Abstract

Ultrasound-modulated optical tomography is a dual-wave sensing technique in which diffusive light in a turbid medium interacts with an imposed acoustic field. A phase-modulated photon field emanates from the interaction region and carries with it information about the optomechanical properties of the medium. We present a technique for detection of ultrasound-induced optical phase modulation using an adaptive, photorefractive-crystal-based interferometry system. Experimental results are presented demonstrating detection of ultrasound-modulated signals in highly scattering media by use of pulsed ultrasound insonation.

© 2004 Optical Society of America

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References

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2003

2001

L. V. Wang, Phys. Rev. Lett. 87, 043903 (2001).
[CrossRef]

2000

1999

1998

L. Wang and G. Ku, Opt. Lett. 23, 975 (1998).
[CrossRef]

1997

1995

L. Wang, S. L. Jacques, and X. Zhao, Opt. Lett. 20, 629 (1995).
[CrossRef] [PubMed]

P. Delaye, L. A. Montmorillon, and G. Roosen, Opt. Commun. 118, 154 (1995).
[CrossRef]

1993

F. A. Marks, H. W. Tomlinson, and G. W. Brooksy, Proc. SPIE 1888, 500 (1993).
[CrossRef]

1991

R. K. Ing and J. P. Monchalin, Appl. Phys. Lett. 59, 3233 (1991).
[CrossRef]

1981

Boccara, A. C.

Brooksy, G. W.

F. A. Marks, H. W. Tomlinson, and G. W. Brooksy, Proc. SPIE 1888, 500 (1993).
[CrossRef]

Delaye, P.

P. Delaye, L. A. Montmorillon, and G. Roosen, Opt. Commun. 118, 154 (1995).
[CrossRef]

Dolfi, D.

D. Dolfi and F. Micheron, “Imaging process and system for transillumination with photon frequency marking,” international patent WO 89/00278 (January 12, 1989).

Genack, A. Z.

Huignard, J. P.

Ing, R. K.

R. K. Ing and J. P. Monchalin, Appl. Phys. Lett. 59, 3233 (1991).
[CrossRef]

Jacques, S. L.

Kempe, M.

Krishnaswamy, S.

Ku, G.

L. Wang and G. Ku, Opt. Lett. 23, 975 (1998).
[CrossRef]

Larionov, M.

Lebec, M.

Lev, A.

Leveque, S.

Marks, F. A.

F. A. Marks, H. W. Tomlinson, and G. W. Brooksy, Proc. SPIE 1888, 500 (1993).
[CrossRef]

Marrakchi, A.

Melloch, M. R.

Micheron, F.

D. Dolfi and F. Micheron, “Imaging process and system for transillumination with photon frequency marking,” international patent WO 89/00278 (January 12, 1989).

Monchalin, J. P.

R. K. Ing and J. P. Monchalin, Appl. Phys. Lett. 59, 3233 (1991).
[CrossRef]

Montmorillon, L. A.

P. Delaye, L. A. Montmorillon, and G. Roosen, Opt. Commun. 118, 154 (1995).
[CrossRef]

Murray, T. W.

Nolte, D. D.

Roosen, G.

P. Delaye, L. A. Montmorillon, and G. Roosen, Opt. Commun. 118, 154 (1995).
[CrossRef]

Saint-Jalmes, H.

Sfez, B. G.

Tomlinson, H. W.

F. A. Marks, H. W. Tomlinson, and G. W. Brooksy, Proc. SPIE 1888, 500 (1993).
[CrossRef]

Tuchin, V. V.

V. V. Tuchin, Handbook of Optical Biomedical Diagnostics (SPIE Press, Bellingham, Wash., 2002).

Tuovinen, H.

Wang, L.

Wang, L. V.

L. V. Wang, Phys. Rev. Lett. 87, 043903 (2001).
[CrossRef]

Yu, P.

Zaslavsky, D.

Zhao, X.

Appl. Opt.

Appl. Phys. Lett.

R. K. Ing and J. P. Monchalin, Appl. Phys. Lett. 59, 3233 (1991).
[CrossRef]

J. Opt. Soc. Am. A

Opt. Lett.

L. Wang and G. Ku, Opt. Lett. 23, 975 (1998).
[CrossRef]

Opt. Commun.

P. Delaye, L. A. Montmorillon, and G. Roosen, Opt. Commun. 118, 154 (1995).
[CrossRef]

Opt. Lett.

Phys. Rev. Lett.

L. V. Wang, Phys. Rev. Lett. 87, 043903 (2001).
[CrossRef]

Proc. SPIE

F. A. Marks, H. W. Tomlinson, and G. W. Brooksy, Proc. SPIE 1888, 500 (1993).
[CrossRef]

Other

D. Dolfi and F. Micheron, “Imaging process and system for transillumination with photon frequency marking,” international patent WO 89/00278 (January 12, 1989).

V. V. Tuchin, Handbook of Optical Biomedical Diagnostics (SPIE Press, Bellingham, Wash., 2002).

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Figures (3)

Fig. 1
Fig. 1

Experimental setup for PRC-based detection of ultrasound-modulated optical signals: VBS, variable beam splitter; RB, reference beam; SB, signal beam; BPF, optical bandpass filter; HV, high-voltage; APD, avalanche photodiode.

Fig. 2
Fig. 2

Experimental results showing (a) ultrasound focal pressure and (b) optical signal observed without a reference beam on the PRC (top) and with a reference beam (bottom).

Fig. 3
Fig. 3

Modulation depth of the envelope signal observed as the transducer is scanned across a 10-mm-diameter optical inhomogeneity buried in a tissue phantom.

Equations (3)

Equations on this page are rendered with MathJax. Learn more.

Ise=exp-αLIsoexpγL-12+1+2 ReexpγL-1*expiϕa sinωat+χr,
Isedc=exp-αLIsoexpγL-12+1+2expγLcosγL-1J0ϕa,
Iseac=4 exp-αLIso expγL×sinγLJ1ϕasinωat+χr.

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