Abstract

We discovered that laser speckle temporal contrast analysis (LSTCA) is able to access the two-dimensional (2D) cerebral blood flow velocity and vessel structure through the intact rat skull. It is demonstrated that LSTCA can significantly suppress the influence of the laser speckle from the stationary structure, such as the skull, and thus reveal the blood flow and morphology of blood vessels through the laser speckle images recorded from the intact rat skull.

© 2006 Optical Society of America

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2006

J. Paul, A. Luft, E. Yew, and F. Sheu, Neuroimage 29, 38 (2006).

2005

A. K. Dunn, A. Devor, A. Dale, and D. Boas, Neuroimage 27, 279 (2005).

2004

T. Durduran, M. G. Burnett, G. Yu, C. Zhou, D. Furuya, A. G. Yodh, J. A. Detre, and J. H. Greenberg, J. Cereb. Blood Flow Metab. 24, 518 (2004).

C. Ayata, H. Shin, S. Salomone, Y. Gursoy, D. Boas, A. Dunn, and M. Moskowitz, J. Cereb. Blood Flow Metab. 24, 1172 (2004).

C. Ayata, A. Dunn, Y. Özdemir, Z. Huang, D. Boas, and M. Moskowitz, J. Cereb. Blood Flow Metab. 24, 744 (2004).

2003

J. Culver, T. Durduran, D. Furuya, C. Cheung, J. Greenberg, and A. Yodh, J. Cereb. Blood Flow Metab. 23, 911 (2003).

H. Cheng, Q. Luo, S. Zeng, S. Chen, J. Cen, and H. Gong, J. Biomed. Opt. 8, 559 (2003).

2001

J. D. Briers, Physiol. Meas 22, R35 (2001).

A. K. Dunn, B. Hayrunnisa, M. Moskowitz, and D. Boas, J. Cereb. Blood Flow Metab. 21, 195 (2001).

1999

Y. Aizu and T. Asakura, J. Biomed. Opt. 4, 61 (1999).

1995

Aizu, Y.

Y. Aizu and T. Asakura, J. Biomed. Opt. 4, 61 (1999).

Asakura, T.

Y. Aizu and T. Asakura, J. Biomed. Opt. 4, 61 (1999).

Ayata, C.

C. Ayata, H. Shin, S. Salomone, Y. Gursoy, D. Boas, A. Dunn, and M. Moskowitz, J. Cereb. Blood Flow Metab. 24, 1172 (2004).

C. Ayata, A. Dunn, Y. Özdemir, Z. Huang, D. Boas, and M. Moskowitz, J. Cereb. Blood Flow Metab. 24, 744 (2004).

Boas, D.

A. K. Dunn, A. Devor, A. Dale, and D. Boas, Neuroimage 27, 279 (2005).

C. Ayata, H. Shin, S. Salomone, Y. Gursoy, D. Boas, A. Dunn, and M. Moskowitz, J. Cereb. Blood Flow Metab. 24, 1172 (2004).

C. Ayata, A. Dunn, Y. Özdemir, Z. Huang, D. Boas, and M. Moskowitz, J. Cereb. Blood Flow Metab. 24, 744 (2004).

A. K. Dunn, B. Hayrunnisa, M. Moskowitz, and D. Boas, J. Cereb. Blood Flow Metab. 21, 195 (2001).

Briers, J. D.

J. D. Briers, Physiol. Meas 22, R35 (2001).

Burnett, M. G.

T. Durduran, M. G. Burnett, G. Yu, C. Zhou, D. Furuya, A. G. Yodh, J. A. Detre, and J. H. Greenberg, J. Cereb. Blood Flow Metab. 24, 518 (2004).

Cen, J.

H. Cheng, Q. Luo, S. Zeng, S. Chen, J. Cen, and H. Gong, J. Biomed. Opt. 8, 559 (2003).

Chen, S.

H. Cheng, Q. Luo, S. Zeng, S. Chen, J. Cen, and H. Gong, J. Biomed. Opt. 8, 559 (2003).

Cheng, H.

H. Cheng, Q. Luo, S. Zeng, S. Chen, J. Cen, and H. Gong, J. Biomed. Opt. 8, 559 (2003).

Cheung, C.

J. Culver, T. Durduran, D. Furuya, C. Cheung, J. Greenberg, and A. Yodh, J. Cereb. Blood Flow Metab. 23, 911 (2003).

Culver, J.

J. Culver, T. Durduran, D. Furuya, C. Cheung, J. Greenberg, and A. Yodh, J. Cereb. Blood Flow Metab. 23, 911 (2003).

Dale, A.

A. K. Dunn, A. Devor, A. Dale, and D. Boas, Neuroimage 27, 279 (2005).

Detre, J. A.

T. Durduran, M. G. Burnett, G. Yu, C. Zhou, D. Furuya, A. G. Yodh, J. A. Detre, and J. H. Greenberg, J. Cereb. Blood Flow Metab. 24, 518 (2004).

Devor, A.

A. K. Dunn, A. Devor, A. Dale, and D. Boas, Neuroimage 27, 279 (2005).

Dilworth, D.

Dunn, A.

C. Ayata, H. Shin, S. Salomone, Y. Gursoy, D. Boas, A. Dunn, and M. Moskowitz, J. Cereb. Blood Flow Metab. 24, 1172 (2004).

C. Ayata, A. Dunn, Y. Özdemir, Z. Huang, D. Boas, and M. Moskowitz, J. Cereb. Blood Flow Metab. 24, 744 (2004).

Dunn, A. K.

A. K. Dunn, A. Devor, A. Dale, and D. Boas, Neuroimage 27, 279 (2005).

A. K. Dunn, B. Hayrunnisa, M. Moskowitz, and D. Boas, J. Cereb. Blood Flow Metab. 21, 195 (2001).

Durduran, T.

T. Durduran, M. G. Burnett, G. Yu, C. Zhou, D. Furuya, A. G. Yodh, J. A. Detre, and J. H. Greenberg, J. Cereb. Blood Flow Metab. 24, 518 (2004).

J. Culver, T. Durduran, D. Furuya, C. Cheung, J. Greenberg, and A. Yodh, J. Cereb. Blood Flow Metab. 23, 911 (2003).

Furuya, D.

T. Durduran, M. G. Burnett, G. Yu, C. Zhou, D. Furuya, A. G. Yodh, J. A. Detre, and J. H. Greenberg, J. Cereb. Blood Flow Metab. 24, 518 (2004).

J. Culver, T. Durduran, D. Furuya, C. Cheung, J. Greenberg, and A. Yodh, J. Cereb. Blood Flow Metab. 23, 911 (2003).

Gong, H.

H. Cheng, Q. Luo, S. Zeng, S. Chen, J. Cen, and H. Gong, J. Biomed. Opt. 8, 559 (2003).

Greenberg, J.

J. Culver, T. Durduran, D. Furuya, C. Cheung, J. Greenberg, and A. Yodh, J. Cereb. Blood Flow Metab. 23, 911 (2003).

Greenberg, J. H.

T. Durduran, M. G. Burnett, G. Yu, C. Zhou, D. Furuya, A. G. Yodh, J. A. Detre, and J. H. Greenberg, J. Cereb. Blood Flow Metab. 24, 518 (2004).

Gursoy, Y.

C. Ayata, H. Shin, S. Salomone, Y. Gursoy, D. Boas, A. Dunn, and M. Moskowitz, J. Cereb. Blood Flow Metab. 24, 1172 (2004).

Hayrunnisa, B.

A. K. Dunn, B. Hayrunnisa, M. Moskowitz, and D. Boas, J. Cereb. Blood Flow Metab. 21, 195 (2001).

Huang, Z.

C. Ayata, A. Dunn, Y. Özdemir, Z. Huang, D. Boas, and M. Moskowitz, J. Cereb. Blood Flow Metab. 24, 744 (2004).

Leith, E.

Lopez, J.

Luft, A.

J. Paul, A. Luft, E. Yew, and F. Sheu, Neuroimage 29, 38 (2006).

Luo, Q.

H. Cheng, Q. Luo, S. Zeng, S. Chen, J. Cen, and H. Gong, J. Biomed. Opt. 8, 559 (2003).

Moskowitz, M.

C. Ayata, A. Dunn, Y. Özdemir, Z. Huang, D. Boas, and M. Moskowitz, J. Cereb. Blood Flow Metab. 24, 744 (2004).

C. Ayata, H. Shin, S. Salomone, Y. Gursoy, D. Boas, A. Dunn, and M. Moskowitz, J. Cereb. Blood Flow Metab. 24, 1172 (2004).

A. K. Dunn, B. Hayrunnisa, M. Moskowitz, and D. Boas, J. Cereb. Blood Flow Metab. 21, 195 (2001).

Naulleau, P.

Özdemir, Y.

C. Ayata, A. Dunn, Y. Özdemir, Z. Huang, D. Boas, and M. Moskowitz, J. Cereb. Blood Flow Metab. 24, 744 (2004).

Paul, J.

J. Paul, A. Luft, E. Yew, and F. Sheu, Neuroimage 29, 38 (2006).

Salomone, S.

C. Ayata, H. Shin, S. Salomone, Y. Gursoy, D. Boas, A. Dunn, and M. Moskowitz, J. Cereb. Blood Flow Metab. 24, 1172 (2004).

Sheu, F.

J. Paul, A. Luft, E. Yew, and F. Sheu, Neuroimage 29, 38 (2006).

Shin, H.

C. Ayata, H. Shin, S. Salomone, Y. Gursoy, D. Boas, A. Dunn, and M. Moskowitz, J. Cereb. Blood Flow Metab. 24, 1172 (2004).

Yew, E.

J. Paul, A. Luft, E. Yew, and F. Sheu, Neuroimage 29, 38 (2006).

Yodh, A.

J. Culver, T. Durduran, D. Furuya, C. Cheung, J. Greenberg, and A. Yodh, J. Cereb. Blood Flow Metab. 23, 911 (2003).

Yodh, A. G.

T. Durduran, M. G. Burnett, G. Yu, C. Zhou, D. Furuya, A. G. Yodh, J. A. Detre, and J. H. Greenberg, J. Cereb. Blood Flow Metab. 24, 518 (2004).

Yu, G.

T. Durduran, M. G. Burnett, G. Yu, C. Zhou, D. Furuya, A. G. Yodh, J. A. Detre, and J. H. Greenberg, J. Cereb. Blood Flow Metab. 24, 518 (2004).

Zeng, S.

H. Cheng, Q. Luo, S. Zeng, S. Chen, J. Cen, and H. Gong, J. Biomed. Opt. 8, 559 (2003).

Zhou, C.

T. Durduran, M. G. Burnett, G. Yu, C. Zhou, D. Furuya, A. G. Yodh, J. A. Detre, and J. H. Greenberg, J. Cereb. Blood Flow Metab. 24, 518 (2004).

J. Biomed. Opt.

Y. Aizu and T. Asakura, J. Biomed. Opt. 4, 61 (1999).

H. Cheng, Q. Luo, S. Zeng, S. Chen, J. Cen, and H. Gong, J. Biomed. Opt. 8, 559 (2003).

J. Cereb. Blood Flow Metab.

C. Ayata, H. Shin, S. Salomone, Y. Gursoy, D. Boas, A. Dunn, and M. Moskowitz, J. Cereb. Blood Flow Metab. 24, 1172 (2004).

C. Ayata, A. Dunn, Y. Özdemir, Z. Huang, D. Boas, and M. Moskowitz, J. Cereb. Blood Flow Metab. 24, 744 (2004).

J. Culver, T. Durduran, D. Furuya, C. Cheung, J. Greenberg, and A. Yodh, J. Cereb. Blood Flow Metab. 23, 911 (2003).

T. Durduran, M. G. Burnett, G. Yu, C. Zhou, D. Furuya, A. G. Yodh, J. A. Detre, and J. H. Greenberg, J. Cereb. Blood Flow Metab. 24, 518 (2004).

A. K. Dunn, B. Hayrunnisa, M. Moskowitz, and D. Boas, J. Cereb. Blood Flow Metab. 21, 195 (2001).

Neuroimage

J. Paul, A. Luft, E. Yew, and F. Sheu, Neuroimage 29, 38 (2006).

A. K. Dunn, A. Devor, A. Dale, and D. Boas, Neuroimage 27, 279 (2005).

Opt. Lett.

Physiol. Meas

J. D. Briers, Physiol. Meas 22, R35 (2001).

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