Abstract

We demonstrate highly efficient evanescent-wave detection of fluorophore-labeled biomolecules in aqueous solutions positioned in the air holes of the microstructured part of a photonic crystal fiber. The air-suspended silica structures located between three neighboring air holes in the cladding crystal guide light with a large fraction of the optical field penetrating into the sample even at wavelengths in the visible range. An effective interaction length of several centimeters is obtained when a sample volume of less than 1 µL is used.

© 2004 Optical Society of America

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References

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  1. J. C. Knight, T. A. Birks, P. St. J. Russell, and D. M. Atkin, Opt. Lett. 21, 1547 (1996).
    [CrossRef] [PubMed]
  2. T. M. Monro, D. J. Richardson, and P. J. Bennett, Electron. Lett. 35, 1188 (1999).
    [CrossRef]
  3. Y. L. Hoo, W. Jin, C. Shi, H. L. Ho, D. N. Wang, and S. C. Ruan, Appl. Opt. 42, 3509 (2003).
    [CrossRef] [PubMed]
  4. J. B. Jensen, L. H. Pedersen, A. Carlsen, P. E. Hoiby, L. B. Nielsen, A. Bjarklev, and T. P. Hansen, in Conference on Lasers and Electro Optics, Vol. 89 of OSA Trends in Optics and Photonics Series (Optical Society of America, Washington, D.C., 2003), paper CTuP5.
  5. S. G. Johnson and J. D. Joannopoulos, Opt. Express 8, 173 (2001), http://www.opticsexpress.org .
    [CrossRef] [PubMed]
  6. P. N. Prasad, Introduction to Biophotonics (Wiley, New York, 2003), p. 105.

2003 (1)

2001 (1)

1999 (1)

T. M. Monro, D. J. Richardson, and P. J. Bennett, Electron. Lett. 35, 1188 (1999).
[CrossRef]

1996 (1)

Atkin, D. M.

Bennett, P. J.

T. M. Monro, D. J. Richardson, and P. J. Bennett, Electron. Lett. 35, 1188 (1999).
[CrossRef]

Birks, T. A.

Bjarklev, A.

J. B. Jensen, L. H. Pedersen, A. Carlsen, P. E. Hoiby, L. B. Nielsen, A. Bjarklev, and T. P. Hansen, in Conference on Lasers and Electro Optics, Vol. 89 of OSA Trends in Optics and Photonics Series (Optical Society of America, Washington, D.C., 2003), paper CTuP5.

Carlsen, A.

J. B. Jensen, L. H. Pedersen, A. Carlsen, P. E. Hoiby, L. B. Nielsen, A. Bjarklev, and T. P. Hansen, in Conference on Lasers and Electro Optics, Vol. 89 of OSA Trends in Optics and Photonics Series (Optical Society of America, Washington, D.C., 2003), paper CTuP5.

Hansen, T. P.

J. B. Jensen, L. H. Pedersen, A. Carlsen, P. E. Hoiby, L. B. Nielsen, A. Bjarklev, and T. P. Hansen, in Conference on Lasers and Electro Optics, Vol. 89 of OSA Trends in Optics and Photonics Series (Optical Society of America, Washington, D.C., 2003), paper CTuP5.

Ho, H. L.

Hoiby, P. E.

J. B. Jensen, L. H. Pedersen, A. Carlsen, P. E. Hoiby, L. B. Nielsen, A. Bjarklev, and T. P. Hansen, in Conference on Lasers and Electro Optics, Vol. 89 of OSA Trends in Optics and Photonics Series (Optical Society of America, Washington, D.C., 2003), paper CTuP5.

Hoo, Y. L.

Jensen, J. B.

J. B. Jensen, L. H. Pedersen, A. Carlsen, P. E. Hoiby, L. B. Nielsen, A. Bjarklev, and T. P. Hansen, in Conference on Lasers and Electro Optics, Vol. 89 of OSA Trends in Optics and Photonics Series (Optical Society of America, Washington, D.C., 2003), paper CTuP5.

Jin, W.

Joannopoulos, J. D.

Johnson, S. G.

Knight, J. C.

Monro, T. M.

T. M. Monro, D. J. Richardson, and P. J. Bennett, Electron. Lett. 35, 1188 (1999).
[CrossRef]

Nielsen, L. B.

J. B. Jensen, L. H. Pedersen, A. Carlsen, P. E. Hoiby, L. B. Nielsen, A. Bjarklev, and T. P. Hansen, in Conference on Lasers and Electro Optics, Vol. 89 of OSA Trends in Optics and Photonics Series (Optical Society of America, Washington, D.C., 2003), paper CTuP5.

Pedersen, L. H.

J. B. Jensen, L. H. Pedersen, A. Carlsen, P. E. Hoiby, L. B. Nielsen, A. Bjarklev, and T. P. Hansen, in Conference on Lasers and Electro Optics, Vol. 89 of OSA Trends in Optics and Photonics Series (Optical Society of America, Washington, D.C., 2003), paper CTuP5.

Prasad, P. N.

P. N. Prasad, Introduction to Biophotonics (Wiley, New York, 2003), p. 105.

Richardson, D. J.

T. M. Monro, D. J. Richardson, and P. J. Bennett, Electron. Lett. 35, 1188 (1999).
[CrossRef]

Ruan, S. C.

Russell, P. St. J.

Shi, C.

Wang, D. N.

Appl. Opt. (1)

Electron. Lett. (1)

T. M. Monro, D. J. Richardson, and P. J. Bennett, Electron. Lett. 35, 1188 (1999).
[CrossRef]

Opt. Express (1)

Opt. Lett. (1)

Other (2)

J. B. Jensen, L. H. Pedersen, A. Carlsen, P. E. Hoiby, L. B. Nielsen, A. Bjarklev, and T. P. Hansen, in Conference on Lasers and Electro Optics, Vol. 89 of OSA Trends in Optics and Photonics Series (Optical Society of America, Washington, D.C., 2003), paper CTuP5.

P. N. Prasad, Introduction to Biophotonics (Wiley, New York, 2003), p. 105.

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Figures (2)

Fig. 1
Fig. 1

a, Micrograph of the microstructured part of the SP-PCF. b, Close-up of the white-outlined section in a, showing the air-suspended corelike structures in the cladding crystal. c, Micrograph of the fiber with the entire cladding crystal illuminated from the opposite fiber end. d, Field distribution in the sample-filled fiber calculated with the plane-wave method.5 e, f, Mode field profiles calculated along the dotted lines shown in the respective insets.

Fig. 2
Fig. 2

Transmission spectra of SP-PCFs with a 5µM Cy5-labeled DNA solution (solid curve) and pure water for reference (dashed curve), respectively. Inset, derived absorbance in the sample containing the Cy5-labeled DNA solution.

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