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Label-free detection of microarrays of biomolecules by oblique-incidence reflectivity difference microscopy

J. P. Landry, X. D. Zhu, and J. P. Gregg

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Abstract

We developed an oblique-incidence reflectivity difference (OI-RD) scanning microscope for label-free imaging of microarrays of biomolecules upon solid substrates. We demonstrate that hybridization reactions in an oligonucleotide microarray fabricated upon a glass slide can be detected by such an OI-RD microscope.

© 2004 Optical Society of America

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