Abstract

The use of spectroscopic optical coherence tomography to assess hemoglobin oxygen saturation of whole blood is investigated. We propose to use the differential attenuation coefficient to determine the degree of saturation. Our data show qualitative agreement between the measured differential attenuation coefficients as a function of saturation and predictions based on the oxygen-saturation-dependent absorption and scattering properties of blood.

© 2005 Optical Society of America

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References

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2004 (6)

2003 (1)

2001 (1)

2000 (2)

1999 (1)

A. Roggan, M. Friebel, K. Dörschel, A. Hahn, and G. Müller, J. Biomed. Opt. 4, 36 (1999).
[CrossRef] [PubMed]

1998 (2)

A. G. Borovoi, E. I. Naats, and U. G. Oppel, J. Biomed. Opt. 3, 364 (1998).
[CrossRef] [PubMed]

J. M. Schmitt, S. H. Xiang, and K. M. Yung, J. Opt. Soc. Am. A 15, 2288 (1998).
[CrossRef]

1997 (1)

1970 (1)

Aalders, M. C.G.

Bizheva, K.

Boppart, S. A.

Borovoi, A. G.

A. G. Borovoi, E. I. Naats, and U. G. Oppel, J. Biomed. Opt. 3, 364 (1998).
[CrossRef] [PubMed]

Choma, M. A.

Do, M. N.

Dörschel, K.

A. Roggan, M. Friebel, K. Dörschel, A. Hahn, and G. Müller, J. Biomed. Opt. 4, 36 (1999).
[CrossRef] [PubMed]

Drexler, W.

Esenaliev, R. O.

Faber, D. J.

Fercher, A. F.

Friebel, M.

A. Roggan, M. Friebel, K. Dörschel, A. Hahn, and G. Müller, J. Biomed. Opt. 4, 36 (1999).
[CrossRef] [PubMed]

Fujimoto, J. G.

Hahn, A.

A. Roggan, M. Friebel, K. Dörschel, A. Hahn, and G. Müller, J. Biomed. Opt. 4, 36 (1999).
[CrossRef] [PubMed]

Hermann, B.

Hitzenberger, C. K.

Hooper, B. A.

D. J. Faber, M. C.G. Aalders, E. G. Mik, B. A. Hooper, M. J.C. van Gemert, and T. G. van Leeuwen, Phys. Rev. Lett. 93, 028102 (2004).
[CrossRef]

Ippen, E. P.

Izatt, J. A.

Kärtner, F. X.

Knüttel, A.

Kowalczyk, A.

Lamb, L. E.

Larin, K. V.

Larina, I. V.

Leitgeb, R.

Li, X. D.

Marks, D. L.

Mik, E. G.

D. J. Faber, M. C.G. Aalders, E. G. Mik, B. A. Hooper, M. J.C. van Gemert, and T. G. van Leeuwen, Phys. Rev. Lett. 93, 028102 (2004).
[CrossRef]

D. J. Faber, E. G. Mik, M. C.G. Aalders, and T. G. van Leeuwen, Opt. Lett. 28, 1436 (2003).
[CrossRef] [PubMed]

Morgner, U.

Motamedi, M.

Müller, G.

A. Roggan, M. Friebel, K. Dörschel, A. Hahn, and G. Müller, J. Biomed. Opt. 4, 36 (1999).
[CrossRef] [PubMed]

Naats, E. I.

A. G. Borovoi, E. I. Naats, and U. G. Oppel, J. Biomed. Opt. 3, 364 (1998).
[CrossRef] [PubMed]

Oppel, U. G.

A. G. Borovoi, E. I. Naats, and U. G. Oppel, J. Biomed. Opt. 3, 364 (1998).
[CrossRef] [PubMed]

Pitris, C.

Povožay, B.

Prahl, S.

Data tabulated from various sources compiled by S. Prahl, http://omlc.ogi.edu/spectra.

Roggan, A.

A. Roggan, M. Friebel, K. Dörschel, A. Hahn, and G. Müller, J. Biomed. Opt. 4, 36 (1999).
[CrossRef] [PubMed]

Sattmann, H.

Schmetterer, L.

Schmitt, J. M.

Simon, J. D.

Sticker, M.

Twerksy, V.

Unterhuber, A.

van der Meer, F. J.

van Gemert, M. J.C.

D. J. Faber, M. C.G. Aalders, E. G. Mik, B. A. Hooper, M. J.C. van Gemert, and T. G. van Leeuwen, Phys. Rev. Lett. 93, 028102 (2004).
[CrossRef]

van Leeuwen, T. G.

Wojtkowski, M.

Xiang, S. H.

Xu, C.

Yang, C.

Ye, J.

Yung, K. M.

J. Biomed. Opt. (2)

A. G. Borovoi, E. I. Naats, and U. G. Oppel, J. Biomed. Opt. 3, 364 (1998).
[CrossRef] [PubMed]

A. Roggan, M. Friebel, K. Dörschel, A. Hahn, and G. Müller, J. Biomed. Opt. 4, 36 (1999).
[CrossRef] [PubMed]

J. Opt. Soc. Am. (1)

J. Opt. Soc. Am. A (2)

Opt. Express (3)

Opt. Lett. (6)

Phys. Rev. Lett. (1)

D. J. Faber, M. C.G. Aalders, E. G. Mik, B. A. Hooper, M. J.C. van Gemert, and T. G. van Leeuwen, Phys. Rev. Lett. 93, 028102 (2004).
[CrossRef]

Other (2)

V. V. Tuchin, ed., Handbook of Biomedical Optics (SPIE Press, Bellingham, Wash., 2002).

Data tabulated from various sources compiled by S. Prahl, http://omlc.ogi.edu/spectra.

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Figures (3)

Fig. 1
Fig. 1

(A) Absorption cross-section spectra of oxygenated and deoxygenated Hb calculated from their molar extinction coefficients, by use of a concentration value of 150 g L .[9] (B) Computed scattering cross section of oxygenated and deoxygenated RBCs. The uncertainty in the data is σ s < 8 % .[10]

Fig. 2
Fig. 2

Attenuation spectra of oxygenated and deoxygenated whole blood (first experiment). The lines were drawn as a guide to the eye.

Fig. 3
Fig. 3

Δ μ t at 780 and 820 nm determined from the cuvette boundaries [second experiment (A)] and from the blood layer itself [third experiment (B)]. Errors in Δ μ t are < 0.25 mm 1 . Solid lines, fits of the measured data with their correlation coefficients and statistical significance. Dashed curves, 95% confidence bounds of the linear fit.

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