Abstract

A spatially adaptive two-dimensional wavelet filter is used to reduce speckle noise in time-domain and Fourier-domain optical coherence tomography (OCT) images. Edges can be separated from discontinuities that are due to noise, and noise power can be attenuated in the wavelet domain without significantly compromising image sharpness. A single parameter controls the degree of noise reduction. When this filter is applied to ophthalmic OCT images, signal-to-noise ratio improvements of >7 dB are attained, with a sharpness reduction of <3%.

© 2004 Optical Society of America

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  1. D. Huang, E. A. Swanson, C. P. Lin, J. C. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
    [CrossRef] [PubMed]
  2. J. M. Schmitt, S. H. Xiang, and K. M. Yung, J. Biomed. Opt. 4, 95 (1999).
    [CrossRef] [PubMed]
  3. N. Iftimia, B. E. Bouma, and G. J. Tearney, J. Biomed. Opt. 8, 260 (2003).
    [CrossRef] [PubMed]
  4. M. Pircher, E. Gotzinger, R. Leitgeb, A. F. Fercher, and C. K. Hitzenberger, J. Biomed. Opt. 8, 565 (2003).
    [CrossRef] [PubMed]
  5. J. Rogowska and M. E. Brezinski, Phys. Med. Biol. 47, 641 (2002).
    [CrossRef] [PubMed]
  6. H. Choi, T. E. Milner, and A. C. Bovik, presented at A New Beginning for Human Health: Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Cancun Mexico, September 17–21, 2003.
  7. S. G. Chang, B. Yu, and M. Vetterli, IEEE Trans. Image Process 9, 1522 (2000).
    [CrossRef]
  8. R. R. Coifman and D. L. Donoho, Translation Invariant Denoising (Springer-Verlag, Berlin, 1994).
  9. T. H. Ko, D. C. Adler, D. Mamedov, V. Prokhorov, V. Shidlovski, S. Yakubovich, and J. G. Fujimoto, Opt. Express 12, 2112 (2004), http://www.opticsexpress.org .
    [CrossRef] [PubMed]
  10. M. Wojtkowski, V. J. Srinivasan, T. H. Ko, J. G. Fujimoto, A. Kowalczyk, and J. S. Duker, Opt. Express 12, 2404 (2004), http://www.opticsexpress.org .
    [CrossRef] [PubMed]
  11. F. Sattar, L. Floreby, G. Salomonsson, and B. Lovstrom, IEEE Trans. Image Process. 6, 888 (1997).
    [CrossRef]

2004 (2)

2003 (2)

N. Iftimia, B. E. Bouma, and G. J. Tearney, J. Biomed. Opt. 8, 260 (2003).
[CrossRef] [PubMed]

M. Pircher, E. Gotzinger, R. Leitgeb, A. F. Fercher, and C. K. Hitzenberger, J. Biomed. Opt. 8, 565 (2003).
[CrossRef] [PubMed]

2002 (1)

J. Rogowska and M. E. Brezinski, Phys. Med. Biol. 47, 641 (2002).
[CrossRef] [PubMed]

2000 (1)

S. G. Chang, B. Yu, and M. Vetterli, IEEE Trans. Image Process 9, 1522 (2000).
[CrossRef]

1999 (1)

J. M. Schmitt, S. H. Xiang, and K. M. Yung, J. Biomed. Opt. 4, 95 (1999).
[CrossRef] [PubMed]

1997 (1)

F. Sattar, L. Floreby, G. Salomonsson, and B. Lovstrom, IEEE Trans. Image Process. 6, 888 (1997).
[CrossRef]

1991 (1)

D. Huang, E. A. Swanson, C. P. Lin, J. C. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Adler, D. C.

Bouma, B. E.

N. Iftimia, B. E. Bouma, and G. J. Tearney, J. Biomed. Opt. 8, 260 (2003).
[CrossRef] [PubMed]

Bovik, A. C.

H. Choi, T. E. Milner, and A. C. Bovik, presented at A New Beginning for Human Health: Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Cancun Mexico, September 17–21, 2003.

Brezinski, M. E.

J. Rogowska and M. E. Brezinski, Phys. Med. Biol. 47, 641 (2002).
[CrossRef] [PubMed]

Chang, S. G.

S. G. Chang, B. Yu, and M. Vetterli, IEEE Trans. Image Process 9, 1522 (2000).
[CrossRef]

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. C. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Choi, H.

H. Choi, T. E. Milner, and A. C. Bovik, presented at A New Beginning for Human Health: Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Cancun Mexico, September 17–21, 2003.

Coifman, R. R.

R. R. Coifman and D. L. Donoho, Translation Invariant Denoising (Springer-Verlag, Berlin, 1994).

Donoho, D. L.

R. R. Coifman and D. L. Donoho, Translation Invariant Denoising (Springer-Verlag, Berlin, 1994).

Duker, J. S.

Fercher, A. F.

M. Pircher, E. Gotzinger, R. Leitgeb, A. F. Fercher, and C. K. Hitzenberger, J. Biomed. Opt. 8, 565 (2003).
[CrossRef] [PubMed]

Floreby, L.

F. Sattar, L. Floreby, G. Salomonsson, and B. Lovstrom, IEEE Trans. Image Process. 6, 888 (1997).
[CrossRef]

Flotte, T.

D. Huang, E. A. Swanson, C. P. Lin, J. C. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Fujimoto, J. G.

Gotzinger, E.

M. Pircher, E. Gotzinger, R. Leitgeb, A. F. Fercher, and C. K. Hitzenberger, J. Biomed. Opt. 8, 565 (2003).
[CrossRef] [PubMed]

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. C. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Hee, M. R.

D. Huang, E. A. Swanson, C. P. Lin, J. C. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Hitzenberger, C. K.

M. Pircher, E. Gotzinger, R. Leitgeb, A. F. Fercher, and C. K. Hitzenberger, J. Biomed. Opt. 8, 565 (2003).
[CrossRef] [PubMed]

Huang, D.

D. Huang, E. A. Swanson, C. P. Lin, J. C. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Iftimia, N.

N. Iftimia, B. E. Bouma, and G. J. Tearney, J. Biomed. Opt. 8, 260 (2003).
[CrossRef] [PubMed]

Ko, T. H.

Kowalczyk, A.

Leitgeb, R.

M. Pircher, E. Gotzinger, R. Leitgeb, A. F. Fercher, and C. K. Hitzenberger, J. Biomed. Opt. 8, 565 (2003).
[CrossRef] [PubMed]

Lin, C. P.

D. Huang, E. A. Swanson, C. P. Lin, J. C. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Lovstrom, B.

F. Sattar, L. Floreby, G. Salomonsson, and B. Lovstrom, IEEE Trans. Image Process. 6, 888 (1997).
[CrossRef]

Mamedov, D.

Milner, T. E.

H. Choi, T. E. Milner, and A. C. Bovik, presented at A New Beginning for Human Health: Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Cancun Mexico, September 17–21, 2003.

Pircher, M.

M. Pircher, E. Gotzinger, R. Leitgeb, A. F. Fercher, and C. K. Hitzenberger, J. Biomed. Opt. 8, 565 (2003).
[CrossRef] [PubMed]

Prokhorov, V.

Puliafito, C. A.

D. Huang, E. A. Swanson, C. P. Lin, J. C. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Rogowska, J.

J. Rogowska and M. E. Brezinski, Phys. Med. Biol. 47, 641 (2002).
[CrossRef] [PubMed]

Salomonsson, G.

F. Sattar, L. Floreby, G. Salomonsson, and B. Lovstrom, IEEE Trans. Image Process. 6, 888 (1997).
[CrossRef]

Sattar, F.

F. Sattar, L. Floreby, G. Salomonsson, and B. Lovstrom, IEEE Trans. Image Process. 6, 888 (1997).
[CrossRef]

Schmitt, J. M.

J. M. Schmitt, S. H. Xiang, and K. M. Yung, J. Biomed. Opt. 4, 95 (1999).
[CrossRef] [PubMed]

Schuman, J. C.

D. Huang, E. A. Swanson, C. P. Lin, J. C. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Shidlovski, V.

Srinivasan, V. J.

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. C. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Swanson, E. A.

D. Huang, E. A. Swanson, C. P. Lin, J. C. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Tearney, G. J.

N. Iftimia, B. E. Bouma, and G. J. Tearney, J. Biomed. Opt. 8, 260 (2003).
[CrossRef] [PubMed]

Vetterli, M.

S. G. Chang, B. Yu, and M. Vetterli, IEEE Trans. Image Process 9, 1522 (2000).
[CrossRef]

Wojtkowski, M.

Xiang, S. H.

J. M. Schmitt, S. H. Xiang, and K. M. Yung, J. Biomed. Opt. 4, 95 (1999).
[CrossRef] [PubMed]

Yakubovich, S.

Yu, B.

S. G. Chang, B. Yu, and M. Vetterli, IEEE Trans. Image Process 9, 1522 (2000).
[CrossRef]

Yung, K. M.

J. M. Schmitt, S. H. Xiang, and K. M. Yung, J. Biomed. Opt. 4, 95 (1999).
[CrossRef] [PubMed]

IEEE Trans. Image Process (1)

S. G. Chang, B. Yu, and M. Vetterli, IEEE Trans. Image Process 9, 1522 (2000).
[CrossRef]

IEEE Trans. Image Process. (1)

F. Sattar, L. Floreby, G. Salomonsson, and B. Lovstrom, IEEE Trans. Image Process. 6, 888 (1997).
[CrossRef]

J. Biomed. Opt. (3)

J. M. Schmitt, S. H. Xiang, and K. M. Yung, J. Biomed. Opt. 4, 95 (1999).
[CrossRef] [PubMed]

N. Iftimia, B. E. Bouma, and G. J. Tearney, J. Biomed. Opt. 8, 260 (2003).
[CrossRef] [PubMed]

M. Pircher, E. Gotzinger, R. Leitgeb, A. F. Fercher, and C. K. Hitzenberger, J. Biomed. Opt. 8, 565 (2003).
[CrossRef] [PubMed]

Opt. Express (2)

Phys. Med. Biol. (1)

J. Rogowska and M. E. Brezinski, Phys. Med. Biol. 47, 641 (2002).
[CrossRef] [PubMed]

Science (1)

D. Huang, E. A. Swanson, C. P. Lin, J. C. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Other (2)

H. Choi, T. E. Milner, and A. C. Bovik, presented at A New Beginning for Human Health: Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Cancun Mexico, September 17–21, 2003.

R. R. Coifman and D. L. Donoho, Translation Invariant Denoising (Springer-Verlag, Berlin, 1994).

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Figures (3)

Fig. 1
Fig. 1

Measured SNR improvement and sharpness degradation of a representative TD ophthalmic OCT image as K is varied from 0.5 to 5. The maximum SNR is achieved with K=4, with sharpness degraded by 3%.

Fig. 2
Fig. 2

Wavelet denoising of a TD OCT retinal image taken with a broadband superluminescent diode source. The image has 600×500 (axial × transverse) pixels with 3.2µm axial resolution. Top, original image with ROIs overlaid in white. Middle, image after pixel thresholding. Bottom, image after wavelet denoising with K=4. The SNR is improved by 7.05 dB.

Fig. 3
Fig. 3

Wavelet denoising of an FD OCT retinal image taken with a Ti:sapphire light source. The image has 500×500 (axial × transverse) pixels with 2.1µm axial resolution. Top, image after pixel thresholding. Bottom, image after wavelet denoising with K=9. The SNR is improved by 4.85 dB.

Tables (1)

Tables Icon

Table 1 Image Quality Metrics for TD Images

Metrics