Gong, J. Biomed. Opt. 8, 559 (2003).
[CrossRef] [PubMed]

2001 (2)

J. D. Briers, Physiol. Meas 22, R35 (2001).
[CrossRef]

A. K. Dunn, B. Hayrunnisa, M. Moskowitz, and D. Boas, J. Cereb. Blood Flow Metab. 21, 195 (2001).
[CrossRef] [PubMed]

1999 (1)

Y. Aizu and T. Asakura, J. Biomed. Opt. 4, 61 (1999).
[CrossRef]

1995 (1)

Aizu, Y.

Y. Aizu and T. Asakura, J. Biomed. Opt. 4, 61 (1999).
[CrossRef]

Asakura, T.

Y. Aizu and T. Asakura, J. Biomed. Opt. 4, 61 (1999).
[CrossRef]

Ayata, C.

C. Ayata, H. Shin, S. Salomone, Y. Gursoy, D. Boas, A. Dunn, and M. Moskowitz, J. Cereb. Blood Flow Metab. 24, 1172 (2004).
[CrossRef] [PubMed]

C. Ayata, A. Dunn, Y. Özdemir, Z. Huang, D. Boas, and M. Moskowitz, J. Cereb. Blood Flow Metab. 24, 744 (2004).
[CrossRef] [PubMed]

Boas, D.

A. K. Dunn, A. Devor, A. Dale, and D. Boas, Neuroimage 27, 279 (2005).
[CrossRef] [PubMed]

C. Ayata, H. Shin, S. Salomone, Y. Gursoy, D. Boas, A. Dunn, and M. Moskowitz, J. Cereb. Blood Flow Metab. 24, 1172 (2004).
[CrossRef] [PubMed]

C. Ayata, A. Dunn, Y. Özdemir, Z. Huang, D. Boas, and M. Moskowitz, J. Cereb. Blood Flow Metab. 24, 744 (2004).
[CrossRef] [PubMed]

A. K. Dunn, B. Hayrunnisa, M. Moskowitz, and D. Boas, J. Cereb. Blood Flow Metab. 21, 195 (2001).
[CrossRef] [PubMed]

Briers, J. D.

J. D. Briers, Physiol. Meas 22, R35 (2001).
[CrossRef]

Burnett, M. G.

T. Durduran, M. G. Burnett, G. Yu, C. Zhou, D. Furuya, A. G. Yodh, J. A. Detre, and J. H. Greenberg, J. Cereb. Blood Flow Metab. 24, 518 (2004).
[CrossRef] [PubMed]

Cen, J.

H. Cheng, Q. Luo, S. Zeng, S. Chen, J. Cen, and H. Gong, J. Biomed. Opt. 8, 559 (2003).
[CrossRef] [PubMed]

Chen, S.

H. Cheng, Q. Luo, S. Zeng, S. Chen, J. Cen, and H. Gong, J. Biomed. Opt. 8, 559 (2003).
[CrossRef] [PubMed]

Cheng, H.

H. Cheng, Q. Luo, S. Zeng, S. Chen, J. Cen, and H. Gong, J. Biomed. Opt. 8, 559 (2003).
[CrossRef] [PubMed]

Cheung, C.

J. Culver, T. Durduran, D. Furuya, C. Cheung, J. Greenberg, and A. Yodh, J. Cereb. Blood Flow Metab. 23, 911 (2003).
[CrossRef] [PubMed]

Culver, J.

J. Culver, T. Durduran, D. Furuya, C. Cheung, J. Greenberg, and A. Yodh, J. Cereb. Blood Flow Metab. 23, 911 (2003).
[CrossRef] [PubMed]

Dale, A.

A. K. Dunn, A. Devor, A. Dale, and D. Boas, Neuroimage 27, 279 (2005).
[CrossRef] [PubMed]

Detre, J. A.

T. Durduran, M. G. Burnett, G. Yu, C. Zhou, D. Furuya, A. G. Yodh, J. A. Detre, and J. H. Greenberg, J. Cereb. Blood Flow Metab. 24, 518 (2004).
[CrossRef] [PubMed]

Devor, A.

A. K. Dunn, A. Devor, A. Dale, and D. Boas, Neuroimage 27, 279 (2005).
[CrossRef] [PubMed]

Dilworth, D.

Dunn, A.

C. Ayata, H. Shin, S. Salomone, Y. Gursoy, D. Boas, A. Dunn, and M. Moskowitz, J. Cereb. Blood Flow Metab. 24, 1172 (2004).
[CrossRef] [PubMed]

C. Ayata, A. Dunn, Y. Özdemir, Z. Huang, D. Boas, and M. Moskowitz, J. Cereb. Blood Flow Metab. 24, 744 (2004).
[CrossRef] [PubMed]

Dunn, A. K.

A. K. Dunn, A. Devor, A. Dale, and D. Boas, Neuroimage 27, 279 (2005).
[CrossRef] [PubMed]

A. K. Dunn, B. Hayrunnisa, M. Moskowitz, and D. Boas, J. Cereb. Blood Flow Metab. 21, 195 (2001).
[CrossRef] [PubMed]

Durduran, T.

T. Durduran, M. G. Burnett, G. Yu, C. Zhou, D. Furuya, A. G. Yodh, J. A. Detre, and J. H. Greenberg, J. Cereb. Blood Flow Metab. 24, 518 (2004).
[CrossRef] [PubMed]

J. Culver, T. Durduran, D. Furuya, C. Cheung, J. Greenberg, and A. Yodh, J. Cereb. Blood Flow Metab. 23, 911 (2003).
[CrossRef] [PubMed]

Furuya, D.

T. Durduran, M. G. Burnett, G. Yu, C. Zhou, D. Furuya, A. G. Yodh, J. A. Detre, and J. H. Greenberg, J. Cereb. Blood Flow Metab. 24, 518 (2004).
[CrossRef] [PubMed]

J. Culver, T. Durduran, D. Furuya, C. Cheung, J. Greenberg, and A. Yodh, J. Cereb. Blood Flow Metab. 23, 911 (2003).
[CrossRef] [PubMed]

Gong, H.

H. Cheng, Q. Luo, S. Zeng, S. Chen, J. Cen, and H. Gong, J. Biomed. Opt. 8, 559 (2003).
[CrossRef] [PubMed]

Greenberg, J.

J. Culver, T. Durduran, D. Furuya, C. Cheung, J. Greenberg, and A. Yodh, J. Cereb. Blood Flow Metab. 23, 911 (2003).
[CrossRef] [PubMed]

Greenberg, J. H.

T. Durduran, M. G. Burnett, G. Yu, C. Zhou, D. Furuya, A. G. Yodh, J. A. Detre, and J. H. Greenberg, J. Cereb. Blood Flow Metab. 24, 518 (2004).
[CrossRef] [PubMed]

Gursoy, Y.

C. Ayata, H. Shin, S. Salomone, Y. Gursoy, D. Boas, A. Dunn, and M. Moskowitz, J. Cereb. Blood Flow Metab. 24, 1172 (2004).
[CrossRef] [PubMed]

Hayrunnisa, B.

A. K. Dunn, B. Hayrunnisa, M. Moskowitz, and D. Boas, J. Cereb. Blood Flow Metab. 21, 195 (2001).
[CrossRef] [PubMed]

Huang, Z.

C. Ayata, A. Dunn, Y. Özdemir, Z. Huang, D. Boas, and M. Moskowitz, J. Cereb. Blood Flow Metab. 24, 744 (2004).
[CrossRef] [PubMed]

Leith, E.

Lopez, J.

Luft, A.

J. Paul, A. Luft, E. Yew, and F. Sheu, Neuroimage 29, 38 (2006).
[CrossRef]

Luo, Q.

H. Cheng, Q. Luo, S. Zeng, S. Chen, J. Cen, and H. Gong, J. Biomed. Opt. 8, 559 (2003).
[CrossRef] [PubMed]

Moskowitz, M.

C. Ayata, A. Dunn, Y. Özdemir, Z. Huang, D. Boas, and M. Moskowitz, J. Cereb. Blood Flow Metab. 24, 744 (2004).
[CrossRef] [PubMed]

C. Ayata, H. Shin, S. Salomone, Y. Gursoy, D. Boas, A. Dunn, and M. Moskowitz, J. Cereb. Blood Flow Metab. 24, 1172 (2004).
[CrossRef] [PubMed]

A. K. Dunn, B. Hayrunnisa, M. Moskowitz, and D. Boas, J. Cereb. Blood Flow Metab. 21, 195 (2001).
[CrossRef] [PubMed]

Naulleau, P.

Özdemir, Y.

C. Ayata, A. Dunn, Y. Özdemir, Z. Huang, D. Boas, and M. Moskowitz, J. Cereb. Blood Flow Metab. 24, 744 (2004).
[CrossRef] [PubMed]

Paul, J.

J. Paul, A. Luft, E. Yew, and F. Sheu, Neuroimage 29, 38 (2006).
[CrossRef]

Salomone, S.

C. Ayata, H. Shin, S. Salomone, Y. Gursoy, D. Boas, A. Dunn, and M. Moskowitz, J. Cereb. Blood Flow Metab. 24, 1172 (2004).
[CrossRef] [PubMed]

Sheu, F.

J. Paul, A. Luft, E. Yew, and F. Sheu, Neuroimage 29, 38 (2006).
[CrossRef]

Shin, H.

C. Ayata, H. Shin, S. Salomone, Y. Gursoy, D. Boas, A. Dunn, and M. Moskowitz, J. Cereb. Blood Flow Metab. 24, 1172 (2004).
[CrossRef] [PubMed]

Yew, E.

J. Paul, A. Luft, E. Yew, and F. Sheu, Neuroimage 29, 38 (2006).
[CrossRef]

Yodh, A.

J. Culver, T. Durduran, D. Furuya, C. Cheung, J. Greenberg, and A. Yodh, J. Cereb. Blood Flow Metab. 23, 911 (2003).
[CrossRef] [PubMed]

Yodh, A. G.

T. Durduran, M. G. Burnett, G. Yu, C. Zhou, D. Furuya, A. G. Yodh, J. A. Detre, and J. H. Greenberg, J. Cereb. Blood Flow Metab. 24, 518 (2004).
[CrossRef] [PubMed]

Yu, G.

T. Durduran, M. G. Burnett, G. Yu, C. Zhou, D. Furuya, A. G. Yodh, J. A. Detre, and J. H. Greenberg, J. Cereb. Blood Flow Metab. 24, 518 (2004).
[CrossRef] [PubMed]

Zeng, S.

H. Cheng, Q. Luo, S. Zeng, S. Chen, J. Cen, and H. Gong, J. Biomed. Opt. 8, 559 (2003).
[CrossRef] [PubMed]

Zhou, C.

T. Durduran, M. G. Burnett, G. Yu, C. Zhou, D. Furuya, A. G. Yodh, J. A. Detre, and J. H. Greenberg, J. Cereb. Blood Flow Metab. 24, 518 (2004).
[CrossRef] [PubMed]

J. Biomed. Opt. (2)

Y. Aizu and T. Asakura, J. Biomed. Opt. 4, 61 (1999).
[CrossRef]

H. Cheng, Q. Luo, S. Zeng, S. Chen, J. Cen, and H. Gong, J. Biomed. Opt. 8, 559 (2003).
[CrossRef] [PubMed]

J. Cereb. Blood Flow Metab. (5)

C. Ayata, H. Shin, S. Salomone, Y. Gursoy, D. Boas, A. Dunn, and M. Moskowitz, J. Cereb. Blood Flow Metab. 24, 1172 (2004).
[CrossRef] [PubMed]

C. Ayata, A. Dunn, Y. Özdemir, Z. Huang, D. Boas, and M. Moskowitz, J. Cereb. Blood Flow Metab. 24, 744 (2004).
[CrossRef] [PubMed]

J. Culver, T. Durduran, D. Furuya, C. Cheung, J. Greenberg, and A. Yodh, J. Cereb. Blood Flow Metab. 23, 911 (2003).
[CrossRef] [PubMed]

T. Durduran, M. G. Burnett, G. Yu, C. Zhou, D. Furuya, A. G. Yodh, J. A. Detre, and J. H. Greenberg, J. Cereb. Blood Flow Metab. 24, 518 (2004).
[CrossRef] [PubMed]

A. K. Dunn, B. Hayrunnisa, M. Moskowitz, and D. Boas, J. Cereb. Blood Flow Metab. 21, 195 (2001).
[CrossRef] [PubMed]

Neuroimage (2)

J. Paul, A. Luft, E. Yew, and F. Sheu, Neuroimage 29, 38 (2006).
[CrossRef]

A. K. Dunn, A. Devor, A. Dale, and D. Boas, Neuroimage 27, 279 (2005).
[CrossRef] [PubMed]

Opt. Lett. (1)

Physiol. Meas (1)

J. D. Briers, Physiol. Meas 22, R35 (2001).
[CrossRef]

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Figures (3)

Fig. 1
Fig. 1

Schematic of the experimental setup.

Fig. 2
Fig. 2

(a) Reflection image recorded from an intact rat skull under illumination by incoherent light. (b) Reflection image recorded from the exposed cortex of the same rat under illumination by white light. (c) Averaged speckle spatial contrast image constructed from 40 speckle images recorded from the intact rat skull. (d) Speckle temporal contrast image constructed from the same data set used for producing (c). (e) Profiles of the speckle spatial and temporal contrast values along the horizontal dashed line in (c) and (d). (f) Profile of the optical intensity along the indicated horizontal dashed line in (b). The gray-scale bar indicates the value of speckle contrast in (c) and (d), and the two images share the same scale.

Fig. 3
Fig. 3

Dependence of speckle temporal contrast and speckle spatial contrast on the velocity of a moving porcelain plate.

Equations (1)

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K t ( x , y ) = σ x , y I x , y = 1 N 1 { n = 1 N [ I x , y ( n ) I x , y ] 2 } I x , y ,

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