Abstract

Ultrasound-modulated optical tomography is a dual-wave sensing technique in which diffusive light in a turbid medium interacts with an imposed acoustic field. A phase-modulated photon field emanates from the interaction region and carries with it information about the optomechanical properties of the medium. We present a technique for detection of ultrasound-induced optical phase modulation using an adaptive, photorefractive-crystal-based interferometry system. Experimental results are presented demonstrating detection of ultrasound-modulated signals in highly scattering media by use of pulsed ultrasound insonation.

© 2004 Optical Society of America

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References

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2003 (2)

2001 (1)

L. V. Wang, Phys. Rev. Lett. 87, 043903 (2001).
[Crossref]

2000 (1)

1999 (1)

1998 (1)

1997 (1)

1995 (2)

L. Wang, S. L. Jacques, and X. Zhao, Opt. Lett. 20, 629 (1995).
[Crossref] [PubMed]

P. Delaye, L. A. Montmorillon, and G. Roosen, Opt. Commun. 118, 154 (1995).
[Crossref]

1993 (1)

F. A. Marks, H. W. Tomlinson, and G. W. Brooksy, Proc. SPIE 1888, 500 (1993).
[Crossref]

1991 (1)

R. K. Ing and J. P. Monchalin, Appl. Phys. Lett. 59, 3233 (1991).
[Crossref]

1981 (1)

Boccara, A. C.

Brooksy, G. W.

F. A. Marks, H. W. Tomlinson, and G. W. Brooksy, Proc. SPIE 1888, 500 (1993).
[Crossref]

Delaye, P.

P. Delaye, L. A. Montmorillon, and G. Roosen, Opt. Commun. 118, 154 (1995).
[Crossref]

Dolfi, D.

D. Dolfi and F. Micheron, “Imaging process and system for transillumination with photon frequency marking,” international patentWO 89/00278 (January12, 1989).

Genack, A. Z.

Huignard, J. P.

Ing, R. K.

R. K. Ing and J. P. Monchalin, Appl. Phys. Lett. 59, 3233 (1991).
[Crossref]

Jacques, S. L.

Kempe, M.

Krishnaswamy, S.

Ku, G.

Larionov, M.

Lebec, M.

Lev, A.

Leveque, S.

Marks, F. A.

F. A. Marks, H. W. Tomlinson, and G. W. Brooksy, Proc. SPIE 1888, 500 (1993).
[Crossref]

Marrakchi, A.

Melloch, M. R.

Micheron, F.

D. Dolfi and F. Micheron, “Imaging process and system for transillumination with photon frequency marking,” international patentWO 89/00278 (January12, 1989).

Monchalin, J. P.

R. K. Ing and J. P. Monchalin, Appl. Phys. Lett. 59, 3233 (1991).
[Crossref]

Montmorillon, L. A.

P. Delaye, L. A. Montmorillon, and G. Roosen, Opt. Commun. 118, 154 (1995).
[Crossref]

Murray, T. W.

Nolte, D. D.

Roosen, G.

P. Delaye, L. A. Montmorillon, and G. Roosen, Opt. Commun. 118, 154 (1995).
[Crossref]

Saint-Jalmes, H.

Sfez, B. G.

Tomlinson, H. W.

F. A. Marks, H. W. Tomlinson, and G. W. Brooksy, Proc. SPIE 1888, 500 (1993).
[Crossref]

Tuchin, V. V.

V. V. Tuchin, Handbook of Optical Biomedical Diagnostics (SPIE Press, Bellingham, Wash., 2002).

Tuovinen, H.

Wang, L.

Wang, L. V.

L. V. Wang, Phys. Rev. Lett. 87, 043903 (2001).
[Crossref]

Yu, P.

Zaslavsky, D.

Zhao, X.

Appl. Opt. (1)

Appl. Phys. Lett. (1)

R. K. Ing and J. P. Monchalin, Appl. Phys. Lett. 59, 3233 (1991).
[Crossref]

J. Opt. Soc. Am. A (1)

Opt. Commun. (1)

P. Delaye, L. A. Montmorillon, and G. Roosen, Opt. Commun. 118, 154 (1995).
[Crossref]

Opt. Lett. (6)

Phys. Rev. Lett. (1)

L. V. Wang, Phys. Rev. Lett. 87, 043903 (2001).
[Crossref]

Proc. SPIE (1)

F. A. Marks, H. W. Tomlinson, and G. W. Brooksy, Proc. SPIE 1888, 500 (1993).
[Crossref]

Other (2)

V. V. Tuchin, Handbook of Optical Biomedical Diagnostics (SPIE Press, Bellingham, Wash., 2002).

D. Dolfi and F. Micheron, “Imaging process and system for transillumination with photon frequency marking,” international patentWO 89/00278 (January12, 1989).

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Figures (3)

Fig. 1
Fig. 1

Experimental setup for PRC-based detection of ultrasound-modulated optical signals: VBS, variable beam splitter; RB, reference beam; SB, signal beam; BPF, optical bandpass filter; HV, high-voltage; APD, avalanche photodiode.

Fig. 2
Fig. 2

Experimental results showing (a) ultrasound focal pressure and (b) optical signal observed without a reference beam on the PRC (top) and with a reference beam (bottom).

Fig. 3
Fig. 3

Modulation depth of the envelope signal observed as the transducer is scanned across a 10-mm-diameter optical inhomogeneity buried in a tissue phantom.

Equations (3)

Equations on this page are rendered with MathJax. Learn more.

Ise=exp-αLIsoexpγL-12+1+2 ReexpγL-1*expiϕa sinωat+χr,
Isedc=exp-αLIsoexpγL-12+1+2expγLcosγL-1J0ϕa,
Iseac=4 exp-αLIso expγL×sinγLJ1ϕasinωat+χr.

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