Abstract

We present a preliminary series of clinical experiments showing that ultrasound modulation of light in tissues allows tissue properties to be determined well inside the tissue. In this series of clinical experiments the optical scattering coefficient determined by the optical technique is compared with the bone density obtained by dual x-ray absorption. A correlation of 0.84 (p=0.005) was found for a limited number of patients, showing the potential of this technique for the assessment of osteoporosis.

© 2005 Optical Society of America

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References

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  1. D. Dolfi and F. Micheron, ‘‘Imaging process and system for transillumination with photon frequency marking,’’ PCT number W 89/ 00278 (January 12, 1989)
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    [CrossRef]
  6. A. Lev and B. Sfez, J. Opt. Soc. Am. A 20, 12 (2003).
    [CrossRef]
  7. A. Lev, Z. Kotler, and B. Sfez, Opt. Lett. 25, 378 (2000).
    [CrossRef]
  8. A. Lev and B. Sfez, Opt. Lett. 27, 473 (2002).
    [CrossRef]
  9. H. G. Eberle, J. Beuthan, and G. Muller, Z. Med. Phys. 10, 177 (2000).
  10. A. Takeuchi, R. Akari, S. G. Proskurin, Y. Takahashi, Y. Yamada, J. Ishil, S. Katayama, and A. Itabashi, J. Bone Miner. Res. 12, 261 (1997).
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    [CrossRef] [PubMed]
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    [CrossRef]
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    [CrossRef]
  14. C. A. Mautalen and E. M. Vega in Quantitative Ultrasound, Assessment of Osteoporosis and Bone Status, C. F. Njeh, D. Hans, T. Fuerst, C.-C. Glüer, and H. K. Genant, eds. (Martin Dunitz, 1999), p. 377.

2004 (1)

N. Ugryumova, S. J. Matcher, and D. P. Attenburrow, Phys. Med. Biol. 49, 469 (2004).
[CrossRef] [PubMed]

2003 (2)

A. Lev and B. Sfez, Opt. Lett. 28, 17 (2003).
[CrossRef]

A. Lev and B. Sfez, J. Opt. Soc. Am. A 20, 12 (2003).
[CrossRef]

2002 (1)

2001 (1)

2000 (2)

A. Lev, Z. Kotler, and B. Sfez, Opt. Lett. 25, 378 (2000).
[CrossRef]

H. G. Eberle, J. Beuthan, and G. Muller, Z. Med. Phys. 10, 177 (2000).

1999 (1)

1997 (2)

A. Takeuchi, R. Akari, S. G. Proskurin, Y. Takahashi, Y. Yamada, J. Ishil, S. Katayama, and A. Itabashi, J. Bone Miner. Res. 12, 261 (1997).
[CrossRef] [PubMed]

M. Kempe, M. Larionov, D. Zaslavski, and A. Z. Genack, J. Opt. Soc. Am. A 14, 1151 (1997).
[CrossRef]

1995 (2)

Akari, R.

A. Takeuchi, R. Akari, S. G. Proskurin, Y. Takahashi, Y. Yamada, J. Ishil, S. Katayama, and A. Itabashi, J. Bone Miner. Res. 12, 261 (1997).
[CrossRef] [PubMed]

Attenburrow, D. P.

N. Ugryumova, S. J. Matcher, and D. P. Attenburrow, Phys. Med. Biol. 49, 469 (2004).
[CrossRef] [PubMed]

Beuthan, J.

H. G. Eberle, J. Beuthan, and G. Muller, Z. Med. Phys. 10, 177 (2000).

Boccara, A. C.

Dolfi, D.

D. Dolfi and F. Micheron, ‘‘Imaging process and system for transillumination with photon frequency marking,’’ PCT number W 89/ 00278 (January 12, 1989)

Eberle, H. G.

H. G. Eberle, J. Beuthan, and G. Muller, Z. Med. Phys. 10, 177 (2000).

Genack, A. Z.

Granot, E.

Ishil, J.

A. Takeuchi, R. Akari, S. G. Proskurin, Y. Takahashi, Y. Yamada, J. Ishil, S. Katayama, and A. Itabashi, J. Bone Miner. Res. 12, 261 (1997).
[CrossRef] [PubMed]

Itabashi, A.

A. Takeuchi, R. Akari, S. G. Proskurin, Y. Takahashi, Y. Yamada, J. Ishil, S. Katayama, and A. Itabashi, J. Bone Miner. Res. 12, 261 (1997).
[CrossRef] [PubMed]

Jacques, S. L.

Katayama, S.

A. Takeuchi, R. Akari, S. G. Proskurin, Y. Takahashi, Y. Yamada, J. Ishil, S. Katayama, and A. Itabashi, J. Bone Miner. Res. 12, 261 (1997).
[CrossRef] [PubMed]

Kempe, M.

Kotler, Z.

Larionov, M.

Lebec, M.

Leutz, W.

W. Leutz and G. Maret, Physica B 204, 14 (1995).
[CrossRef]

Lev, A.

Leveque, S.

Maret, G.

W. Leutz and G. Maret, Physica B 204, 14 (1995).
[CrossRef]

Matcher, S. J.

N. Ugryumova, S. J. Matcher, and D. P. Attenburrow, Phys. Med. Biol. 49, 469 (2004).
[CrossRef] [PubMed]

Mautalen, C. A.

C. A. Mautalen and E. M. Vega in Quantitative Ultrasound, Assessment of Osteoporosis and Bone Status, C. F. Njeh, D. Hans, T. Fuerst, C.-C. Glüer, and H. K. Genant, eds. (Martin Dunitz, 1999), p. 377.

Micheron, F.

D. Dolfi and F. Micheron, ‘‘Imaging process and system for transillumination with photon frequency marking,’’ PCT number W 89/ 00278 (January 12, 1989)

Muller, G.

H. G. Eberle, J. Beuthan, and G. Muller, Z. Med. Phys. 10, 177 (2000).

Proskurin, S. G.

A. Takeuchi, R. Akari, S. G. Proskurin, Y. Takahashi, Y. Yamada, J. Ishil, S. Katayama, and A. Itabashi, J. Bone Miner. Res. 12, 261 (1997).
[CrossRef] [PubMed]

Saint-Jalmes, H.

Sfez, B.

A. Lev and B. Sfez, Opt. Lett. 28, 17 (2003).
[CrossRef]

A. Lev and B. Sfez, J. Opt. Soc. Am. A 20, 12 (2003).
[CrossRef]

A. Lev and B. Sfez, Opt. Lett. 27, 473 (2002).
[CrossRef]

A. Lev, Z. Kotler, and B. Sfez, Opt. Lett. 25, 378 (2000).
[CrossRef]

Sfez, B. G.

Taitelbaum, H.

Takahashi, Y.

A. Takeuchi, R. Akari, S. G. Proskurin, Y. Takahashi, Y. Yamada, J. Ishil, S. Katayama, and A. Itabashi, J. Bone Miner. Res. 12, 261 (1997).
[CrossRef] [PubMed]

Takeuchi, A.

A. Takeuchi, R. Akari, S. G. Proskurin, Y. Takahashi, Y. Yamada, J. Ishil, S. Katayama, and A. Itabashi, J. Bone Miner. Res. 12, 261 (1997).
[CrossRef] [PubMed]

Ugryumova, N.

N. Ugryumova, S. J. Matcher, and D. P. Attenburrow, Phys. Med. Biol. 49, 469 (2004).
[CrossRef] [PubMed]

Vega, E. M.

C. A. Mautalen and E. M. Vega in Quantitative Ultrasound, Assessment of Osteoporosis and Bone Status, C. F. Njeh, D. Hans, T. Fuerst, C.-C. Glüer, and H. K. Genant, eds. (Martin Dunitz, 1999), p. 377.

Wang, L.

Yamada, Y.

A. Takeuchi, R. Akari, S. G. Proskurin, Y. Takahashi, Y. Yamada, J. Ishil, S. Katayama, and A. Itabashi, J. Bone Miner. Res. 12, 261 (1997).
[CrossRef] [PubMed]

Zaslavski, D.

Zhao, X.

J. Bone Miner. Res. (1)

A. Takeuchi, R. Akari, S. G. Proskurin, Y. Takahashi, Y. Yamada, J. Ishil, S. Katayama, and A. Itabashi, J. Bone Miner. Res. 12, 261 (1997).
[CrossRef] [PubMed]

J. Opt. Soc. Am. A (3)

Opt. Lett. (5)

Phys. Med. Biol. (1)

N. Ugryumova, S. J. Matcher, and D. P. Attenburrow, Phys. Med. Biol. 49, 469 (2004).
[CrossRef] [PubMed]

Physica B (1)

W. Leutz and G. Maret, Physica B 204, 14 (1995).
[CrossRef]

Z. Med. Phys. (1)

H. G. Eberle, J. Beuthan, and G. Muller, Z. Med. Phys. 10, 177 (2000).

Other (2)

D. Dolfi and F. Micheron, ‘‘Imaging process and system for transillumination with photon frequency marking,’’ PCT number W 89/ 00278 (January 12, 1989)

C. A. Mautalen and E. M. Vega in Quantitative Ultrasound, Assessment of Osteoporosis and Bone Status, C. F. Njeh, D. Hans, T. Fuerst, C.-C. Glüer, and H. K. Genant, eds. (Martin Dunitz, 1999), p. 377.

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Figures (4)

Fig. 1
Fig. 1

Ultrasound-modulated light experimental system. The left hand is in tight contact with the light sensor, and the ultrasound bath is coupled to the wrist from the top.

Fig. 2
Fig. 2

DXA experimental image of the left forearm. In the picture the 30 mm metal wire is clearly shown, and the measurement locations are marked.

Fig. 3
Fig. 3

Typical experimental pulsed configuration for two cases: healthy bone ( μ = 8.3 cm 1 ; squares) and osteoporotic bone ( μ = 4.3 cm 1 ; circles). Insets, fits of the data with the second-order polynomial described in the text.

Fig. 4
Fig. 4

Correlation of optical attenuation coefficient μ with the DXA measurement of BMD for the nine cases included in the study.

Equations (5)

Equations on this page are rendered with MathJax. Learn more.

f ( r ) = f 0 1 + μ r r 3 exp ( μ r ) ,
f ( X ) = A X 2 + B ,
B = f 0 ( 1 + μ d ) exp ( μ d ) ,
A = B 2 d 2 [ μ d 1 + μ d ( 3 + μ d ) ] ,
r 2 = d 2 + X 2 ,

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