Abstract

A fiber-optic sensor is designed based on multicavity Fabry–Perot interferometry for the study of optical thickness in self-assembled thin-film layers. This miniature sensor is applicable not only to the measurement of self-assembled polyelectrolyte layers but also to the immobilization of proteins such as immunoglobulin G (IgG). The binding of IgG and the corresponding antigen is observed, and the nonspecific binding characteristics are investigated. The optical thickness changes are used to evaluate the immobilization of the IgG and the immunological activities of the immobilized layers.

© 2005 Optical Society of America

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References

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  1. G. Decher, J. D. Hong, and J. Schmitt, Thin Solid Films 210/211, 831 (1992).
    [CrossRef]
  2. G. M. Lowman and S. K. Buratto, Thin Solid Films 405, 135 (2002).
    [CrossRef]
  3. P. Lavalle, C. Gergely, F. J. G. Cuisinier, G. Decher, P. Schaaf, J. C. Voegel, and C. Picart, Macromolecules 35, 4458 (2002).
    [CrossRef]
  4. F. J. Arregui, I. R. Matias, Y. Liu, K. M. Lenahan, and R. O. Claus, Opt. Lett. 24, 596 (1999).
    [CrossRef]
  5. J. D. Hong, K. Lowack, J. Schmitt, and G. Decher, Prog. Colloid Polym. Sci. 93, 98 (1993).
    [CrossRef]
  6. J. Buijs, J. W. T. Lichtenbelt, W. Norde, and J. Lyklema, Colloids Surf. B 5, 11 (1995).
    [CrossRef]
  7. M. V. Klein and T. E. Furtak, Optics, 2nd ed. (Wiley, New York, 1986), pp. 295–301.
  8. J. J. Ramsden, Y. M. Lvov, and G. Decher, Thin Solid Films 254, 246 (1995).
    [CrossRef]
  9. F. Caruso, K. Niikura, D. N. Furlong, and Y. Okahata, Langmuir 13, 3427 (1997).
    [CrossRef]
  10. N. J. Geddes, A. S. Martin, F. Caruso, R. S. Urquhart, D. N. Furlong, J. R. Sambles, K. A. Than, and J. A. Edgar, J. Immunol. Methods 175, 149 (1994).
    [CrossRef] [PubMed]
  11. F. Caruso, E. Rodda, and D. N. Furlong, J. Colloid Interface Sci. 178, 104 (1996).
    [CrossRef]

2002

G. M. Lowman and S. K. Buratto, Thin Solid Films 405, 135 (2002).
[CrossRef]

P. Lavalle, C. Gergely, F. J. G. Cuisinier, G. Decher, P. Schaaf, J. C. Voegel, and C. Picart, Macromolecules 35, 4458 (2002).
[CrossRef]

1999

1997

F. Caruso, K. Niikura, D. N. Furlong, and Y. Okahata, Langmuir 13, 3427 (1997).
[CrossRef]

1996

F. Caruso, E. Rodda, and D. N. Furlong, J. Colloid Interface Sci. 178, 104 (1996).
[CrossRef]

1995

J. Buijs, J. W. T. Lichtenbelt, W. Norde, and J. Lyklema, Colloids Surf. B 5, 11 (1995).
[CrossRef]

J. J. Ramsden, Y. M. Lvov, and G. Decher, Thin Solid Films 254, 246 (1995).
[CrossRef]

1994

N. J. Geddes, A. S. Martin, F. Caruso, R. S. Urquhart, D. N. Furlong, J. R. Sambles, K. A. Than, and J. A. Edgar, J. Immunol. Methods 175, 149 (1994).
[CrossRef] [PubMed]

1993

J. D. Hong, K. Lowack, J. Schmitt, and G. Decher, Prog. Colloid Polym. Sci. 93, 98 (1993).
[CrossRef]

1992

G. Decher, J. D. Hong, and J. Schmitt, Thin Solid Films 210/211, 831 (1992).
[CrossRef]

Arregui, F. J.

Buijs, J.

J. Buijs, J. W. T. Lichtenbelt, W. Norde, and J. Lyklema, Colloids Surf. B 5, 11 (1995).
[CrossRef]

Buratto, S. K.

G. M. Lowman and S. K. Buratto, Thin Solid Films 405, 135 (2002).
[CrossRef]

Caruso, F.

F. Caruso, K. Niikura, D. N. Furlong, and Y. Okahata, Langmuir 13, 3427 (1997).
[CrossRef]

F. Caruso, E. Rodda, and D. N. Furlong, J. Colloid Interface Sci. 178, 104 (1996).
[CrossRef]

N. J. Geddes, A. S. Martin, F. Caruso, R. S. Urquhart, D. N. Furlong, J. R. Sambles, K. A. Than, and J. A. Edgar, J. Immunol. Methods 175, 149 (1994).
[CrossRef] [PubMed]

Claus, R. O.

Cuisinier, F. J. G.

P. Lavalle, C. Gergely, F. J. G. Cuisinier, G. Decher, P. Schaaf, J. C. Voegel, and C. Picart, Macromolecules 35, 4458 (2002).
[CrossRef]

Decher, G.

P. Lavalle, C. Gergely, F. J. G. Cuisinier, G. Decher, P. Schaaf, J. C. Voegel, and C. Picart, Macromolecules 35, 4458 (2002).
[CrossRef]

J. J. Ramsden, Y. M. Lvov, and G. Decher, Thin Solid Films 254, 246 (1995).
[CrossRef]

J. D. Hong, K. Lowack, J. Schmitt, and G. Decher, Prog. Colloid Polym. Sci. 93, 98 (1993).
[CrossRef]

G. Decher, J. D. Hong, and J. Schmitt, Thin Solid Films 210/211, 831 (1992).
[CrossRef]

Edgar, J. A.

N. J. Geddes, A. S. Martin, F. Caruso, R. S. Urquhart, D. N. Furlong, J. R. Sambles, K. A. Than, and J. A. Edgar, J. Immunol. Methods 175, 149 (1994).
[CrossRef] [PubMed]

Furlong, D. N.

F. Caruso, K. Niikura, D. N. Furlong, and Y. Okahata, Langmuir 13, 3427 (1997).
[CrossRef]

F. Caruso, E. Rodda, and D. N. Furlong, J. Colloid Interface Sci. 178, 104 (1996).
[CrossRef]

N. J. Geddes, A. S. Martin, F. Caruso, R. S. Urquhart, D. N. Furlong, J. R. Sambles, K. A. Than, and J. A. Edgar, J. Immunol. Methods 175, 149 (1994).
[CrossRef] [PubMed]

Furtak, T. E.

M. V. Klein and T. E. Furtak, Optics, 2nd ed. (Wiley, New York, 1986), pp. 295–301.

Geddes, N. J.

N. J. Geddes, A. S. Martin, F. Caruso, R. S. Urquhart, D. N. Furlong, J. R. Sambles, K. A. Than, and J. A. Edgar, J. Immunol. Methods 175, 149 (1994).
[CrossRef] [PubMed]

Gergely, C.

P. Lavalle, C. Gergely, F. J. G. Cuisinier, G. Decher, P. Schaaf, J. C. Voegel, and C. Picart, Macromolecules 35, 4458 (2002).
[CrossRef]

Hong, J. D.

J. D. Hong, K. Lowack, J. Schmitt, and G. Decher, Prog. Colloid Polym. Sci. 93, 98 (1993).
[CrossRef]

G. Decher, J. D. Hong, and J. Schmitt, Thin Solid Films 210/211, 831 (1992).
[CrossRef]

Klein, M. V.

M. V. Klein and T. E. Furtak, Optics, 2nd ed. (Wiley, New York, 1986), pp. 295–301.

Lavalle, P.

P. Lavalle, C. Gergely, F. J. G. Cuisinier, G. Decher, P. Schaaf, J. C. Voegel, and C. Picart, Macromolecules 35, 4458 (2002).
[CrossRef]

Lenahan, K. M.

Lichtenbelt, J. W. T.

J. Buijs, J. W. T. Lichtenbelt, W. Norde, and J. Lyklema, Colloids Surf. B 5, 11 (1995).
[CrossRef]

Liu, Y.

Lowack, K.

J. D. Hong, K. Lowack, J. Schmitt, and G. Decher, Prog. Colloid Polym. Sci. 93, 98 (1993).
[CrossRef]

Lowman, G. M.

G. M. Lowman and S. K. Buratto, Thin Solid Films 405, 135 (2002).
[CrossRef]

Lvov, Y. M.

J. J. Ramsden, Y. M. Lvov, and G. Decher, Thin Solid Films 254, 246 (1995).
[CrossRef]

Lyklema, J.

J. Buijs, J. W. T. Lichtenbelt, W. Norde, and J. Lyklema, Colloids Surf. B 5, 11 (1995).
[CrossRef]

Martin, A. S.

N. J. Geddes, A. S. Martin, F. Caruso, R. S. Urquhart, D. N. Furlong, J. R. Sambles, K. A. Than, and J. A. Edgar, J. Immunol. Methods 175, 149 (1994).
[CrossRef] [PubMed]

Matias, I. R.

Niikura, K.

F. Caruso, K. Niikura, D. N. Furlong, and Y. Okahata, Langmuir 13, 3427 (1997).
[CrossRef]

Norde, W.

J. Buijs, J. W. T. Lichtenbelt, W. Norde, and J. Lyklema, Colloids Surf. B 5, 11 (1995).
[CrossRef]

Okahata, Y.

F. Caruso, K. Niikura, D. N. Furlong, and Y. Okahata, Langmuir 13, 3427 (1997).
[CrossRef]

Picart, C.

P. Lavalle, C. Gergely, F. J. G. Cuisinier, G. Decher, P. Schaaf, J. C. Voegel, and C. Picart, Macromolecules 35, 4458 (2002).
[CrossRef]

Ramsden, J. J.

J. J. Ramsden, Y. M. Lvov, and G. Decher, Thin Solid Films 254, 246 (1995).
[CrossRef]

Rodda, E.

F. Caruso, E. Rodda, and D. N. Furlong, J. Colloid Interface Sci. 178, 104 (1996).
[CrossRef]

Sambles, J. R.

N. J. Geddes, A. S. Martin, F. Caruso, R. S. Urquhart, D. N. Furlong, J. R. Sambles, K. A. Than, and J. A. Edgar, J. Immunol. Methods 175, 149 (1994).
[CrossRef] [PubMed]

Schaaf, P.

P. Lavalle, C. Gergely, F. J. G. Cuisinier, G. Decher, P. Schaaf, J. C. Voegel, and C. Picart, Macromolecules 35, 4458 (2002).
[CrossRef]

Schmitt, J.

J. D. Hong, K. Lowack, J. Schmitt, and G. Decher, Prog. Colloid Polym. Sci. 93, 98 (1993).
[CrossRef]

G. Decher, J. D. Hong, and J. Schmitt, Thin Solid Films 210/211, 831 (1992).
[CrossRef]

Than, K. A.

N. J. Geddes, A. S. Martin, F. Caruso, R. S. Urquhart, D. N. Furlong, J. R. Sambles, K. A. Than, and J. A. Edgar, J. Immunol. Methods 175, 149 (1994).
[CrossRef] [PubMed]

Urquhart, R. S.

N. J. Geddes, A. S. Martin, F. Caruso, R. S. Urquhart, D. N. Furlong, J. R. Sambles, K. A. Than, and J. A. Edgar, J. Immunol. Methods 175, 149 (1994).
[CrossRef] [PubMed]

Voegel, J. C.

P. Lavalle, C. Gergely, F. J. G. Cuisinier, G. Decher, P. Schaaf, J. C. Voegel, and C. Picart, Macromolecules 35, 4458 (2002).
[CrossRef]

Colloids Surf. B

J. Buijs, J. W. T. Lichtenbelt, W. Norde, and J. Lyklema, Colloids Surf. B 5, 11 (1995).
[CrossRef]

J. Colloid Interface Sci.

F. Caruso, E. Rodda, and D. N. Furlong, J. Colloid Interface Sci. 178, 104 (1996).
[CrossRef]

J. Immunol. Methods

N. J. Geddes, A. S. Martin, F. Caruso, R. S. Urquhart, D. N. Furlong, J. R. Sambles, K. A. Than, and J. A. Edgar, J. Immunol. Methods 175, 149 (1994).
[CrossRef] [PubMed]

Langmuir

F. Caruso, K. Niikura, D. N. Furlong, and Y. Okahata, Langmuir 13, 3427 (1997).
[CrossRef]

Macromolecules

P. Lavalle, C. Gergely, F. J. G. Cuisinier, G. Decher, P. Schaaf, J. C. Voegel, and C. Picart, Macromolecules 35, 4458 (2002).
[CrossRef]

Opt. Lett.

Prog. Colloid Polym. Sci.

J. D. Hong, K. Lowack, J. Schmitt, and G. Decher, Prog. Colloid Polym. Sci. 93, 98 (1993).
[CrossRef]

Thin Solid Films

G. Decher, J. D. Hong, and J. Schmitt, Thin Solid Films 210/211, 831 (1992).
[CrossRef]

G. M. Lowman and S. K. Buratto, Thin Solid Films 405, 135 (2002).
[CrossRef]

J. J. Ramsden, Y. M. Lvov, and G. Decher, Thin Solid Films 254, 246 (1995).
[CrossRef]

Other

M. V. Klein and T. E. Furtak, Optics, 2nd ed. (Wiley, New York, 1986), pp. 295–301.

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Figures (5)

Fig. 1
Fig. 1

Schematic of the multicavity FP sensor system.

Fig. 2
Fig. 2

Structure of the multicavity FP sensor.

Fig. 3
Fig. 3

Reflection spectrum of a multicavity FP sensor.

Fig. 4
Fig. 4

Increase in optical thickness with the number of polymer layers. Optical thickness is the product of thickness in nanometers and refractive index n.

Fig. 5
Fig. 5

Optical thickness changes in the fiber–film cavity during self-assembly of the polymer film and immobilization of IgG and anti-IgG. Optical thickness is the product of the cavity length in nanometers and the refractive index.

Equations (5)

Equations on this page are rendered with MathJax. Learn more.

H 12 = 1 τ 12 ( 1 ρ 12 ρ 12 1 ) ,
H 23 = 1 τ 23 ( 1 ρ 23 ρ 23 1 ) , H 34 = 1 τ 34 ( 1 ρ 34 ρ 34 1 ) ,
L 2 = [ exp ( i β 2 ) 0 0 exp ( i β 2 ) ] ,
L 3 = [ exp ( i β 3 ) 0 0 exp ( i β 3 ) ] ,
R = S 12 S 22 2 = R 1 + R 2 + R 3 + R 1 R 2 R 3 2 ( R 1 R 2 ) 1 2 ( R 3 + 1 ) cos ( 2 β 2 ) 1 + R 1 R 2 + R 2 R 3 + R 1 R 3 2 ( R 1 R 2 ) 1 2 ( R 3 + 1 ) cos ( 2 β 2 ) 2 ( R 2 R 3 ) 1 2 ( R 1 + 1 ) cos ( 2 β 3 ) + 2 ( R 1 R 3 ) 1 2 cos 2 ( β 2 + β 3 ) + 2 ( R 1 R 3 ) 1 2 R 2 cos 2 ( β 2 β 3 ) 2 ( R 2 R 3 ) 1 2 ( R 1 + 1 ) cos ( 2 β 3 ) + 2 ( R 1 R 3 ) 1 2 cos 2 ( β 2 + β 3 ) + 2 ( R 1 R 3 ) 1 2 R 2 cos 2 ( β 2 β 3 ) ,

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